Sandra Citi

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. doi request reprint The tight junction protein cingulin regulates gene expression and RhoA signaling
    Sandra Citi
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Ann N Y Acad Sci 1165:88-98. 2009
  2. doi request reprint Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex
    Sandra Citi
    Department of Molecular Biology, University of Geneva, Switzerland
    Ann N Y Acad Sci 1257:125-32. 2012
  3. doi request reprint Regulation of small GTPases at epithelial cell-cell junctions
    Sandra Citi
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Mol Membr Biol 28:427-44. 2011
  4. pmc A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells
    Pamela Pulimeno
    Department of Molecular Biology, University of Geneva, 4 Boulevard d Yvoy, 1205 Geneva, Switzerland
    J Biol Chem 286:16743-50. 2011
  5. doi request reprint Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions
    Serge Paschoud
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Mol Membr Biol 28:123-35. 2011
  6. pmc Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    Mol Biol Cell 19:4442-53. 2008
  7. pmc Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly
    Serge Paschoud
    Department of Molecular Biology, University of Geneva, 4 Boulevard d Yvoy, 1205 Geneva, Switzerland
    J Biol Chem 287:13159-69. 2012
  8. pmc PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin
    Pamela Pulimeno
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    PLoS ONE 5:e12207. 2010
  9. doi request reprint Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    J Cell Sci 125:5005-14. 2012
  10. ncbi request reprint Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression
    Serge Paschoud
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Mol Membr Biol 25:1-13. 2008

Collaborators

  • Ignazio Castagliuolo
  • Daniela Pizzuti
  • Paola Brun
  • P Meda
  • Laurent Guillemot
  • Serge Paschoud
  • Pamela Pulimeno
  • Lionel Jond
  • Domenica Spadaro
  • Fabio D'Atri
  • Massimo Bongiovanni
  • Andrea Foglia
  • Christoph Bauer
  • Mauro Bordin
  • Yann Schneider
  • Diego Martines
  • Rocio Tapia
  • Jerrold R Turner
  • Dan Yu
  • Jeffrey Stutz
  • Jean Claude Pache
  • Jorge Ritz
  • Dorothee Caille
  • Christian Kaister
  • Eva Hammar
  • Fabio Nadalutti

Detail Information

Publications19

  1. doi request reprint The tight junction protein cingulin regulates gene expression and RhoA signaling
    Sandra Citi
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Ann N Y Acad Sci 1165:88-98. 2009
    ..These results extend our previous studies and provide new perspectives for the mechanistic analysis of cingulin function...
  2. doi request reprint Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex
    Sandra Citi
    Department of Molecular Biology, University of Geneva, Switzerland
    Ann N Y Acad Sci 1257:125-32. 2012
    ....
  3. doi request reprint Regulation of small GTPases at epithelial cell-cell junctions
    Sandra Citi
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Mol Membr Biol 28:427-44. 2011
    ..Understanding these mechanisms will help to clarify at the molecular level how small GTPases control the morphogenesis and physiology of epithelial tissues, and how they are disregulated in disease...
  4. pmc A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells
    Pamela Pulimeno
    Department of Molecular Biology, University of Geneva, 4 Boulevard d Yvoy, 1205 Geneva, Switzerland
    J Biol Chem 286:16743-50. 2011
    ..In summary, we characterize ZO-1 and PLEKHA7 as paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively...
  5. doi request reprint Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions
    Serge Paschoud
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Mol Membr Biol 28:123-35. 2011
    ..In summary, cingulin and paracingulin show a similar dynamic behaviour, but partially distinct localizations and functional interactions with the cytoskeleton, and are recruited independently to junctions...
  6. pmc Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    Mol Biol Cell 19:4442-53. 2008
    ..Our results provide the first description of a junctional protein that interacts with GEFs for both Rac1 and RhoA, and identify a novel molecular mechanism whereby Rac1 is activated during junction formation...
  7. pmc Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly
    Serge Paschoud
    Department of Molecular Biology, University of Geneva, 4 Boulevard d Yvoy, 1205 Geneva, Switzerland
    J Biol Chem 287:13159-69. 2012
    ..In summary, we characterize the functionally important domains of paracingulin that distinguish it from cingulin...
  8. pmc PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin
    Pamela Pulimeno
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    PLoS ONE 5:e12207. 2010
    ....
  9. doi request reprint Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    J Cell Sci 125:5005-14. 2012
    ....
  10. ncbi request reprint Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression
    Serge Paschoud
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Mol Membr Biol 25:1-13. 2008
    ..These results suggest that compensatory mechanisms prevent dominant-negative effects in this model system, and that modulation of cellular functions by cingulin occurs within physiological protein levels...
  11. pmc Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    Mol Biol Cell 17:3569-77. 2006
    ..These results provide novel insights about the mechanisms of cingulin function and the signaling pathways controlling claudin-2 expression in MDCK cells...
  12. ncbi request reprint Histone deacetylase inhibitors up-regulate the expression of tight junction proteins
    Mauro Bordin
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Mol Cancer Res 2:692-701. 2004
    ..These results indicate that cellular differentiation correlates with kinase-dependent up-regulation of the expression of specific TJ proteins...
  13. pmc The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    PLoS ONE 8:e55873. 2013
    ....
  14. ncbi request reprint Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    J Cell Sci 117:5245-56. 2004
    ..Thus, lack of junctional cingulin does not prevent tight-junction formation, but gene expression and tight junction protein levels are altered by the cingulin mutation...
  15. doi request reprint The cytoplasmic plaque of tight junctions: a scaffolding and signalling center
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, Switzerland
    Biochim Biophys Acta 1778:601-13. 2008
    ..Analysis of knockdown and knockout model systems shows that several TJ proteins are essential for the formation of epithelial tissues and early embryonic development, whereas others appear to have redundant functions...
  16. ncbi request reprint Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas
    Serge Paschoud
    Department of Molecular Biology, Faculty of Sciences, University of Geneva, Geneva, Switzerland
    Mod Pathol 20:947-54. 2007
    ..These results indicate that characterization of tight junction protein expression in human lung tumors can be an additional diagnostic tool and provide new insights on their histogenesis...
  17. doi request reprint The control of gene expression and cell proliferation by the epithelial apical junctional complex
    Domenica Spadaro
    Department of Molecular Biology, University of Geneva, 4 Boulevard d Yvoy, CH 1211 4 Geneva, Switzerland
    Essays Biochem 53:83-93. 2012
    ..The interplay between junctional protein complexes, the actin cytoskeleton and signalling pathways is of crucial importance in the regulation of gene expression and cell proliferation...
  18. ncbi request reprint Molecular complexity of vertebrate tight junctions (Review)
    Fabio D'Atri
    Department of Molecular Biology, University of Geneva, Switzerland
    Mol Membr Biol 19:103-12. 2002
    ..How these molecules functionally interact to provide TJ with their functions, and what roles these molecules play in control of cell growth and differentiation is a fundamental problem in cell biology...
  19. ncbi request reprint Evidence for a functional interaction between cingulin and ZO-1 in cultured cells
    Fabio D'Atri
    Department of Molecular Biology, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 277:27757-64. 2002
    ....