Affiliation: University Hospital
- [Echinococcosis: the threat of the urban fox]F Chappuis
Service de médecine internationale et humanitaire, Departement de Medecine, communautaire, de premier recours et des urgences, HUG, 1211 Geneve 14
Rev Med Suisse 8:989-90, 992-3. 2012..Curative radical surgery is possible in only 25 to 35% of cases. In non-operable cases, long standing antiparasitic therapy allows to stop the progression of lesions...
- Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of CongoJacqueline Tong
Medecins Sans Frontieres, Rue de Lausanne 78, 1211 Geneva, Switzerland
Confl Health 5:7. 2011..abstract:..
- Estimates of the duration of the early and late stage of gambiense sleeping sicknessFrancesco Checchi
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E7HT, UK
BMC Infect Dis 8:16. 2008..Here, we outline a method to estimate these parameters...
- [Indications for PCR in travel medicine]F Chappuis
Service de médecine internationale et humanitaire, Département de médecine communautaire, de premier recours et des urgences HUG, 1211 Geneve 14
Rev Med Suisse 7:991-2, 994. 2011....
- Validation of a rapid immunochromatographic assay for diagnosis of Trypanosoma cruzi infection among Latin-American Migrants in Geneva, SwitzerlandFrancois Chappuis
Division of International and Humanitarian Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211 Geneva 14, Switzerland
J Clin Microbiol 48:2948-52. 2010....
- Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to goFrancois Chappuis
Travel and Migration Medicine Unit, Geneva University Hospital, and Medecins Sans Frontieres, Swiss Section, 1202 Geneva, Switzerland
Clin Infect Dis 45:1443-5. 2007
- Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?Francois Chappuis
Travel and Migration Medicine Unit, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Nat Rev Microbiol 5:873-82. 2007..New diagnostic tools and new treatment strategies will only have an impact if they are made widely available to patients...
- A meta-analysis of the diagnostic performance of the direct agglutination test and rK39 dipstick for visceral leishmaniasisFrancois Chappuis
Geneva University Hospitals, Travel and Migration Medicine Unit, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
BMJ 333:723. 2006..To compare the performance of the direct agglutination test and rK39 dipstick for the diagnosis of visceral leishmaniasis...
- Field validity, reproducibility and feasibility of diagnostic tests for visceral leishmaniasis in rural NepalFrancois Chappuis
Travel and Migration Medicine Unit, Geneva University Hospital, Geneva, Switzerland
Trop Med Int Health 11:31-40. 2006..To assess the field accuracy, reproducibility and feasibility of the formol gel test (FGT), the urine latex agglutination test (KAtex) and a rK39 antigen-based dipstick for the diagnosis of visceral leishmaniasis (VL) in rural Nepal...
- Diagnostic accuracy of two rK39 antigen-based dipsticks and the formol gel test for rapid diagnosis of visceral leishmaniasis in northeastern UgandaFrancois Chappuis
Travel and Migration Medicine Unit, Geneva University Hospital, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
J Clin Microbiol 43:5973-7. 2005..The two rK39 dipsticks can be used for diagnostic confirmation of VL in this region. The DUAL-IT L/M without its malaria diagnostic component (DiaMed-IT LEISH) will be adopted as first-line test for VL in Uganda...
- Prospective evaluation and comparison of the direct agglutination test and an rK39-antigen-based dipstick test for the diagnosis of suspected kala-azar in NepalF Chappuis
Department of Community Medicine, Geneva University Hospital, Geneva, Switzerland
Trop Med Int Health 8:277-85. 2003..The rK39 dipstick is cheaper and easier to use than the DAT and could be used widely provided that both its performance and production remain stable...
- Field evaluation of the CATT/Trypanosoma brucei gambiense on blood-impregnated filter papers for diagnosis of human African trypanosomiasis in southern SudanF Chappuis
Médecins Sans Frontières MSF Switzerland, Geneva, Switzerland
Trop Med Int Health 7:942-8. 2002..Further studies on larger population samples in different endemic foci are still needed before the CATT-FP can be recommended for universal use...
- Card agglutination test for trypanosomiasis (CATT) end-dilution titer and cerebrospinal fluid cell count as predictors of human African Trypanosomiasis (Trypanosoma brucei gambiense) among serologically suspected individuals in southern SudanFrancois Chappuis
Medecins Sans Frontieres, Swiss Section, Geneva, Switzerland
Am J Trop Med Hyg 71:313-7. 2004..In conclusion, treatment with pentamidine should be considered for all serologically suspected individuals with a CATT-P end-dilution titer >/= 1:16 in areas of a moderate to high prevalence of HAT...
- Options for field diagnosis of human african trypanosomiasisFrancois Chappuis
Travel and Migration Medicine Unit, Geneva University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Clin Microbiol Rev 18:133-46. 2005..Apart from the urgent need for better tools for the field diagnosis of this neglected disease, improved access to diagnosis and treatment for the population at risk remains the greatest challenge for the coming years...
- Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasisFrancois Chappuis
Medecins Sans Frontieres, Geneva University Hospitals, Geneva, Switzerland
Clin Infect Dis 41:748-51. 2005..2 and experienced significantly fewer cutaneous and neurological adverse effects than did patients who were treated with melarsoprol in 2001 and 2002 (n = 708)...
- Prevalence, clinical staging and risk for blood-borne transmission of Chagas disease among Latin American migrants in Geneva, SwitzerlandYves Jackson
Division of Primary Care Medicine, Department of Community Medicine and Primary Care, University Hospitals of Geneva and Faculty of Medicine, Geneva University, Geneva, Switzerland
PLoS Negl Trop Dis 4:e592. 2010..We assessed the prevalence and risk factors for Chagas disease, staged the disease and evaluated attitudes towards blood transfusion and organ transplant among Latin American migrants in Geneva, Switzerland...
- Immunological determinants of clinical outcome in Peruvian patients with tegumentary leishmaniasis treated with pentavalent antimonialsAnne Maurer-Cecchini
Immunology and Allergy, Geneva University Hospital, 1211 Geneva 14, Switzerland
Infect Immun 77:2022-9. 2009..The persistence of high levels of IL-10 in CL is characteristically associated with a poor response to treatment...
- Tolerance and safety of nifurtimox in patients with chronic chagas diseaseYves Jackson
Divisionof Primary Care Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Clin Infect Dis 51:e69-75. 2010..We aimed to evaluate nifurtimox tolerance and safety in a cohort of Trypanosoma cruzi-infected adult patients in a country of nonendemicity...
- The use of a rapid diagnostic test to determine malaria as a cause of deathFrancois Chappuis
Division of Hematology, Department of Internal Medicine, Geneva University Hospital, Geneva, Switzerland
J Travel Med 10:356-7. 2003..This report describes the novel use of a diagnostic test for a tropical disease in the postmortem examination of the cause of death...
- Urbanisation and infectious diseases in a globalised worldEmilie Alirol
Division of International and Humanitarian Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals, Geneva, Switzerland
Lancet Infect Dis 11:131-41. 2011..Furthermore, health should be a major consideration in town planning to ensure urbanisation works to reduce the burden of infectious diseases in the future...
- Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school childrenGilles Eperon
Medecins Sans Frontieres, Rue de Lausanne 78, 1202 Geneva, Switzerland
Acta Trop 101:31-9. 2007..Here, we described the demographic, clinical, diagnostic, treatment and outcome characteristics of HAT in pre-school children from Kajo-Keji County, South Sudan in comparison with older patients...
- Metabolic, mental health, behavioural and socioeconomic characteristics of migrants with Chagas disease in a non-endemic countryYves Jackson
Department of Community Medicine, Primary Care and Emergency Medicine, University Hospitals Geneva, Switzerland
Trop Med Int Health 17:595-603. 2012..Somatic, mental, behavioural and social characteristics of the 80,000 Latino migrants with Chagas disease in Europe are not known. We postulate that they may accumulate these factors for poor health--notably cardiovascular-outcomes...
- Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern UgandaYolanda Mueller
Medecins Sans Frontieres, Geneva, Switzerland
Trop Med Int Health 14:910-7. 2009..To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda...
- Congenital transmission of Chagas disease in Latin American immigrants in SwitzerlandYves Jackson
Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Emerg Infect Dis 15:601-3. 2009..A retrospective study to detect Chagas disease showed a prevalence of 9.7% among 72 Latin American women tested during pregnancy in Switzerland...
- [Chagas disease in Switzerland: managing an emerging infection and interrupting its transmission]Yves Jackson
Unité de médecine des voyages et migrations, Département de médecine communautaire et de premier recours HUG, Geneve
Rev Med Suisse 4:1212-4, 1216-7. 2008....
- Dengue fever and long thoracic nerve palsy in a traveler returning from ThailandFrancois Chappuis
Travel and Migration Medicine Unit, Department of Community Medicine, Geneva University Hospital, Switzerland
J Travel Med 11:112-4. 2004
- Protection against snake bites by sleeping under a bed net in southeastern NepalFrancois Chappuis
Travel and Migration Medicine Unit, and Department of Community Medicine, Geneva University Hospitals, Geneva, Switzerland
Am J Trop Med Hyg 77:197-9. 2007..007-0.07, P < 0.0001), whereas the place of sleeping in the household and the use of a cot were not associated with the risk of snake bite. These findings provide further support for use of bed nets in this region...
- Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?Yves Jackson
Travel and Migration Medicine Unit, Geneva University Hospital, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
Malar J 5:81. 2006..falciparum acquired in Africa, who failed to respond to artemisinin-based therapy. Sub-therapeutic dosing in accordance with the manufacturers' recommendations was the probable cause...
- High immunogenicity of delayed third dose of hepatitis B vaccine in travellersYves Jackson
Travel and Migration Medicine Unit, Geneva University Hospitals, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
Vaccine 25:3482-4. 2007..1%) travellers who had an interval of more than 5 years between second and third vaccine dose. We did not find any risk factor associated with insufficient response...
- Influence of Leishmania (Viannia) species on the response to antimonial treatment in patients with American tegumentary leishmaniasisJorge Arevalo
Instituto de Medicina Tropical Alexander von Humboldt, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru, and Hôpitaux Universitaires de Genève, Department of Community Medicine, Switzerland
J Infect Dis 195:1846-51. 2007..There are, however, reports of the occurrence of treatment failure with these drugs. Few studies in Latin America have compared the response to SbV treatment in ATL caused by different Leishmania species...
- Snake bite in South Asia: a reviewEmilie Alirol
Division of International and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland
PLoS Negl Trop Dis 4:e603. 2010..The deficiency of snake bite management in South Asia is multi-causal and requires joint collaborative efforts from researchers, antivenom manufacturers, policy makers, public health authorities and international funders...