Constantin Bouras

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Humoral immunity in brain aging and Alzheimer's disease
    Constantin Bouras
    Department of Psychiatry, University Hospitals of Geneva, 1225 Geneva, Switzerland
    Brain Res Brain Res Rev 48:477-87. 2005
  2. ncbi request reprint Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status
    Constantin Bouras
    Departments of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    J Neuropathol Exp Neurol 65:235-44. 2006
  3. ncbi request reprint Induction of MC-1 immunoreactivity in axons after injection of the Fc fragment of human immunoglobulins in macaque monkeys
    Constantin Bouras
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Acta Neuropathol 105:58-64. 2003
  4. ncbi request reprint Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm?
    Anouk Imhof
    Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 257:72-9. 2007
  5. ncbi request reprint Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia
    Gabriel Gold
    Department of Geriatrics, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 36:1184-8. 2005
  6. ncbi request reprint Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience
    Panteleimon Giannakopoulos
    Division of Geriatric Psychiatry, Department of Psychiatry, University of Geneva School of Medicine, 1225 Chene Bourg, Geneva, Switzerland
    Acta Neuropathol 113:1-12. 2007
  7. ncbi request reprint Cortical microinfarcts and demyelination significantly affect cognition in brain aging
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 35:410-4. 2004
  8. ncbi request reprint Sorting out the clinical consequences of ischemic lesions in brain aging: a clinicopathological approach
    Gabriel Gold
    Department of Geriatrics, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 257:17-22. 2007
  9. doi request reprint Pathological substrates of cognitive decline in Alzheimer's disease
    Panteleimon Giannakopoulos
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Geneva, Switzerland
    Front Neurol Neurosci 24:20-9. 2009
  10. ncbi request reprint Validation of clinical criteria for possible vascular dementia in the oldest-old
    Jean Pierre Bacchetta
    Department of Psychiatry, University Hospitals of Geneva, Switzerland
    Neurobiol Aging 28:579-85. 2007

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Humoral immunity in brain aging and Alzheimer's disease
    Constantin Bouras
    Department of Psychiatry, University Hospitals of Geneva, 1225 Geneva, Switzerland
    Brain Res Brain Res Rev 48:477-87. 2005
    ..Subsequent experiments needed to test this new working hypothesis are addressed at the end of the review...
  2. ncbi request reprint Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status
    Constantin Bouras
    Departments of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    J Neuropathol Exp Neurol 65:235-44. 2006
    ....
  3. ncbi request reprint Induction of MC-1 immunoreactivity in axons after injection of the Fc fragment of human immunoglobulins in macaque monkeys
    Constantin Bouras
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Acta Neuropathol 105:58-64. 2003
    ....
  4. ncbi request reprint Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm?
    Anouk Imhof
    Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 257:72-9. 2007
    ....
  5. ncbi request reprint Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia
    Gabriel Gold
    Department of Geriatrics, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 36:1184-8. 2005
    ....
  6. ncbi request reprint Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience
    Panteleimon Giannakopoulos
    Division of Geriatric Psychiatry, Department of Psychiatry, University of Geneva School of Medicine, 1225 Chene Bourg, Geneva, Switzerland
    Acta Neuropathol 113:1-12. 2007
    ....
  7. ncbi request reprint Cortical microinfarcts and demyelination significantly affect cognition in brain aging
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 35:410-4. 2004
    ..To evaluate the cognitive consequences of such lesions, we prospectively investigated elderly individuals with various degrees of cognitive impairment but without significant neurofibrillary tangle pathology or macrovascular lesions...
  8. ncbi request reprint Sorting out the clinical consequences of ischemic lesions in brain aging: a clinicopathological approach
    Gabriel Gold
    Department of Geriatrics, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 257:17-22. 2007
    ..Vascular lesions are particularly common in the aged brain. However, it is still unclear whether all such lesions affect cognition...
  9. doi request reprint Pathological substrates of cognitive decline in Alzheimer's disease
    Panteleimon Giannakopoulos
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Geneva, Switzerland
    Front Neurol Neurosci 24:20-9. 2009
    ..The present review discusses the complex structure/function relationships in brain aging and AD within the theoretical framework of the functional neuropathology of brain aging...
  10. ncbi request reprint Validation of clinical criteria for possible vascular dementia in the oldest-old
    Jean Pierre Bacchetta
    Department of Psychiatry, University Hospitals of Geneva, Switzerland
    Neurobiol Aging 28:579-85. 2007
    ..Although their specificity was significantly lower in this age group compared to younger cohorts, all of them successfully exclude AD cases...
  11. doi request reprint Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction
    Genevieve Leuba
    Center for Psychiatric Neuroscience, Department of Psychiatry, CHUV, Lausanne, Switzerland
    Neurobiol Dis 30:408-19. 2008
    ....
  12. pmc The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells
    Lorenza Eder-Colli
    Department of Fundamental Neuroscience, University of Geneva School of Medicine, Geneva University, CH 1211 Geneva, Switzerland
    Brain Res Bull 80:296-301. 2009
    ..Our data raise the possibility that these alterations in embryonic development might contribute to increase the severity of the Alzheimer's disease phenotype later in adulthood...
  13. doi request reprint Differential impact of lacunes and microvascular lesions on poststroke depression
    Micaela Santos
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    Stroke 40:3557-62. 2009
    ..We performed a detailed analysis of all types of microvascular lesions and lacunes in 41 prospectively documented and consecutively autopsied stroke cases...
  14. doi request reprint Small vascular and Alzheimer disease-related pathologic determinants of dementia in the oldest-old
    Lidia Sinka
    Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland
    J Neuropathol Exp Neurol 69:1247-55. 2010
    ..Most importantly, single cutoff scores for these variables that could be used in the future to formulate neuropathologic criteria for mixed dementia in this age group were identified...
  15. doi request reprint Microvascular burden and Alzheimer-type lesions across the age spectrum
    Alessandra Costanza
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    J Alzheimers Dis 32:643-52. 2012
    ....
  16. doi request reprint Microvascular pathology in late-life depression
    Micaela Santos
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    J Neurol Sci 322:46-9. 2012
    ..A more complex model in late-life depression combining different modalities could be an elucidating approach to the disease's etiopathogeny in the future...
  17. ncbi request reprint Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Acta Neuropathol 106:83-8. 2003
    ..They also suggest that LB formation in limbic areas may be crucial for the development of PD dementia...
  18. pmc The impact of vascular burden on late-life depression
    Micaela Santos
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Switzerland
    Brain Res Rev 62:19-32. 2009
    ..Based on these observations, we propose that the accumulation of small vascular and microvascular lesions constitutes a common neuropathological platform for both cognitive decline and depressive episodes in old age...
  19. ncbi request reprint Cortical ubiquitin-positive inclusions in frontotemporal dementia without motor neuron disease: a quantitative immunocytochemical study
    Eniko Kovari
    Departments of Psychiatry and Geriatrics, HUG Belle Idée, University of Geneva School of Medicine, 1225, Geneva, Switzerland
    Acta Neuropathol 108:207-12. 2004
    ..They also reveal that the development of ubiquitin-positive inclusion densities in the dentate gyrus may be associated with a more aggressive form of the disease...
  20. doi request reprint Clusterin increases post-ischemic damages in organotypic hippocampal slice cultures
    David Hakkoum
    Department of Psychiatry, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland
    J Neurochem 106:1791-803. 2008
    ..The present data indicate that in an in vitro model of ischemia characterized by the predominance of NMDA-mediated cell death, clusterin exerts a negative effect on the structural integrity and functionality of hippocampal neurons...
  21. ncbi request reprint Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22
    Armand Savioz
    Department of Psychiatry, University of Geneva School of Medicine, 1225 Geneva, Switzerland
    Neurobiol Dis 12:46-55. 2003
    ..Altogether, these data indicate principally that the Swiss kindred is unlinked to locus 17q21-22, and that tau is not at the origin of FTD in this family...
  22. ncbi request reprint Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers
    Gabriel Gold
    Department of Geriatrics, Belle Idée Hospital Center, University Hospitals of Geneva, Geneva, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 119:44-7. 2003
    ....
  23. pmc Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals
    Maciej J Lazarczyk
    Department of Mental Health and Psychiatry, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, 1225 Geneva, Switzerland
    BMC Med 10:127. 2012
    ..We critically review the currently available early AD markers, discuss their clinical relevance, and propose a novel classification of preclinical AD, designating these non-progressing cases as 'stable asymptomatic cerebral amyloidosis'...
  24. pmc The neuroanatomical model of post-stroke depression: towards a change of focus?
    Micaela Santos
    Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 283:158-62. 2009
    ..We suggest that vascular burden due to the chronic accumulation of small macrovascular and microvascular lesions may be a crucial determinant of the development and evolution of PSD...
  25. ncbi request reprint Lewy body dysphagia
    Eniko Kovari
    Department of Psychiatry, University of Geneva School of Medicine, 1225, Geneva, Switzerland
    Acta Neuropathol 114:295-8. 2007
    ..These findings confirm the existence of isolated LB dysphagia and emphasize the importance of detailed neuropathological and immunohistochemical examination in cases of dysphagia...
  26. pmc The Geneva brain collection
    Eniko Kovari
    Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland
    Ann N Y Acad Sci 1225:E131-46. 2011
    ..The large number of cases, including some very rare conditions, provides a unique resource and an opportunity for worldwide collaborations...
  27. pmc Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase
    Jocelyn D Laughton
    Department of Psychiatry, Service of Neuropsychiatry, University Hospitals of Geneva, Belle Idee, Switzerland
    BMC Neurosci 8:35. 2007
    ..1.1.27) that catalyses the interconversion of lactate and pyruvate and the pyruvate dehydrogenase complex that irreversibly funnels pyruvate towards the mitochondrial TCA and oxydative phosphorylation...
  28. doi request reprint Neuropathological substrates and structural changes in late-life depression: the impact of vascular burden
    Aikaterini Xekardaki
    Department of Mental Health and Psychiatry, Faculty of Medicine, University Hospitals of Geneva, University of Geneva, Chene Bourg, Switzerland
    Acta Neuropathol 124:453-64. 2012
    ..These three paradigms are discussed in the light of the complex relationships between psychosocial determinants and biological vulnerability in affective disorders...
  29. doi request reprint Neuropathology of Lewy body disorders
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University Hospitals of Geneva, Switzerland
    Brain Res Bull 80:203-10. 2009
    ..The recent progress of neuropathology in this field made it possible to define clinical and neuropathological guidelines for the diagnosis. This review briefly describes the most important data of all Lewy body related disorders...
  30. ncbi request reprint Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sites
    Patrick A Keller
    Department of Cell Physiology and Metabolism, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Peptides 27:1328-34. 2006
    ..In brain sections, CART displaceable binding sites were observed on cell bodies mainly localized in hypothalamic periventricular areas...
  31. ncbi request reprint Neuropathological analysis of an adult case of the Cornelia de Lange syndrome
    Nicolas Vuilleumier
    Department of Psychiatry, University of Geneva School of Medicine, 1225 Chene Bourg, Geneva, Switzerland
    Acta Neuropathol 104:327-32. 2002
    ..In the light of previous studies in younger CDLS patients, the vascular and degenerative lesions observed in the present case may be secondary to his severe congenital heart abnormalities and self-injury behavior, respectively...
  32. ncbi request reprint Stereologic characterization and spatial distribution patterns of Betz cells in the human primary motor cortex
    Claire Bénédicte Rivara
    Department of Psychiatry, Neuropsychiatry Division, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Anat Rec A Discov Mol Cell Evol Biol 270:137-51. 2003
    ....
  33. ncbi request reprint Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells
    Dung Vu
    Department of Psychiatry, University of Geneva School of Medicine, CH 1225, Geneva, Switzerland
    Brain Res Mol Brain Res 115:93-103. 2003
    ..Consequently, changes in Lmo4 RNA expression levels might alter the rate of neuritic outgrowth in the developing and adult nervous system...
  34. ncbi request reprint Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels
    Fabienne de Bilbao
    Department of Psychiatry, University Hospitals Geneva, Geneva, Switzerland
    J Neurochem 89:1283-92. 2004
    ..Moreover, our data imply that UCP2 is not directly involved in the regulation of ROS production but acts by regulating mitochondrial GSH levels in microglia...
  35. pmc Clinicopathologic correlates in the oldest-old: Commentary on "No disease in the brain of a 115-year-old woman"
    Panteleimon Giannakopoulos
    Department of Psychiatry, University Hospitals of Geneva, 1225 Geneva, Switzerland
    Neurobiol Aging 29:1137-9. 2008
    ..This work is discussed in the context of current efforts to identify the biological and genetic parameters of human longevity...
  36. ncbi request reprint Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neuropathol Exp Neurol 62:55-67. 2003
    ....
  37. ncbi request reprint Human immunoglobulins and Fc fragments promote microtubule assembly via tau proteins and induce conformational changes of neuronal microtubules in vitro
    Irène M Riederer
    Institut de Biologie Cellulaire et de Morphologie, Faculte de Medecine, Universite de Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    Neuroreport 14:117-21. 2003
    ..In conjunction with previous neuropathological data, they suggest that Ig could participate in early stages of neurodegeneration by affecting the microtubule stability in vivo...
  38. ncbi request reprint Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: evidence for sparing of the entorhinal cortex and CA1 field
    Armin von Gunten
    Service of Old Age Psychiatry, University of Lausanne School of Medicine, 1008 Prilly, Lausanne, Switzerland
    Exp Neurol 193:198-206. 2005
    ..They also suggest that dementia in extreme aging depends more on the damage of hippocampal subdivisions commonly less affected than on severe NFT formation and neuronal loss in the CA1 field and entorhinal cortex...
  39. pmc Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease
    Afia Akram
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 29:1296-307. 2008
    ..6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations...
  40. pmc Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens
    Alexandra Jean
    Centre National de Recherche Scientifique, Unite Mixte de Recherche 5203, Institut National de Santé et de Recherche Médicale, U661, Université Montpellier I and II, Institut de Genomique Fonctionnelle, département de neurobiologie, Montpellier, France
    Proc Natl Acad Sci U S A 104:16335-40. 2007
    ..Collectively, these results demonstrate that 5-HT(4)R-mediated up-regulation of CART in the NAc triggers the appetite-suppressant effects of ecstasy...
  41. ncbi request reprint Cerebrospinal fluid tau and Abeta42 concentrations in healthy subjects: delineation of reference intervals and their limitations
    Pierre R Burkhard
    Department of Neurology, Cantonal Hospital, Geneva, Switzerland
    Clin Chem Lab Med 42:396-407. 2004
    ..We propose that the issue of defining reference limits for both cerebrospinal fluid tau and Abeta42 may ultimately be settled by studying large numbers of autopsy-proven neurologically intact individuals only...
  42. ncbi request reprint Analysis of glial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease
    Raymonde Porchet
    Institut de Biologie Cellulaire et de Morphologie, Universite de Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    Proteomics 3:1476-85. 2003
    ..GFAP may be used as an additional but not exclusive diagnostic tool in the evaluation of neurodegenerative diseases because its levels change with age and respond to senile plaque and tangle formation...
  43. ncbi request reprint Neurofibrillary tangles in elderly patients with late onset schizophrenia
    Vasilis P Bozikas
    1st Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Neurosci Lett 324:109-12. 2002
    ..Thus, patients with schizophrenia, regardless of the age of onset of their symptoms, are no more prone to the development of Alzheimer's disease than the general population...
  44. ncbi request reprint Clinicopathological validation study of four sets of clinical criteria for vascular dementia
    Gabriel Gold
    Department of Geriatrics, University Hospital of Geneva, Switzerland
    Am J Psychiatry 159:82-7. 2002
    ....
  45. ncbi request reprint Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9
    Thierry Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029
    J Comp Neurol 463:281-302. 2003
    ..Their preferential involvement suggests that neurons providing specific corticocortical connections between association areas are at high risk for degeneration in AD...
  46. ncbi request reprint Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease
    Armin von Gunten
    Service of Old Age Psychiatry, University of Lausanne School of Medicine, 1008 Prilly, Lausanne, Switzerland
    Neurobiol Aging 27:270-7. 2006
    ..Moreover, they show that less than 50% of the cognitive variability may be attributable to AD neuronal pathology in these areas...
  47. ncbi request reprint Increased expression of tyrosine hydroxylase immunoreactivity in paraventricular and supraoptic neurons in illnesses with prolonged osmotic or nonosmotic stimulation of vasopressin release
    Maria T Panayotacopoulou
    Department of Psychiatry, University of Athens, Athens, Greece
    Neuroendocrinology 76:254-66. 2002
    ..We conclude that somatic illnesses leading to prolonged osmotic or nonosmotic stimulation of VP release may induce increased expression of TH immunoreactivity in the human neurosecretory neurons related to neuronal activation...
  48. ncbi request reprint A systematic review of existing data on long-term lithium therapy: neuroprotective or neurotoxic?
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    Int J Neuropsychopharmacol 11:269-87. 2008
    ..It is desirable to keep lithium blood levels as low as feasible with prophylaxis...
  49. ncbi request reprint Identification of Alzheimer and vascular lesion thresholds for mixed dementia
    Gabriel Gold
    Department of Geriatrics, University of Geneva School of Medicine, Geneva
    Brain 130:2830-6. 2007
    ..Proposed thresholds for vascular and degenerative lesions predict the presence of dementia with great accuracy and provide a basis for distinguishing pure vascular dementia or AD from mixed cases...
  50. ncbi request reprint Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease
    Armin von Gunten
    Division of Old Age Psychiatry, Department of Psychiatry CHUV, Prilly Lausanne, Switzerland
    Brain Res Rev 51:176-211. 2006
    ....