O Boss

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13
    O Boss
    Faculty of Medicine, University of Geneva, 1 Michel Servet, Geneva 4, 1211, Switzerland
    Genomics 47:425-6. 1998
  2. ncbi Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression
    O Boss
    Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland
    FEBS Lett 408:39-42. 1997
  3. ncbi Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold
    O Boss
    Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland
    FEBS Lett 412:111-4. 1997
  4. ncbi Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
    O Boss
    Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, 1 Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 273:5-8. 1998
  5. ncbi Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat
    O Boss
    Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland
    FASEB J 12:335-9. 1998
  6. ncbi The uncoupling proteins, a review
    O Boss
    Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland
    Eur J Endocrinol 139:1-9. 1998
  7. ncbi Uncoupling protein 3: its possible biological role and mode of regulation in rodents and humans
    P Muzzin
    Department of Medical Biochemistry, University of Geneva, Switzerland
    J Bioenerg Biomembr 31:467-73. 1999
  8. ncbi Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture
    C Deng
    Department of Medical Biochemistry, University Medical Center, Geneva, Switzerland
    Endocrinology 138:548-52. 1997
  9. ncbi Effects of estrous cycle and steroid replacement on the expression of leptin and uncoupling proteins in adipose tissue in the rat
    V Luukkaa
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
    Gynecol Endocrinol 15:103-12. 2001
  10. ncbi Cloning and functional characterization of an uncoupling protein homolog in hummingbirds
    C R Vianna
    Department of Physiology, Biosciences Institute, University of Sao Paulo, , Brazil
    Physiol Genomics 5:137-45. 2001

Collaborators

  • J P Giacobino
  • P Muzzin
  • F Assimacopoulos-Jeannet
  • A Paoloni-Giacobino
  • BRADFORD LOWELL
  • K A Virtanen
  • F Rohner-Jeanrenaud
  • José Eduardo P W Bicudo
  • Abdul G Dulloo
  • C B Chan
  • C Y Zhang
  • D Mainieri
  • T Hagen
  • Y B Kim
  • G I Shulman
  • J Seydoux
  • A J Vidal-Puig
  • V Luukkaa
  • E D Abel
  • C R Vianna
  • O Peroni
  • J K Kim
  • B B Kahn
  • D Grujic
  • L D Klaman
  • J P Montani
  • C Deng
  • J P Revelli
  • C A Siegrist-Kaiser
  • F Preitner
  • E Savontaus
  • J Rouru
  • M Koulu
  • U Pesonen
  • S Krauss
  • T Minnemann
  • R Huupponen
  • A C Bianco
  • B Gereben
  • E Hadro
  • E Bachman
  • G Baffy
  • X X Zheng
  • P Perret
  • I Huhtaniemi
  • M B Wheeler
  • A S Moriscot
  • D M Muoio
  • A H Sharpe
  • N Moghal
  • J L Martino
  • J M Zabolotny
  • M Lubkin
  • V Mootha
  • B G Neel
  • A Szczepanik
  • A Stricker-Krongrad
  • J Wade
  • R Cortright
  • Y Ido
  • O D Peroni
  • J Zapf
  • C A Meier
  • P Muniesa
  • C Ody
  • F Kuehne
  • A G Burger
  • J Huarte
  • M Moinat
  • A Pernin
  • S Samec
  • A Nadakal
  • V Pauli
  • L Curtis
  • J D Vassalli
  • W W Chin
  • I Cusin
  • C E Juge-Aubry

Detail Information

Publications18

  1. ncbi Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13
    O Boss
    Faculty of Medicine, University of Geneva, 1 Michel Servet, Geneva 4, 1211, Switzerland
    Genomics 47:425-6. 1998
  2. ncbi Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression
    O Boss
    Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland
    FEBS Lett 408:39-42. 1997
    ..This new member of the UCP family is a candidate protein for the modulation of the respiratory control in skeletal muscle...
  3. ncbi Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold
    O Boss
    Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland
    FEBS Lett 412:111-4. 1997
    ....
  4. ncbi Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
    O Boss
    Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, 1 Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 273:5-8. 1998
    ..The notion that UCP3 expression is modulated by food intake is of importance to better understand the pathophysiology of obesity in humans...
  5. ncbi Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat
    O Boss
    Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland
    FASEB J 12:335-9. 1998
    ..The down-regulation of UCP3 and UCP2 expressions might also contribute to the rapid weight gain known to occur when exercise training ceased...
  6. ncbi The uncoupling proteins, a review
    O Boss
    Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland
    Eur J Endocrinol 139:1-9. 1998
  7. ncbi Uncoupling protein 3: its possible biological role and mode of regulation in rodents and humans
    P Muzzin
    Department of Medical Biochemistry, University of Geneva, Switzerland
    J Bioenerg Biomembr 31:467-73. 1999
    ..Finally, we hypothesize a role for UCP3 in the metabolic adaptation of the mitochondria to the degradation of fatty acids...
  8. ncbi Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture
    C Deng
    Department of Medical Biochemistry, University Medical Center, Geneva, Switzerland
    Endocrinology 138:548-52. 1997
    ..The results suggest the existence in brown adipose tissue of a retroregulatory pathway by which leptin production in inhibited when the sympathetic nervous system is stimulated...
  9. ncbi Effects of estrous cycle and steroid replacement on the expression of leptin and uncoupling proteins in adipose tissue in the rat
    V Luukkaa
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
    Gynecol Endocrinol 15:103-12. 2001
    ....
  10. ncbi Cloning and functional characterization of an uncoupling protein homolog in hummingbirds
    C R Vianna
    Department of Physiology, Biosciences Institute, University of Sao Paulo, , Brazil
    Physiol Genomics 5:137-45. 2001
    ..5- to 3.4-fold higher during torpor. In conclusion, this is the first report of an UCP homolog in birds. The data indicate that HmUCP has the potential to function as an UCP and could play a thermogenic role during rewarming...
  11. ncbi Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    C Y Zhang
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02115, USA
    Cell 105:745-55. 2001
    ..These results establish UCP2 as a key component of beta cell glucose sensing, and as a critical link between obesity, beta cell dysfunction, and type 2 diabetes...
  12. pmc Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
    L D Klaman
    Cancer Biology Program, Division of Hematology Oncology, Boston, Massachusetts 02215, USA
    Mol Cell Biol 20:5479-89. 2000
    ..Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo...
  13. ncbi Energy metabolism in uncoupling protein 3 gene knockout mice
    A J Vidal-Puig
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:16258-66. 2000
    ..The consequence of increased mitochondrial coupling in UCP3 KO mice on metabolism and the possible role of yet unidentified compensatory mechanisms, remains to be determined...
  14. ncbi Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1
    O Boss
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Biochem Biophys Res Commun 261:870-6. 1999
    ..This effect is probably indirect, as muscle does not seem to express beta(3)-AR. In addition, our data suggest that BRL 37344 and CGP 12177 act, in part, through an as yet unidentified receptor, possibly a beta(4)-AR...
  15. pmc Direct effects of leptin on brown and white adipose tissue
    C A Siegrist-Kaiser
    Unité de Thyroïde, Division d Endocrinologie et Diabétologie, Hopital Universitaire de Geneve, Geneva, Switzerland
    J Clin Invest 100:2858-64. 1997
    ....
  16. pmc Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition
    J P Revelli
    Departement de Biochimie Medicale, Centre Medical Universitaire, CH 1211 Geneve 4, Switzerland
    J Clin Invest 100:1098-106. 1997
    ..Taken together, these studies demonstrate that beta3-adrenoceptor disruption creates conditions which predispose to the development of obesity...
  17. ncbi Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    E D Abel
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 409:729-33. 2001
    ..G4A-/- mice develop glucose intolerance and hyperinsulinaemia. Thus, downregulation of GLUT4 and glucose transport selectively in adipose tissue can cause insulin resistance and thereby increase the risk of developing diabetes...
  18. ncbi beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis
    D Mainieri
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Int J Obes (Lond) 31:378-81. 2007
    ..Whether approaches that target both SCD1 and molecular effectors of thermogenesis under beta-adrenergic control might be more effective than targeting SCD1 alone are potential avenues for future research in obesity management...