M Christ-Crain

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Am J Respir Crit Care Med 174:84-93. 2006
  2. ncbi request reprint Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD
    Daiana Stolz
    Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 131:1058-67. 2007
  3. doi request reprint Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Matthias Briel
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Arch Intern Med 168:2000-7; discussion 2007-8. 2008
  4. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
  5. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
  6. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
  7. ncbi request reprint Measurement of serum free cortisol shows discordant responsivity to stress and dynamic evaluation
    Mirjam Christ-Crain
    Department of Endocrinology, Barts and The London, Queen Mary s School of Medicine, University of London, London, United Kingdom
    J Clin Endocrinol Metab 92:1729-35. 2007
  8. ncbi request reprint Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections
    B Muller
    University Hospital Basel, Switzerland
    Eur J Clin Invest 37:145-52. 2007
  9. pmc Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Crit Care 10:R96. 2006
  10. ncbi request reprint Effect of gastric bypass and gastric banding on proneurotensin levels in morbidly obese patients
    Mirjam Christ-Crain
    Department of Endocrinology, Charterhouse Square, St Bartholomews Hospital, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 91:3544-7. 2006

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Am J Respir Crit Care Med 174:84-93. 2006
    ..In patients with community-acquired pneumonia, guidelines recommend antibiotic treatment for 7 to 21 d. Procalcitonin is elevated in bacterial infections, and its dynamics have prognostic implications...
  2. ncbi request reprint Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD
    Daiana Stolz
    Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 131:1058-67. 2007
    ....
  3. doi request reprint Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Matthias Briel
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Arch Intern Med 168:2000-7; discussion 2007-8. 2008
    ..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day...
  4. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
    ..The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia...
  5. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  6. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
    ....
  7. ncbi request reprint Measurement of serum free cortisol shows discordant responsivity to stress and dynamic evaluation
    Mirjam Christ-Crain
    Department of Endocrinology, Barts and The London, Queen Mary s School of Medicine, University of London, London, United Kingdom
    J Clin Endocrinol Metab 92:1729-35. 2007
    ..However, there are few data on FC levels during surgical stress and in response to standard pharmacological tests...
  8. ncbi request reprint Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections
    B Muller
    University Hospital Basel, Switzerland
    Eur J Clin Invest 37:145-52. 2007
    ..Lower respiratory tract infections (LRTI) are a precursor of sepsis. Thus, we investigated circulating levels and the prognostic use of copeptin for the severity and outcome in patients with LRTI...
  9. pmc Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Crit Care 10:R96. 2006
    ..A major cause of sepsis is community-acquired pneumonia (CAP). The aim of this study was to investigate the value of proADM levels for severity assessment and outcome prediction in CAP...
  10. ncbi request reprint Effect of gastric bypass and gastric banding on proneurotensin levels in morbidly obese patients
    Mirjam Christ-Crain
    Department of Endocrinology, Charterhouse Square, St Bartholomews Hospital, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 91:3544-7. 2006
    ..Neurotensin is produced mainly in the N cells of the ileum and has a role in appetite regulation; levels are decreased in obese subjects and increase after bariatric surgery. Mature neurotensin is very unstable, with a short half-life...
  11. ncbi request reprint Pro-A-type and N-terminal pro-B-type natriuretic peptides in different thyroid function states
    M Christ-Crain
    Department of Endocrinology, University Hospital Basel, Switzerland
    Swiss Med Wkly 135:549-54. 2005
    ....
  12. ncbi request reprint Value of gonadotropin-releasing hormone testing in the differential diagnosis of androgen deficiency in elderly men
    M Christ-Crain
    Division of Endocrinology, Department of Internal Medicine, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 90:1280-6. 2005
    ..To exclude secondary hypogonadism in PADAM, diagnostic accuracy can be improved by using GnRH testing...
  13. ncbi request reprint Comparison of different methods for the measurement of serum testosterone in the aging male
    M Christ-Crain
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Department of Internal Medicine, University Hospitals, Basel, Switzerland
    Swiss Med Wkly 134:193-7. 2004
    ..However, there is an ongoing controversy as to which T assay is most appropriate in defining T deficiency in the aging male...
  14. ncbi request reprint Is there a clinical relevance of partial androgen deficiency of the aging male?
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, University Hospitals, Basel, Switzerland
    J Urol 172:624-7. 2004
    ..We investigate the association between various T measures and clinical and biochemical parameters of the aging male...
  15. ncbi request reprint Circulating levels of pro-atrial natriuretic peptide in lower respiratory tract infections
    B Muller
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    J Intern Med 260:568-76. 2006
    ..To analyse the mid region of plasma N-terminal pro-atrial natriuretic peptide (MR-proANP) levels in patients with lower respiratory tract infections to evaluate its prognostic use for the severity of disease and outcome...
  16. doi request reprint Use of B-type natriuretic peptide in the risk stratification of community-acquired pneumonia
    M Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    J Intern Med 264:166-76. 2008
    ..Community-acquired pneumonia (CAP) is the leading infectious cause of death in developed countries. Risk stratification has previously been difficult...
  17. ncbi request reprint Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators
    M Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 30:556-73. 2007
    ..In several animal models the modulation and neutralisation of hormokines during infection was shown to improve survival, and thus might open new treatment options for severe infections, especially of the respiratory tract...
  18. pmc Predicting mortality with pneumonia severity scores: importance of model recalibration to local settings
    P Schuetz
    University Hospital Basel, Department of Internal Medicine, Basel, Switzerland
    Epidemiol Infect 136:1628-37. 2008
    ....
  19. ncbi request reprint Radioiodine therapy in hyperthyroidism: inverse correlation of pretherapeutic iodine uptake level and post-therapeutic outcome
    M A Walter
    Institute of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Invest 34:365-70. 2004
    ..The aim of this study was to analyze the influence of RAI uptake on the outcome after RAI treatment and to estimate uptake-dependent success rates...
  20. doi request reprint Prognostic value of procalcitonin in Legionella pneumonia
    J Haeuptle
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Microbiol Infect Dis 28:55-60. 2009
    ..5 had a significantly higher risk of death and/or ICU admission (log rank p = 0.003) during the hospital stay. In patients with CAP due to Legionella, PCT levels on admission might be an interesting predictor for adverse medical outcomes...
  21. doi request reprint The stress hormone copeptin: a new prognostic biomarker in acute illness
    M Katan
    Department of Neurology, University Hospital Basel, Petersgraben 4, 4031 Basel, CH
    Swiss Med Wkly 140:w13101. 2010
    ..Future intervention studies must prove the value of copeptin in clinical decision making and in improving the overall medical management of patients with acute illnesses...
  22. doi request reprint Anterior pituitary axis hormones and outcome in acute ischaemic stroke
    S Neidert
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland
    J Intern Med 269:420-32. 2011
    ..We therefore evaluated the prognostic value of cortisol, triiodothyronine (T3), free thyroxine (fT4), thyroid-stimulating hormone (TSH) and growth hormone (GH) in patients with an acute ischaemic stroke...
  23. ncbi request reprint Radioiodine uptake and thyroid hormone levels on or off simultaneous carbimazole medication: a prospective paired comparison
    M A Walter
    Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031 Basel, Schweiz
    Nuklearmedizin 44:33-6. 2005
    ....
  24. doi request reprint Stress hormones predict cerebrovascular re-events after transient ischemic attacks
    M Katan
    Department of Endocrinology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Neurology 76:563-6. 2011
    ..This study assessed prognostic reliability of 2 distinct stress hormones, copeptin and cortisol, for the risk stratification of re-events in patients with TIA...
  25. ncbi request reprint Basal TSH levels compared with TRH-stimulated TSH levels to diagnose different degrees of TSH suppression: diagnostic and therapeutic impact of assay performance
    M Christ-Crain
    Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospitals, Petersgraben, Basel, Switzerland
    Eur J Clin Invest 32:931-7. 2002
    ..We therefore re-evaluated the diagnostic value of basal and thyrotrop in TRH-stimulated serum TSH measurements using TSH assays with different sensitivities...
  26. doi request reprint Inflammatory responses predict long-term mortality risk in community-acquired pneumonia
    C Guertler
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur Respir J 37:1439-46. 2011
    ..Further studies should address whether closer monitoring of high-risk CAP patients after hospital discharge favourably impacts long-term mortality...
  27. doi request reprint Procalcitonin and other biomarkers to improve assessment and antibiotic stewardship in infections--hope for hype?
    Philipp Schuetz
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 139:318-26. 2009
    ..Future intervention studies must prove if these biomarkers indeed improve clinical decision making and thus the overall medical management of patients...
  28. doi request reprint The role of routine echocardiography in unselected patients with cerebrovascular ischaemic events
    M Wachter
    Department of Cardiology, University Hospital Basel, Switzerland
    Eur J Neurol 18:925-8. 2011
    ..Echocardiography is routinely performed in patients with CIE despite guidelines recommending restriction of echocardiography to patients with clinically suspected cardioembolism...
  29. doi request reprint Comparison of two malnutrition risk screening methods (MNA and NRS 2002) and their association with markers of protein malnutrition in geriatric hospitalized patients
    T Drescher
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Nutr 64:887-93. 2010
    ..The nutritional risk screening 2002 (NRS) has been proposed as universal screening method for hospitalized patients. The aim of our study was to compare both tools as they are correlated with protein malnutrition...
  30. ncbi request reprint Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia
    Mirjam Christ-Crain
    Department of Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Am J Respir Crit Care Med 176:913-20. 2007
    ..Whether FC concentrations better reflect outcome is uncertain. Objectives: To investigate the predictive value of TC and FC in community-acquired pneumonia (CAP)...
  31. doi request reprint Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial
    Fabian Müller
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Chest 138:121-9. 2010
    ..However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP...
  32. doi request reprint Use of B-type natriuretic peptide in the risk stratification of acute exacerbations of COPD
    Daiana Stolz
    Clinic for Pneumology and Respiratory Cell Research, University Hospital Basel, Switzerland
    Chest 133:1088-94. 2008
    ..In patients with COPD, prognosis might be determined at least in part by the extent of cardiac stress induced by hypoxia and pulmonary arterial hypertension...
  33. doi request reprint Increase in high molecular weight adiponectin by bariatric surgery-induced weight loss
    P Linscheid
    Department of Research, University Hospital, Basel, Switzerland
    Diabetes Obes Metab 10:1266-70. 2008
    ..To determine the changes in adiponectin multimers upon marked weight loss...
  34. ncbi request reprint Amino-bisphosphonates in heterotopic ossification: first experience in five consecutive cases
    P Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Spinal Cord 43:604-10. 2005
    ..Retrospective, observational study in five consecutive cases...
  35. doi request reprint Metformin induces glucose uptake in human preadipocyte-derived adipocytes from various fat depots
    M Fischer
    Department of Biomedicine, University Hospital Basel, CH 4031 Basel, Switzerland
    Diabetes Obes Metab 12:356-9. 2010
    ..In adipocytes, metformin seems to induce glucose uptake independent of insulin suggesting an alternative mechanism of action of this drug...
  36. ncbi request reprint What cardiologists do need to know about procalcitonin
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Clin Lab 51:1-4. 2005
    ..49 (p < 0.001), as compared to the standard group. Thus, using a sensitive assay, procalcitonin-guidance substantially and safely reduced antibiotic usage in LRTI...
  37. ncbi request reprint Diagnostic value of signs, symptoms and laboratory values in lower respiratory tract infection
    Daiana Stolz
    Division of Pulmonary Medicine and Cell Research, University of Basel, Basel, Switzerland
    Swiss Med Wkly 136:434-40. 2006
    ..Using the outcome and microbiology findings as gold standard, we determined sensitivity, specificity, positive and negative predictive values of common used signs and symptoms of bacterial LRTI requiring antibiotic therapy...
  38. pmc Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Crit Care 14:203. 2010
    ..None should be used on its own; and none is anything more than an aid in the exercise of clinical judgment based upon a synthesis of available clinical, physiologic and laboratory features in each patient...
  39. ncbi request reprint Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy
    Daiana Stolz
    Clinics of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Chest 131:9-19. 2007
    ..We evaluated the efficacy and safety of procalcitonin guidance compared to standard therapy with antibiotic prescriptions in patients experiencing exacerbations of COPD...
  40. pmc Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    BMC Fam Pract 6:34. 2005
    ..The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care...
  41. doi request reprint Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    JAMA 302:1059-66. 2009
    ..In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs)...
  42. doi request reprint Prognostic impact of plasma lipids in patients with lower respiratory tract infections - an observational study
    Maja Gruber
    Clinic of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Swiss Med Wkly 139:166-72. 2009
    ..Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown...
  43. doi request reprint Long-term stability of procalcitonin in frozen samples and comparison of Kryptor and VIDAS automated immunoassays
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Clin Biochem 43:341-4. 2010
    ..To assess long-term stability of PCT in deep-frozen samples and assess whether Kryptor procalcitonin cutoff ranges can be transferred on the bioMérieux VIDAS system...
  44. pmc Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency department
    Rico Fiumefreddo
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    BMC Pulm Med 9:4. 2009
    ..Accurate clinical predictors to assess the likelihood of Legionella community-acquired pneumonia (CAP) in patients presenting to the emergency department are lacking...
  45. doi request reprint Different strategies to overcome the effect of carbimazole on high- and low-dose radioiodine therapy: results from continuous dose-effect models
    M A Walter
    Institute of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Invest 39:51-7. 2009
    ....
  46. doi request reprint Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland
    J Am Coll Cardiol 56:1045-53. 2010
    ..The purpose of this study was to examine the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients with acute ischemic stroke...
  47. ncbi request reprint Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospitals, CH 4031 Basel, Switzerland
    Atherosclerosis 166:379-86. 2003
    ..In contrast to overt disease, only CRP, but not tHcy values, are affected in SCH, yet without significant improvement after L-thyroxine therapy...
  48. doi request reprint Copeptin: a novel, independent prognostic marker in patients with ischemic stroke
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Switzerland
    Ann Neurol 66:799-808. 2009
    ..Vasopressin is a stress hormone. Its production rate is mirrored in circulating levels of copeptin, a fragment of provasopressin. We evaluated the prognostic value of copeptin in acute stroke patients...
  49. ncbi request reprint Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level
    Mira Katan
    Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Neuro Endocrinol Lett 29:341-6. 2008
    ..Copeptin is a more stable peptide stoichiometrically released from the same precursor molecule. The aim of our study was to compare copeptin and cortisol levels in different stress situations...
  50. pmc Which patients with lower respiratory tract infections need inpatient treatment? Perceptions of physicians, nurses, patients and relatives
    Claudia Baehni
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 10:12. 2010
    ..This survey analyzed perceptions of physicians, nurses, patients and relatives about feasibility of outpatient management and required duration of hospital stay...
  51. doi request reprint Plasma pro-adrenomedullin but not plasma pro-endothelin predicts survival in exacerbations of COPD
    Daiana Stolz
    Clinic of Pneumology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 134:263-72. 2008
    ..We investigated whether plasma pro-endothelin-1 (proET-1) and/or pro-adrenomedullin (proADM) on admission to the hospital for acute exacerbation predict survival in patients with COPD...
  52. ncbi request reprint Serum estradiol after single dose hCG administration correlates with Leydig cell reserve in hypogonadal men: reassessment of the hCG stimulation test
    Christian Meier
    Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Clin Lab 51:509-15. 2005
    ..Assessment of E2 increments would render the test procedure more practical, less time-consuming and more cost-effective than assessing peak T levels after 72 hours...
  53. pmc Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Endothelium 14:345-51. 2007
    ..The ratio of the two counteracting peptides correlates with mortality and shows a prognostic accuracy to predict adverse outcome comparable to the APACHE II score...
  54. ncbi request reprint Biomarkers to improve diagnostic and prognostic accuracy in systemic infections
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Curr Opin Crit Care 13:578-85. 2007
    ..We review the advantages and drawbacks of biomarkers in the diagnostic and prognostic assessment of systemic infections...
  55. ncbi request reprint Outcome of radioiodine therapy without, on or 3 days off carbimazole: a prospective interventional three-group comparison
    Martin A Walter
    Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031, Basel, Switzerland
    Eur J Nucl Med Mol Imaging 33:730-7. 2006
    ..By generating three groups with comparable radioiodine uptake, we also investigated whether the effect of carbimazole depends on the radioiodine uptake...
  56. ncbi request reprint Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects
    Gabor Szinnai
    Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:3973-8. 2007
    ..Copeptin is the C-terminal part of provasopressin and has been shown to be a useful tool to indicate AVP concentration in critically ill patients...
  57. doi request reprint Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 72:305-11. 2010
    ..Mitotane treatment in adrenocortical carcinoma (ACC) results in unreliable measurement of serum total cortisol (TC) levels because of an elevation in corticosteroid-binding globulin (CBG)...
  58. ncbi request reprint Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome
    Blerina Kola
    Centre for Endocrinology, John Vane Science Centre, Barts and the London School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 93:4969-73. 2008
    ..In the current study, we demonstrate the effect of high glucocorticoid levels on AMPK activity of human adipose tissue samples from patients with Cushing's syndrome...
  59. pmc Copeptin: a new and promising diagnostic and prognostic marker
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Crit Care 12:117. 2008
    ..Furthermore, vasopressin is an important hormone in salt and volume regulation. In this context, copeptin is also a diagnostic marker in patients with diabetes insipidus and in patients with disordered water states...
  60. pmc Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    BMC Pulm Med 8:1. 2008
    ....
  61. doi request reprint Circulating levels of GH predict mortality and complement prognostic scores in critically ill medical patients
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Eur J Endocrinol 160:157-63. 2009
    ..We assessed the prognostic implications of GH on admission and during follow-up in critically ill adult patients admitted to a medical intensive care unit...
  62. ncbi request reprint Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay
    Mira Katan
    Department of Endocrinology, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:2640-3. 2007
    ..However, AVP measurement is cumbersome. Copeptin, the stable C-terminal glycopeptide of the AVP prohormone, is stoichiometrically secreted from the posterior pituitary...
  63. ncbi request reprint Restoration of euthyroidism accelerates bone turnover in patients with subclinical hypothyroidism: a randomized controlled trial
    Christian Meier
    Division of Endocrinology, Department of Medicine, University Hospitals, CH 4031, Basel, Switzerland
    Osteoporos Int 15:209-16. 2004
    ..However, long-term studies are needed to confirm this assumption...
  64. doi request reprint Dexamethasone suppression test predicts later development of an impaired adrenal function after a 14-day course of prednisone in healthy volunteers
    Stefanie Neidert
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Endocrinol 162:943-9. 2010
    ..Identification of patients at risk is of clinical importance. We hypothesized that the dexamethasone suppression test predicts the development of corticosteroid-induced impaired adrenal function...
  65. ncbi request reprint Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial
    Mirjam Christ-Crain
    Division of Pneumology, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    Lancet 363:600-7. 2004
    ..We aimed to assess a procalcitonin-based therapeutic strategy to reduce antibiotic use in lower respiratory tract infections with a new rapid and sensitive assay...
  66. pmc Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study
    Nils G Morgenthaler
    Research Department, BRAHMS AG, Biotechnology Center, Hennigsdorf Berlin, Germany
    Crit Care 9:R37-45. 2005
    ....
  67. ncbi request reprint Prolactin dysregulation in women with subclinical hypothyroidism: effect of levothyroxine replacement therapy
    Christian Meier
    Division of Endocrinology, Diabetology, and Clinical Nutrition, Department of Internal Medicine, University Hospitals, Basel, Switzerland
    Thyroid 13:979-85. 2003
    ....
  68. ncbi request reprint Circulating levels of soluble triggering receptor expressed on myeloid cells (sTREM)-1 in community-acquired pneumonia
    Beat Muller
    Crit Care Med 35:990-1. 2007
  69. ncbi request reprint Meta-analysis of procalcitonin for sepsis detection
    Beat Muller
    Lancet Infect Dis 7:498-9; author reply 502-3. 2007
  70. ncbi request reprint Procalcitonin in bacterial infections--hype, hope, more or less?
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 135:451-60. 2005
    ..This review aims to help the clinician to understand the physiopathological basis, to appreciate strengths and weaknesses of this biomarker, and thereby to promote a rational implementation of ProCT in a routine setting...
  71. doi request reprint [Procalcitonin - importance for the diagnosis of bacterial infections]
    Mirjam Christ-Crain
    Bereich Innere Medizin, Universitatsspital Basel
    Ther Umsch 65:559-68. 2008
    ..Together, Procalcitonin has improved the diagnosis of bacterial infections, however should always be used in context with other laboratory markers, clinical exam and medical history...
  72. pmc Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 9:R816-24. 2005
    ..The aim of the present study was to evaluate the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) levels in a cohort of medical intensive care patients and to compare it with other biomarkers and physiological scores...
  73. ncbi request reprint Procalictonin--you only find what you look for, and you only look for what you know
    Mirjam Christ-Crain
    J Am Geriatr Soc 54:546; author reply 547-8. 2006
  74. ncbi request reprint Limits to the use of the procalcitonin level as a diagnostic marker
    Beat Muller
    Clin Infect Dis 39:1867-8. 2004
  75. pmc Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials
    Martin A Walter
    Institute of Nuclear Medicine, University Hospital Basel, Switzerland
    BMJ 334:514. 2007
    ..To determine the effect of adjunctive antithyroid drugs on the risk of treatment failure, hypothyroidism, and adverse events after radioiodine treatment...
  76. ncbi request reprint Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Neuendorfstrasse 25, D 16761 Hennigsdorf bei Berlin, Germany
    Shock 28:219-26. 2007
    ..The availability of a reliable assay for the measurement of AVP release can also prove useful for the assessment of fluid and osmosis status in various diseases...
  77. doi request reprint Graves' disease
    Martin A Walter
    N Engl J Med 359:1407; author reply 1409. 2008
  78. ncbi request reprint Impact of diabetes mellitus and metabolic disorders
    Matthias Turina
    Department of Surgery, Price Institute of Surgical Research, 511 South Floyd Street, MDR Building, Room 312, Louisville, KY 40202, USA
    Surg Clin North Am 85:1153-61, ix. 2005
    ....
  79. doi request reprint Calcitonin peptides--the mediators in sepsis or just another fairy tale?
    Mirjam Christ-Crain
    Crit Care Med 36:1684-7. 2008