L Bubendorf

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression
    C Bowen
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2007, USA
    Cancer Res 60:6111-5. 2000
  2. ncbi [Prostatic carcinoma: from morphology to molecular biology]
    L Bubendorf
    ,
    Praxis (Bern 1994) 92:275-8. 2003
  3. ncbi Consistency of prostate cancer grading results in screened populations across Europe
    T H Van der Kwast
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    BJU Int 92:88-91. 2003
  4. ncbi Does the prostate really need androgens to grow? Transurethral resection of the prostate in a male-to-female transsexual 25 years after sex-changing operation
    R Casella
    University Hospital, Basel, Switzerland
    Urol Int 75:288-90. 2005
  5. ncbi [Molecular pathology of prostate carcinoma. Academic playground or guide for diagnosis and therapy planning?]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel, Basel, Schweiz
    Verh Dtsch Ges Pathol 88:158-64. 2004
  6. ncbi UroVysion® multiprobe FISH in the triage of equivocal urinary cytology cases
    Lukas Bubendorf
    Institute for Pathology, University Hospital Basel University of Basel, Schonbeinstrasse 40, 4031 Basel, Switzerland
    Ann Pathol 32:e52-6, 438-43. 2012
  7. ncbi HER2 gene status in primary breast cancers and matched distant metastases
    Coya Tapia
    University Department of Pathology of Basel and Baselland, Institute for Pathology, Schonbeinstrasse 40, Basel, 4003, Switzerland
    Breast Cancer Res 9:R31. 2007
  8. ncbi [Urinary cytology after renal transplantation]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel
    Ther Umsch 63:609-14. 2006
  9. ncbi [Cytology of the urinary tract: Between uncertainty and clarity]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel, Schönbeinstr 40, 4003 Basel, Schweiz
    Pathologe 30:173-8. 2009
  10. ncbi [Predictive EGFR gene analyses in cytology]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel, Schönbeinstr 40, 4003 Basel, Schweiz
    Pathologe 30:136-9. 2009

Collaborators

Detail Information

Publications39

  1. ncbi Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression
    C Bowen
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2007, USA
    Cancer Res 60:6111-5. 2000
    ..Our data show that NKX3.1 expression is highly, but not exclusively, specific for the prostate. Loss of NKX3.1 expression is strongly associated with hormone-refractory disease and advanced tumor stage in prostate cancer (P < 0.0001)...
  2. ncbi [Prostatic carcinoma: from morphology to molecular biology]
    L Bubendorf
    ,
    Praxis (Bern 1994) 92:275-8. 2003
  3. ncbi Consistency of prostate cancer grading results in screened populations across Europe
    T H Van der Kwast
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    BJU Int 92:88-91. 2003
    ..Currently, tumour stage and grade in prostatectomy specimens represent the most predictive variables for biological behaviour. In prostate needle biopsies the tumour grade is a strong factor for deciding therapy...
  4. ncbi Does the prostate really need androgens to grow? Transurethral resection of the prostate in a male-to-female transsexual 25 years after sex-changing operation
    R Casella
    University Hospital, Basel, Switzerland
    Urol Int 75:288-90. 2005
    ..We present the case of a male-to-female transsexual presenting with obstructive voiding symptoms due to benign prostatic hyperplasia 25 years after sex-changing operation and under continuous estrogen therapy...
  5. ncbi [Molecular pathology of prostate carcinoma. Academic playground or guide for diagnosis and therapy planning?]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel, Basel, Schweiz
    Verh Dtsch Ges Pathol 88:158-64. 2004
    ..Target gene identification of amplifications may lead to new diagnostic tools and therapies of advanced prostate cancer...
  6. ncbi UroVysion® multiprobe FISH in the triage of equivocal urinary cytology cases
    Lukas Bubendorf
    Institute for Pathology, University Hospital Basel University of Basel, Schonbeinstrasse 40, 4031 Basel, Switzerland
    Ann Pathol 32:e52-6, 438-43. 2012
    ....
  7. ncbi HER2 gene status in primary breast cancers and matched distant metastases
    Coya Tapia
    University Department of Pathology of Basel and Baselland, Institute for Pathology, Schonbeinstrasse 40, Basel, 4003, Switzerland
    Breast Cancer Res 9:R31. 2007
    ..Here, we compared HER2 status on cytological specimens of distant metastases with the result from the primary carcinomas, and explored the prevalence of and the reasons for discrepant results...
  8. ncbi [Urinary cytology after renal transplantation]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel
    Ther Umsch 63:609-14. 2006
    ..Historically, urinary cytology was important to screen patients with allograft for analgetic nephropathy for malignant cells, since they were at greatly increased risk of urothelial carcinoma...
  9. ncbi [Cytology of the urinary tract: Between uncertainty and clarity]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel, Schönbeinstr 40, 4003 Basel, Schweiz
    Pathologe 30:173-8. 2009
    ..In contrast, positive cytology does not need further confirmation by FISH analysis. Standardized diagnosis and the possibility for supplementary analyses increase the diagnostic value of urinary cytology...
  10. ncbi [Predictive EGFR gene analyses in cytology]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel, Schönbeinstr 40, 4003 Basel, Schweiz
    Pathologe 30:136-9. 2009
    ..Cytological specimens are equally well suited for EGFR gene analyses and FISH analysis as histological specimens. At present, the value of EGFR-FISH analysis is limited by the lack of validated criteria for FISH positivity...
  11. ncbi Multiprobe fluorescence in situ hybridization (UroVysion) for the detection of urothelial carcinoma - FISHing for the right catch
    Lukas Bubendorf
    Division of Cytopathology, Institute for Pathology, University Hospital Basel, Basel, Switzerland
    Acta Cytol 55:113-9. 2011
    ..It can be particularly useful to clarify equivocal cytological findings. However, some aspects remain to be further addressed including cost efficiency, optimal cut-off values and the true performance under real-life conditions...
  12. ncbi [Preneoplastic lesions of pulmonary carcinoma]
    L Bubendorf
    Institut fur Pathologie, Universitatsspital Basel, Schönbeinstr 40, 4031, Basel, Schweiz
    Pathologe 32:218-23. 2011
    ..This review provides an overview of the current knowledge on preneoplastic lesions of the lungs and their clinical impact...
  13. ncbi [EGFR mutation analysis in non-small-cell lung cancer : Experience from routine diagnostics]
    C Tapia
    Institut fur Pathologie, Universitatsspital Basel, Schweiz
    Pathologe 30:384-92. 2009
    ..Some patients with non-small cell lung cancer (NSCLC) respond well to therapy with tyrosine kinase inhibitors (TKI). Somatic mutation of the epidermal growth factor receptor (EGFR) gene is an important predictive marker for TKI response...
  14. ncbi [Non-small cell lung cancer. Subtyping and predictive molecular marker investigations in cytology]
    S Savic
    Institut fur Pathologie, Universitatsspital Basel, Schönbeinstr 40, 4031, Basel, Schweiz
    Pathologe 33:301-7. 2012
    ..In this paper, we discuss special issues of NSCLC subtyping and currently recommended predictive molecular marker analyses...
  15. ncbi Tissue microarrays for gene amplification surveys in many different tumor types
    P Schraml
    Institute for Pathology, University of Basel, Switzerland
    Clin Cancer Res 5:1966-75. 1999
    ..This demonstrates the power of using minute arrayed tissue specimens for tumor screening...
  16. ncbi High-throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma
    H Moch
    Institute for Pathology and Clinics for Urology, University of Basel, Basel, Switzerland
    Am J Pathol 154:981-6. 1999
    ..It is concluded that the combination of tumor arrays and cDNA arrays is a powerful approach to rapidly identify and further evaluate genes that play a role in tumor biology...
  17. ncbi Discovery of new DNA amplification loci in prostate cancer by comparative genomic hybridization
    A El Gedaily
    Institute for Pathology, University of Basel, CH-4031 Basel, Switzerland
    Prostate 46:184-90. 2001
    ..The detection of amplified chromosomal regions may serve as a starting point to discover novel oncogenes involved in prostate cancer progression...
  18. ncbi Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade
    A Nocito
    Institute for Pathology, University of Basel, Schoenbeinstrasse 40, CH-4003 Basel, Switzerland
    J Pathol 194:349-57. 2001
    ..TMAs are a powerful tool for rapid identification of the biological or clinical significance of molecular alterations in bladder cancer and other tumour types...
  19. ncbi Comprehensive epidermal growth factor receptor gene analysis from cytological specimens of non-small-cell lung cancers
    S Savic
    Institute for Pathology, University Hospital Basel, Basel, Switzerland
    Br J Cancer 98:154-60. 2008
    ..New criteria for a positive EGFR FISH status to predict response to therapy with EGFR-TKI need to be defined for cytological specimens...
  20. ncbi Multiprobe FISH for enhanced detection of bladder cancer in voided urine specimens and bladder washings
    L Bubendorf
    Institute for Pathology, University of Basel, Basel, Switzerland
    Am J Clin Pathol 116:79-86. 2001
    ..Multiprobe FISH markedly improves the sensitivity and specificity of cytology for the detection of bladder cancer in urine specimens...
  21. ncbi KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer
    M Bloch
    Institute for Pathology, University Hospital Basel, Basel, Switzerland
    Oncogene 26:2525-34. 2007
    ..The data demonstrate that 10q22 amplification drives KCNMA1 expression and cell proliferation. Thus, KCNMA1 qualifies as a promising diagnostic and therapeutic target in patients with prostate cancer...
  22. ncbi Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers
    P Went
    Institute of Pathology, University Hospital Basel, Schonbeinstrasse 40, 4003 Basel, Switzerland
    Br J Cancer 94:128-35. 2006
    ....
  23. ncbi Tissue microarray (TMA) technology: miniaturized pathology archives for high-throughput in situ studies
    L Bubendorf
    Institute of Pathology, University of Basel, 4003 Basel, Switzerland
    J Pathol 195:72-9. 2001
    ..Therefore, TMAs will lead to a significant acceleration of the transition of basic research findings into clinical applications...
  24. ncbi Combined transbronchial needle aspiration and positron emission tomography for mediastinal staging of NSCLC
    M Bernasconi
    Pulmonary Medicine, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland
    Eur Respir J 27:889-94. 2006
    ....
  25. ncbi [Fluorescence in situ hybridization. A new diagnostic dimension in cytology]
    S Savic
    Institut fur Pathologie, Universitatsspital Basel, 4003, Basel, Schweiz
    Pathologe 28:384-92. 2007
    ..Co-analysis of HPV and selected genes could become a useful approach in gynecological cytology. The spectrum of diagnostic FISH applications is continuously growing...
  26. ncbi Interstitial lung disease in an intravenous drug user
    D Conen
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Respiration 70:101-3. 2003
  27. ncbi Langerhans cell histiocytosis of the stomach with atypical morphological features
    L Terracciano
    Institute of Pathology, University Hospital of Basel, Switzerland
    Pathol Int 49:553-6. 1999
    ..Typical Birbeck granules could be identified in almost all cells. Cell nuclei analyzed by flow cytometry showed an aneuploid peak, a feature typically associated with malignant disease...
  28. ncbi Use of lung resection and voriconazole for successful treatment of invasive pulmonary Aspergillus ustus infection
    A Azzola
    Division of Hematology, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    J Clin Microbiol 42:4805-8. 2004
    ..In summary, this report describes the successful treatment of invasive pulmonary A. ustus infection by lung resection and antifungal treatment with voriconazole in a neutropenic patient...
  29. ncbi Mesothelioma after lung transplantation
    P N Chhajed
    Pulmonary Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Thorax 61:916-7. 2006
    ....
  30. ncbi [Molecular genetics of urinary bladder cancer progression]
    G Sauter
    , , Schoenbeinstrasse 40, CH-4031 Basel, Schweiz
    Verh Dtsch Ges Pathol 86:49-56. 2002
    ..The high frequency of genetic alterations in invasive carcinomas enables a markedly improved detection of bladder cancer cells in voided urine using fluorescence in situ hybridization (FISH) assays...
  31. ncbi High-throughput microarray technologies: from genomics to clinics
    L Bubendorf
    Institute for Pathology, University of Basel, Switzerland
    Eur Urol 40:231-8. 2001
    ..The sequence of the entire human genome will soon be fully sequenced and provide the 'book of life' as a basis for the understanding of human disease...
  32. ncbi Ciprofloxacin-induced acute interstitial pneumonitis
    D Steiger
    Dept of Internal Medicine, University Hospital, Basel, Switzerland
    Eur Respir J 23:172-4. 2004
    ..Ciprofloxacin can induce interstitial pneumonitis with acute respiratory failure. This is an important fact considering that ciprofloxacin is a widely used antibiotic agent in treatment of urinary tract infection...
  33. ncbi Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer
    O Saramaki
    Laboratory of Cancer Genetics, Institute of Medical Technology, Tampere University Hospital, Tampere, Finland
    Am J Pathol 159:2089-94. 2001
    ..In conclusion, amplification of EIF3S3 gene is common in late-stage prostate cancer suggesting that it may be functionally involved in the progression of the disease...
  34. ncbi Multicenter phase II trial of gefitinib first-line therapy followed by chemotherapy in advanced non-small-cell lung cancer (NSCLC): SAKK protocol 19/03
    G D'Addario
    Department of Oncology, Kantonsspital St Gallen, St Gallen, Switzerland
    Ann Oncol 19:739-45. 2008
    ..Gefitinib is active in patients with pretreated non-small-cell lung cancer (NSCLC). We evaluated the activity and toxicity of gefitinib first-line treatment in advanced NSCLC followed by chemotherapy at disease progression...
  35. ncbi Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling
    S Mousses
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 20:6718-23. 2001
    ....
  36. ncbi [Multiprobe FISH for enhanced prediction of recurrent bladder cancer]
    T Zellweger
    , Liestal, Schweiz
    Verh Dtsch Ges Pathol 88:194-8. 2004
    ..Taken together, both cytology and FISH help to better determine the risk of bladder cancer recurrence in order to establish more individualized follow-up schemes...
  37. ncbi Gene-expression profiles in hereditary breast cancer
    I Hedenfalk
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-4470, USA
    N Engl J Med 344:539-48. 2001
    ..Our results suggest that a heritable mutation influences the gene-expression profile of the cancer...
  38. ncbi ANX7, a candidate tumor suppressor gene for prostate cancer
    M Srivastava
    Departments of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 98:4575-80. 2001
    ..We conclude that the ANX7 gene exhibits many biological and genetic properties expected of a TSG and may play a role in prostate cancer progression...
  39. ncbi Guidelines for processing and reporting of prostatic needle biopsies
    Th H van der Kwast
    Department of Pathology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Pathol 56:336-40. 2003
    ..The definition of parameters for quality control of prostatic needle biopsy diagnostics will further facilitate clinical epidemiological multicentre studies of prostate cancer...