Francois Chappuis

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Human African Trypanosomiasis in Areas without Surveillance
    Francois Chappuis
    Medecins Sans Frontieres, Geneva, Switzerland F Chappuis Geneva University Hospitals, Geneva F Chappuis Medecins sans Frontieres, Barcelona, Spain M A Lima, L Flevaud and Medecins sans Frontieres, Amsterdam, the Netherlands K Ritmeijer
    Emerg Infect Dis 16:354-6. 2010
  2. pmc Validation of two rapid diagnostic tests for visceral leishmaniasis in Kenya
    Jane Mbui
    Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya
    PLoS Negl Trop Dis 7:e2441. 2013
  3. pmc The alcohol use disorders identification test (AUDIT): validation of a Nepali version for the detection of alcohol use disorders and hazardous drinking in medical settings
    Bickram Pradhan
    Department of Internal Medicine, B, P Koirala Institute of Health Sciences, Dharan, Nepal
    Subst Abuse Treat Prev Policy 7:42. 2012
  4. pmc Prevalence and under-detection of gambiense human African trypanosomiasis during mass screening sessions in Uganda and Sudan
    Francesco Checchi
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Parasit Vectors 5:157. 2012
  5. doi request reprint Rapid diagnostic tests for non-malarial febrile illness in the tropics
    F Chappuis
    Division of International and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Clin Microbiol Infect 19:422-31. 2013
  6. ncbi request reprint [Echinococcosis: the threat of the urban fox]
    F Chappuis
    Service de médecine internationale et humanitaire, Departement de Medecine, communautaire, de premier recours et des urgences, HUG, 1211 Geneve 14
    Rev Med Suisse 8:989-90, 992-3. 2012
  7. pmc Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo
    Jacqueline Tong
    Medecins Sans Frontieres, Rue de Lausanne 78, 1211 Geneva, Switzerland
    Confl Health 5:7. 2011
  8. pmc Estimates of the duration of the early and late stage of gambiense sleeping sickness
    Francesco Checchi
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E7HT, UK
    BMC Infect Dis 8:16. 2008
  9. ncbi request reprint Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Nat Rev Microbiol 5:873-82. 2007
  10. pmc Validation of a rapid immunochromatographic assay for diagnosis of Trypanosoma cruzi infection among Latin-American Migrants in Geneva, Switzerland
    Francois Chappuis
    Division of International and Humanitarian Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211 Geneva 14, Switzerland
    J Clin Microbiol 48:2948-52. 2010

Collaborators

Detail Information

Publications46

  1. pmc Human African Trypanosomiasis in Areas without Surveillance
    Francois Chappuis
    Medecins Sans Frontieres, Geneva, Switzerland F Chappuis Geneva University Hospitals, Geneva F Chappuis Medecins sans Frontieres, Barcelona, Spain M A Lima, L Flevaud and Medecins sans Frontieres, Amsterdam, the Netherlands K Ritmeijer
    Emerg Infect Dis 16:354-6. 2010
    ....
  2. pmc Validation of two rapid diagnostic tests for visceral leishmaniasis in Kenya
    Jane Mbui
    Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya
    PLoS Negl Trop Dis 7:e2441. 2013
    ..As this procedure is invasive, it cannot be safely implemented in peripheral health structures, where non-invasive, accurate, easy to use diagnostic tests are needed...
  3. pmc The alcohol use disorders identification test (AUDIT): validation of a Nepali version for the detection of alcohol use disorders and hazardous drinking in medical settings
    Bickram Pradhan
    Department of Internal Medicine, B, P Koirala Institute of Health Sciences, Dharan, Nepal
    Subst Abuse Treat Prev Policy 7:42. 2012
    ..This study aims to validate a Nepali version of AUDIT among patients attending a university hospital and assess the prevalence of alcohol use disorders along the full spectrum of alcohol misuse...
  4. pmc Prevalence and under-detection of gambiense human African trypanosomiasis during mass screening sessions in Uganda and Sudan
    Francesco Checchi
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Parasit Vectors 5:157. 2012
    ..brucei gambiense. However, its impact can be limited by incomplete attendance at screening sessions (screening coverage) and diagnostic inaccuracy...
  5. doi request reprint Rapid diagnostic tests for non-malarial febrile illness in the tropics
    F Chappuis
    Division of International and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Clin Microbiol Infect 19:422-31. 2013
    ....
  6. ncbi request reprint [Echinococcosis: the threat of the urban fox]
    F Chappuis
    Service de médecine internationale et humanitaire, Departement de Medecine, communautaire, de premier recours et des urgences, HUG, 1211 Geneve 14
    Rev Med Suisse 8:989-90, 992-3. 2012
    ..Curative radical surgery is possible in only 25 to 35% of cases. In non-operable cases, long standing antiparasitic therapy allows to stop the progression of lesions...
  7. pmc Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo
    Jacqueline Tong
    Medecins Sans Frontieres, Rue de Lausanne 78, 1211 Geneva, Switzerland
    Confl Health 5:7. 2011
    ..abstract:..
  8. pmc Estimates of the duration of the early and late stage of gambiense sleeping sickness
    Francesco Checchi
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E7HT, UK
    BMC Infect Dis 8:16. 2008
    ..Here, we outline a method to estimate these parameters...
  9. ncbi request reprint Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Nat Rev Microbiol 5:873-82. 2007
    ..New diagnostic tools and new treatment strategies will only have an impact if they are made widely available to patients...
  10. pmc Validation of a rapid immunochromatographic assay for diagnosis of Trypanosoma cruzi infection among Latin-American Migrants in Geneva, Switzerland
    Francois Chappuis
    Division of International and Humanitarian Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211 Geneva 14, Switzerland
    J Clin Microbiol 48:2948-52. 2010
    ....
  11. ncbi request reprint Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospital, and Medecins Sans Frontieres, Swiss Section, 1202 Geneva, Switzerland
    Clin Infect Dis 45:1443-5. 2007
  12. ncbi request reprint [Indications for PCR in travel medicine]
    F Chappuis
    Service de médecine internationale et humanitaire, Département de médecine communautaire, de premier recours et des urgences HUG, 1211 Geneve 14
    Rev Med Suisse 7:991-2, 994. 2011
    ....
  13. pmc A meta-analysis of the diagnostic performance of the direct agglutination test and rK39 dipstick for visceral leishmaniasis
    Francois Chappuis
    Geneva University Hospitals, Travel and Migration Medicine Unit, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
    BMJ 333:723. 2006
    ..To compare the performance of the direct agglutination test and rK39 dipstick for the diagnosis of visceral leishmaniasis...
  14. ncbi request reprint Prospective evaluation and comparison of the direct agglutination test and an rK39-antigen-based dipstick test for the diagnosis of suspected kala-azar in Nepal
    F Chappuis
    Department of Community Medicine, Geneva University Hospital, Geneva, Switzerland
    Trop Med Int Health 8:277-85. 2003
    ..The rK39 dipstick is cheaper and easier to use than the DAT and could be used widely provided that both its performance and production remain stable...
  15. ncbi request reprint Card agglutination test for trypanosomiasis (CATT) end-dilution titer and cerebrospinal fluid cell count as predictors of human African Trypanosomiasis (Trypanosoma brucei gambiense) among serologically suspected individuals in southern Sudan
    Francois Chappuis
    Medecins Sans Frontieres, Swiss Section, Geneva, Switzerland
    Am J Trop Med Hyg 71:313-7. 2004
    ..In conclusion, treatment with pentamidine should be considered for all serologically suspected individuals with a CATT-P end-dilution titer >/= 1:16 in areas of a moderate to high prevalence of HAT...
  16. ncbi request reprint Field validity, reproducibility and feasibility of diagnostic tests for visceral leishmaniasis in rural Nepal
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospital, Geneva, Switzerland
    Trop Med Int Health 11:31-40. 2006
    ..To assess the field accuracy, reproducibility and feasibility of the formol gel test (FGT), the urine latex agglutination test (KAtex) and a rK39 antigen-based dipstick for the diagnosis of visceral leishmaniasis (VL) in rural Nepal...
  17. pmc Options for field diagnosis of human african trypanosomiasis
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Clin Microbiol Rev 18:133-46. 2005
    ..Apart from the urgent need for better tools for the field diagnosis of this neglected disease, improved access to diagnosis and treatment for the population at risk remains the greatest challenge for the coming years...
  18. ncbi request reprint Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis
    Francois Chappuis
    Medecins Sans Frontieres, Geneva University Hospitals, Geneva, Switzerland
    Clin Infect Dis 41:748-51. 2005
    ..2 and experienced significantly fewer cutaneous and neurological adverse effects than did patients who were treated with melarsoprol in 2001 and 2002 (n = 708)...
  19. pmc Diagnostic accuracy of two rK39 antigen-based dipsticks and the formol gel test for rapid diagnosis of visceral leishmaniasis in northeastern Uganda
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospital, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
    J Clin Microbiol 43:5973-7. 2005
    ..The two rK39 dipsticks can be used for diagnostic confirmation of VL in this region. The DUAL-IT L/M without its malaria diagnostic component (DiaMed-IT LEISH) will be adopted as first-line test for VL in Uganda...
  20. ncbi request reprint Field evaluation of the CATT/Trypanosoma brucei gambiense on blood-impregnated filter papers for diagnosis of human African trypanosomiasis in southern Sudan
    F Chappuis
    Médecins Sans Frontières MSF Switzerland, Geneva, Switzerland
    Trop Med Int Health 7:942-8. 2002
    ..Further studies on larger population samples in different endemic foci are still needed before the CATT-FP can be recommended for universal use...
  21. pmc Immunological determinants of clinical outcome in Peruvian patients with tegumentary leishmaniasis treated with pentavalent antimonials
    Anne Maurer-Cecchini
    Immunology and Allergy, Geneva University Hospital, 1211 Geneva 14, Switzerland
    Infect Immun 77:2022-9. 2009
    ..The persistence of high levels of IL-10 in CL is characteristically associated with a poor response to treatment...
  22. pmc Serological and parasitological response in chronic Chagas patients 3 years after nifurtimox treatment
    Yves Jackson
    Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    BMC Infect Dis 13:85. 2013
    ..Recommendations for treatment outcome assessment rely on serological follow-up. We evaluated the serological and parasitological response to nifurtimox in a cohort of adult patients three years post-treatment in Switzerland...
  23. pmc Prevalence, clinical staging and risk for blood-borne transmission of Chagas disease among Latin American migrants in Geneva, Switzerland
    Yves Jackson
    Division of Primary Care Medicine, Department of Community Medicine and Primary Care, University Hospitals of Geneva and Faculty of Medicine, Geneva University, Geneva, Switzerland
    PLoS Negl Trop Dis 4:e592. 2010
    ..We assessed the prevalence and risk factors for Chagas disease, staged the disease and evaluated attitudes towards blood transfusion and organ transplant among Latin American migrants in Geneva, Switzerland...
  24. doi request reprint Tolerance and safety of nifurtimox in patients with chronic chagas disease
    Yves Jackson
    Divisionof Primary Care Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Clin Infect Dis 51:e69-75. 2010
    ..We aimed to evaluate nifurtimox tolerance and safety in a cohort of Trypanosoma cruzi-infected adult patients in a country of nonendemicity...
  25. doi request reprint Post-kala-azar dermal leishmaniasis in visceral leishmaniasis-endemic communities in Bihar, India
    Rudra Pratap Singh
    Banaras Hindu University, Varanasi, India Institute of Tropical Medicine, Antwerp, Belgium Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain Geneva University Hospitals, Geneva, Switzerland
    Trop Med Int Health 17:1345-8. 2012
    ..The prevalence of confirmed PKDL cases was 4.4 per 10 000 individuals and 7.8 if probable cases were also considered. The clinical history and treatment of the post-kala-azar dermal leishmaniasis cases are discussed. ..
  26. doi request reprint Urbanisation and infectious diseases in a globalised world
    Emilie Alirol
    Division of International and Humanitarian Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals, Geneva, Switzerland
    Lancet Infect Dis 11:131-41. 2011
    ..Furthermore, health should be a major consideration in town planning to ensure urbanisation works to reduce the burden of infectious diseases in the future...
  27. ncbi request reprint Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school children
    Gilles Eperon
    Medecins Sans Frontieres, Rue de Lausanne 78, 1202 Geneva, Switzerland
    Acta Trop 101:31-9. 2007
    ..Here, we described the demographic, clinical, diagnostic, treatment and outcome characteristics of HAT in pre-school children from Kajo-Keji County, South Sudan in comparison with older patients...
  28. ncbi request reprint African tick-bite fever: four cases among Swiss travelers returning from South Africa
    Yves Jackson
    Unit of Travel and Migration Medicine, Department of Community Medicine, University Hospital Geneva, Geneva, Switzerland
    J Travel Med 11:225-8. 2004
    ..African tick-bite fever (ATBF) is a recently described disease belonging to the spotted fever group. It is caused by Rickettsia africae, and cases are mainly diagnosed in travelers returning from sub-Saharan Africa...
  29. ncbi request reprint The use of a rapid diagnostic test to determine malaria as a cause of death
    Francois Chappuis
    Division of Hematology, Department of Internal Medicine, Geneva University Hospital, Geneva, Switzerland
    J Travel Med 10:356-7. 2003
    ..This report describes the novel use of a diagnostic test for a tropical disease in the postmortem examination of the cause of death...
  30. doi request reprint Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo
    Emilie Alirol
    Division of International and Humanitarian Medicine, University Hospitals of Geneva, Switzerland
    Clin Infect Dis 56:195-203. 2013
    ..We report here the results of 18 months of experience of NECT use in treatment centers run by Médecins Sans Frontières in the Democratic Republic of the Congo (DRC)...
  31. doi request reprint Metabolic, mental health, behavioural and socioeconomic characteristics of migrants with Chagas disease in a non-endemic country
    Yves Jackson
    Department of Community Medicine, Primary Care and Emergency Medicine, University Hospitals Geneva, Switzerland
    Trop Med Int Health 17:595-603. 2012
    ..Somatic, mental, behavioural and social characteristics of the 80,000 Latino migrants with Chagas disease in Europe are not known. We postulate that they may accumulate these factors for poor health--notably cardiovascular-outcomes...
  32. doi request reprint Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda
    Yolanda Mueller
    Medecins Sans Frontieres, Geneva, Switzerland
    Trop Med Int Health 14:910-7. 2009
    ..To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda...
  33. pmc Congenital transmission of Chagas disease in Latin American immigrants in Switzerland
    Yves Jackson
    Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Emerg Infect Dis 15:601-3. 2009
    ..A retrospective study to detect Chagas disease showed a prevalence of 9.7% among 72 Latin American women tested during pregnancy in Switzerland...
  34. ncbi request reprint [Chagas disease in Switzerland: managing an emerging infection and interrupting its transmission]
    Yves Jackson
    Unité de médecine des voyages et migrations, Département de médecine communautaire et de premier recours HUG, Geneve
    Rev Med Suisse 4:1212-4, 1216-7. 2008
    ....
  35. ncbi request reprint Vaccine-preventable diseases in long-term expatriates
    Jan A Dijkstra
    Hopital Cantonal Universitaire, Unité de médecine des voyages et des migrations, Geneva, Switzerland
    J Travel Med 12:S47-57. 2005
    ..Institutions and organizations sending expatriates to developing countries have a clear responsibility, and it is in their own interests to promote the health of their employees working abroad...
  36. pmc Effectiveness of rapid transport of victims and community health education on snake bite fatalities in rural Nepal
    Sanjib K Sharma
    Department of Medicine, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Am J Trop Med Hyg 89:145-50. 2013
    ..The impact of similar interventions should be assessed elsewhere...
  37. ncbi request reprint Dengue fever and long thoracic nerve palsy in a traveler returning from Thailand
    Francois Chappuis
    Travel and Migration Medicine Unit, Department of Community Medicine, Geneva University Hospital, Switzerland
    J Travel Med 11:112-4. 2004
  38. ncbi request reprint Protection against snake bites by sleeping under a bed net in southeastern Nepal
    Francois Chappuis
    Travel and Migration Medicine Unit, and Department of Community Medicine, Geneva University Hospitals, Geneva, Switzerland
    Am J Trop Med Hyg 77:197-9. 2007
    ..007-0.07, P < 0.0001), whereas the place of sleeping in the household and the use of a cot were not associated with the risk of snake bite. These findings provide further support for use of bed nets in this region...
  39. doi request reprint Pediatric chagas disease in europe: 45 cases from Spain and Switzerland
    Luciana Rodriguez-Guerineau
    From the Department of Pediatrics, University Hospitals of Geneva and University of Geneva, Switzerland Department of Pediatrics Laboratory of Microbiology, Sant Joan de Déu Hospital, University of Barcelona, Spain Department of Gynecology and Obstetrics Division of International and Humanitarian Medicine, Department of Community Medicine, Primary Care and Emergency Medicine and Division of Primary Care, Department of Community Medicine, Primary Care and Emergency Medicine, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland
    Pediatr Infect Dis J 33:458-62. 2014
    ..To date, there is no published information about clinical characteristics in children...
  40. pmc Clinical epidemiology, diagnosis and treatment of visceral leishmaniasis in the Pokot endemic area of Uganda and Kenya
    Yolanda K Mueller
    Epicentre, Paris, France Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, United Kingdom Médecins Sans Frontières, Geneva, Switzerland Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Am J Trop Med Hyg 90:33-9. 2014
    ..Post-kala-azar dermal leishmaniasis was rare but likely to be underdiagnosed. The epidemiological and clinical features of VL in the Pokot area differed markedly from VL in Sudan, the main endemic focus in Africa...
  41. ncbi request reprint [Old World cutaneous leishmaniasis]
    Christelle Weibel Galluzzo
    Service de médecine internationale et humanitaire, Département de médecine communataire, de premier recours et des urgences, HUG, 1211 Geneve 14
    Rev Med Suisse 9:990-5. 2013
    ..Treatment is dependent on the clinical presentation, the species of Leishmania and the comorbidities of the patient...
  42. pmc Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?
    Yves Jackson
    Travel and Migration Medicine Unit, Geneva University Hospital, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
    Malar J 5:81. 2006
    ..falciparum acquired in Africa, who failed to respond to artemisinin-based therapy. Sub-therapeutic dosing in accordance with the manufacturers' recommendations was the probable cause...
  43. ncbi request reprint Influence of Leishmania (Viannia) species on the response to antimonial treatment in patients with American tegumentary leishmaniasis
    Jorge Arevalo
    Instituto de Medicina Tropical Alexander von Humboldt, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru, and Hôpitaux Universitaires de Genève, Department of Community Medicine, Switzerland
    J Infect Dis 195:1846-51. 2007
    ..There are, however, reports of the occurrence of treatment failure with these drugs. Few studies in Latin America have compared the response to SbV treatment in ATL caused by different Leishmania species...
  44. ncbi request reprint High immunogenicity of delayed third dose of hepatitis B vaccine in travellers
    Yves Jackson
    Travel and Migration Medicine Unit, Geneva University Hospitals, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
    Vaccine 25:3482-4. 2007
    ..1%) travellers who had an interval of more than 5 years between second and third vaccine dose. We did not find any risk factor associated with insufficient response...
  45. pmc Liposomal amphotericin B as a treatment for human leishmaniasis
    Manica Balasegaram
    Drugs for Neglected Diseases Initiative, Geneva, Switzerland
    Expert Opin Emerg Drugs 17:493-510. 2012
    ....
  46. pmc Snake bite in South Asia: a review
    Emilie Alirol
    Division of International and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland
    PLoS Negl Trop Dis 4:e603. 2010
    ..The deficiency of snake bite management in South Asia is multi-causal and requires joint collaborative efforts from researchers, antivenom manufacturers, policy makers, public health authorities and international funders...