Research Topics
Genomes and Genes | Gerhard ChristoforiSummaryAffiliation: University of Basel Country: Switzerland Publications
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Publications
Distinct mechanisms of tumor invasion and metastasisMahmut Yilmaz
Department of Clinical Biological Sciences, Center for Biomedicine, University of Basel, Switzerland
Trends Mol Med 13:535-41. 2007..Understanding the distinct mechanisms used by cancer cells to form metastasis will enable better patient evaluation and the design of innovative therapeutic approaches...
NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherinFrancois Lehembre
Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
EMBO J 27:2603-15. 2008..These results establish a mechanistic link between the loss of E-cadherin expression, NCAM function, focal adhesion assembly and cell migration and invasion...- Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progressionGerhard Christofori
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Vesalgasse 1, Switzerland
EMBO J 22:2318-23. 2003..This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy... - New signals from the invasive frontGerhard Christofori
Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Nature 441:444-50. 2006.... - Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasisLucie Kopfstein
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Center of Biomedicine, Mattenstrasse 28, CH 4058 Basel, Switzerland
Am J Pathol 170:1348-61. 2007.... 
Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesisTibor Schomber
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Mol Cancer Ther 8:55-63. 2009....- Myeloid cells contribute to tumor lymphangiogenesisAdrian Zumsteg
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
PLoS ONE 4:e7067. 2009..Together, the results reveal that myeloid cells can contribute to tumor-associated lymphatic vessels, thus extending the findings on the previously reported role of hematopoietic cells in lymphatic vessel formation... - A bioluminescent mouse model of pancreatic {beta}-cell carcinogenesisAdrian Zumsteg
Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Switzerland
Carcinogenesis 31:1465-74. 2010.... - Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4Fabienne Jäggi
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Basel, Switzerland
Mol Cancer Res 6:468-82. 2008..In contrast, transgenic expression of mSpry4 during beta-cell carcinogenesis does not significantly affect tumor outgrowth and progression to tumor malignancy. Rather, tumor cells seem to escape mSpry4 transgene expression... - EMT, the cytoskeleton, and cancer cell invasionMahmut Yilmaz
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
Cancer Metastasis Rev 28:15-33. 2009..In this review, we have summarized recent novel insights into the molecular processes and players underlying EMT on one side and the formation of invasive membrane protrusions on the other side... - Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinomaAdrian Zumsteg
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel 4058, Switzerland
Mol Cancer Res 10:800-9. 2012..The reduction of tumor invasion upon IGF1R blockade on the other hand indicates a critical function of IGF1R signaling for the acquisition of a malignant phenotype... - Placental growth factor-1 attenuates vascular endothelial growth factor-A-dependent tumor angiogenesis during beta cell carcinogenesisTibor Schomber
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Basel, Switzerland
Cancer Res 67:10840-8. 2007.... - Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin functionAngelika Kren
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
EMBO J 26:2832-42. 2007..The results indicate a critical role of beta(1)-integrin function in mediating metastatic dissemination and preventing tumor cell senescence... - Mechanisms of motility in metastasizing cellsMahmut Yilmaz
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Mol Cancer Res 8:629-42. 2010..The molecular mechanisms defining the different modes of cancer cell migration remain in most parts to be delineated... - Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesisImke Albrecht
Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
PLoS ONE 5:e14109. 2010..Herein, we investigate the function of VEGF-B by the generation of mouse models of cancer with transgenic expression of VEGF-B or homozygous deletion of Vegfb... - Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of SnailStefan Grotegut
Department of Clinical Biological Sciences, Institute of Biochemistry and Genetics, Center of Biomedicine, University of Basel, Basel, Switzerland
EMBO J 25:3534-45. 2006..These findings indicate that Snail upregulation by HGF is mediated via the MAPK/Egr-1 signaling pathway and that both Snail and Egr-1 play a critical role in HGF-induced cell scattering, migration, and invasion... - Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic miceBirgit Schaffhauser
Department of Clinical Biological Sciences, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
J Leukoc Biol 80:669-76. 2006..These results have important implications about the modes of delivery used in antiangiogenic, therapeutic strategies, which are based on the antiangiogenic activities of ES... - EMT as the ultimate survival mechanism of cancer cellsNeha Tiwari
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
Semin Cancer Biol 22:194-207. 2012..Notably, EMT seems to play a critical role in the generation and maintenance of cancer stem cells, highly consistent with the notion that metastatic cells carry the ability to initiate new tumors... - Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesisErnesta Fagiani
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
Cancer Res 71:5717-27. 2011..The poor perfusion of immature blood vessels results in retarded tumor growth, defining an important pathophysiologic pathway required for efficient tumorigenesis... - Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeletonAndreas Wicki
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, 4058 Basel, Switzerland
Cancer Cell 9:261-72. 2006..In conclusion, podoplanin induces an alternative pathway of tumor cell invasion in the absence of epithelial-mesenchymal transition (EMT)... - Molecular mechanisms of lymphangiogenesis in development and cancerImke Albrecht
Department of Biomedicine, University of Basel, Basel, Switzerland
Int J Dev Biol 55:483-94. 2011..Therefore, the specific targeting of the lymphatic vasculature at the tumor site could be a promising approach to prevent metastasis formation... - Metastatic colon cancer cells negotiate the intravasation notchGerhard Christofori
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Cancer Cell 19:6-8. 2011..Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis... - Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesisIvana Crnic
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Basel, Switzerland
Cancer Res 64:8630-8. 2004..These results also establish Rip1Tag2;NCAM-deficient mice as a unique model for stochastic, endogenous tumor lymphangiogenesis and lymph node metastasis in immunocompetent mice... - The angiogenic switch in carcinogenesisVanessa Baeriswyl
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Semin Cancer Biol 19:329-37. 2009..These experiments have provided first important concepts to improve anti-angiogenic therapy and thus directly contribute to their translation to the clinical setting... - Novel technologies and recent advances in metastasis researchIvana Crnic
Institute of Biochemistry and Genetics, Department of Clinical-Biological Sciences, University of Basel, CH-4051 Basel, Switzerland
Int J Dev Biol 48:573-81. 2004..Fashionable as scientists are, this new endeavor may be called systems biology... - Mouse models of breast cancer metastasisAnna Fantozzi
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences DKBW, Center of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Breast Cancer Res 8:212. 2006.... - [Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinomaAndreas Wicki
Institute of Biochemistry and Genetics, DKBW, Medical School, University of Basel, Basel, Switzerland
Clin Cancer Res 13:3696-705. 2007..In this study, we investigated the therapeutic potential of [Lys(40)(Ahx-DTPA-(111)In)NH(2)]-Exendin-4, an (111)In-labeled agonist of GLP-1, in a transgenic mouse model of human insulinoma... - Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8)Neha Tiwari
Department of Biomedicine, University of Basel, Basel, Switzerland
PLoS ONE 8:e57329. 2013..The data demonstrate a central role of Klf4 in the maintenance of epithelial cell differentiation and the prevention of EMT and metastasis... - Angiopoietins in angiogenesisErnesta Fagiani
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
Cancer Lett 328:18-26. 2013..Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer... - Corrupt policemen: inflammatory cells promote tumor angiogenesisAdrian Zumsteg
Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
Curr Opin Oncol 21:60-70. 2009.... - Targeting tumor-associated endothelial cells: anti-VEGFR2 immunoliposomes mediate tumor vessel disruption and inhibit tumor growthAndreas Wicki
Division of Oncology, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
Clin Cancer Res 18:454-64. 2012..Accordingly, therapeutic approaches against the VEGF/VEGFR2 signaling axis have been designed. However, an efficient and specific chemotherapeutic targeting of tumor-associated endothelial cells has not yet been achieved... - Myeloid cells and lymphangiogenesisAdrian Zumsteg
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, CH 4058 Basel, Switzerland
Cold Spring Harb Perspect Med 2:a006494. 2012..Here, we present an overview of the current understanding of how lymphatic vessels and the hematopoietic system, in particular myeloid cells, interact during embryonic development, in normal organ physiology, and in disease... - Sprouty proteins, masterminds of receptor tyrosine kinase signalingMiguel A Cabrita
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland
Angiogenesis 11:53-62. 2008..This review describes Spry functions in the context of endothelial biology and angiogenesis, and provides an update on Spry-interacting proteins and Spry mechanisms of action... - Multitasking in tumor progression: signaling functions of cell adhesion moleculesUgo Cavallaro
Institute of Biochemistry and Genetics, Department of Clinical-Biological Sciences, University of Basel, Vesalgasse 1, CH - 4051 Basel, Switzerland
Ann N Y Acad Sci 1014:58-66. 2004.... - [Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targetingDamian Wild
Clinic and Institute of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
J Nucl Med 47:2025-33. 2006..In addition, Rip1Tag2 transgenic mice represent a suitable animal tumor model for GLP-1 receptor targeting... - Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CTDamian Wild
Clinic and Institute of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
J Nucl Med 51:1059-67. 2010..The aim of this study was the preclinical evaluation of [Lys(40)(Ahx-DOTA-(68)Ga)NH(2)]-exendin-4 for PET/CT and [Lys(40)(Ahx-hydrazinonicotinamide [HYNIC]-(99m)Tc)NH(2)]-exendin-4 for SPECT/CT... - Recent advances in cancer research: mouse models of tumorigenesisMichaela Herzig
Research Institute of Molecular Pathology, Vienna, Austria
Biochim Biophys Acta 1602:97-113. 2002..In particular, we focus on transgenic and knockout mouse models that closely mimic human cancer and thus can be used as model systems for cancer research... - Cell adhesion and signalling by cadherins and Ig-CAMs in cancerUgo Cavallaro
Institute of Biochemistry and Genetics, Department of Clincal-Biological Sciences, University of Basel. Switzerland
Nat Rev Cancer 4:118-32. 2004 - Cadherins and the tumour progression: is it all in a switch?Ugo Cavallaro
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Cancer Lett 176:123-8. 2002.... - Protein 4.1B in mouse islets of Langerhans and beta-cell tumorigenesisNobuo Terada
Department of Anatomy, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Tamaho, 409 3898 Yamanashi, Japan
Histochem Cell Biol 120:277-83. 2003..Therefore, we propose a role of protein 4.1B as a connecting and/or signaling molecule between membrane architecture, cell adhesion, and tumor cell invasion in mouse pancreatic endocrine cells... - Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancerGeert Berx
Department for Molecular Biomedical Research, Molecular and Cellular Oncology, VIB, Technologiepark 927, 9052, Ghent Zwijnaarde, Belgium
Clin Exp Metastasis 24:587-97. 2007..Finally we review the recent literature concerning the mechanisms that regulate EMT in the tumour context, with a particular focus on breast cancer... - The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumorsUlrike Fiedler
Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Strasse 117, D-79106 Freiburg, Germany
Am J Pathol 168:1045-53. 2006..The data warrant further exploration of CD34 in tumor-associated LECs as a prognostic tumor marker... - Overexpression of vascular endothelial growth factor-A165 enhances tumor angiogenesis but not metastasis during beta-cell carcinogenesisGrainne Gannon
Research Institute of Molecular Pathology, A 1030 Vienna, Austria
Cancer Res 62:603-8. 2002..Our findings indicate that in beta-cell tumorigenesis, overexpression of VEGF-A165 accelerates the onset of tumor angiogenesis and with it tumor progression but is not sufficient to induce tumor metastasis... - Neural cell adhesion molecule regulates the cellular response to fibroblast growth factorChiara Francavilla
IFOM FIRC Institute of Molecular Oncology, I 20139 Milano, Italy
J Cell Sci 120:4388-94. 2007.... - Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formationTuomas Tammela
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
Nature 454:656-60. 2008..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors... - Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid beta-cell tumorsFrancesca Galbiati
Department of Medicine, San Raffaele Scientific Institute, Milan 20132, Italy
Endocrinology 143:4018-30. 2002..Together, these findings provide the rationale for testing the efficacy of calcitriol in the treatment of patients with solid beta-cell tumors... - Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cellsFrancesca Galbiati
Division of General Medicine, Unit of Endocrinology and Metabolic Disease, San Raffaele Scientific Institute, 20132 Milan, Italy
Endocrinology 144:1832-41. 2003.... - Split personalities: the agonistic antagonist SproutyGerhard Christofori
Nat Cell Biol 5:377-9. 2003 - Temporal effects of Sprouty on lung morphogenesisAnne Karina T Perl
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Dev Biol 258:154-68. 2003..These findings demonstrate that the embryonic-pseudoglandular stage is a critical time period during which Spry-sensitive pathways are required for branching morphogenesis, lobulation, and formation of the peripheral lung parenchyma... - Cancer: division of labourGerhard Christofori
Nature 446:735-6. 2007