H C Bucher

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis
    Sandra Mathis
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    PLoS ONE 6:e22003. 2011
  2. pmc Learning from failure--rationale and design for a study about discontinuation of randomized trials (DISCO study)
    Benjamin Kasenda
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    BMC Med Res Methodol 12:131. 2012
  3. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
  4. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
  5. ncbi request reprint [Benefit and pitfalls in the use of data from surrogate endpoint trials for clinical decision making]
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, Universitatsspital Basel
    Z Evid Fortbild Qual Gesundhwes 104:230-7; discussion 237-8. 2010
  6. ncbi request reprint [Surrogate endpoint trials: benefit and pitfalls for clinical decision making]
    H C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, Universitatsspital Basel, 4031, Basel, Switzerland
    Internist (Berl) 49:681-7. 2008
  7. doi request reprint Interruptions of cART limits CD4 T-cell recovery and increases the risk for opportunistic complications and death
    Gilbert R Kaufmann
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland
    AIDS 25:441-51. 2011
  8. ncbi request reprint Ageing with HIV: medication use and risk for potential drug-drug interactions
    Catia Marzolini
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    J Antimicrob Chemother 66:2107-11. 2011
  9. ncbi request reprint Discontinuation of enfuvirtide in heavily pretreated HIV-infected individuals
    Luigia Elzi
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    HIV Clin Trials 10:207-14. 2009
  10. doi request reprint Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Basel, Basel, Switzerland
    Clin Infect Dis 48:1459-66. 2009

Detail Information

Publications36

  1. pmc Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis
    Sandra Mathis
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    PLoS ONE 6:e22003. 2011
    ..There is insufficient evidence whether simplification to ritonavir boosted protease inhibitor (PI/r) monotherapy in virologically suppressed HIV-infected patients is effective and safe to reduce cART side effects and costs...
  2. pmc Learning from failure--rationale and design for a study about discontinuation of randomized trials (DISCO study)
    Benjamin Kasenda
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    BMC Med Res Methodol 12:131. 2012
    ..Currently, little is known regarding the frequency and characteristics of discontinued RCTs...
  3. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
    ..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
  4. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
    ....
  5. ncbi request reprint [Benefit and pitfalls in the use of data from surrogate endpoint trials for clinical decision making]
    Heiner C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, Universitatsspital Basel
    Z Evid Fortbild Qual Gesundhwes 104:230-7; discussion 237-8. 2010
    ....
  6. ncbi request reprint [Surrogate endpoint trials: benefit and pitfalls for clinical decision making]
    H C Bucher
    Basel Institute for Clinical Epidemiology and Biostatistics, Universitatsspital Basel, 4031, Basel, Switzerland
    Internist (Berl) 49:681-7. 2008
    ....
  7. doi request reprint Interruptions of cART limits CD4 T-cell recovery and increases the risk for opportunistic complications and death
    Gilbert R Kaufmann
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland
    AIDS 25:441-51. 2011
    ..Interruptions of ART are still frequent. The long-term effect on CD4 T-cell recovery and clinical events remains unknown...
  8. ncbi request reprint Ageing with HIV: medication use and risk for potential drug-drug interactions
    Catia Marzolini
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    J Antimicrob Chemother 66:2107-11. 2011
    ..To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and efficacy in HIV-infected individuals according to age, ≥ 50 years or <50 years...
  9. ncbi request reprint Discontinuation of enfuvirtide in heavily pretreated HIV-infected individuals
    Luigia Elzi
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    HIV Clin Trials 10:207-14. 2009
    ..We aimed to evaluate the efficacy and the impact of discontinuing and/or switching enfuvirtide on virologic and clinical parameters in clinical practice...
  10. doi request reprint Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Basel, Basel, Switzerland
    Clin Infect Dis 48:1459-66. 2009
    ..We investigated the incidence and outcome of progressive multifocal leukoencephalopathy (PML) in human immunodeficiency virus (HIV)-infected individuals before and after the introduction of combination antiretroviral therapy (cART) in 1996...
  11. ncbi request reprint Prevalence of comedications and effect of potential drug-drug interactions in the Swiss HIV Cohort Study
    Catia Marzolini
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Antivir Ther 15:413-23. 2010
    ..We investigated the prevalence of comedications and PDDIs within a large HIV cohort, and their effect on ART efficacy and tolerability...
  12. ncbi request reprint Longitudinal analysis of patterns and predictors of changes in self-reported adherence to antiretroviral therapy: Swiss HIV Cohort Study
    Tracy R Glass
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    J Acquir Immune Defic Syndr 54:197-203. 2010
    ..Adherence to combination antiretroviral therapy (cART) is a dynamic process, however, changes in adherence behavior over time are insufficiently understood...
  13. doi request reprint Hierarchical modeling gave plausible estimates of associations between metabolic syndrome and components of antiretroviral therapy
    Jim Young
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    J Clin Epidemiol 62:632-41. 2009
    ..Hierarchical modeling has been proposed as a solution to the multiple exposure problem. We estimate associations between metabolic syndrome and different components of antiretroviral therapy using both conventional and hierarchical models...
  14. ncbi request reprint Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study
    M Wolbers
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    HIV Med 9:397-405. 2008
    ..To investigate delayed HIV diagnosis and late initiation of antiretroviral therapy (ART) in the Swiss HIV Cohort Study...
  15. doi request reprint Efficacy, tolerability and risk factors for virological failure of darunavir-based therapy for treatment-experienced HIV-infected patients: the Swiss HIV Cohort Study
    J Young
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    HIV Med 12:299-307. 2011
    ..We assessed the efficacy, tolerability and risk factors for virological failure of darunavir for treatment-experienced patients seen in clinical practice...
  16. doi request reprint Antiretroviral therapy during pregnancy and premature birth: analysis of Swiss data
    C Rudin
    Division of Infectious Diseases, University Children s Hospital, Basel, Switzerland
    HIV Med 12:228-35. 2011
    ..There is an ongoing debate as to whether combined antiretroviral treatment (cART) during pregnancy is an independent risk factor for prematurity in HIV-1-infected women...
  17. ncbi request reprint Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected children
    Christoph Rudin
    Division of Infectious Diseases, University Children s Hospital, Basel, Switzerland
    Arch Dis Child 95:478-81. 2010
    ..To evaluate the long-term safety and effectiveness of lopinavir/ritonavir (LPV/r) in a population-based cohort of HIV-1-infected children...
  18. doi request reprint Pregnancy and delivery outcomes of HIV infected women in Switzerland 2003-2008
    Karoline Aebi-Popp
    Division of Obstetrics and Gynaecology, University Hospital Basel, Switzerland
    J Perinat Med 38:353-8. 2010
    ..In this study, data from the Swiss Mother and Child HIV Cohort Study were used to describe maternal characteristics and their association with pregnancy outcomes in HIV positive women...
  19. doi request reprint Quality of spirometry in primary care for case finding of airway obstruction in smokers
    J D Leuppi
    Clinic for Pneumology, University Hospital, Basel, Switzerland
    Respiration 79:469-74. 2010
    ..Diagnosis of chronic obstructive pulmonary disease (COPD) and its severity determination is based on spirometry. The quality of spirometry is crucial...
  20. doi request reprint Factors associated with positive blood cultures in outpatients with suspected bacteremia
    K Wildi
    Division of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Microbiol Infect Dis 30:1615-9. 2011
    ..With simple clinical assessment and few laboratory tests indicative of infection, it is possible to define a group at higher risk for bacteremia in outpatients...
  21. doi request reprint CD4+ T cell count recovery in HIV type 1-infected patients is independent of class of antiretroviral therapy
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland
    Clin Infect Dis 47:1093-101. 2008
    ....
  22. pmc Predicting mortality with pneumonia severity scores: importance of model recalibration to local settings
    P Schuetz
    University Hospital Basel, Department of Internal Medicine, Basel, Switzerland
    Epidemiol Infect 136:1628-37. 2008
    ....
  23. ncbi request reprint Response to first protease inhibitor- and efavirenz-containing antiretroviral combination therapy. The Swiss HIV Cohort Study
    A C Friedl
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital Zurich, Switzerland
    AIDS 15:1793-800. 2001
    ..The relevance of these observations remains to be determined in studies with longer follow-up...
  24. ncbi request reprint Ritonavir plus saquinavir versus single protease inhibitor therapy in protease inhibitor-naive HIV-infected patients: the Swiss HIV Cohort Study
    H C Bucher
    Basel Center for HIV Research, Internal Medicine Outpatient Clinic University Hospital Basel, Switzerland
    HIV Med 3:247-53. 2002
    ..To compare the response to ritonavir (RTV) plus saquinavir (SQV) with single protease inhibitor (PI) therapies among PI-naive HIV-1 infected individuals...
  25. ncbi request reprint Demographics and prevalent risk factors of chronic subdural haematoma: results of a large single-center cohort study
    H Baechli
    Department of Neurosurgery, University Hospital Basle, Spitalstrasse 21, Basel, Switzerland
    Neurosurg Rev 27:263-6. 2004
    ..The indication for these medications, especially in elderly patients at risk for falls, should be carefully evaluated and controlled...
  26. ncbi request reprint [Evidence-based medicine and patient-doctor relationships]
    H C Bucher
    Klinische Epidemiologie, Universitatsspital Basel
    Praxis (Bern 1994) 94:1521-3. 2005
  27. ncbi request reprint Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV-infection
    M Briel
    University Hospital Basel, Basel Institute for Clinical Epidemiology, Internal Medicine, Hebelstrasse 10, Basel, Switzerland 4031
    Cochrane Database Syst Rev 3:CD006150. 2006
    ..It was suggested that in these patients corticosteroids adjunctive to standard treatment for PCP could prevent the need for mechanical ventilation and decrease mortality...
  28. ncbi request reprint Prevalence of risk factors for cardiovascular disease in HIV-infected patients over time: the Swiss HIV Cohort Study
    T R Glass
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
    HIV Med 7:404-10. 2006
    ..We evaluated changes in the prevalence of cardiovascular risk factors (CVRFs) and 10-year risk of CHD in a large cohort of HIV-infected individuals...
  29. ncbi request reprint HAART and the heart: changes in coronary risk factors and implications for coronary risk in men starting antiretroviral therapy
    J A C Sterne
    Department of Social Medicine, University of Bristol, Bristol, UK
    J Intern Med 261:255-67. 2007
    ..To estimate changes in coronary risk factors and their implications for coronary heart disease (CHD) rates in men starting highly active antiretroviral therapy (HAART)...
  30. ncbi request reprint Respiratory symptoms, atopy and bronchial hyperreactivity in professional firefighters
    D Miedinger
    Department of Internal Medicine, University Hospital, 4031 Basel, Switzerland
    Eur Respir J 30:538-44. 2007
    ..It remains unclear whether these findings were present at recruitment or developed after joining the workforce...
  31. ncbi request reprint Durability and outcome of initial antiretroviral treatments received during 2000--2005 by patients in the Swiss HIV Cohort Study
    Thi Tuyet Nhung Vo
    VCHAP Project, Tropical Disease Hospital, Ho Chi Minh City, Vietnam
    J Infect Dis 197:1685-94. 2008
    ..Little is known about time trends, predictors, and consequences of changes made to antiretroviral therapy (ART) regimens early after patients initially start treatment...
  32. pmc Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared
    Olivia Keiser
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS Med 5:e148. 2008
    ..We compared virologic response, changes to first-line regimens, and mortality in HIV-infected patients starting HAART in South Africa and Switzerland...
  33. ncbi request reprint [Evidence-based clinical decision making]
    H C Bucher
    Praxis (Bern 1994) 94:541. 2005
  34. ncbi request reprint HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy
    Andri Rauch
    Division of Infectious Diseases, University Hospital Bern and University of Bern, Switzerland
    Clin Infect Dis 46:1921-5. 2008
    ..01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy...
  35. ncbi request reprint [Hospitalizations in a cohort of 175 severely drug-addicted patients of a medically managed opiate withdrawal project]
    M Hoffmann
    ,
    Praxis (Bern 1994) 90:2094-101. 2001
    ..However, as shown in earlier studies, the incidence of HIV drastically dropped. Hence, it may be that a longer follow-up may prove beneficial regarding the incidence of hospitalisations...
  36. ncbi request reprint Onset and pattern of substance use in intravenous drug users of an opiate maintenance program
    C Zinkernagel
    Outpatient Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland
    Drug Alcohol Depend 64:105-9. 2001
    ..CONCLUSIONS: Specific knowledge about the age of onset and sequence of substances used by drug addicts may help to prevent substance use more age specifically...