Dirk Bumann

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Parallel exploitation of diverse host nutrients enhances Salmonella virulence
    Benjamin Steeb
    Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    PLoS Pathog 9:e1003301. 2013
  2. pmc Immunity to intracellular Salmonella depends on surface-associated antigens
    Somedutta Barat
    Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    PLoS Pathog 8:e1002966. 2012
  3. pmc Extensive in vivo resilience of persistent Salmonella
    Somedutta Barat
    Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    PLoS ONE 7:e42007. 2012
  4. pmc Intestinal inflammation responds to microbial tissue load independent of pathogen/non-pathogen discrimination
    Yvonne Willer
    Junior Group Mucosal Infections, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e35992. 2012
  5. pmc Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota
    Christian Stelter
    Junior Group, Mucosal Infections, Institute of Immunology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e20749. 2011
  6. pmc A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2
    Ines Thiele
    Center for Systems Biology, University of Iceland, Reykjavik, Iceland
    BMC Syst Biol 5:8. 2011
  7. doi request reprint Pathogen proteomes during infection: A basis for infection research and novel control strategies
    Dirk Bumann
    Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Proteomics 73:2267-76. 2010
  8. ncbi request reprint System-level analysis of Salmonella metabolism during infection
    Dirk Bumann
    Infection Biology, Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Curr Opin Microbiol 12:559-67. 2009
  9. doi request reprint Has nature already identified all useful antibacterial targets?
    Dirk Bumann
    Infection Biology, Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Curr Opin Microbiol 11:387-92. 2008
  10. doi request reprint Systemic, nasal and oral live vaccines against Pseudomonas aeruginosa: a clinical trial of immunogenicity in lower airways of human volunteers
    Dirk Bumann
    Junior Research Group Mucosal Immunology, Department of Immunology, Hanover Medical School, Hannover, Germany
    Vaccine 28:707-13. 2010

Collaborators

Detail Information

Publications17

  1. pmc Parallel exploitation of diverse host nutrients enhances Salmonella virulence
    Benjamin Steeb
    Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    PLoS Pathog 9:e1003301. 2013
    ..Comparison of metabolic networks of other pathogens suggested that complex host/pathogen nutritional interfaces are a common feature underlying many infectious diseases...
  2. pmc Immunity to intracellular Salmonella depends on surface-associated antigens
    Somedutta Barat
    Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    PLoS Pathog 8:e1002966. 2012
    ....
  3. pmc Extensive in vivo resilience of persistent Salmonella
    Somedutta Barat
    Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    PLoS ONE 7:e42007. 2012
    ..Disrupted synthesis of unsaturated/cyclopropane fatty acids was the only defect that resulted in rapid Salmonella clearance suggesting that this pathway might contain suitable targets for antimicrobial chemotherapy of chronic infection...
  4. pmc Intestinal inflammation responds to microbial tissue load independent of pathogen/non-pathogen discrimination
    Yvonne Willer
    Junior Group Mucosal Infections, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e35992. 2012
    ..Instead, appropriate intestinal responses to gut microbiota might be ensured by immediate inflammatory responses to any rise in microbial tissue loads, and desensitization after bacterial clearance...
  5. pmc Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota
    Christian Stelter
    Junior Group, Mucosal Infections, Institute of Immunology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e20749. 2011
    ..These data suggest that RegIIIβ production by the host can promote S. Typhimurium infection by eliminating inhibitory gut microbiota...
  6. pmc A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2
    Ines Thiele
    Center for Systems Biology, University of Iceland, Reykjavik, Iceland
    BMC Syst Biol 5:8. 2011
    ..Salmonella enterica subspecies I serovar Typhimurium is a human pathogen, causes various diseases and its increasing antibiotic resistance poses a public health problem...
  7. doi request reprint Pathogen proteomes during infection: A basis for infection research and novel control strategies
    Dirk Bumann
    Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Proteomics 73:2267-76. 2010
    ..Integration of these data with complementary large-scale data helps to further prioritize candidates for in-depth experimental analysis. Here, I discuss some of these approaches with a special emphasis on the model pathogen Salmonella...
  8. ncbi request reprint System-level analysis of Salmonella metabolism during infection
    Dirk Bumann
    Infection Biology, Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Curr Opin Microbiol 12:559-67. 2009
    ....
  9. doi request reprint Has nature already identified all useful antibacterial targets?
    Dirk Bumann
    Infection Biology, Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Curr Opin Microbiol 11:387-92. 2008
    ..Remaining opportunities under these circumstances include the development of narrow-spectrum antibiotics against specific pathogens and the exploration of target combinations...
  10. doi request reprint Systemic, nasal and oral live vaccines against Pseudomonas aeruginosa: a clinical trial of immunogenicity in lower airways of human volunteers
    Dirk Bumann
    Junior Research Group Mucosal Immunology, Department of Immunology, Hanover Medical School, Hannover, Germany
    Vaccine 28:707-13. 2010
    ..We conclude that nasal and oral OprF-OprI vaccines are promising candidates for development of antipseudomonal immunisation through inducing a specific antibody response in the lung...
  11. ncbi request reprint Disparate impact of oxidative host defenses determines the fate of Salmonella during systemic infection in mice
    Neil A Burton
    Focal Area Infection Biology, University of Basel, 4056 Basel, Switzerland
    Cell Host Microbe 15:72-83. 2014
    ..Thus, reactive oxygen and nitrogen species influence dramatically different outcomes of disparate Salmonella-host cell encounters, which together determine overall disease progression...
  12. ncbi request reprint FACS-isolation of Salmonella-infected cells with defined bacterial load from mouse spleen
    Friederike Thöne
    Hannover Medical School, Junior Research Group Mucosal Infections OE 9421, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Microbiol Methods 71:220-4. 2007
    ..Our method will facilitate future characterization of the different subpopulations and the identification of bacterial and host factors that control Salmonella load and proliferation in vivo...
  13. ncbi request reprint Identification of host-induced pathogen genes by differential fluorescence induction reporter systems
    Dirk Bumann
    Junior Research Group Mucosal Infections OE 9421, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Nat Protoc 2:770-7. 2007
    ..Library construction, promoter identification and analysis can be done in 4-8 weeks...
  14. pmc Solitary intestinal lymphoid tissue provides a productive port of entry for Salmonella enterica serovar Typhimurium
    Stephan Halle
    Institute of Immunology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Infect Immun 75:1577-85. 2007
    ..In conclusion, SILT, a lymphoid compartment mostly neglected in earlier studies, represents a major site for Salmonella invasion and ensuing mucosal pathology...
  15. ncbi request reprint Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
    Etienne Meunier
    Focal Area Infection Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Nature 509:366-70. 2014
    ..These results indicate that host-mediated lysis of pathogen-containing vacuoles is an essential immune function and is necessary for efficient recognition of pathogens by inflammasome complexes in the cytosol. ..
  16. ncbi request reprint The Central Metabolism Regulator EIIA(Glc) Switches Salmonella from Growth Arrest to Acute Virulence through Activation of Virulence Factor Secretion
    Alain Mazé
    Focal Area Infection Biology, Biozentrum, University of Basel, 4056 Basel, Switzerland Synthetic Biology, UMR7242, ESBS, University of Strasbourg, 67412 Illkirch, France
    Cell Rep 7:1426-33. 2014
    ..This unexpected role of EIIA(Glc) reveals a striking direct link between central Salmonella metabolism and a crucial virulence mechanism. ..
  17. pmc Enhanced immunogenicity in the murine airway mucosa with an attenuated Salmonella live vaccine expressing OprF-OprI from Pseudomonas aeruginosa
    Heinz Arnold
    Department of Pediatric Pulmonology and Neonatology, Hannover Medical School, 30623, Germany
    Infect Immun 72:6546-53. 2004
    ..We conclude that an oral primary systemic booster vaccination strategy with an appropriate mucosal vector may be advantageous in diseases with the risk of P. aeruginosa airway infection, such as cystic fibrosis...