Research Topics
| Michael BodmerSummaryAffiliation: University Hospital Country: Switzerland Publications
| Collaborators
|
Detail Information
Publications
[Poisoning with antidepressants]Michael Bodmer
Notfallstation und Abteilung für Klinische Pharmakologie und Toxikologie, Kantonsspital Basel, Basel
Ther Umsch 66:335-41. 2009..The selective serotonin reuptake inhibitors (SSRI) and the atypical antidepressants are far less toxic than tricyclics. They may lead to serotonin toxicity (serotonin syndrome)...- Metformin does not alter the risk of lung cancer: a case-control analysisMichael Bodmer
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Switzerland
Lung Cancer 78:133-7. 2012..Metformin use has been linked to a decreased cancer risk. We explored the association between use of metformin or other antidiabetic drugs and the risk of lung cancer... 
Lichenoid eruption associated with the use of nebivololMichael Bodmer
Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland
Ann Pharmacother 40:1688-90. 2006..To report a case of lichenoid drug eruption (LDE) after starting antihypertensive treatment with nebivolol, a cardioselective beta-blocker...- Focal segmental glomerulosclerosis associated with long-term treatment with zoledronate in a myeloma patientMichael Bodmer
Department of Clinical Pharmacology and Toxicology, University Hospital Basel, Switzerland
Nephrol Dial Transplant 22:2366-70. 2007 - Safety of non-therapeutic levetiracetam ingestions--a poison center based studyMichael Bodmer
Rocky Mountain Poison and Drug Center, Denver, CO, USA
Pharmacoepidemiol Drug Saf 20:366-9. 2011..Very limited data is available regarding the safety of levetiracetam in cases of unintentional or intentional ingestions... - [Intoxication with an unknown sedative substance]M Bodmer
Abteilung für Klinische Pharmakologie und Toxikologie, Universitatsspital Basel, Basel
Praxis (Bern 1994) 97:820-5. 2008..Phenobarbital was detected in the blood. Decontamination procedures and therapy in patients with phenobarbital intoxication are delineated and discussed... - Pharmacokinetics and pharmacodynamics of quetiapine in a patient with a massive overdoseMichael Bodmer
Department of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Ther Drug Monit 30:553-6. 2008..The final elimination of the drug from the body occurred after approximately 34 hours at much slower rate, most probably reflecting redistribution from tissues into blood and consecutive hepatic clearance of the drug... 
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysisMichael Bodmer
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Diabetes Care 31:2086-91. 2008..Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral antidiabetes drugs...- Use of antidiabetic agents and the risk of pancreatic cancer: a case-control analysisMichael Bodmer
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
Am J Gastroenterol 107:620-6. 2012..The objective of this study was to explore the association between use of metformin or other antidiabetic drugs, diabetes, and the risk of pancreatic cancer... - Pharmacokinetics of intravenous and oral midazolam in plasma and saliva in humans: usefulness of saliva as matrix for CYP3A phenotypingBettina Link
Division of Clinical Pharmacology and Toxicology and Department of Research, University Hospital, Basel, Switzerland
Br J Clin Pharmacol 66:473-84. 2008..To compare midazolam kinetics between plasma and saliva and to find out whether saliva is suitable for CYP3A phenotyping... - Long-term metformin use is associated with decreased risk of breast cancerMichael Bodmer
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Diabetes Care 33:1304-8. 2010..To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women... - Use of metformin and the risk of ovarian cancer: a case-control analysisMichael Bodmer
Department of Pharmaceutical Sciences, University of Basel, Switzerland
Gynecol Oncol 123:200-4. 2011..To explore the association between use of metformin or other antidiabetic drugs and the risk of ovarian cancer... - Use of metformin is not associated with a decreased risk of colorectal cancer: a case-control analysisMichael Bodmer
Basel Pharmacoepidemiology Unit, Hospital Pharmacy, University Hospital Basel, Spitalstrasse 26, CH 4031 Basel, Switzerland
Cancer Epidemiol Biomarkers Prev 21:280-6. 2012..To explore the association between use of metformin or other antidiabetic drugs and the risk of colorectal cancer... - Risk of fractures with glitazones: a critical review of the evidence to dateMichael Bodmer
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Drug Saf 32:539-47. 2009..As a consequence of these observations, clinicians should carefully assess the fracture risk in patients with type 2 diabetes before starting therapy with glitazones... - Statin use and risk of gallstone disease followed by cholecystectomyMichael Bodmer
Division of Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland
JAMA 302:2001-7. 2009..Statins decrease hepatic cholesterol biosynthesis and may therefore lower the risk of cholesterol gallstones by reducing the cholesterol concentration in the bile. Data on this association in humans are scarce... - Diabetes mellitus and the risk of cholecystectomyMichael Bodmer
Emergency Department, University Hospital Basel, Switzerland
Dig Liver Dis 43:742-7. 2011..Whether diabetes mellitus is associated with an increased risk of cholecystectomy remains controversial... - Pharmacokinetics of midazolam and metabolites in a patient with refractory status epilepticus treated with extraordinary doses of midazolamMichael Bodmer
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Ther Drug Monit 30:120-4. 2008..Even in patients with hepatic CYP3A induction, the half-life of MDZ increases with high doses as a result of a rise in its volume of distribution, which is a consequence of an increase in the free fraction of MDZ... - Drug-related emergency department visits by elderly patients presenting with non-specific complaintsChristian H Nickel
Department of Emergency Medicine, University Hospital Basel, Basel, Switzerland
Scand J Trauma Resusc Emerg Med 21:15. 2013.... - Comparison of the dissolution and pharmacokinetic profiles of two galenical formulations of the endothelin receptor antagonist macitentanOliver Kummer
Division of Clinical Pharmacology and Toxicology and Department of Biomedicine, University Hospital, CH 4031 Basel, Switzerland
Eur J Pharm Sci 38:384-8. 2009..We conclude that the absorption profile of the tablet differs from the capsule in peak but not in total exposure, which is not expected to be of clinical significance... - Proton pump inhibitors and fracture risk: true effect or residual confounding?Michael Bodmer
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Drug Saf 33:843-52. 2010.... - Use of thiazolidinediones and fracture riskChristian Meier
Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Basel, Hebelstrasse 2, CH 4031 Basel, Switzerland
Arch Intern Med 168:820-5. 2008..Thiazolidinediones may adversely affect the skeleton owing to decreased bone formation and accelerated bone loss... - Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control studyPatrick Imfeld
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
J Am Geriatr Soc 60:916-21. 2012..To explore the risk of developing Alzheimer's disease (AD) in individuals with diabetes mellitus treated with metformin or other antidiabetic drugs... - Pharmacokinetics and pharmacodynamics of sildenafil in a patient treated with human immunodeficiency virus protease inhibitorsYvonne Zysset Aschmann
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Ther Drug Monit 30:130-4. 2008..Patients treated concomitantly with protease inhibitors and sildenafil need close monitoring of plasma levels, pharmacodynamics, and toxicity of sildenafil in order to be treated optimally... - [Drug-induced microscopic colitis]O Kummer
Klinische Pharmakologie and Toxikologie,
Praxis (Bern 1994) 96:1293-7. 2007 - Seizures in patients with Alzheimer's disease or vascular dementia: A population-based nested case-control analysisPatrick Imfeld
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland Hospital Pharmacy, University Hospital Basel, Basel, Switzerland F Hoffmann La Roche Ltd, Basel, Switzerland Boston Collaborative Drug Surveillance Program, Boston University School of Public Health, Lexington, Massachusetts, U S A
Epilepsia 54:700-7. 2013..Significance: Seizures or epilepsy were substantially more common in patients with AD and VD than in dementia-free patients. The role of disease duration as a risk factor for seizures/epilepsy seems to differ between AD and VD... - Pharmacokinetics and metabolism of idebenone in healthy male subjectsMichael Bodmer
Department of Clinical Pharmacology, University Hospital Basel, Basel, Switzerland
Eur J Clin Pharmacol 65:493-501. 2009..Since in previous pharmacokinetic trials only lower doses were studied, it was the aim of this study to evaluate the pharmacokinetics of idebenone in higher doses of up to 2,250 mg/day... - Effect of therapeutic doses of acetaminophen (up to 4 g/day) on serum alanine aminotransferase levels in subjects consuming ethanol: systematic review and meta-analysis of randomized controlled trialsBarry Rumack
Denver Health and Hospital Authority Rocky Mountain Poison and Drug Center, Denver, Colorado 80204, USA
Pharmacotherapy 32:784-91. 2012..To quantify the effect of therapeutic doses of acetaminophen on serum alanine aminotransferase (ALT) levels in subjects who consumed ethanol... - Heat exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjectsMartin Eichler
Departments of Clinical Pharmacology and Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, Basel, Switzerland
Planta Med 78:686-91. 2012..These results indicate that use of unheated extracts may lead to a beneficial change in metabolic pattern and possibly better tolerability... - Dextromethorphan, chlorphenamine and serotonin toxicity: case report and systematic literature reviewAndrew A Monte
Rocky Mountain Poison and Drug Center, Denver University of Colorado Denver School of Medicine, Aurora, USA
Br J Clin Pharmacol 70:794-8. 2010..Chlorphenamine is a serotonergic medication and combinations of chlorphenamine and dextromethorphan may be dangerous in overdose due to an increased risk of serotonin toxicity... - Low-molecular-weight heparin overdose: management by observationAndrew A Monte
Rocky Mountain Poison and Drug Center, University of Colorado Denver, USA
Ann Pharmacother 44:1836-9. 2010..To describe 3 episodes of low-molecular-weight heparin (LMWH) overdose in 2 patients and discuss the clinical presentations, outcomes, and therapeutic options... - Acute liver failure in two patients with regular alcohol consumption ingesting paracetamol at therapeutic dosageStephan Krahenbuhl
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Digestion 75:232-7. 2007..The possible role of alcohol in the development of hepatotoxicity associated with therapeutic doses of paracetamol (acetaminophen) is currently debated... - Diuretic use, RAAS blockade and morbidity in elderly patients presenting to the Emergency Department with non-specific complaintsJuliane M Ruedinger
Department of Emergency Medicine, University Hospital Basel, Switzerland
Swiss Med Wkly 142:w13568. 2012..The hypothesis was tested that the use of diuretics and RAAS blockade could be associated with an increased incidence of serious conditions in those patients... - Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2Liliane Todesco
Division of Clinical Pharmacology and Toxicology and Department of Research, University Hospital, CH 4031 Basel, Switzerland
Chem Biol Interact 180:472-7. 2009..Hypocarnitinemia in such patients therefore develops due to massive renal losses of pivaloylcarnitine and not due to inhibition of carnitine reabsorption by pivaloylcarnitine... - Hepatitis with fibrin-ring granulomasB Khanlari
Dept Internal Medicine, University Hospital, Basel, Switzerland
Infection 36:381-3. 2008..The history revealed a travel to Malta 2 years earlier. Despite adequate treatment with liposomal amphotericin B the patient deteriorated and finally died in septic shock... - [Intoxication with lithium]K Fiegler
Departement fur Innere Medizin, Universitatsspital Basel, Basel
Praxis (Bern 1994) 98:685-90; quiz 691-2. 2009..The pharmacokinetic characteristics of lithium is described and the risk factors leading to lithium intoxication and treatment of intoxication are discussed...