Christian Cajochen

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, University of Basel, CH 4025 Basel, Switzerland
    Eur J Neurosci 23:1082-6. 2006
  2. ncbi request reprint Alerting effects of light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Sleep Med Rev 11:453-64. 2007
  3. doi request reprint Interhemispheric EEG asymmetries during unilateral bright-light exposure and subsequent sleep in humans
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 294:R1053-60. 2008
  4. doi request reprint Effects of artificial dawn and morning blue light on daytime cognitive performance, well-being, cortisol and melatonin levels
    Virginie Gabel
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Chronobiol Int 30:988-97. 2013
  5. ncbi request reprint Age-related attenuation of the evening circadian arousal signal in humans
    Mirjam Munch
    Centre for Chronobiology, University Psychiatric Hospitals, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Neurobiol Aging 26:1307-19. 2005
  6. doi request reprint Young women with major depression live on higher homeostatic sleep pressure than healthy controls
    Sylvia Frey
    Centre for Chronobiology, Psychiatric Hospital of University of Basel, Basel, Switzerland
    Chronobiol Int 29:278-94. 2012
  7. ncbi request reprint Circadian modulation of sequence learning under high and low sleep pressure conditions
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, University of Basel, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 151:167-76. 2004
  8. ncbi request reprint Age-related changes in the circadian modulation of sleep-spindle frequency during nap sleep
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Hospitals, Wilhelm Kleinstr, Basel, Switzerland
    Sleep 28:1093-101. 2005
  9. ncbi request reprint Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions
    Katharina Blatter
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 168:312-7. 2006
  10. doi request reprint Subjective well-being is modulated by circadian phase, sleep pressure, age, and gender
    Angelina Birchler-Pedross
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    J Biol Rhythms 24:232-42. 2009

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, University of Basel, CH 4025 Basel, Switzerland
    Eur J Neurosci 23:1082-6. 2006
    ..The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders...
  2. ncbi request reprint Alerting effects of light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Sleep Med Rev 11:453-64. 2007
    ..A brief outlook of promising clinical and non-clinical applications of lights' alerting properties will be given, and its involvement in the design of more effective lighting at home and in the workplace will be considered...
  3. doi request reprint Interhemispheric EEG asymmetries during unilateral bright-light exposure and subsequent sleep in humans
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 294:R1053-60. 2008
    ..However, the observed shift in the spindle hemispheric dominance in the occipital cortex may still represent subtle local use-dependent recovery functions during sleep in a frequency range different from the delta range...
  4. doi request reprint Effects of artificial dawn and morning blue light on daytime cognitive performance, well-being, cortisol and melatonin levels
    Virginie Gabel
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Chronobiol Int 30:988-97. 2013
    ..Thus, DsL may provide an effective strategy for enhancing cognitive performance, well-being, and mood under mild sleep restriction...
  5. ncbi request reprint Age-related attenuation of the evening circadian arousal signal in humans
    Mirjam Munch
    Centre for Chronobiology, University Psychiatric Hospitals, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Neurobiol Aging 26:1307-19. 2005
    ..Thus, our data indicate that age-related changes in sleep propensity are clearly related to a reduced circadian signal opposing the homeostatic drive for sleep...
  6. doi request reprint Young women with major depression live on higher homeostatic sleep pressure than healthy controls
    Sylvia Frey
    Centre for Chronobiology, Psychiatric Hospital of University of Basel, Basel, Switzerland
    Chronobiol Int 29:278-94. 2012
    ..This finding may have important repercussions on the treatment of the illness as such that a selective suppression of EEG slow-wave activity could promote acute mood improvement...
  7. ncbi request reprint Circadian modulation of sequence learning under high and low sleep pressure conditions
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, University of Basel, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 151:167-76. 2004
    ..Our data indicate that sequence learning is modulated by circadian phase, and the neurophysiological medium required for this type of learning is related to sleep...
  8. ncbi request reprint Age-related changes in the circadian modulation of sleep-spindle frequency during nap sleep
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Hospitals, Wilhelm Kleinstr, Basel, Switzerland
    Sleep 28:1093-101. 2005
    ..We investigated whether this circadian modulation of spindle characteristics changes with age...
  9. ncbi request reprint Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions
    Katharina Blatter
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 168:312-7. 2006
    ..Not only sleepiness and circadian phase, but also age and gender are major factors that may contribute to attentional failures in extended work shifts and during nighttime work shifts...
  10. doi request reprint Subjective well-being is modulated by circadian phase, sleep pressure, age, and gender
    Angelina Birchler-Pedross
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    J Biol Rhythms 24:232-42. 2009
    ..The results demonstrate age- and/or gender-related modifications of well-being related to sleep deprivation and circadian phase and thus point to specific biological components of mood vulnerability...
  11. doi request reprint Cortical activation patterns herald successful dream recall after NREM and REM sleep
    Sarah Laxhmi Chellappa
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm, Kleinstrasse 27, CH 4025 Basel, Switzerland
    Biol Psychol 87:251-6. 2011
    ..This dual NREM-REM sleep modulation holds strong implications for the mechanistic understanding of this complex ongoing cognitive process...
  12. ncbi request reprint Age-related changes in the circadian and homeostatic regulation of human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Chronobiol Int 23:461-74. 2006
    ..Our data suggest that manipulations of the circadian timing system, rather than the sleep homeostat, may offer a potential strategy to alleviate age-related decrements in sleep and daytime alertness levels...
  13. doi request reprint Estimation of human circadian phase via a multi-channel ambulatory monitoring system and a multiple regression model
    Vitaliy Kolodyazhniy
    Department of Clinical Psychology and Psychotherapy, Faculty for Psychology, University of Basel, Basel, Switzerland
    J Biol Rhythms 26:55-67. 2011
    ..The proposed noninvasive measurement method could find applications in sleep medicine or in other domains where knowing the exact endogenous circadian phase is important (e.g., for the timing of light therapy)...
  14. ncbi request reprint High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    J Clin Endocrinol Metab 90:1311-6. 2005
    ....
  15. ncbi request reprint Evidence that the lunar cycle influences human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, 4012 Basel, Switzerland
    Curr Biol 23:1485-8. 2013
    ..This is the first reliable evidence that a lunar rhythm can modulate sleep structure in humans when measured under the highly controlled conditions of a circadian laboratory study protocol without time cues. ..
  16. ncbi request reprint Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men
    Mirjam Munch
    Centre for Chronobiology, Psychiatric Univ Clinics, University of Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R1421-8. 2006
    ..Our results can be interpreted in terms of an induction of a circadian phase delay and/or repercussions of a stronger alerting effect after blue light, persisting into the sleep episode...
  17. ncbi request reprint Challenging the sleep homeostat does not influence the thermoregulatory system in men: evidence from a nap vs. sleep-deprivation study
    Kurt Krauchi
    Psychiatric University Clinics, Centre for Chronobiology, Wilhelm Klein Strasse 27, H4025 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R1052-61. 2006
    ..In summary, the thermoregulatory system seems to be independent of the sleep homeostat, but the circadian modulation of sleepiness and sleep inertia is clearly associated with thermoregulatory changes...
  18. pmc Higher frontal EEG synchronization in young women with major depression: a marker for increased homeostatic sleep pressure?
    Angelina Birchler-Pedross
    Centre for Chronobiology, Psychiatric Hospitals of the University of Basel, Basel, Switzerland
    Sleep 34:1699-706. 2011
    ..Major depressive disorder (MDD) is often associated with disturbances in circadian and/or sleep-wake dependent processes, which both regulate daytime energy and sleepiness levels...
  19. doi request reprint Impact of age, sleep pressure and circadian phase on time-of-day estimates
    Jakub Späti
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Behav Brain Res 201:48-52. 2009
    ..The effects of age, duration of wake time and circadian phase on temporal position finding are in line with predictions based on the idea that awareness about current position in time is derived from interval timing processes...
  20. ncbi request reprint Encoding difficulty promotes postlearning changes in sleep spindle activity during napping
    Christina Schmidt
    Centre for Chronobiology, Psychiatric University Clinics, CH 4025 Basel, Switzerland
    J Neurosci 26:8976-82. 2006
    ..Furthermore, we demonstrate here that the nature of the learning material is a determinant factor for sleep-related alterations after declarative learning...
  21. doi request reprint Sleep-wake cycles and cognitive functioning in schizophrenia
    Vivien Bromundt
    Centre for Chronobiology, Psychiatric Hospital, University of Basel, Switzerland
    Br J Psychiatry 198:269-76. 2011
    ..Irregular sleep-wake cycles and cognitive impairment are frequently observed in schizophrenia, however, how they interact remains unclear...
  22. doi request reprint Age effects on spectral electroencephalogram activity prior to dream recall
    Sarah L Chellappa
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    J Sleep Res 21:247-56. 2012
    ..Thus, the spectral correlates of dreaming can help to understand the cortical pathways of dreaming...
  23. ncbi request reprint Sleep loss-related decrements in planning performance in healthy elderly depend on task difficulty
    Katharina Blatter
    Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    J Sleep Res 14:409-17. 2005
    ..These results indicate that sleep loss-related decrements in planning performance depend on difficulty level, and that apparently insensitive tasks can turn out to be sensitive to sleep loss and circadian variation...
  24. pmc Is homeostatic sleep regulation under low sleep pressure modified by age?
    Mirjam Munch
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Sleep 30:781-92. 2007
    ..Here, we investigated age-related changes in homeostatic sleep regulation under low sleep pressure conditions, with respect to regional EEG differences and their dynamics...
  25. ncbi request reprint Thermoregulatory effects of melatonin in relation to sleepiness
    Kurt Krauchi
    Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 23:475-84. 2006
    ..Besides the role of melatonin as "nature's soporific", it can also serve as nature's nocturnal vascular modulator...
  26. doi request reprint Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance
    Christian Cajochen
    Centre for Chronobiology, Psychiatric Hospitals of the University of Basel, Basel, Switzerland
    J Appl Physiol (1985) 110:1432-8. 2011
    ..The challenge will be to design a computer screen with a spectral profile that can be individually programmed to add timed, essential light information to the circadian system in humans...
  27. pmc Non-visual effects of light on melatonin, alertness and cognitive performance: can blue-enriched light keep us alert?
    Sarah Laxhmi Chellappa
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    PLoS ONE 6:e16429. 2011
    ..Here we investigated if commercially available compact fluorescent lamps with different colour temperatures can impact on alertness and cognitive performance...
  28. ncbi request reprint Insights into behavioral vulnerability to differential sleep pressure and circadian phase from a functional ADA polymorphism
    Carolin F Reichert
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    J Biol Rhythms 29:119-30. 2014
    ..Moreover, they indicate that napping might be suitable to counteract endogenously heightened sleep pressure depending on the neurobehavioral domain...
  29. ncbi request reprint Circadian and wake-dependent modulation of fastest and slowest reaction times during the psychomotor vigilance task
    Peter Graw
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025, Basel, Switzerland
    Physiol Behav 80:695-701. 2004
    ..On the other hand, decrements in PVT performance which were related to circadian phase did not depend significantly on any categorization (such as percentiles of the RTs)...
  30. doi request reprint Daytime sleepiness in renal transplant recipients is associated with immunosuppressive non-adherence: a cross-sectional, multi-center study
    Hanna Burkhalter
    Institute of Nursing Science, University of Basel, Basel, Switzerland Division of Transplant Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Clin Transplant 28:58-66. 2014
    ....
  31. doi request reprint Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism
    Antoine U Viola
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Neurobiol Aging 33:1010.e17-27. 2012
    ..Our results indicate that the polymorphism in the clock gene PER3 may contribute to interindividual differences in sleep and circadian physiology in older people...
  32. ncbi request reprint The frontal predominance in human EEG delta activity after sleep loss decreases with age
    Mirjam Munch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, 4025 Basel, Switzerland
    Eur J Neurosci 20:1402-10. 2004
    ..These findings provide quantitative evidence for the hypothesis that frontal brain regions are particularly vulnerable to the effects of elevated sleep pressure ('prefrontal tiredness') and ageing ('frontal ageing')...
  33. doi request reprint Can light make us bright? Effects of light on cognition and sleep
    Sarah Laxhmi Chellappa
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Prog Brain Res 190:119-33. 2011
    ..A thorough understanding of how light affects sleep and cognitive performance may help to improve light settings at home and at the workplace in order to improve well-being...
  34. doi request reprint The circadian rest-activity cycle in Korsakoff psychosis
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Hospital of University Basel, Basel, Switzerland
    Am J Geriatr Psychiatry 18:33-41. 2010
    ..This pilot study investigated the rest-activity cycle of KP to see whether there were sleep-wake cycle disturbances similar to those that the authors had observed in patients with AD...
  35. ncbi request reprint Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine
    Egemen Savaskan
    Geriatric Psychiatry, University Psychiatric Hospitals, CH 4025 Basel, Switzerland
    Int J Neuropsychopharmacol 9:507-16. 2006
    ..The study provides evidence that quetiapine at a moderate dose may be efficacious in treating behavioural disturbances in AD, with better tolerability than haloperidol...
  36. ncbi request reprint Thermophysiologic aspects of the three-process-model of sleepiness regulation
    Kurt Krauchi
    Psychiatric University Clinic, Centre for Chronobiology, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    Clin Sports Med 24:287-300, ix. 2005
    ..Sleep per se has no further thermoregulatory effect. Taken together, a thermophysiologic approach may provide a successful strategy to treat sleep-onset insomnia and alleviate sleep inertia...
  37. ncbi request reprint Circadian rhythms in cognitive performance: methodological constraints, protocols, theoretical underpinnings
    Katharina Blatter
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Physiol Behav 90:196-208. 2007
    ..This promises a fascinating challenge for future research on sleep-wake related and circadian aspects of different cognitive domains...
  38. ncbi request reprint Waking up properly: is there a role of thermoregulation in sleep inertia?
    Kurt Krauchi
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Sleep Res 13:121-7. 2004
    ..In order to directly test our hypothesis, further studies with thermophysiological interventions (e.g. cooling the extremities) are needed...
  39. pmc Self-reported sleep disturbances in renal transplant recipients
    Hanna Burkhalter
    Institute of Nursing Science, University of Basel, Basel, Switzerland
    BMC Nephrol 14:220. 2013
    ..Poor sleep quality (SQ) and daytime sleepiness (DS) are common in renal transplant (RTx) recipients; however, related data are rare. This study describes the prevalence and frequency of self-reported sleep disturbances in RTx recipients...
  40. doi request reprint Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3
    Sarah L Chellappa
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Kleinstrasse 27, CH 4012 Basel, Switzerland
    J Clin Endocrinol Metab 97:E433-7. 2012
    ..Light exposure, particularly at the short-wavelength range, triggers several nonvisual responses in humans. However, the extent to which the melatonin-suppressing and alerting effect of light differs among individuals remains unknown...
  41. ncbi request reprint Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onset
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 36:192-4. 2004
    ..Melatonin suppression is not necessary for a phase shift by light, and melatonin is not a 'weak' Zeitgeber relative to bright light when ambient lighting is strictly controlled...
  42. ncbi request reprint Regional differences in the circadian modulation of human sleep spindle characteristics
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, 4025 Basel, Switzerland
    Eur J Neurosci 18:155-63. 2003
    ..Our data provide evidence that the circadian pacemaker actively promotes low-frequency sleep spindles during the biological night with a parietal predominance...
  43. ncbi request reprint Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly
    Paola Fontana Gasio
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Exp Gerontol 38:207-16. 2003
    ..Increasing zeitgeber strength is an important strategy for improving sleep quality and timing in dementia, and DDS light therapy may provide one of the appropriate means to do so...
  44. ncbi request reprint Human sleep spindle characteristics after sleep deprivation
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    Clin Neurophysiol 114:2258-67. 2003
    ..The effect of a 40 h sleep deprivation (SD) on spindle characteristics along the antero-posterior axis was investigated...
  45. pmc Serum factors in older individuals change cellular clock properties
    Lucia Pagani
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, CH 4012 Basel, Switzerland
    Proc Natl Acad Sci U S A 108:7218-23. 2011
    ..Thus, even though the molecular machinery of peripheral circadian clocks does not change with age, some age-related circadian dysfunction observed in vivo might be of hormonal origin and therefore might be pharmacologically remediable...
  46. ncbi request reprint Extraocular light via the ear canal does not acutely affect human circadian physiology, alertness and psychomotor vigilance performance
    Vivien Bromundt
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Chronobiol Int 31:343-8. 2014
    ..We conclude that extraocular transcranial light exposure in the late evening does not suppress melatonin, reduce subjective sleepiness or improve performance, and therefore, does not acutely influence the human circadian timing system...
  47. doi request reprint Validation of a single item to assess daytime sleepiness for the Swiss Transplant Cohort Study
    Hanna Burkhalter
    University of Basel, Switzerland University Hospital Basel, Switzerland
    Prog Transplant 23:220-8. 2013
    ..Thus there is a need to assess daytime sleepiness in clinical practice and transplant registries...
  48. pmc Age-related changes in sleep and circadian rhythms: impact on cognitive performance and underlying neuroanatomical networks
    Christina Schmidt
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel Basel, Switzerland
    Front Neurol 3:118. 2012
    ....
  49. ncbi request reprint Alteration of internal circadian phase relationships after morning versus evening carbohydrate-rich meals in humans
    Kurt Krauchi
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Biol Rhythms 17:364-76. 2002
    ..Food may be a zeitgeber in humans for the food-entrainable peripheral oscillators, but melatonin data do not support such a conclusion for the light-entrainable oscillator in the suprachiasmatic nucleus...
  50. pmc Consequences of the timing of menarche on female adolescent sleep phase preference
    Sylvia Frey
    Centre for Chronobiology, Psychiatric University Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 4:e5217. 2009
    ....
  51. ncbi request reprint TAK-375 Takeda
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Curr Opin Investig Drugs 6:114-21. 2005
    ..TAK-375 (Ramelteon), a melatonin ML1/MT1 receptor agonist for the potential treatment of primary insomnia, is being developed by Takeda. Takeda submitted an NDA to the FDA for TAK-375 in September 2004...
  52. ncbi request reprint Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness
    James K Wyatt
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Sleep 27:374-81. 2004
    ....
  53. pmc A phase response curve to single bright light pulses in human subjects
    Sat Bir S Khalsa
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 549:945-52. 2003
    ..Phase shifts derived using the melatonin onsets showed larger magnitudes than those derived from the melatonin offsets. These data provide a comprehensive characterization of the human PRC under highly controlled laboratory conditions...
  54. ncbi request reprint A time to think: circadian rhythms in human cognition
    Christina Schmidt
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Cogn Neuropsychol 24:755-89. 2007
    ....
  55. ncbi request reprint Is sleep per se a zeitgeber in humans?
    Konstantin V Danilenko
    Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences, 630003 Novosibirsk, Russia
    J Biol Rhythms 18:170-8. 2003
    ..02) and by 0.27 +/- 0.14 h for melatonin rhythms (p = 0.09). However, this advance was small to medium according to effect size. Sleep per se may feed back onto the circadian pacemaker, but it appears to be a weak zeitgeber in humans...
  56. ncbi request reprint Human circadian melatonin rhythm phase delay during a fixed sleep-wake schedule interspersed with nights of sleep deprivation
    Christian Cajochen
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    J Pineal Res 35:149-57. 2003
    ..The data indicate that under conditions of reduced zeitgeber strength, the phase of the human circadian pacemaker, using plasma melatonin as a marker, can be phase delayed by one night of SD and the associated dim light exposure...