Gerhard Christofori

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Distinct mechanisms of tumor invasion and metastasis
    Mahmut Yilmaz
    Department of Clinical Biological Sciences, Center for Biomedicine, University of Basel, Switzerland
    Trends Mol Med 13:535-41. 2007
  2. pmc NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin
    Francois Lehembre
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
    EMBO J 27:2603-15. 2008
  3. pmc Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo
    Lorenz Waldmeier
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS ONE 7:e48651. 2012
  4. pmc Myeloid cells contribute to tumor lymphangiogenesis
    Adrian Zumsteg
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS ONE 4:e7067. 2009
  5. pmc Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8)
    Neha Tiwari
    Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS ONE 8:e57329. 2013
  6. pmc The potential role of podoplanin in tumour invasion
    A Wicki
    Department of Clinical Biological Sciences, Institute of Biochemistry and Genetics, Centre for Biomedicine, University of Basel, Basel, Switzerland
    Br J Cancer 96:1-5. 2007
  7. ncbi request reprint New signals from the invasive front
    Gerhard Christofori
    Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nature 441:444-50. 2006
  8. pmc Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression
    Gerhard Christofori
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Vesalgasse 1, Switzerland
    EMBO J 22:2318-23. 2003
  9. ncbi request reprint [Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma
    Andreas Wicki
    Institute of Biochemistry and Genetics, DKBW, Medical School, University of Basel, Basel, Switzerland
    Clin Cancer Res 13:3696-705. 2007
  10. doi request reprint Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis
    Imke Albrecht
    Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland
    Angiogenesis 16:795-807. 2013

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Distinct mechanisms of tumor invasion and metastasis
    Mahmut Yilmaz
    Department of Clinical Biological Sciences, Center for Biomedicine, University of Basel, Switzerland
    Trends Mol Med 13:535-41. 2007
    ..Understanding the distinct mechanisms used by cancer cells to form metastasis will enable better patient evaluation and the design of innovative therapeutic approaches...
  2. pmc NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin
    Francois Lehembre
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
    EMBO J 27:2603-15. 2008
    ..These results establish a mechanistic link between the loss of E-cadherin expression, NCAM function, focal adhesion assembly and cell migration and invasion...
  3. pmc Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo
    Lorenz Waldmeier
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS ONE 7:e48651. 2012
    ....
  4. pmc Myeloid cells contribute to tumor lymphangiogenesis
    Adrian Zumsteg
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS ONE 4:e7067. 2009
    ..Together, the results reveal that myeloid cells can contribute to tumor-associated lymphatic vessels, thus extending the findings on the previously reported role of hematopoietic cells in lymphatic vessel formation...
  5. pmc Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8)
    Neha Tiwari
    Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS ONE 8:e57329. 2013
    ..The data demonstrate a central role of Klf4 in the maintenance of epithelial cell differentiation and the prevention of EMT and metastasis...
  6. pmc The potential role of podoplanin in tumour invasion
    A Wicki
    Department of Clinical Biological Sciences, Institute of Biochemistry and Genetics, Centre for Biomedicine, University of Basel, Basel, Switzerland
    Br J Cancer 96:1-5. 2007
    ..Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion...
  7. ncbi request reprint New signals from the invasive front
    Gerhard Christofori
    Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nature 441:444-50. 2006
    ....
  8. pmc Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression
    Gerhard Christofori
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Vesalgasse 1, Switzerland
    EMBO J 22:2318-23. 2003
    ..This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy...
  9. ncbi request reprint [Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma
    Andreas Wicki
    Institute of Biochemistry and Genetics, DKBW, Medical School, University of Basel, Basel, Switzerland
    Clin Cancer Res 13:3696-705. 2007
    ..In this study, we investigated the therapeutic potential of [Lys(40)(Ahx-DTPA-(111)In)NH(2)]-Exendin-4, an (111)In-labeled agonist of GLP-1, in a transgenic mouse model of human insulinoma...
  10. doi request reprint Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis
    Imke Albrecht
    Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland
    Angiogenesis 16:795-807. 2013
    ..Similar to its function in neurons, it may link the cytoskeleton to the plasma membrane and thereby modulate lymphatic endothelial cell adhesion, migration and lymphangiogenesis. ..
  11. pmc Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis
    Lucie Kopfstein
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Center of Biomedicine, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Am J Pathol 170:1348-61. 2007
    ....
  12. doi request reprint Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis
    Tibor Schomber
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Mol Cancer Ther 8:55-63. 2009
    ....
  13. doi request reprint EMT, the cytoskeleton, and cancer cell invasion
    Mahmut Yilmaz
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Cancer Metastasis Rev 28:15-33. 2009
    ..In this review, we have summarized recent novel insights into the molecular processes and players underlying EMT on one side and the formation of invasive membrane protrusions on the other side...
  14. doi request reprint Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT
    Damian Wild
    Clinic and Institute of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
    J Nucl Med 51:1059-67. 2010
    ..The aim of this study was the preclinical evaluation of [Lys(40)(Ahx-DOTA-(68)Ga)NH(2)]-exendin-4 for PET/CT and [Lys(40)(Ahx-hydrazinonicotinamide [HYNIC]-(99m)Tc)NH(2)]-exendin-4 for SPECT/CT...
  15. doi request reprint A bioluminescent mouse model of pancreatic {beta}-cell carcinogenesis
    Adrian Zumsteg
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Switzerland
    Carcinogenesis 31:1465-74. 2010
    ....
  16. doi request reprint Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4
    Fabienne Jäggi
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Basel, Switzerland
    Mol Cancer Res 6:468-82. 2008
    ..In contrast, transgenic expression of mSpry4 during beta-cell carcinogenesis does not significantly affect tumor outgrowth and progression to tumor malignancy. Rather, tumor cells seem to escape mSpry4 transgene expression...
  17. ncbi request reprint Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton
    Andreas Wicki
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Cancer Cell 9:261-72. 2006
    ..In conclusion, podoplanin induces an alternative pathway of tumor cell invasion in the absence of epithelial-mesenchymal transition (EMT)...
  18. doi request reprint Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming
    Neha Tiwari
    Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Cancer Cell 23:768-83. 2013
    ..Our results identify Sox4 as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2...
  19. doi request reprint Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma
    Adrian Zumsteg
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel 4058, Switzerland
    Mol Cancer Res 10:800-9. 2012
    ..The reduction of tumor invasion upon IGF1R blockade on the other hand indicates a critical function of IGF1R signaling for the acquisition of a malignant phenotype...
  20. pmc Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function
    Angelika Kren
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
    EMBO J 26:2832-42. 2007
    ..The results indicate a critical role of beta(1)-integrin function in mediating metastatic dissemination and preventing tumor cell senescence...
  21. ncbi request reprint Placental growth factor-1 attenuates vascular endothelial growth factor-A-dependent tumor angiogenesis during beta cell carcinogenesis
    Tibor Schomber
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Basel, Switzerland
    Cancer Res 67:10840-8. 2007
    ....
  22. ncbi request reprint Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice
    Birgit Schaffhauser
    Department of Clinical Biological Sciences, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    J Leukoc Biol 80:669-76. 2006
    ..These results have important implications about the modes of delivery used in antiangiogenic, therapeutic strategies, which are based on the antiangiogenic activities of ES...
  23. doi request reprint Mechanisms of motility in metastasizing cells
    Mahmut Yilmaz
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Mol Cancer Res 8:629-42. 2010
    ..The molecular mechanisms defining the different modes of cancer cell migration remain in most parts to be delineated...
  24. ncbi request reprint VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation
    Anna Fantozzi
    Authors Affiliations Department of Biomedicine, University of Basel and Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Res 74:1566-75. 2014
    ..On the basis of these data, we propose a novel interpretation of the features of CSCs with EMT-induced, VEGF-A-mediated angiogenesis as the connecting mechanism between cancer cell stemness and tumor initiation...
  25. pmc Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
    Stefan Grotegut
    Department of Clinical Biological Sciences, Institute of Biochemistry and Genetics, Center of Biomedicine, University of Basel, Basel, Switzerland
    EMBO J 25:3534-45. 2006
    ..These findings indicate that Snail upregulation by HGF is mediated via the MAPK/Egr-1 signaling pathway and that both Snail and Egr-1 play a critical role in HGF-induced cell scattering, migration, and invasion...
  26. pmc Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis
    Imke Albrecht
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
    PLoS ONE 5:e14109. 2010
    ..Herein, we investigate the function of VEGF-B by the generation of mouse models of cancer with transgenic expression of VEGF-B or homozygous deletion of Vegfb...
  27. doi request reprint EMT as the ultimate survival mechanism of cancer cells
    Neha Tiwari
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Semin Cancer Biol 22:194-207. 2012
    ..Notably, EMT seems to play a critical role in the generation and maintenance of cancer stem cells, highly consistent with the notion that metastatic cells carry the ability to initiate new tumors...
  28. ncbi request reprint Novel technologies and recent advances in metastasis research
    Ivana Crnic
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, CH 4051 Basel, Switzerland
    Int J Dev Biol 48:573-81. 2004
    ..Fashionable as scientists are, this new endeavor may be called systems biology...
  29. ncbi request reprint Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis
    Ivana Crnic
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Basel, Switzerland
    Cancer Res 64:8630-8. 2004
    ..These results also establish Rip1Tag2;NCAM-deficient mice as a unique model for stochastic, endogenous tumor lymphangiogenesis and lymph node metastasis in immunocompetent mice...
  30. ncbi request reprint [Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting
    Damian Wild
    Clinic and Institute of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
    J Nucl Med 47:2025-33. 2006
    ..The goal of this study was to establish a tumor model for GLP-1 receptor targeting and to use a newly designed exendin-4-DTPA (DTPA is diethylenetriaminepentaacetic acid) conjugate for GLP-1 receptor targeting...
  31. pmc Myeloid cells and lymphangiogenesis
    Adrian Zumsteg
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, CH 4058 Basel, Switzerland
    Cold Spring Harb Perspect Med 2:a006494. 2012
    ..Here, we present an overview of the current understanding of how lymphatic vessels and the hematopoietic system, in particular myeloid cells, interact during embryonic development, in normal organ physiology, and in disease...
  32. doi request reprint Molecular mechanisms of lymphangiogenesis in development and cancer
    Imke Albrecht
    Department of Biomedicine, University of Basel, Basel, Switzerland
    Int J Dev Biol 55:483-94. 2011
    ..Therefore, the specific targeting of the lymphatic vasculature at the tumor site could be a promising approach to prevent metastasis formation...
  33. doi request reprint Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis
    Ernesta Fagiani
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Cancer Res 71:5717-27. 2011
    ..The poor perfusion of immature blood vessels results in retarded tumor growth, defining an important pathophysiologic pathway required for efficient tumorigenesis...
  34. ncbi request reprint Metastatic colon cancer cells negotiate the intravasation notch
    Gerhard Christofori
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Cancer Cell 19:6-8. 2011
    ..Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis...
  35. doi request reprint Corrupt policemen: inflammatory cells promote tumor angiogenesis
    Adrian Zumsteg
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
    Curr Opin Oncol 21:60-70. 2009
    ....
  36. ncbi request reprint Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition
    Maren Diepenbruck
    Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    J Cell Sci 127:1523-36. 2014
    ..The results demonstrate that Tead transcription factors are crucial regulators of the cellular distribution of Yap and Taz, and together they control the expression of genes critical for EMT and metastasis...
  37. pmc Mouse models of breast cancer metastasis
    Anna Fantozzi
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences DKBW, Center of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Breast Cancer Res 8:212. 2006
    ....
  38. doi request reprint The angiogenic switch in carcinogenesis
    Vanessa Baeriswyl
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Semin Cancer Biol 19:329-37. 2009
    ..These experiments have provided first important concepts to improve anti-angiogenic therapy and thus directly contribute to their translation to the clinical setting...
  39. pmc Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis
    Mahmut Yilmaz
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
    EMBO J 30:4489-99. 2011
    ..These results establish Dlx2 as one critical player in shifting TGFβ from its tumour suppressive to its tumour-promoting functions...
  40. ncbi request reprint Multitasking in tumor progression: signaling functions of cell adhesion molecules
    Ugo Cavallaro
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Vesalgasse 1, CH 4051 Basel, Switzerland
    Ann N Y Acad Sci 1014:58-66. 2004
    ....
  41. ncbi request reprint LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling
    Aleksandar Kuzmanov
    Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
    Mol Oncol 8:401-16. 2014
    ....
  42. doi request reprint Rebuilding cancer metastasis in the mouse
    Meera Saxena
    Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
    Mol Oncol 7:283-96. 2013
    ..Such models not only aid in deciphering the pathomechanisms of metastasis, but are also instrumental for the preclinical testing of anti-metastatic therapies and further refinement and generation of improved models...
  43. doi request reprint Angiopoietins in angiogenesis
    Ernesta Fagiani
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Cancer Lett 328:18-26. 2013
    ..Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer...
  44. doi request reprint Targeting tumor-associated endothelial cells: anti-VEGFR2 immunoliposomes mediate tumor vessel disruption and inhibit tumor growth
    Andreas Wicki
    Division of Oncology, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Clin Cancer Res 18:454-64. 2012
    ..Accordingly, therapeutic approaches against the VEGF/VEGFR2 signaling axis have been designed. However, an efficient and specific chemotherapeutic targeting of tumor-associated endothelial cells has not yet been achieved...
  45. pmc The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity
    Chrysiis Michaloglou
    Novartis Institutes for BioMedical Research, Disease Area Oncology, Basel, Switzerland
    PLoS ONE 8:e61916. 2013
    ..Finally, we demonstrate that PTPN14 downregulation can phenocopy YAP activation in mammary epithelial cells and synergize with YAP to induce oncogenic transformation...
  46. doi request reprint Sprouty proteins, masterminds of receptor tyrosine kinase signaling
    Miguel A Cabrita
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland
    Angiogenesis 11:53-62. 2008
    ..This review describes Spry functions in the context of endothelial biology and angiogenesis, and provides an update on Spry-interacting proteins and Spry mechanisms of action...
  47. ncbi request reprint Recent advances in cancer research: mouse models of tumorigenesis
    Michaela Herzig
    Research Institute of Molecular Pathology, Vienna, Austria
    Biochim Biophys Acta 1602:97-113. 2002
    ..In particular, we focus on transgenic and knockout mouse models that closely mimic human cancer and thus can be used as model systems for cancer research...
  48. ncbi request reprint Cadherins and the tumour progression: is it all in a switch?
    Ugo Cavallaro
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cancer Lett 176:123-8. 2002
    ....
  49. ncbi request reprint Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    Ugo Cavallaro
    Institute of Biochemistry and Genetics, Department of Clincal Biological Sciences, University of Basel Switzerland
    Nat Rev Cancer 4:118-32. 2004
  50. ncbi request reprint Protein 4.1B in mouse islets of Langerhans and beta-cell tumorigenesis
    Nobuo Terada
    Department of Anatomy, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Tamaho, 409 3898 Yamanashi, Japan
    Histochem Cell Biol 120:277-83. 2003
    ..Therefore, we propose a role of protein 4.1B as a connecting and/or signaling molecule between membrane architecture, cell adhesion, and tumor cell invasion in mouse pancreatic endocrine cells...
  51. ncbi request reprint Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor
    Chiara Francavilla
    IFOM FIRC Institute of Molecular Oncology, I 20139 Milano, Italy
    J Cell Sci 120:4388-94. 2007
    ....
  52. ncbi request reprint Overexpression of vascular endothelial growth factor-A165 enhances tumor angiogenesis but not metastasis during beta-cell carcinogenesis
    Grainne Gannon
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Cancer Res 62:603-8. 2002
    ..Our findings indicate that in beta-cell tumorigenesis, overexpression of VEGF-A165 accelerates the onset of tumor angiogenesis and with it tumor progression but is not sufficient to induce tumor metastasis...
  53. ncbi request reprint Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer
    Geert Berx
    Department for Molecular Biomedical Research, Molecular and Cellular Oncology, VIB, Technologiepark 927, 9052, Ghent Zwijnaarde, Belgium
    Clin Exp Metastasis 24:587-97. 2007
    ..Finally we review the recent literature concerning the mechanisms that regulate EMT in the tumour context, with a particular focus on breast cancer...
  54. ncbi request reprint Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid beta-cell tumors
    Francesca Galbiati
    Department of Medicine, San Raffaele Scientific Institute, Milan 20132, Italy
    Endocrinology 143:4018-30. 2002
    ..Together, these findings provide the rationale for testing the efficacy of calcitriol in the treatment of patients with solid beta-cell tumors...
  55. ncbi request reprint Cancer: division of labour
    Gerhard Christofori
    Nature 446:735-6. 2007
  56. ncbi request reprint Temporal effects of Sprouty on lung morphogenesis
    Anne Karina T Perl
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Dev Biol 258:154-68. 2003
    ..These findings demonstrate that the embryonic-pseudoglandular stage is a critical time period during which Spry-sensitive pathways are required for branching morphogenesis, lobulation, and formation of the peripheral lung parenchyma...
  57. pmc The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Strasse 117, D 79106 Freiburg, Germany
    Am J Pathol 168:1045-53. 2006
    ..The data warrant further exploration of CD34 in tumor-associated LECs as a prognostic tumor marker...
  58. ncbi request reprint Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells
    Francesca Galbiati
    Division of General Medicine, Unit of Endocrinology and Metabolic Disease, San Raffaele Scientific Institute, 20132 Milan, Italy
    Endocrinology 144:1832-41. 2003
    ....
  59. ncbi request reprint Split personalities: the agonistic antagonist Sprouty
    Gerhard Christofori
    Nat Cell Biol 5:377-9. 2003
  60. doi request reprint Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
    ..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors...