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Genomes and Genes | Constantin BourasSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Publications
Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive statusConstantin Bouras
Departments of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
J Neuropathol Exp Neurol 65:235-44. 2006....- Humoral immunity in brain aging and Alzheimer's diseaseConstantin Bouras
Department of Psychiatry, University Hospitals of Geneva, 1225 Geneva, Switzerland
Brain Res Brain Res Rev 48:477-87. 2005..Subsequent experiments needed to test this new working hypothesis are addressed at the end of the review... - Induction of MC-1 immunoreactivity in axons after injection of the Fc fragment of human immunoglobulins in macaque monkeysConstantin Bouras
Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
Acta Neuropathol 105:58-64. 2003.... - Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm?Anouk Imhof
Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
J Neurol Sci 257:72-9. 2007.... - Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementiaGabriel Gold
Department of Geriatrics, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
Stroke 36:1184-8. 2005.... - Cortical microinfarcts and demyelination significantly affect cognition in brain agingEniko Kovari
Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
Stroke 35:410-4. 2004..To evaluate the cognitive consequences of such lesions, we prospectively investigated elderly individuals with various degrees of cognitive impairment but without significant neurofibrillary tangle pathology or macrovascular lesions... - Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experiencePanteleimon Giannakopoulos
Division of Geriatric Psychiatry, Department of Psychiatry, University of Geneva School of Medicine, 1225 Chene Bourg, Geneva, Switzerland
Acta Neuropathol 113:1-12. 2007.... - Sorting out the clinical consequences of ischemic lesions in brain aging: a clinicopathological approachGabriel Gold
Department of Geriatrics, University of Geneva School of Medicine, Geneva, Switzerland
J Neurol Sci 257:17-22. 2007..Vascular lesions are particularly common in the aged brain. However, it is still unclear whether all such lesions affect cognition... 
Pathological substrates of cognitive decline in Alzheimer's diseasePanteleimon Giannakopoulos
Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Geneva, Switzerland
Front Neurol Neurosci 24:20-9. 2009..The present review discusses the complex structure/function relationships in brain aging and AD within the theoretical framework of the functional neuropathology of brain aging...- Validation of clinical criteria for possible vascular dementia in the oldest-oldJean Pierre Bacchetta
Department of Psychiatry, University Hospitals of Geneva, Switzerland
Neurobiol Aging 28:579-85. 2007..Although their specificity was significantly lower in this age group compared to younger cohorts, all of them successfully exclude AD cases... - Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retractionGenevieve Leuba
Center for Psychiatric Neuroscience, Department of Psychiatry, CHUV, Lausanne, Switzerland
Neurobiol Dis 30:408-19. 2008.... - Small vascular and Alzheimer disease-related pathologic determinants of dementia in the oldest-oldLidia Sinka
Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland
J Neuropathol Exp Neurol 69:1247-55. 2010..Most importantly, single cutoff scores for these variables that could be used in the future to formulate neuropathologic criteria for mixed dementia in this age group were identified... - Differential impact of lacunes and microvascular lesions on poststroke depressionMicaela Santos
Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
Stroke 40:3557-62. 2009..We performed a detailed analysis of all types of microvascular lesions and lacunes in 41 prospectively documented and consecutively autopsied stroke cases... 
The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cellsLorenza Eder-Colli
Department of Fundamental Neuroscience, University of Geneva School of Medicine, Geneva University, CH 1211 Geneva, Switzerland
Brain Res Bull 80:296-301. 2009..Our data raise the possibility that these alterations in embryonic development might contribute to increase the severity of the Alzheimer's disease phenotype later in adulthood...- Microvascular pathology in late-life depressionMicaela Santos
Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
J Neurol Sci 322:46-9. 2012..A more complex model in late-life depression combining different modalities could be an elucidating approach to the disease's etiopathogeny in the future... - Cortical ubiquitin-positive inclusions in frontotemporal dementia without motor neuron disease: a quantitative immunocytochemical studyEniko Kovari
Departments of Psychiatry and Geriatrics, HUG Belle Idée, University of Geneva School of Medicine, 1225, Geneva, Switzerland
Acta Neuropathol 108:207-12. 2004..They also reveal that the development of ubiquitin-positive inclusion densities in the dentate gyrus may be associated with a more aggressive form of the disease... - The impact of vascular burden on late-life depressionMicaela Santos
Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Switzerland
Brain Res Rev 62:19-32. 2009..Based on these observations, we propose that the accumulation of small vascular and microvascular lesions constitutes a common neuropathological platform for both cognitive decline and depressive episodes in old age... - Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's diseaseEniko Kovari
Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
Acta Neuropathol 106:83-8. 2003..They also suggest that LB formation in limbic areas may be crucial for the development of PD dementia... - Clusterin increases post-ischemic damages in organotypic hippocampal slice culturesDavid Hakkoum
Department of Psychiatry, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland
J Neurochem 106:1791-803. 2008..The present data indicate that in an in vitro model of ischemia characterized by the predominance of NMDA-mediated cell death, clusterin exerts a negative effect on the structural integrity and functionality of hippocampal neurons... - Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22Armand Savioz
Department of Psychiatry, University of Geneva School of Medicine, 1225 Geneva, Switzerland
Neurobiol Dis 12:46-55. 2003..Altogether, these data indicate principally that the Swiss kindred is unlinked to locus 17q21-22, and that tau is not at the origin of FTD in this family... - Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individualsMaciej J Lazarczyk
Department of Mental Health and Psychiatry, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, 1225 Geneva, Switzerland
BMC Med 10:127. 2012..We critically review the currently available early AD markers, discuss their clinical relevance, and propose a novel classification of preclinical AD, designating these non-progressing cases as 'stable asymptomatic cerebral amyloidosis'... - Lewy body dysphagiaEniko Kovari
Department of Psychiatry, University of Geneva School of Medicine, 1225, Geneva, Switzerland
Acta Neuropathol 114:295-8. 2007..These findings confirm the existence of isolated LB dysphagia and emphasize the importance of detailed neuropathological and immunohistochemical examination in cases of dysphagia... - Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenaseJocelyn D Laughton
Department of Psychiatry, Service of Neuropsychiatry, University Hospitals of Geneva, Belle Idee, Switzerland
BMC Neurosci 8:35. 2007..1.1.27) that catalyses the interconversion of lactate and pyruvate and the pyruvate dehydrogenase complex that irreversibly funnels pyruvate towards the mitochondrial TCA and oxydative phosphorylation... - The Geneva brain collectionEniko Kovari
Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland
Ann N Y Acad Sci 1225:E131-46. 2011..The large number of cases, including some very rare conditions, provides a unique resource and an opportunity for worldwide collaborations... - The neuroanatomical model of post-stroke depression: towards a change of focus?Micaela Santos
Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
J Neurol Sci 283:158-62. 2009..We suggest that vascular burden due to the chronic accumulation of small macrovascular and microvascular lesions may be a crucial determinant of the development and evolution of PSD... - Stereologic characterization and spatial distribution patterns of Betz cells in the human primary motor cortexClaire Bénédicte Rivara
Department of Psychiatry, Neuropsychiatry Division, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
Anat Rec A Discov Mol Cell Evol Biol 270:137-51. 2003.... - Microvascular burden and Alzheimer-type lesions across the age spectrumAlessandra Costanza
Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
J Alzheimers Dis 32:643-52. 2012.... - Neuropathology of Lewy body disordersEniko Kovari
Department of Psychiatry, HUG Belle Idée, University Hospitals of Geneva, Switzerland
Brain Res Bull 80:203-10. 2009..The recent progress of neuropathology in this field made it possible to define clinical and neuropathological guidelines for the diagnosis. This review briefly describes the most important data of all Lewy body related disorders... - Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriersGabriel Gold
Department of Geriatrics, Belle Idée Hospital Center, University Hospitals of Geneva, Geneva, Switzerland
Am J Med Genet B Neuropsychiatr Genet 119:44-7. 2003.... - Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sitesPatrick A Keller
Department of Cell Physiology and Metabolism, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Peptides 27:1328-34. 2006..In brain sections, CART displaceable binding sites were observed on cell bodies mainly localized in hypothalamic periventricular areas... - Neuropathological substrates and structural changes in late-life depression: the impact of vascular burdenAikaterini Xekardaki
Department of Mental Health and Psychiatry, Faculty of Medicine, University Hospitals of Geneva, University of Geneva, Chene Bourg, Switzerland
Acta Neuropathol 124:453-64. 2012..These three paradigms are discussed in the light of the complex relationships between psychosocial determinants and biological vulnerability in affective disorders... - Neuropathological analysis of an adult case of the Cornelia de Lange syndromeNicolas Vuilleumier
Department of Psychiatry, University of Geneva School of Medicine, , Geneva, Switzerland
Acta Neuropathol (Berl) 104:327-32. 2002..In the light of previous studies in younger CDLS patients, the vascular and degenerative lesions observed in the present case may be secondary to his severe congenital heart abnormalities and self-injury behavior, respectively... - Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levelsFabienne de Bilbao
Department of Psychiatry, University Hospitals Geneva, Geneva, Switzerland
J Neurochem 89:1283-92. 2004..Moreover, our data imply that UCP2 is not directly involved in the regulation of ROS production but acts by regulating mitochondrial GSH levels in microglia... - Clinicopathologic correlates in the oldest-old: Commentary on "No disease in the brain of a 115-year-old woman"Panteleimon Giannakopoulos
Department of Psychiatry, University Hospitals of Geneva, 1225 Geneva, Switzerland
Neurobiol Aging 29:1137-9. 2008..This work is discussed in the context of current efforts to identify the biological and genetic parameters of human longevity... - Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cellsDung Vu
Department of Psychiatry, University of Geneva School of Medicine, CH 1225, Geneva, Switzerland
Brain Res Mol Brain Res 115:93-103. 2003..Consequently, changes in Lmo4 RNA expression levels might alter the rate of neuritic outgrowth in the developing and adult nervous system... - Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer diseasePatrick R Hof
Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
J Neuropathol Exp Neurol 62:55-67. 2003.... - Human immunoglobulins and Fc fragments promote microtubule assembly via tau proteins and induce conformational changes of neuronal microtubules in vitroIrène M Riederer
Institut de Biologie Cellulaire et de Morphologie, Faculte de Medecine, Universite de Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
Neuroreport 14:117-21. 2003..In conjunction with previous neuropathological data, they suggest that Ig could participate in early stages of neurodegeneration by affecting the microtubule stability in vivo... - Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: evidence for sparing of the entorhinal cortex and CA1 fieldArmin von Gunten
Service of Old Age Psychiatry, University of Lausanne School of Medicine, 1008 Prilly, Lausanne, Switzerland
Exp Neurol 193:198-206. 2005..They also suggest that dementia in extreme aging depends more on the damage of hippocampal subdivisions commonly less affected than on severe NFT formation and neuronal loss in the CA1 field and entorhinal cortex... - Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's diseaseAfia Akram
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Neurobiol Aging 29:1296-307. 2008..6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations... - Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's diseaseArmin von Gunten
Service of Old Age Psychiatry, University of Lausanne School of Medicine, 1008 Prilly, Lausanne, Switzerland
Neurobiol Aging 27:270-7. 2006..Moreover, they show that less than 50% of the cognitive variability may be attributable to AD neuronal pathology in these areas... - Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's diseaseArmin von Gunten
Division of Old Age Psychiatry, Department of Psychiatry CHUV, Prilly Lausanne, Switzerland
Brain Res Rev 51:176-211. 2006.... - Cerebrospinal fluid tau and Abeta42 concentrations in healthy subjects: delineation of reference intervals and their limitationsPierre R Burkhard
Department of Neurology, Cantonal Hospital, Geneva, Switzerland
Clin Chem Lab Med 42:396-407. 2004..We propose that the issue of defining reference limits for both cerebrospinal fluid tau and Abeta42 may ultimately be settled by studying large numbers of autopsy-proven neurologically intact individuals only... - Analysis of glial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's diseaseRaymonde Porchet
Institut de Biologie Cellulaire et de Morphologie, , Rue du Bugnon 9, 1005 Lausanne, Switzerland
Proteomics 3:1476-85. 2003..GFAP may be used as an additional but not exclusive diagnostic tool in the evaluation of neurodegenerative diseases because its levels change with age and respond to senile plaque and tangle formation... - Neurofibrillary tangles in elderly patients with late onset schizophreniaVasilis P Bozikas
1st Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
Neurosci Lett 324:109-12. 2002..Thus, patients with schizophrenia, regardless of the age of onset of their symptoms, are no more prone to the development of Alzheimer's disease than the general population... - Clinicopathological validation study of four sets of clinical criteria for vascular dementiaGabriel Gold
Department of Geriatrics, University Hospital of Geneva, Switzerland
Am J Psychiatry 159:82-7. 2002.... - Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9Thierry Bussiere
Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029
J Comp Neurol 463:281-302. 2003..Their preferential involvement suggests that neurons providing specific corticocortical connections between association areas are at high risk for degeneration in AD... - Increased expression of tyrosine hydroxylase immunoreactivity in paraventricular and supraoptic neurons in illnesses with prolonged osmotic or nonosmotic stimulation of vasopressin releaseMaria T Panayotacopoulou
Department of Psychiatry, University of Athens, Athens, Greece
Neuroendocrinology 76:254-66. 2002..We conclude that somatic illnesses leading to prolonged osmotic or nonosmotic stimulation of VP release may induce increased expression of TH immunoreactivity in the human neurosecretory neurons related to neuronal activation... - A systematic review of existing data on long-term lithium therapy: neuroprotective or neurotoxic?Konstantinos N Fountoulakis
3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
Int J Neuropsychopharmacol 11:269-87. 2008..It is desirable to keep lithium blood levels as low as feasible with prophylaxis... - Identification of Alzheimer and vascular lesion thresholds for mixed dementiaGabriel Gold
Department of Geriatrics, University of Geneva School of Medicine, Geneva
Brain 130:2830-6. 2007..Proposed thresholds for vascular and degenerative lesions predict the presence of dementia with great accuracy and provide a basis for distinguishing pure vascular dementia or AD from mixed cases... - Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbensAlexandra Jean
Centre National de Recherche Scientifique, Unite Mixte de Recherche 5203, Institut National de Santé et de Recherche Médicale, U661, Université Montpellier I and II, Institut de Genomique Fonctionnelle, département de neurobiologie, Montpellier, France
Proc Natl Acad Sci U S A 104:16335-40. 2007..Collectively, these results demonstrate that 5-HT(4)R-mediated up-regulation of CART in the NAc triggers the appetite-suppressant effects of ecstasy...