Stefan Borgwardt

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Effects of cannabis use on human brain structure in psychosis: a systematic review combining in vivo structural neuroimaging and post mortem studies
    Charlotte Rapp
    Department of Psychiatry, University of Basel, c o University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Curr Pharm Des 18:5070-80. 2012
  2. pmc Insular volume abnormalities associated with different transition probabilities to psychosis
    R Smieskova
    Department of Psychiatry, University of Basel, Switzerland
    Psychol Med 42:1613-25. 2012
  3. pmc Distinguishing prodromal from first-episode psychosis using neuroanatomical single-subject pattern recognition
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Schizophr Bull 39:1105-14. 2013
  4. doi Neural effects of green tea extract on dorsolateral prefrontal cortex
    S Borgwardt
    University Hospital Basel, Medical Image Analysis Centre, University of Basel, Basel, Switzerland
    Eur J Clin Nutr 66:1187-92. 2012
  5. pmc Why are psychiatric imaging methods clinically unreliable? Conclusions and practical guidelines for authors, editors and reviewers
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Behav Brain Funct 8:46. 2012
  6. doi Gray matters!--mapping the transition to psychosis
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Schizophr Res 133:63-7. 2011
  7. ncbi Third-generation neuroimaging in early schizophrenia: translating research evidence into clinical utility
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, c o University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Br J Psychiatry 200:270-2. 2012
  8. doi Reductions in frontal, temporal and parietal volume associated with the onset of psychosis
    Stefan J Borgwardt
    Psychiatric Outpatient Department, University Hospital Basel, Petersgraben, CH 031 Basel, Switzerland
    Schizophr Res 106:108-14. 2008
  9. ncbi Anterior cingulate pathology in the prodromal stage of schizophrenia
    Stefan J Borgwardt
    Institute of Psychiatry, King s College London, UK
    Neuroimage 39:553-4. 2008
  10. ncbi Regional gray matter volume abnormalities in the at risk mental state
    Stefan J Borgwardt
    Psychiatric Outpatient Department, University Hospital Basel, Switzerland
    Biol Psychiatry 61:1148-56. 2007

Detail Information

Publications39

  1. pmc Effects of cannabis use on human brain structure in psychosis: a systematic review combining in vivo structural neuroimaging and post mortem studies
    Charlotte Rapp
    Department of Psychiatry, University of Basel, c o University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Curr Pharm Des 18:5070-80. 2012
    ....
  2. pmc Insular volume abnormalities associated with different transition probabilities to psychosis
    R Smieskova
    Department of Psychiatry, University of Basel, Switzerland
    Psychol Med 42:1613-25. 2012
    ..The present study addresses this issue by means of voxel-based morphometry (VBM)...
  3. pmc Distinguishing prodromal from first-episode psychosis using neuroanatomical single-subject pattern recognition
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Schizophr Bull 39:1105-14. 2013
    ..However, it is unknown whether the development of these brain alterations predates the clinical deterioration of at-risk individuals, or alternatively, whether it parallels the transition to psychosis at the single-subject level...
  4. doi Neural effects of green tea extract on dorsolateral prefrontal cortex
    S Borgwardt
    University Hospital Basel, Medical Image Analysis Centre, University of Basel, Basel, Switzerland
    Eur J Clin Nutr 66:1187-92. 2012
    ..In vivo studies provide preliminary evidence that green tea intake may have a positive role in improving effects on cognitive functions. We aimed to examine the neural effects of green tea extract on brain activation in humans...
  5. pmc Why are psychiatric imaging methods clinically unreliable? Conclusions and practical guidelines for authors, editors and reviewers
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Behav Brain Funct 8:46. 2012
    ..We provide guidelines to authors, editors and reviewers in the implementation/evaluation of neuroimaging studies to bend neuroimaging to be more than basic neuroscience...
  6. doi Gray matters!--mapping the transition to psychosis
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Schizophr Res 133:63-7. 2011
    ..Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis...
  7. ncbi Third-generation neuroimaging in early schizophrenia: translating research evidence into clinical utility
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, c o University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Br J Psychiatry 200:270-2. 2012
    ....
  8. doi Reductions in frontal, temporal and parietal volume associated with the onset of psychosis
    Stefan J Borgwardt
    Psychiatric Outpatient Department, University Hospital Basel, Petersgraben, CH 031 Basel, Switzerland
    Schizophr Res 106:108-14. 2008
    ..The aim of the study was to compare regional gray matter volume in people before and after the onset of psychosis using a within-subject prospective design...
  9. ncbi Anterior cingulate pathology in the prodromal stage of schizophrenia
    Stefan J Borgwardt
    Institute of Psychiatry, King s College London, UK
    Neuroimage 39:553-4. 2008
  10. ncbi Regional gray matter volume abnormalities in the at risk mental state
    Stefan J Borgwardt
    Psychiatric Outpatient Department, University Hospital Basel, Switzerland
    Biol Psychiatry 61:1148-56. 2007
    ..We addressed this issue by studying gray matter volume in this group with magnetic resonance imaging (MRI)...
  11. doi Duration of untreated psychosis and cognitive functioning
    Charlotte Rapp
    University of Basel Psychiatric Clinics, c o University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Schizophr Res 145:43-9. 2013
    ..Because methodological operationalization of cognitive functioning in previous studies is highly heterogeneous, we aimed to compare different approaches...
  12. ncbi Cannabis use and brain structural alterations of the cingulate cortex in early psychosis
    Charlotte Rapp
    University of Basel Psychiatric Clinics, Center for Gender Research and Early Detection, c o University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Psychiatry Res 214:102-8. 2013
    ..As this finding has not been consistently found in healthy controls, it might suggest that both ARMS and FEP subjects are particularly sensitive to exogenous activation of these receptors. ..
  13. doi Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing
    Sagnik Bhattacharyya
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, England
    Arch Gen Psychiatry 69:27-36. 2012
    ..Cannabis can induce acute psychotic symptoms, and its chronic use may increase the risk of schizophrenia. We investigated whether its psychotic effects are mediated through an influence on attentional salience processing...
  14. doi Brain connectivity abnormalities predating the onset of psychosis: correlation with the effect of medication
    Andre Schmidt
    Department of Psychiatry, University of Basel, Basel, Switzerland2Medical Image Analysis Centre, University Hospital Basel, Basel, Switzerland
    JAMA Psychiatry 70:903-12. 2013
    ..Furthermore, antipsychotic treatment can modulate brain activity and functional connectivity during cognitive tasks...
  15. doi Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol
    Paolo Fusar-Poli
    Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Int J Neuropsychopharmacol 13:421-32. 2010
    ..This is the first study to show that the disruption of prefrontal-subocritical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties...
  16. doi Hippocampal volume in subjects at high risk of psychosis: a longitudinal MRI study
    Anna Walter
    Department of Psychiatry, University of Basel, Wilhelm Klein Strasse 27, CH 4012 Basel, Switzerland
    Schizophr Res 142:217-22. 2012
    ..The aim was to investigate the timing of HV changes in ARMS in the early phase of psychosis...
  17. pmc Reduction in cerebral perfusion after heroin administration: a resting state arterial spin labeling study
    Niklaus Denier
    University Hospital of Psychiatry, Basel, Switzerland
    PLoS ONE 8:e71461. 2013
    ..Analysis of extracted perfusion values indicate strong effect sizes and no gender related differences. Reduced perfusion in these brain areas may indicate self- and emotional regulation effects of heroin in maintenance treatment. ..
  18. doi Cognitive functioning in prodromal psychosis: a meta-analysis
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, England, UK
    Arch Gen Psychiatry 69:562-71. 2012
    ..Cognitive deficits may predate the onset of psychosis and may be useful as markers of increased vulnerability to illness...
  19. pmc Inferior frontal cortex modulation with an acute dose of heroin during cognitive control
    Andre Schmidt
    1 Department of Psychiatry UPK, University of Basel, Basel, Switzerland 2 Medical Image Analysis Center MIAC, University Hospital Basel, Basel, Switzerland
    Neuropsychopharmacology 38:2231-9. 2013
    ....
  20. pmc Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology
    Sagnik Bhattacharyya
    Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 35:764-74. 2010
    ..Delta-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Delta-9-THC...
  21. pmc Neuroanatomical maps of psychosis onset: voxel-wise meta-analysis of antipsychotic-naive VBM studies
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Department of Psychosis Studies, Institute of Psychiatry, King s College London, 16 De Crespigny Park, London SE58AF, UK
    Schizophr Bull 38:1297-307. 2012
    ..Available structural imaging literature in the field is undermined by several methodological caveats and a number of confounders such as exposure to antipsychotic treatment...
  22. doi First self-perceived signs and symptoms in emerging psychosis compared with depression
    Jacqueline Aston
    University of Basel Psychiatric Clinics, Psychiatric Outpatient Department, University Hospital Basel, Basel, Switzerland
    Early Interv Psychiatry 6:455-9. 2012
    ..To investigate differences between the early symptoms of schizophrenia and depressive disorders...
  23. ncbi Neuroimaging and resilience factors--staging of the at-risk mental state?
    Renata Smieskova
    Department of Psychiatry, University of Basel, 4031 Basel, Switzerland
    Curr Pharm Des 18:416-21. 2012
    ..Resilience, understood as ability to recover from change, can be thus applied in the early intervention for high clinical risk for psychosis individuals...
  24. doi Hyperprolactinaemia in early psychosis-not only due to antipsychotics
    Jacqueline Aston
    Psychiatric University Outpatient Department, Psychiatric University Clinics Basel, c o University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Prog Neuropsychopharmacol Biol Psychiatry 34:1342-4. 2010
    ..Hyperprolactinaemia was found in 25.6% of ARMS and 46.2% of FEP. Within 60 antipsychotic-naïve ARMS and FEP, hyperprolactinaemia was found in 26.7%. Hyperprolactinaemia may be pre-existing in a subgroup of patients with schizophrenia...
  25. pmc Effects of cannabis on impulsivity: a systematic review of neuroimaging findings
    Johannes Wrege
    Department of Psychiatry UPK, University of Basel, Petersgraben 4, 4031 Basel, Switzerland
    Curr Pharm Des 20:2126-37. 2014
    ..To address the question whether impulsivity as a trait precedes cannabis consumption or whether cannabis aggravates impulsivity and discontinuation of usage more longitudinal study designs are warranted. ..
  26. ncbi Fine motor function and neuropsychological deficits in individuals at risk for schizophrenia
    Ute Gschwandtner
    Psychiatric Outpatient Department, University Hospital Basel, Petersgraben 4 6, 4031 Basel, Switzerland
    Eur Arch Psychiatry Clin Neurosci 256:201-6. 2006
    ..A multilevel approach might therefore be a valuable contribution to detecting beginning schizophrenia...
  27. ncbi Cingulate volume abnormalities in emerging psychosis
    Michel Röthlisberger
    Department of Psychiatry, c o University Hospital Basel, University of Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Curr Pharm Des 18:495-504. 2012
    ..We reviewed previous studies of subjects in a prodromal stage of psychosis and tested cingulate volume changes during the transition to psychosis...
  28. doi Are neurological soft signs pre-existing markers in individuals with an at-risk mental state for psychosis?
    Corinne Tamagni
    University of Basel Psychiatric Clinics, Center for Gender Research and Early Detection, Petersgraben 4, CH 4031 Basel, Switzerland
    Psychiatry Res 210:427-31. 2013
    ..Furthermore, our findings might indicate that ARMS-NT individuals also suffer from some sort of neurodevelopmental abnormalities. ..
  29. ncbi The psychosis high-risk state: a comprehensive state-of-the-art review
    Paolo Fusar-Poli
    Department of Psychosis Studies, King s College London, London, UK
    JAMA Psychiatry 70:107-20. 2013
    ..The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5...
  30. doi Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Arch Gen Psychiatry 69:220-9. 2012
    ..However, the risk of transition to psychosis varies between centers, and some recent work suggests that the risk of transition may be declining...
  31. ncbi Is cannabis neurotoxic for the healthy brain? A meta-analytical review of structural brain alterations in non-psychotic users
    Matteo Rocchetti
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
    Psychiatry Clin Neurosci 67:483-92. 2013
    ..There appears to be a need to evaluate the existing imaging data on the neuroanatomical effects of cannabis use on non-psychotic populations...
  32. pmc Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies
    Paolo Fusar-Poli
    Institute of Psychiatry, Department of Psychosis Studies, King s College London, London, United Kingdom
    J Psychiatry Neurosci 37:170-84. 2012
    ..Although early interventions in individuals with bipolar disorder may reduce the associated personal and economic burden, the neurobiologic markers of enhanced risk are unknown...
  33. ncbi Moving beyond transition outcomes: meta-analysis of remission rates in individuals at high clinical risk for psychosis
    Andor E Simon
    University Psychiatry Clinics, University of Basel, 4031 Basel, Switzerland Specialized Early Psychosis Outpatient Service for Adolescents and Young Adults, Department of Psychiatry, 4101 Bruderholz, Switzerland University Hospital of Psychiatry, University of Bern, 3010 Bern, Switzerland
    Psychiatry Res 209:266-72. 2013
    ..The CHR state is associated with a significant proportion of remitting subjects that can be accounted by the effective treatments received, a lead time bias, a dilution effect, a comorbid effect of other psychiatric diagnoses. ..
  34. ncbi Evidence of reporting biases in voxel-based morphometry (VBM) studies of psychiatric and neurological disorders
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom OASIS team, South London and the Maudsley NHS Foundation Trust, London, United Kingdom
    Hum Brain Mapp 35:3052-65. 2014
    ..To evaluate whether biases may influence the findings of whole-brain structural imaging literature...
  35. pmc White matter pathology--an endophenotype for bipolar disorder?
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    BMC Psychiatry 12:138. 2012
    ..They are not confounded by the presence of illness duration or previous treatment with medication and may ultimately inform evaluation of risk for subsequent development of BD and subsequent therapeutic intervention...
  36. doi Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis
    Sagnik Bhattacharyya
    Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, Box P067, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:442-51. 2009
    ..Cannabis sativa use can impair verbal learning, provoke acute psychosis, and increase the risk of schizophrenia. It is unclear where C. sativa acts in the human brain to modulate verbal learning and to induce psychotic symptoms...
  37. doi Abnormal effective connectivity in the psychosis high-risk state
    Andre Schmidt
    Department of Psychiatry UPK, University of Basel, Petersgraben 4, Basel 4031, Switzerland
    Neuroimage 81:119-20. 2013
    ....
  38. doi Molecular mechanisms of depression: perspectives on new treatment strategies
    Undine E Lang
    University Hospital of Basel, Department of Psychiatry and Psychotherapy, Basel, Switzerland
    Cell Physiol Biochem 31:761-77. 2013
    ..In this review, an attempt is made to overview concepts of the disease and search for perspectives on antidepressant treatment strategies beyond approved medications. ..
  39. ncbi Resting state abnormalities in psychosis compared to acute cannabinoids and opioids challenges: a systematic review of functional imaging studies
    Niklaus Denier
    Department of Psychiatry, University of Basel, c o University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Curr Pharm Des 18:5081-92. 2012
    ....