H C Bucher

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. doi request reprint Small dense lipoproteins, apolipoprotein B, and risk of coronary events in HIV-infected patients on antiretroviral therapy: the Swiss HIV Cohort Study
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    J Acquir Immune Defic Syndr 60:135-42. 2012
  2. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
  3. pmc Accuracy of drug advertisements in medical journals under new law regulating the marketing of pharmaceutical products in Switzerland
    Macarena Gonzalez Santiago
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, CH 4031 Basel, Switzerland
    BMC Med Inform Decis Mak 8:61. 2008
  4. pmc Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV infection: a meta-analysis of randomised controlled trials
    Matthias Briel
    Institut für Klinische Epidemiologie, Universitatsspital Basel, 4031 Basel, Switzerland
    BMC Infect Dis 5:101. 2005
  5. pmc Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    BMC Fam Pract 6:34. 2005
  6. ncbi request reprint Protease inhibitor-sparing simplified maintenance therapy: a need for perspective
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology, Division of Infectious Diseases, University Hospital Basel, CH 4031 Basel, Switzerland
    J Antimicrob Chemother 54:303-5. 2004
  7. ncbi request reprint Ritonavir plus saquinavir versus single protease inhibitor therapy in protease inhibitor-naive HIV-infected patients: the Swiss HIV Cohort Study
    H C Bucher
    Basel Center for HIV Research, Internal Medicine Outpatient Clinic University Hospital Basel, Switzerland
    HIV Med 3:247-53. 2002
  8. ncbi request reprint Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis: a placebo-controlled, double-blind, randomized trial in general practice
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology, Medizinische Universitäts Poliklinik, and Universitätsklinik für Hals, Nasen und Ohrenkrankheiten, Kantonsspital Basel, Basel, Switzerland
    Arch Intern Med 163:1793-8. 2003
  9. doi request reprint Randomized trial of a computerized coronary heart disease risk assessment tool in HIV-infected patients receiving combination antiretroviral therapy
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, Basel, Switzerland
    Antivir Ther 15:31-40. 2010
  10. ncbi request reprint [Evidence-based medicine and patient-doctor relationships]
    H C Bucher
    Klinische Epidemiologie, Universitatsspital Basel
    Praxis (Bern 1994) 94:1521-3. 2005

Detail Information

Publications102 found, 100 shown here

  1. doi request reprint Small dense lipoproteins, apolipoprotein B, and risk of coronary events in HIV-infected patients on antiretroviral therapy: the Swiss HIV Cohort Study
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    J Acquir Immune Defic Syndr 60:135-42. 2012
    ..We investigated the association of highly atherogenic small dense low-density lipoproteins (LDLs) and apolipoprotein B and coronary events in HIV-infected individuals receiving antiretroviral therapy...
  2. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
    ..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit...
  3. pmc Accuracy of drug advertisements in medical journals under new law regulating the marketing of pharmaceutical products in Switzerland
    Macarena Gonzalez Santiago
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, CH 4031 Basel, Switzerland
    BMC Med Inform Decis Mak 8:61. 2008
    ..We investigated whether claims in drug advertisements citing published scientific studies were justified by these studies after the introduction of these new regulations...
  4. pmc Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV infection: a meta-analysis of randomised controlled trials
    Matthias Briel
    Institut für Klinische Epidemiologie, Universitatsspital Basel, 4031 Basel, Switzerland
    BMC Infect Dis 5:101. 2005
    ....
  5. pmc Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    BMC Fam Pract 6:34. 2005
    ..The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care...
  6. ncbi request reprint Protease inhibitor-sparing simplified maintenance therapy: a need for perspective
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology, Division of Infectious Diseases, University Hospital Basel, CH 4031 Basel, Switzerland
    J Antimicrob Chemother 54:303-5. 2004
    ..The advent of simpler formulations for all drug classes, and new PIs with less metabolic toxicity, is likely to reshape completely the role of SMT...
  7. ncbi request reprint Ritonavir plus saquinavir versus single protease inhibitor therapy in protease inhibitor-naive HIV-infected patients: the Swiss HIV Cohort Study
    H C Bucher
    Basel Center for HIV Research, Internal Medicine Outpatient Clinic University Hospital Basel, Switzerland
    HIV Med 3:247-53. 2002
    ..To compare the response to ritonavir (RTV) plus saquinavir (SQV) with single protease inhibitor (PI) therapies among PI-naive HIV-1 infected individuals...
  8. ncbi request reprint Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis: a placebo-controlled, double-blind, randomized trial in general practice
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology, Medizinische Universitäts Poliklinik, and Universitätsklinik für Hals, Nasen und Ohrenkrankheiten, Kantonsspital Basel, Basel, Switzerland
    Arch Intern Med 163:1793-8. 2003
    ..We evaluated the effect of a combination product of amoxicillin-potassium clavulanate on adults with acute rhinosinusitis that was clinically diagnosed in a general practice setting...
  9. doi request reprint Randomized trial of a computerized coronary heart disease risk assessment tool in HIV-infected patients receiving combination antiretroviral therapy
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, Basel, Switzerland
    Antivir Ther 15:31-40. 2010
    ..Computerized clinical decision support systems have been advocated to improve the management of patients at risk for CHD but it is unclear whether such systems reduce patients' risk for CHD...
  10. ncbi request reprint [Evidence-based medicine and patient-doctor relationships]
    H C Bucher
    Klinische Epidemiologie, Universitatsspital Basel
    Praxis (Bern 1994) 94:1521-3. 2005
  11. pmc Percutaneous transluminal coronary angioplasty versus medical treatment for non-acute coronary heart disease: meta-analysis of randomised controlled trials
    H C Bucher
    Medizinische Universitäts Poliklinik, Kantonsspital Basel, CH 4031 Basle, Switzerland
    BMJ 321:73-7. 2000
    ..To determine whether percutaneous transluminal coronary angioplasty (angioplasty) is superior to medical treatment in non-acute coronary artery disease...
  12. doi request reprint Hierarchical modeling gave plausible estimates of associations between metabolic syndrome and components of antiretroviral therapy
    Jim Young
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    J Clin Epidemiol 62:632-41. 2009
    ..Hierarchical modeling has been proposed as a solution to the multiple exposure problem. We estimate associations between metabolic syndrome and different components of antiretroviral therapy using both conventional and hierarchical models...
  13. ncbi request reprint Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study
    M Wolbers
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    HIV Med 9:397-405. 2008
    ..To investigate delayed HIV diagnosis and late initiation of antiretroviral therapy (ART) in the Swiss HIV Cohort Study...
  14. ncbi request reprint Prevalence of comedications and effect of potential drug-drug interactions in the Swiss HIV Cohort Study
    Catia Marzolini
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Antivir Ther 15:413-23. 2010
    ..We investigated the prevalence of comedications and PDDIs within a large HIV cohort, and their effect on ART efficacy and tolerability...
  15. doi request reprint Discontinuation of enfuvirtide in heavily pretreated HIV-infected individuals
    Luigia Elzi
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    HIV Clin Trials 10:207-14. 2009
    ..We aimed to evaluate the efficacy and the impact of discontinuing and/or switching enfuvirtide on virologic and clinical parameters in clinical practice...
  16. doi request reprint CD4+ T cell count recovery in HIV type 1-infected patients is independent of class of antiretroviral therapy
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland
    Clin Infect Dis 47:1093-101. 2008
    ....
  17. ncbi request reprint Ageing with HIV: medication use and risk for potential drug-drug interactions
    Catia Marzolini
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    J Antimicrob Chemother 66:2107-11. 2011
    ..To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and efficacy in HIV-infected individuals according to age, ≥ 50 years or <50 years...
  18. doi request reprint Interruptions of cART limits CD4 T-cell recovery and increases the risk for opportunistic complications and death
    Gilbert R Kaufmann
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland
    AIDS 25:441-51. 2011
    ..Interruptions of ART are still frequent. The long-term effect on CD4 T-cell recovery and clinical events remains unknown...
  19. doi request reprint Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Basel, Basel, Switzerland
    Clin Infect Dis 48:1459-66. 2009
    ..We investigated the incidence and outcome of progressive multifocal leukoencephalopathy (PML) in human immunodeficiency virus (HIV)-infected individuals before and after the introduction of combination antiretroviral therapy (cART) in 1996...
  20. ncbi request reprint Longitudinal analysis of patterns and predictors of changes in self-reported adherence to antiretroviral therapy: Swiss HIV Cohort Study
    Tracy R Glass
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    J Acquir Immune Defic Syndr 54:197-203. 2010
    ..Adherence to combination antiretroviral therapy (cART) is a dynamic process, however, changes in adherence behavior over time are insufficiently understood...
  21. doi request reprint Efficacy, tolerability and risk factors for virological failure of darunavir-based therapy for treatment-experienced HIV-infected patients: the Swiss HIV Cohort Study
    J Young
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    HIV Med 12:299-307. 2011
    ..We assessed the efficacy, tolerability and risk factors for virological failure of darunavir for treatment-experienced patients seen in clinical practice...
  22. ncbi request reprint Prevalence of risk factors for cardiovascular disease in HIV-infected patients over time: the Swiss HIV Cohort Study
    T R Glass
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
    HIV Med 7:404-10. 2006
    ..We evaluated changes in the prevalence of cardiovascular risk factors (CVRFs) and 10-year risk of CHD in a large cohort of HIV-infected individuals...
  23. ncbi request reprint Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected children
    Christoph Rudin
    Division of Infectious Diseases, University Children s Hospital, Basel, Switzerland
    Arch Dis Child 95:478-81. 2010
    ..To evaluate the long-term safety and effectiveness of lopinavir/ritonavir (LPV/r) in a population-based cohort of HIV-1-infected children...
  24. doi request reprint Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008
    Luigia Elzi
    University Hospital Basel, Switzerland
    Arch Intern Med 170:57-65. 2010
    ..Adverse effects of combination antiretroviral therapy (CART) commonly result in treatment modification and poor adherence...
  25. doi request reprint Lipid and lipoprotein profile in HIV-infected patients treated with lopinavir/ritonavir as a component of the first combination antiretroviral therapy
    L Magenta
    Division of Infectious Diseases, Hospital of Lugano, Switzerland
    AIDS Res Hum Retroviruses 27:525-33. 2011
    ..Despite an increase in the majority of measured lipids and lipoproteins particularly in the first year after initiation, we could not detect an obvious increase of cardiovascular risk resulting from the observed lipid changes...
  26. ncbi request reprint Predictors of optimal viral suppression in patients switched to abacavir, lamivudine, and zidovudine: the Swiss HIV Cohort Study
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    AIDS 21:2201-7. 2007
    ....
  27. ncbi request reprint Meta-analysis of randomized controlled trials of simplified versus continued protease inhibitor-based antiretroviral therapy in HIV-1-infected patients
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Kantonsspital Basel, Switzerland
    AIDS 17:2451-9. 2003
    ..To evaluate the efficacy and safety of simplified maintenance therapy (SMT) compared with continued protease inhibitor (PI) therapy...
  28. doi request reprint Antiretroviral therapy during pregnancy and premature birth: analysis of Swiss data
    C Rudin
    Division of Infectious Diseases, University Children s Hospital, Basel, Switzerland
    HIV Med 12:228-35. 2011
    ..There is an ongoing debate as to whether combined antiretroviral treatment (cART) during pregnancy is an independent risk factor for prematurity in HIV-1-infected women...
  29. doi request reprint Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Matthias Briel
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Arch Intern Med 168:2000-7; discussion 2007-8. 2008
    ..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day...
  30. doi request reprint Pregnancy and delivery outcomes of HIV infected women in Switzerland 2003-2008
    Karoline Aebi-Popp
    Division of Obstetrics and Gynaecology, University Hospital Basel, Switzerland
    J Perinat Med 38:353-8. 2010
    ..In this study, data from the Swiss Mother and Child HIV Cohort Study were used to describe maternal characteristics and their association with pregnancy outcomes in HIV positive women...
  31. ncbi request reprint Switching from protease inhibitors to efavirenz: differences in efficacy and tolerance among risk groups: a case-control study from the Swiss HIV Cohort
    Bernard Hirschel
    Division of Infectious Diseases, Geneva University Hospital, CH 1211 Geneva 14, Switzerland
    AIDS 16:381-5. 2002
    ..Switchers were matched to non-switchers on the basis of calendar time, CD4 cell count, and viral load...
  32. ncbi request reprint HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy
    Andri Rauch
    Division of Infectious Diseases, University Hospital Bern and University of Bern, Switzerland
    Clin Infect Dis 46:1921-5. 2008
    ..01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy...
  33. pmc Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals--the Swiss HIV Cohort Study
    Jan Fehr
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Transl Med 9:14. 2011
    ..The aim was to investigate whether the addition of rPRT to genotypic resistance testing (GRT) compared to GRT alone is beneficial for obtaining a virological response in heavily pre-treated HIV-infected patients...
  34. ncbi request reprint Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV-infection
    M Briel
    University Hospital Basel, Basel Institute for Clinical Epidemiology, Internal Medicine, Hebelstrasse 10, Basel, Switzerland 4031
    Cochrane Database Syst Rev 3:CD006150. 2006
    ..It was suggested that in these patients corticosteroids adjunctive to standard treatment for PCP could prevent the need for mechanical ventilation and decrease mortality...
  35. ncbi request reprint Respiratory symptoms, atopy and bronchial hyperreactivity in professional firefighters
    D Miedinger
    Department of Internal Medicine, University Hospital, 4031 Basel, Switzerland
    Eur Respir J 30:538-44. 2007
    ..It remains unclear whether these findings were present at recruitment or developed after joining the workforce...
  36. ncbi request reprint Demographics and prevalent risk factors of chronic subdural haematoma: results of a large single-center cohort study
    H Baechli
    Department of Neurosurgery, University Hospital Basle, Spitalstrasse 21, Basel, Switzerland
    Neurosurg Rev 27:263-6. 2004
    ..The indication for these medications, especially in elderly patients at risk for falls, should be carefully evaluated and controlled...
  37. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
    ....
  38. ncbi request reprint Validity of the Framingham point scores in the elderly: results from the Rotterdam study
    Michael T Koller
    Basel Institute for Clinical Epidemiology, Basel, Switzerland
    Am Heart J 154:87-93. 2007
    ..Individuals with a risk >20% are classified as high risk and are candidates for preventive intervention. We aimed to validate the FPS in a European population of elderly subjects...
  39. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
    ..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
  40. ncbi request reprint Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials
    Alain J Nordmann
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, CH 4031 Basel, Switzerland
    Arch Intern Med 166:285-93. 2006
    ..Low-carbohydrate diets have become increasingly popular for weight loss. However, evidence from individual trials about benefits and risks of these diets to achieve weight loss and modify cardiovascular risk factors is preliminary...
  41. ncbi request reprint Shared-decision making in general practice: do patients with respiratory tract infections actually want it?
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    Swiss Med Wkly 137:483-5. 2007
    ..There is conflicting evidence on whether patients wish to be involved in medical decisions...
  42. ncbi request reprint Patient-reported respiratory symptoms and pre-bronchodilator airflow limitation among smokers in Switzerland
    David Miedinger
    Pulmonary Medicine, Department of Internal Medicine, University Hospital, Basel, Switzerland
    Prim Care Respir J 19:163-9. 2010
    ..To evaluate the prevalence and predictors of airflow limitation among smokers aged > or =40 years visiting primary care practices in Switzerland, and the correlation between airflow limitation and patient-reported symptoms...
  43. ncbi request reprint Tenofovir use is associated with a reduction in calculated glomerular filtration rates in the Swiss HIV Cohort Study
    Christoph A Fux
    Division of Infectious Diseases, University Hospital Berne, Berne, Switzerland
    Antivir Ther 12:1165-73. 2007
    ..A growing number of case reports have described tenofovir (TDF)-related proximal renal tubulopathy and impaired calculated glomerular filtration rates (cGFR). We assessed TDF-associated changes in cGFR in a large observational HIV cohort...
  44. doi request reprint Antibiotics for adults with clinically diagnosed acute rhinosinusitis: a meta-analysis of individual patient data
    Jim Young
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
    Lancet 371:908-14. 2008
    ..We undertook a meta-analysis of randomised trials based on individual patients' data to assess whether common signs and symptoms can be used to identify a subgroup of patients who benefit from antibiotics...
  45. pmc Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    BMJ 338:b92. 2009
    ....
  46. doi request reprint Death without prior appropriate implantable cardioverter-defibrillator therapy: a competing risk study
    Michael T Koller
    University Hospital Basel, Basel Institute for Clinical Epidemiology, CH 4031 Basel, Switzerland
    Circulation 117:1918-26. 2008
    ..Competing death without prior appropriate ICD therapy might preclude benefit from ICD implantation in a less selected routine-care population...
  47. doi request reprint Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP study
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Virulence 1:88-92. 2010
    ..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection...
  48. ncbi request reprint [Benefit and pitfalls in the use of data from surrogate endpoint trials for clinical decision making]
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, Universitatsspital Basel
    Z Evid Fortbild Qual Gesundhwes 104:230-7; discussion 237-8. 2010
    ....
  49. ncbi request reprint Virological and immunological responses to efavirenz or boosted lopinavir as first-line therapy for patients with HIV
    Jim Young
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    Antivir Ther 14:771-9. 2009
    ..It is uncertain which therapy is more effective for patients starting therapy with an advanced infection...
  50. ncbi request reprint Ecological study of the predictors of successful management of dyslipidemia in HIV-infected patients on ART: the Swiss HIV Cohort Study
    Tracy R Glass
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    HIV Clin Trials 8:77-85. 2007
    ..Based on a health care system approach, we investigated predictors for normalization of dyslipidemia in HIV-infected individuals receiving ART...
  51. ncbi request reprint Prevalence and influence of diagnostic tests for acute respiratory tract infections in primary care
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    Swiss Med Wkly 136:248-53. 2006
    ..We investigated the prevalence of these tests, and how tests are associated with diagnosis, treatment and patient satisfaction...
  52. ncbi request reprint Clinical outcomes of primary stenting versus balloon angioplasty in patients with myocardial infarction: a meta-analysis of randomized controlled trials
    Alain J Nordmann
    Basel Institute for Clinical Epidemiology, Basel, Switzerland
    Am J Med 116:253-62. 2004
    ..To examine whether primary stenting as compared with primary balloon angioplasty reduces clinical outcomes in patients with myocardial infarction...
  53. ncbi request reprint Effects of statins on stroke prevention in patients with and without coronary heart disease: a meta-analysis of randomized controlled trials
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    Am J Med 117:596-606. 2004
    ..To assess if lipid-lowering interventions (statins, fibrates, resins, n-3 fatty acids, diet) prevent nonfatal and fatal strokes in patients with and without coronary heart disease...
  54. ncbi request reprint Clinical outcomes of stents versus balloon angioplasty in non-acute coronary artery disease. A meta-analysis of randomized controlled trials
    Alain J Nordmann
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, 4031 Basel, Switzerland
    Eur Heart J 25:69-80. 2004
    ..To evaluate whether stents as compared to balloon angioplasty reduce mortality in patients with non-acute coronary artery disease...
  55. ncbi request reprint Body fat changes among antiretroviral-naive patients on PI- and NNRTI-based HAART in the Swiss HIV cohort study
    Jim Young
    Institut für Klinische Epidemiologie, Universitatsspital Basel, Basel, Switzerland
    Antivir Ther 10:73-81. 2005
    ..Our objective is to show whether such associations are more or less likely for patients on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based HAART...
  56. ncbi request reprint Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study
    Andri Rauch
    Division of Infectious Diseases, University Hospital Berne, Switzerland
    Clin Infect Dis 41:395-402. 2005
    ..Data on the incidence of hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV)-infected persons are sparse. It is controversial whether and how frequently HCV is transmitted by unprotected sexual intercourse...
  57. ncbi request reprint Lipid profiles for antiretroviral-naive patients starting PI- and NNRTI-based therapy in the Swiss HIV cohort study
    Jim Young
    Institut für klinisehe Epidemiologie, Universitatsspital Basel, Basel, Switzerland
    Antivir Ther 10:585-91. 2005
    ..We report on medium-term lipid profiles (up to 5 years) for antiretroviral-naive patients starting NNRTI- and PI-based HAART in the Swiss HIV Cohort Study...
  58. ncbi request reprint Patients' expectations about the benefit of antibiotic treatment: lessons from a randomised controlled trial
    Jim Young
    Institut für Klinische Epidemiologie, Universitatsspital Basel, Switzerland
    Forsch Komplementarmed Klass Naturheilkd 12:347-9. 2005
    ..Patient expectations may be an important component of a placebo effect, and yet few studies assess how patients' pre-existing expectations affect subsequent health outcomes...
  59. ncbi request reprint Correlates of self-reported nonadherence to antiretroviral therapy in HIV-infected patients: the Swiss HIV Cohort Study
    Tracy R Glass
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4056 Basel, Switzerland
    J Acquir Immune Defic Syndr 41:385-92. 2006
    ..Adherence is one of the most crucial issues in the clinical management of HIV-infected patients receiving antiretroviral therapy (ART)...
  60. ncbi request reprint Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
    JAMA 295:2046-56. 2006
    ..The short-term effects of early treatment with statins in patients after the onset of acute coronary syndromes (ACS) for the outcomes of death, myocardial infarction (MI), and stroke are unclear...
  61. ncbi request reprint Communication training and antibiotic use in acute respiratory tract infections. A cluster randomised controlled trial in general practice
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    Swiss Med Wkly 136:241-7. 2006
    ..A cluster-randomised controlled trial in general practice..
  62. doi request reprint Factors associated with positive blood cultures in outpatients with suspected bacteremia
    K Wildi
    Division of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Microbiol Infect Dis 30:1615-9. 2011
    ..With simple clinical assessment and few laboratory tests indicative of infection, it is possible to define a group at higher risk for bacteremia in outpatients...
  63. ncbi request reprint Systematic review on the risk and benefit of different cholesterol-lowering interventions
    H C Bucher
    Medizinsche Universitäts Poliklinik, Kantonsspital Basel, Basel
    Arterioscler Thromb Vasc Biol 19:187-95. 1999
    ..The greater effect of statins is likely due to the larger reduction in cholesterol...
  64. doi request reprint Prescribed medications and pharmacy interventions for acute respiratory tract infections in Swiss primary care
    K E Hersberger
    Institute of Clinical Pharmacy, University of Basel, Basel, Switzerland
    J Clin Pharm Ther 34:387-95. 2009
    ..Our study objectives were to examine prescribing patterns of antibiotics and symptomatic medications for ARTI in Swiss primary care and to monitor pharmacists' interventions during the prescription-dispensing process...
  65. ncbi request reprint Effect of different antilipidemic agents and diets on mortality: a systematic review
    Marco Studer
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    Arch Intern Med 165:725-30. 2005
    ..Mortality data are the most reliable data to assess efficacy of interventions. We aimed to assess efficacy and safety of different lipid-lowering interventions based on mortality data...
  66. ncbi request reprint CD4+ T-cell count increase in HIV-1-infected patients with suppressed viral load within 1 year after start of antiretroviral therapy
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    Antivir Ther 12:889-97. 2007
    ..This study aimed to identify predictive factors for long-term CD4+ T-cell increase in treatment-naive patients starting combination antiretroviral therapy (cART)...
  67. ncbi request reprint Tenofovir use is associated with an increase in serum alkaline phosphatase in the Swiss HIV Cohort Study
    Christoph A Fux
    Division of Infectious Diseases, University Hospital Berne and University of Berne, Berne, Switzerland
    Antivir Ther 13:1077-82. 2008
    ..A few small studies have reported a positive correlation between renal phosphate losses, increased bone turnover and sAP...
  68. ncbi request reprint Treatment and prognosis of AIDS-related lymphoma in the era of highly active antiretroviral therapy: findings from the Swiss HIV Cohort Study
    Mathew Simcock
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland
    Antivir Ther 12:931-9. 2007
    ..To assess the characteristics of combination antiretroviral therapy (cART) administered concomitantly with chemotherapy and to establish prognostic determinants of patients with AIDS-related non-Hodgkin's lymphoma...
  69. ncbi request reprint When time is more than money: the allocation of time between work and leisure in HIV-infected patients
    Pedram Sendi
    Division of Infectious Diseases and Hospital Epidemiology, Basel University Hospital, Basel, Switzerland
    Soc Sci Med 64:2355-61. 2007
    ..e., wage rate), and that (ii) availability of non-labour income induces income effects, i.e. individuals demand more leisure time...
  70. ncbi request reprint Long-term safety of discontinuation of secondary prophylaxis against Pneumocystis pneumonia: prospective multicentre study
    Claudine Zellweger
    Division of Infectious Diseases, University Hospital of Berne, Berne, Switzerland
    AIDS 18:2047-53. 2004
    ..To assess the long-term safety of discontinuation of secondary anti-Pneumocystis prophylaxis in HIV-infected adults treated with antiretroviral combination therapy and who have a sustained increase in CD4 cell counts...
  71. ncbi request reprint Prevalence of unsafe sexual behavior among HIV-infected individuals: the Swiss HIV Cohort Study
    Katja Wolf
    Basel Institute for Clinical Epidemiology and dagger Division of Infectious Diseases, University Hospital Basel, Switzerland
    J Acquir Immune Defic Syndr 33:494-9. 2003
    ..There is no evidence that self-reported unsafe sexual behavior is more prevalent among HIV-infected individuals with optimal viral suppression. However, unsafe sex is associated with other factors...
  72. ncbi request reprint Is unsafe sexual behaviour increasing among HIV-infected individuals?
    Tracy R Glass
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    AIDS 18:1707-14. 2004
    ..The number of new diagnoses of HIV infection is rising in the northwestern hemisphere and it is becoming increasingly important to understand the mechanisms behind this trend...
  73. pmc Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study
    Jim Young
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, Basle, CH 4031, Switzerland
    BMJ 328:15. 2004
    ..To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART)...
  74. ncbi request reprint Self-reported non-adherence to antiretroviral therapy repeatedly assessed by two questions predicts treatment failure in virologically suppressed patients
    Tracy R Glass
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
    Antivir Ther 13:77-85. 2008
    ..The aim of this study was to explore the predictive value of longitudinal self-reported adherence data on viral rebound...
  75. doi request reprint Quality of spirometry in primary care for case finding of airway obstruction in smokers
    J D Leuppi
    Clinic for Pneumology, University Hospital, Basel, Switzerland
    Respiration 79:469-74. 2010
    ..Diagnosis of chronic obstructive pulmonary disease (COPD) and its severity determination is based on spirometry. The quality of spirometry is crucial...
  76. pmc Predicting mortality with pneumonia severity scores: importance of model recalibration to local settings
    P Schuetz
    University Hospital Basel, Department of Internal Medicine, Basel, Switzerland
    Epidemiol Infect 136:1628-37. 2008
    ....
  77. ncbi request reprint Self-reported alcohol consumption and its association with adherence and outcome of antiretroviral therapy in the Swiss HIV Cohort Study
    Anna Conen
    Divison of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland
    Antivir Ther 14:349-57. 2009
    ..Here, we aimed to study self-reported alcohol consumption and to determine its association with adherence to antiretroviral therapy (ART) and HIV surrogate markers...
  78. pmc Pretreatment CD4 cell slope and progression to AIDS or death in HIV-infected patients initiating antiretroviral therapy--the CASCADE collaboration: a collaboration of 23 cohort studies
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    PLoS Med 7:e1000239. 2010
    ..It is not known whether the rate of CD4 cell decline prior to therapy is related to prognosis and should, therefore, influence the decision on when to initiate cART...
  79. doi request reprint Effect of prolonged treatment with compression stockings to prevent post-thrombotic sequelae: a randomized controlled trial
    Markus Aschwanden
    Department of Angiology, University Hospital Basel, Basel, Switzerland
    J Vasc Surg 47:1015-21. 2008
    ..This study assessed the effect of prolonged compression therapy after a standard treatment of 6 months after acute deep vein thrombosis...
  80. doi request reprint Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial
    Fabian Müller
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Chest 138:121-9. 2010
    ..However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP...
  81. ncbi request reprint Statin therapy for prevention and treatment of acute and chronic cardiovascular disease: update on recent trials and metaanalyses
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
    Curr Opin Lipidol 16:601-5. 2005
    ....
  82. ncbi request reprint N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials
    Heiner C Bucher
    Institut für Klinische Epidemiologie, Kantonsspital Basel, Basel, Switzerland
    Am J Med 112:298-304. 2002
    ..We investigated the effects of dietary and non-dietary (supplemental) intake of n-3 polyunsaturated fatty acids on coronary heart disease...
  83. pmc Which patients with lower respiratory tract infections need inpatient treatment? Perceptions of physicians, nurses, patients and relatives
    Claudia Baehni
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 10:12. 2010
    ..This survey analyzed perceptions of physicians, nurses, patients and relatives about feasibility of outpatient management and required duration of hospital stay...
  84. doi request reprint [Surrogate endpoint trials: benefit and pitfalls for clinical decision making]
    H C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, Universitatsspital Basel, 4031, Basel, Switzerland
    Internist (Berl) 49:681-7. 2008
    ....
  85. ncbi request reprint Onset and pattern of substance use in intravenous drug users of an opiate maintenance program
    C Zinkernagel
    Outpatient Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland
    Drug Alcohol Depend 64:105-9. 2001
    ..CONCLUSIONS: Specific knowledge about the age of onset and sequence of substances used by drug addicts may help to prevent substance use more age specifically...
  86. doi request reprint Antibiotic use in adult outpatients in Switzerland in relation to regions, seasonality and point of care tests
    R Achermann
    Division of Health Economics and Health Policy, Helsana, Zurich, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    Clin Microbiol Infect 17:855-61. 2011
    ..Ecological studies are prone to bias and whether point of care tests reduce antibiotic use has to be investigated in pragmatic primary care trials...
  87. ncbi request reprint HIV-enteropathy and bile acid malabsorption: response to cholestyramine
    M Steuerwald
    Department of Internal Medicine, University Hospital, Kantonsspital Basel, Switzerland
    Am J Gastroenterol 90:2051-3. 1995
    ..A 75SeHCAT test demonstrated that the diarrhea was mainly due to bile acid malabsorption. Therapy with cholestyramine dramatically reduced bowel movements and led to significant reversal of weight loss...
  88. ncbi request reprint Inflammatory bowel perforation during immune restoration after one year of antiretroviral and antituberculous therapy in an HIV-1-infected patient: report of a case
    Anne Catherine Guex
    Basel Center for HIV Research, Outpatient Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Dis Colon Rectum 45:977-8. 2002
    ..This article reports an unusual presentation of bowel perforation...
  89. ncbi request reprint Infections requiring hospitalization of injection drug users who participated in an injection opiate maintenance program
    Stefano Bassetti
    Section of Infectious Diseases, University Hospital Basel, CH 4031 Basel, Switzerland
    Clin Infect Dis 34:711-3. 2002
    ..6 years). Skin infections were the main reason for hospitalization. The injection opiate maintenance program did not reduce the incidence of infection leading to hospitalization among the injection drug users studied...
  90. ncbi request reprint Potential benefit and limitations of a broad access to potent antiretroviral therapy in developing countries
    Gilbert R Kaufmann
    Basel Center for HIV Research, Division of Infectious Diseases, University Hospital Basel, Switzerland
    Expert Opin Investig Drugs 11:1303-13. 2002
    ....
  91. ncbi request reprint Intravenous opiate maintenance in a cohort of injecting drug addicts
    Pedram Sendi
    Outpatient Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Drug Alcohol Depend 69:183-8. 2003
    ..In this paper we report the performance of this drug policy in terms of retention and analyse treatment withdrawals and hospitalisations...
  92. ncbi request reprint Productivity costs and determinants of productivity in HIV-infected patients
    Pedram Sendi
    Division of Infectious Diseases, Basel University Hospital, Basel, Switzerland
    Clin Ther 26:791-800. 2004
    ..In HIV-infected patients, reduced ability to work may be an important component of the societal costs of this disease. Few data about productivity costs in HIV-infected patients are available...
  93. ncbi request reprint Cost-effectiveness of ramipril in patients at high risk for cardiovascular events: a Swiss perspective
    Angelika Aurbach
    InForMed GmbH Outcomes Research and Health Economics, Ingolstadt, Germany
    Swiss Med Wkly 134:399-405. 2004
    ..In addition, the cost-effectiveness of ramipril in the subgroup of diabetic patients was assessed...
  94. ncbi request reprint Plasma leptin levels in men are not related to the development of lipoatrophy during antiretroviral therapy
    Dorothea Wunder
    Department of Obstetrics and Gynaecology, University Hospital of Berne, Switzerland
    AIDS 19:1837-42. 2005
    ..To assess the correlations between the hormone leptin and lipoatrophy in HIV-positive, treatment-naive patients on combination antiretroviral therapy (cART)...
  95. ncbi request reprint Sexual risk behavior in HIV-infected injection drug users
    Manuel Battegay
    Clin Infect Dis 38:1175-7. 2004
  96. ncbi request reprint Long-term antibiotic cost savings from a comprehensive intervention program in a medical department of a university-affiliated teaching hospital
    Sigmund Rüttimann
    Department of Internal Medicine, Kantonsspital Schaffhausen, Switzerland
    Clin Infect Dis 38:348-56. 2004
    ..This comprehensive intervention program, which aimed to reduce antibiotic consumption and costs, was highly successful and had long-lasting effects...
  97. ncbi request reprint Two versus three-class antiretroviral therapy in antiretroviral-naive patients in different time periods of the HAART era
    Patrick Taffe
    AIDS 21:537-8. 2007
  98. ncbi request reprint Numbers needed to treat derived from meta-analysis: a word of caution
    Arthur Marx
    Basel Institute for Clinical Epidemiology, Basel, Switzerland
    ACP J Club 138:A11-2. 2003
  99. ncbi request reprint A smoking cessation programme in HIV-infected individuals: a pilot study
    Luigia Elzi
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel
    Antivir Ther 11:787-95. 2006
    ..Antiretroviral therapy (ART) is a risk factor for cardiovascular disease (CVD) and smoking the most important modifiable cardiovascular risk factor...
  100. pmc Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials
    Martin A Walter
    Institute of Nuclear Medicine, University Hospital Basel, Switzerland
    BMJ 334:514. 2007
    ..To determine the effect of adjunctive antithyroid drugs on the risk of treatment failure, hypothyroidism, and adverse events after radioiodine treatment...
  101. ncbi request reprint Randomized trials stopped early for benefit: a systematic review
    Victor M Montori
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 294:2203-9. 2005
    ..Their prevalence, the magnitude and plausibility of their treatment effects, and the extent to which they report information about how investigators decided to stop early are, however, unknown...