C Cajochen

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness
    C Cajochen
    Department of Medicine, Circadian, Neuroendocrine and Sleep Disorders Section, Endocrinology and Hypertension Division, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Behav Brain Res 115:75-83. 2000
  2. ncbi Role of melatonin in the regulation of human circadian rhythms and sleep
    C Cajochen
    Center for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstrasse 27, CH 4025 Basel, Switzerland
    J Neuroendocrinol 15:432-7. 2003
  3. ncbi TAK-375 Takeda
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Curr Opin Investig Drugs 6:114-21. 2005
  4. ncbi High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    J Clin Endocrinol Metab 90:1311-6. 2005
  5. ncbi Human circadian melatonin rhythm phase delay during a fixed sleep-wake schedule interspersed with nights of sleep deprivation
    Christian Cajochen
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    J Pineal Res 35:149-57. 2003
  6. ncbi Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulness
    C Cajochen
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 114:1047-60. 2002
  7. ncbi Dynamics of frontal EEG activity, sleepiness and body temperature under high and low sleep pressure
    C Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr. 27, CH-4025 Basel, Switzerland
    Neuroreport 12:2277-81. 2001
  8. ncbi Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans
    C Cajochen
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Sleep Res Online 2:65-9. 1999
  9. ncbi Early morning melatonin administration impairs psychomotor vigilance
    P Graw
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Strasse, 27, 4025 Basel, Switzerland
    Behav Brain Res 121:167-72. 2001
  10. ncbi EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss
    C Cajochen
    Circadian, Neuroendocrine and Sleep Disorders Section, Endocrine Hypertension Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:R640-9. 1999

Collaborators

Detail Information

Publications52

  1. ncbi Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness
    C Cajochen
    Department of Medicine, Circadian, Neuroendocrine and Sleep Disorders Section, Endocrinology and Hypertension Division, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Behav Brain Res 115:75-83. 2000
    ....
  2. ncbi Role of melatonin in the regulation of human circadian rhythms and sleep
    C Cajochen
    Center for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstrasse 27, CH 4025 Basel, Switzerland
    J Neuroendocrinol 15:432-7. 2003
    ..We describe the role of melatonin in the regulation of sleep, and the use of exogenous melatonin to treat sleep or circadian rhythm disorders...
  3. ncbi TAK-375 Takeda
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Curr Opin Investig Drugs 6:114-21. 2005
    ..TAK-375 (Ramelteon), a melatonin ML1/MT1 receptor agonist for the potential treatment of primary insomnia, is being developed by Takeda. Takeda submitted an NDA to the FDA for TAK-375 in September 2004...
  4. ncbi High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    J Clin Endocrinol Metab 90:1311-6. 2005
    ....
  5. ncbi Human circadian melatonin rhythm phase delay during a fixed sleep-wake schedule interspersed with nights of sleep deprivation
    Christian Cajochen
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    J Pineal Res 35:149-57. 2003
    ..The data indicate that under conditions of reduced zeitgeber strength, the phase of the human circadian pacemaker, using plasma melatonin as a marker, can be phase delayed by one night of SD and the associated dim light exposure...
  6. ncbi Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulness
    C Cajochen
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 114:1047-60. 2002
    ....
  7. ncbi Dynamics of frontal EEG activity, sleepiness and body temperature under high and low sleep pressure
    C Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr. 27, CH-4025 Basel, Switzerland
    Neuroreport 12:2277-81. 2001
    ..The data demonstrate that changes in FLA during wakefulness are to a large extent determined by the sleep-wake dependent process with little circadian modulation, and reflect differential levels of sleep pressure in the awake subject...
  8. ncbi Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans
    C Cajochen
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Sleep Res Online 2:65-9. 1999
    ..The data demonstrate that the enhancement of slow wave EEG activity during sleep following extended wakefulness is most pronounced in frontal cortical areas...
  9. ncbi Early morning melatonin administration impairs psychomotor vigilance
    P Graw
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Strasse, 27, 4025 Basel, Switzerland
    Behav Brain Res 121:167-72. 2001
    ..A subjective soporific effect was present but less pronounced. Thus, melatonin taken in the morning requires caution in situations where high attention is needed...
  10. ncbi EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss
    C Cajochen
    Circadian, Neuroendocrine and Sleep Disorders Section, Endocrine Hypertension Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:R640-9. 1999
    ..Frontal EEG activity and ocular parameters may be used to monitor and predict changes in neurobehavioral performance associated with sleep loss and circadian misalignment...
  11. ncbi Evening administration of melatonin and bright light: interactions on the EEG during sleep and wakefulness
    C Cajochen
    Psychiatric University Clinic, Basel, Switzerland
    J Sleep Res 7:145-57. 1998
    ....
  12. ncbi A schizophrenic patient with an arrhythmic circadian rest-activity cycle
    A Wirz-Justice
    Chronobiology and Sleep Laboratory, Psychiatric University Clinic, Basel, Switzerland
    Psychiatry Res 73:83-90. 1997
    ..Measurement of the circadian rest-activity cycle may be a useful non-invasive method to follow functional consequences of neuroleptic treatment...
  13. doi Challenging the sleep homeostat: sleep in depression is not premature aging
    S Frey
    Centre for Chronobiology, Psychiatric University Clinics of the University of Basel, Wilhelm Kleinstrasse 27, CH 4025 Basel, Switzerland
    Sleep Med 13:933-45. 2012
    ..In this study, we aimed at quantifying the homeostatic sleep-wake regulation in young women with major depression and healthy young and older controls under high sleep pressure conditions...
  14. ncbi Functional link between distal vasodilation and sleep-onset latency?
    K Krauchi
    Chronobiology and Sleep Laboratory, Psychiatric University Clinic, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 278:R741-8. 2000
    ..This study provides evidence that selective vasodilation of distal skin regions (and hence heat loss) promotes the rapid onset of sleep...
  15. ncbi Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG
    C Cajochen
    Chronobiology and Sleep Laboratory, Psychiatric University Clinic, Basel, Switzerland
    Neurosci Lett 207:209-13. 1996
    ..There was a significant correlation between salivary melatonin levels and the timing of increased subjective sleepiness. Melatonin had no effects on mood...
  16. ncbi Challenging the sleep homeostat does not influence the thermoregulatory system in men: evidence from a nap vs. sleep-deprivation study
    Kurt Krauchi
    Psychiatric University Clinics, Centre for Chronobiology, Wilhelm Klein Strasse 27, H4025 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R1052-61. 2006
    ..In summary, the thermoregulatory system seems to be independent of the sleep homeostat, but the circadian modulation of sleepiness and sleep inertia is clearly associated with thermoregulatory changes...
  17. ncbi Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness
    James K Wyatt
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Sleep 27:374-81. 2004
    ....
  18. doi Subjective well-being is modulated by circadian phase, sleep pressure, age, and gender
    Angelina Birchler-Pedross
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    J Biol Rhythms 24:232-42. 2009
    ..The results demonstrate age- and/or gender-related modifications of well-being related to sleep deprivation and circadian phase and thus point to specific biological components of mood vulnerability...
  19. ncbi Age-related changes in the circadian and homeostatic regulation of human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Chronobiol Int 23:461-74. 2006
    ..Our data suggest that manipulations of the circadian timing system, rather than the sleep homeostat, may offer a potential strategy to alleviate age-related decrements in sleep and daytime alertness levels...
  20. ncbi Power density in theta/alpha frequencies of the waking EEG progressively increases during sustained wakefulness
    C Cajochen
    Psychiatric University Clinic, Basel, Switzerland
    Sleep 18:890-4. 1995
    ..Our data demonstrate the presence of a homeostatic component in the control of EEG power density in the 6.25- to 9.0-Hz range...
  21. ncbi Homeostatic control of slow-wave and spindle frequency activity during human sleep: effect of differential sleep pressure and brain topography
    V Knoblauch
    Center for Chronobiology, Psychiatric University Clinic, CH 4025 Basel, Switzerland
    Cereb Cortex 12:1092-100. 2002
    ....
  22. ncbi Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions
    Katharina Blatter
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 168:312-7. 2006
    ..Not only sleepiness and circadian phase, but also age and gender are major factors that may contribute to attentional failures in extended work shifts and during nighttime work shifts...
  23. ncbi Thermoregulatory effects of melatonin in relation to sleepiness
    Kurt Krauchi
    Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 23:475-84. 2006
    ..Besides the role of melatonin as "nature's soporific", it can also serve as nature's nocturnal vascular modulator...
  24. ncbi Circadian modulation of sequence learning under high and low sleep pressure conditions
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, University of Basel, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 151:167-76. 2004
    ..Our data indicate that sequence learning is modulated by circadian phase, and the neurophysiological medium required for this type of learning is related to sleep...
  25. ncbi Encoding difficulty promotes postlearning changes in sleep spindle activity during napping
    Christina Schmidt
    Centre for Chronobiology, Psychiatric University Clinics, CH 4025 Basel, Switzerland
    J Neurosci 26:8976-82. 2006
    ..Furthermore, we demonstrate here that the nature of the learning material is a determinant factor for sleep-related alterations after declarative learning...
  26. ncbi Age-related changes in the circadian modulation of sleep-spindle frequency during nap sleep
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Hospitals, Wilhelm Kleinstr, Basel, Switzerland
    Sleep 28:1093-101. 2005
    ..We investigated whether this circadian modulation of spindle characteristics changes with age...
  27. ncbi Age-related attenuation of the evening circadian arousal signal in humans
    Mirjam Munch
    Centre for Chronobiology, University Psychiatric Hospitals, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Neurobiol Aging 26:1307-19. 2005
    ..Thus, our data indicate that age-related changes in sleep propensity are clearly related to a reduced circadian signal opposing the homeostatic drive for sleep...
  28. ncbi Thermophysiologic aspects of the three-process-model of sleepiness regulation
    Kurt Krauchi
    Psychiatric University Clinic, Centre for Chronobiology, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    Clin Sports Med 24:287-300, ix. 2005
    ..Sleep per se has no further thermoregulatory effect. Taken together, a thermophysiologic approach may provide a successful strategy to treat sleep-onset insomnia and alleviate sleep inertia...
  29. doi Impact of age, sleep pressure and circadian phase on time-of-day estimates
    Jakub Späti
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Behav Brain Res 201:48-52. 2009
    ..The effects of age, duration of wake time and circadian phase on temporal position finding are in line with predictions based on the idea that awareness about current position in time is derived from interval timing processes...
  30. ncbi Regional differences in the circadian modulation of human sleep spindle characteristics
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, 4025 Basel, Switzerland
    Eur J Neurosci 18:155-63. 2003
    ..Our data provide evidence that the circadian pacemaker actively promotes low-frequency sleep spindles during the biological night with a parietal predominance...
  31. ncbi Circadian and wake-dependent modulation of fastest and slowest reaction times during the psychomotor vigilance task
    Peter Graw
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025, Basel, Switzerland
    Physiol Behav 80:695-701. 2004
    ..On the other hand, decrements in PVT performance which were related to circadian phase did not depend significantly on any categorization (such as percentiles of the RTs)...
  32. ncbi Waking up properly: is there a role of thermoregulation in sleep inertia?
    Kurt Krauchi
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Sleep Res 13:121-7. 2004
    ..In order to directly test our hypothesis, further studies with thermophysiological interventions (e.g. cooling the extremities) are needed...
  33. ncbi Alteration of internal circadian phase relationships after morning versus evening carbohydrate-rich meals in humans
    Kurt Krauchi
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Biol Rhythms 17:364-76. 2002
    ..Food may be a zeitgeber in humans for the food-entrainable peripheral oscillators, but melatonin data do not support such a conclusion for the light-entrainable oscillator in the suprachiasmatic nucleus...
  34. ncbi Alerting effects of light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Sleep Med Rev 11:453-64. 2007
    ..A brief outlook of promising clinical and non-clinical applications of lights' alerting properties will be given, and its involvement in the design of more effective lighting at home and in the workplace will be considered...
  35. ncbi Circadian rhythms in cognitive performance: methodological constraints, protocols, theoretical underpinnings
    Katharina Blatter
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Physiol Behav 90:196-208. 2007
    ..This promises a fascinating challenge for future research on sleep-wake related and circadian aspects of different cognitive domains...
  36. ncbi Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men
    Mirjam Munch
    Centre for Chronobiology, Psychiatric Univ Clinics, University of Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R1421-8. 2006
    ..Our results can be interpreted in terms of an induction of a circadian phase delay and/or repercussions of a stronger alerting effect after blue light, persisting into the sleep episode...
  37. ncbi Disturbed circadian rest-activity cycles in schizophrenia patients: an effect of drugs?
    A Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Schizophr Bull 27:497-502. 2001
    ..This is the first documentation of circadian rest-activity cycle disturbances in schizophrenia related to class of drug...
  38. pmc Is homeostatic sleep regulation under low sleep pressure modified by age?
    Mirjam Munch
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Sleep 30:781-92. 2007
    ..Here, we investigated age-related changes in homeostatic sleep regulation under low sleep pressure conditions, with respect to regional EEG differences and their dynamics...
  39. ncbi Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly
    Paola Fontana Gasio
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Exp Gerontol 38:207-16. 2003
    ..Increasing zeitgeber strength is an important strategy for improving sleep quality and timing in dementia, and DDS light therapy may provide one of the appropriate means to do so...
  40. ncbi Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, University of Basel, CH 4025 Basel, Switzerland
    Eur J Neurosci 23:1082-6. 2006
    ..The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders...
  41. ncbi Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onset
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 36:192-4. 2004
    ..Melatonin suppression is not necessary for a phase shift by light, and melatonin is not a 'weak' Zeitgeber relative to bright light when ambient lighting is strictly controlled...
  42. ncbi Sleep loss-related decrements in planning performance in healthy elderly depend on task difficulty
    Katharina Blatter
    Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    J Sleep Res 14:409-17. 2005
    ..These results indicate that sleep loss-related decrements in planning performance depend on difficulty level, and that apparently insensitive tasks can turn out to be sensitive to sleep loss and circadian variation...
  43. pmc A phase response curve to single bright light pulses in human subjects
    Sat Bir S Khalsa
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 549:945-52. 2003
    ..Phase shifts derived using the melatonin onsets showed larger magnitudes than those derived from the melatonin offsets. These data provide a comprehensive characterization of the human PRC under highly controlled laboratory conditions...
  44. ncbi The frontal predominance in human EEG delta activity after sleep loss decreases with age
    Mirjam Munch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, 4025 Basel, Switzerland
    Eur J Neurosci 20:1402-10. 2004
    ..These findings provide quantitative evidence for the hypothesis that frontal brain regions are particularly vulnerable to the effects of elevated sleep pressure ('prefrontal tiredness') and ageing ('frontal ageing')...
  45. ncbi Human sleep spindle characteristics after sleep deprivation
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    Clin Neurophysiol 114:2258-67. 2003
    ..The effect of a 40 h sleep deprivation (SD) on spindle characteristics along the antero-posterior axis was investigated...
  46. doi Interhemispheric EEG asymmetries during unilateral bright-light exposure and subsequent sleep in humans
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 294:R1053-60. 2008
    ..However, the observed shift in the spindle hemispheric dominance in the occipital cortex may still represent subtle local use-dependent recovery functions during sleep in a frequency range different from the delta range...
  47. pmc Consequences of the timing of menarche on female adolescent sleep phase preference
    Sylvia Frey
    Centre for Chronobiology, Psychiatric University Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 4:e5217. 2009
    ....
  48. ncbi Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine
    Egemen Savaskan
    Geriatric Psychiatry, University Psychiatric Hospitals, CH 4025 Basel, Switzerland
    Int J Neuropsychopharmacol 9:507-16. 2006
    ..The study provides evidence that quetiapine at a moderate dose may be efficacious in treating behavioural disturbances in AD, with better tolerability than haloperidol...
  49. doi The circadian rest-activity cycle in Korsakoff psychosis
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Hospital of University Basel, Basel, Switzerland
    Am J Geriatr Psychiatry 18:33-41. 2010
    ..This pilot study investigated the rest-activity cycle of KP to see whether there were sleep-wake cycle disturbances similar to those that the authors had observed in patients with AD...
  50. doi Age-dependent alterations in human PER2 levels after early morning blue light exposure
    Corinne Jud
    Department of Medicine, University of Fribourg, Switzerland
    Chronobiol Int 26:1462-9. 2009
    ..Additionally, our results indicate that the influence of light on clock-gene expression in humans is altered with age...
  51. ncbi A time to think: circadian rhythms in human cognition
    Christina Schmidt
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Cogn Neuropsychol 24:755-89. 2007
    ....
  52. ncbi Is sleep per se a zeitgeber in humans?
    Konstantin V Danilenko
    Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences, 630003 Novosibirsk, Russia
    J Biol Rhythms 18:170-8. 2003
    ..02) and by 0.27 +/- 0.14 h for melatonin rhythms (p = 0.09). However, this advance was small to medium according to effect size. Sleep per se may feed back onto the circadian pacemaker, but it appears to be a weak zeitgeber in humans...