Joseph Caverzasio

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. doi Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms
    Joseph Caverzasio
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Bone 42:1131-6. 2008
  2. ncbi Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells
    Joseph Caverzasio
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Endocrinology 148:5323-30. 2007
  3. ncbi [Wnt/LRP5, a new regulation osteoblastic pathway involved in reaching peak bone masses]
    Joseph Caverzasio
    Service des maladies osseuses Département de réhabilitation et gériatrie HUG
    Rev Med Suisse Romande 124:81-2. 2004
  4. doi The p38α MAPK positively regulates osteoblast function and postnatal bone acquisition
    Cyril Thouverey
    Department of Internal Medicine, Service of Bone Diseases, University Hospital of Geneva, 64 Avenue de la Roseraie, 1205, Geneva, Switzerland
    Cell Mol Life Sci 69:3115-25. 2012
  5. ncbi Prostaglandin-dependent activation of ERK mediates cell proliferation induced by transforming growth factor beta in mouse osteoblastic cells
    Chafik Ghayor
    Department of Rehabilitation and Geriatrics, Service of Bone Diseases, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Bone 36:93-100. 2005
  6. ncbi Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiation
    Jérome Lemonnier
    Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    J Biol Chem 279:259-64. 2004
  7. doi Predominant role of PDGF receptor transactivation in Wnt3a-induced osteoblastic cell proliferation
    Joseph Caverzasio
    Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 28:260-70. 2013
  8. doi Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor
    Joseph Caverzasio
    Department of Rehabilitation and Geriatrics, Service of Bone Diseases, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 23:1389-97. 2008
  9. ncbi Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation
    Alexandre Rey
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital, 1211 Geneva 14, Switzerland
    J Biol Chem 281:38181-8. 2006
  10. doi Activation of FGF receptors is a new mechanism by which strontium ranelate induces osteoblastic cell growth
    Joseph Caverzasio
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, Geneva, Switzerland
    Cell Physiol Biochem 27:243-50. 2011

Collaborators

Detail Information

Publications14

  1. doi Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms
    Joseph Caverzasio
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Bone 42:1131-6. 2008
    ....
  2. ncbi Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells
    Joseph Caverzasio
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Endocrinology 148:5323-30. 2007
    ..These observations suggest that MAPKs ERK and p38 are probably essential pathways activated by Wnt proteins for the development of mesenchymal cells into osteoprogenitors...
  3. ncbi [Wnt/LRP5, a new regulation osteoblastic pathway involved in reaching peak bone masses]
    Joseph Caverzasio
    Service des maladies osseuses Département de réhabilitation et gériatrie HUG
    Rev Med Suisse Romande 124:81-2. 2004
    ..Analysis of the cellular mechanism by which Wnt/LRP5 activates osteoblastic cells is of potential interest for the development of new molecules capable of selectively increasing bone mass for the treatment of osteoporosis...
  4. doi The p38α MAPK positively regulates osteoblast function and postnatal bone acquisition
    Cyril Thouverey
    Department of Internal Medicine, Service of Bone Diseases, University Hospital of Geneva, 64 Avenue de la Roseraie, 1205, Geneva, Switzerland
    Cell Mol Life Sci 69:3115-25. 2012
    ..These findings indicate that p38α is an essential positive regulator of osteoblast function and postnatal bone formation in vivo...
  5. ncbi Prostaglandin-dependent activation of ERK mediates cell proliferation induced by transforming growth factor beta in mouse osteoblastic cells
    Chafik Ghayor
    Department of Rehabilitation and Geriatrics, Service of Bone Diseases, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Bone 36:93-100. 2005
    ..This effect is mediated by the ERK pathway activated by a PKC-dependent mechanism...
  6. ncbi Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiation
    Jérome Lemonnier
    Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    J Biol Chem 279:259-64. 2004
    ..Thus, this pathway, in addition to Smads, appears to be essential for the effect of BMP-2 on osteoblastic cell differentiation...
  7. doi Predominant role of PDGF receptor transactivation in Wnt3a-induced osteoblastic cell proliferation
    Joseph Caverzasio
    Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 28:260-70. 2013
    ....
  8. doi Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor
    Joseph Caverzasio
    Department of Rehabilitation and Geriatrics, Service of Bone Diseases, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 23:1389-97. 2008
    ....
  9. ncbi Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation
    Alexandre Rey
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital, 1211 Geneva 14, Switzerland
    J Biol Chem 281:38181-8. 2006
    ....
  10. doi Activation of FGF receptors is a new mechanism by which strontium ranelate induces osteoblastic cell growth
    Joseph Caverzasio
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, Geneva, Switzerland
    Cell Physiol Biochem 27:243-50. 2011
    ..In the present study, we investigated the CaSR-independent molecular mechanism by which SrRan stimulates osteoblast growth...
  11. doi Fibroblast growth factor 2 inhibits up-regulation of bone morphogenic proteins and their receptors during osteoblastic differentiation of human mesenchymal stem cells
    Emmanuel Biver
    Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer, France
    Biochem Biophys Res Commun 427:737-42. 2012
    ..These crosstalks between growth and osteogenic factors should be considered in the use of recombinant BMPs in therapeutic purpose of fracture repair or skeletal bioengineering...
  12. ncbi Enhanced expression of the inorganic phosphate transporter Pit-1 is involved in BMP-2-induced matrix mineralization in osteoblast-like cells
    Atsushi Suzuki
    Division of Endocrinology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
    J Bone Miner Res 21:674-83. 2006
    ..The role of Pi transport in BMP-2-induced matrix calcification was studied. BMP-2 enhances Pit-1 Pi transporters in osteogenic cells. Experimental analysis suggest that this response is required for bone matrix calcification...
  13. ncbi Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation
    Karim Kaabeche
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, University Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    J Biol Chem 279:36259-67. 2004
    ....
  14. ncbi Primary human articular chondrocytes, dedifferentiated chondrocytes, and synoviocytes exhibit differential responsiveness to interleukin-4: correlation with the expression pattern of the common receptor gamma chain
    Jerome Guicheux
    Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    J Cell Physiol 192:93-101. 2002
    ..The difference in IL-4 responsiveness between primary and dedifferentiated chondrocytes correlated with changes in proximal signaling events and in the expression pattern of IL-4R subunits during cell dedifferentiation...