Research Topics
| M BrielSummaryAffiliation: University Hospital Country: Switzerland Publications
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Detail Information
Publications
Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysisMatthias Briel
Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
BMJ 338:b92. 2009....- Updated evidence on early statin therapy for acute coronary syndromes: meta-analysis of 18 randomized trials involving over 14,000 patientsMatthias Briel
Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Switzerland
Int J Cardiol 158:93-100. 2012..Our objective was to update the evidence on patient relevant outcomes from all randomized trials comparing early statin therapy with placebo or usual care at 1 and 4 months following ACS... - Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)Matthias Briel
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Trials 10:49. 2009..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit... - Effects of statins on stroke prevention in patients with and without coronary heart disease: a meta-analysis of randomized controlled trialsMatthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
Am J Med 117:596-606. 2004..To assess if lipid-lowering interventions (statins, fibrates, resins, n-3 fatty acids, diet) prevent nonfatal and fatal strokes in patients with and without coronary heart disease... - Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV-infectionM Briel
University Hospital Basel, Basel Institute for Clinical Epidemiology, Internal Medicine, Hebelstrasse 10, Basel, Switzerland 4031
Cochrane Database Syst Rev 3:CD006150. 2006..It was suggested that in these patients corticosteroids adjunctive to standard treatment for PCP could prevent the need for mechanical ventilation and decrease mortality... - Prevalence and influence of diagnostic tests for acute respiratory tract infections in primary careMatthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
Swiss Med Wkly 136:248-53. 2006..We investigated the prevalence of these tests, and how tests are associated with diagnosis, treatment and patient satisfaction... - Communication training and antibiotic use in acute respiratory tract infections. A cluster randomised controlled trial in general practiceMatthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
Swiss Med Wkly 136:241-7. 2006..A cluster-randomised controlled trial in general practice.. - Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]Matthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
BMC Fam Pract 6:34. 2005..The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care... - Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV infection: a meta-analysis of randomised controlled trialsMatthias Briel
Institut für Klinische Epidemiologie, Universitatsspital Basel, 4031 Basel, Switzerland
BMC Infect Dis 5:101. 2005.... - Prescribed medications and pharmacy interventions for acute respiratory tract infections in Swiss primary careK E Hersberger
Institute of Clinical Pharmacy, University of Basel, Basel, Switzerland
J Clin Pharm Ther 34:387-95. 2009..Our study objectives were to examine prescribing patterns of antibiotics and symptomatic medications for ARTI in Swiss primary care and to monitor pharmacists' interventions during the prescription-dispensing process... - Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary careMatthias Briel
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
Arch Intern Med 168:2000-7; discussion 2007-8. 2008..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day... - Mortality in randomized controlled trials comparing drug-eluting vs. bare metal stents in coronary artery disease: a meta-analysisAlain Joel Nordmann
Basel Institute for Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, 4031 Basel, Switzerland
Eur Heart J 27:2784-814. 2006..To evaluate the effect of drug-eluting vs. bare metal stents for the treatment of coronary artery disease on overall, cardiac, and non-cardiac mortalities... - Shared-decision making in general practice: do patients with respiratory tract infections actually want it?Matthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
Swiss Med Wkly 137:483-5. 2007..There is conflicting evidence on whether patients wish to be involved in medical decisions... - Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trialsAlain J Nordmann
Basel Institute for Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, CH 4031 Basel, Switzerland
Arch Intern Med 166:285-93. 2006..Low-carbohydrate diets have become increasingly popular for weight loss. However, evidence from individual trials about benefits and risks of these diets to achieve weight loss and modify cardiovascular risk factors is preliminary... - Effect of different antilipidemic agents and diets on mortality: a systematic reviewMarco Studer
Basel Institute for Clinical Epidemiology, University Hospital Basel, CH-4031 Basel, Switzerland
Arch Intern Med 165:725-30. 2005..Any potential reduction in cardiac mortality from fibrates is offset by an increased risk of death from noncardiovascular causes... - Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trialsMatthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
JAMA 295:2046-56. 2006..CONCLUSION: Based on available evidence, initiation of statin therapy within 14 days following onset of ACS does not reduce death, MI, or stroke up to 4 months... - Statin therapy for prevention and treatment of acute and chronic cardiovascular disease: update on recent trials and metaanalysesMatthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
Curr Opin Lipidol 16:601-5. 2005..Ongoing trials are further investigating the safety of lower target values in patients at various risk of coronary artery disease... - Randomized trials stopped early for benefit: a systematic reviewVictor M Montori
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
JAMA 294:2203-9. 2005..These findings suggest clinicians should view the results of such trials with skepticism... - Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trialsXin Sun
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Trials 10:101. 2009.... - Systematic reviewers neglect bias that results from trials stopped early for benefitDirk Bassler
The Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Clin Epidemiol 60:869-73. 2007.... - Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trialsMartin A Walter
Institute of Nuclear Medicine, University Hospital Basel, Switzerland
BMJ 334:514. 2007..To determine the effect of adjunctive antithyroid drugs on the risk of treatment failure, hypothyroidism, and adverse events after radioiodine treatment... - Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trialsFrancois Lamontagne
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Crit Care 25:420-35. 2010..We sought to determine whether systemic corticosteroids reduce hospital mortality from these illnesses... - Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysisDirk Bassler
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
JAMA 303:1180-7. 2010..Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping...