Research Topics
Genomes and Genes | P BischofSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Apoptosis in the first trimester human placenta: the role in maintaining immune privilege at the maternal-foetal interface and in the trophoblast remodellingMalgorzata Jerzak
Laboratory of Reproductive Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R Weigl St, 53 114, Wroclaw, Poland
Eur J Obstet Gynecol Reprod Biol 100:138-42. 2002..In addition, in this review contribution of programmed cell death to placental cell turnover and remodelling during first trimester of pregnancy is also discussed...- The human cytotrophoblastic cell, a mononuclear chameleonPaul Bischof
Hormone Laboratory, Department of Obstetrics and Gynecology, University of Geneva, Maternity, 1211 Geneva 14, Switzerland
Int J Biochem Cell Biol 37:1-16. 2005..This review is intended to stimulate investigators not acquainted with the field of placental biology to use CTB as a model to study important biological functions in vitro, such as cell fusion, cell invasion and cell transformation... - Regulation of trophoblastic gelatinases by proto-oncogenesP Bischof
Department of Obstetrics and Gynaecology, University of Geneva, Box 232 Addenbrooke s Hospital, Maternité, Switzerland
Placenta 24:155-63. 2003..We conclude that AP-1 is necessary but may not be sufficient for transactivation of the MMP-9 gene in human CTB... - Effects of decidua-conditioned medium and insulin-like growth factor binding protein-1 on trophoblastic matrix metalloproteinases and their inhibitorsP Bischof
Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
Placenta 19:457-64. 1998..The possibility of an integrin-mediated effect of IGFBP-1 on CTB is discussed... - Control of MMP-9 expression at the maternal-fetal interfacePaul Bischof
Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
J Reprod Immunol 55:3-10. 2002..This review is not intended to be an exhaustive catalogue of potential regulators of trophoblastic MMP-9 secretion but is aimed at summarising the most important signalling pathways involved in MMP-9 regulation... - A putative role for oncogenes in trophoblast invasion?P Bischof
Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
Hum Reprod 15:51-8. 2000.... - Implantation of the human embryo: research lines and models. From the implantation research network 'Fruitful'P Bischof
University of Geneva, Geneva, Switzerland
Gynecol Obstet Invest 62:206-16. 2006..The 'Fruitful' research network was created to encourage collaborations within the consortium and to describe our different research potentials to granting agencies or private sponsors... - Comparison of the effects of GnRH-I and GnRH-II on HCG synthesis and secretion by first trimester trophoblastD Islami
Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211 Geneva, Switzerland
Mol Hum Reprod 7:3-9. 2001..This difference could be explained by different pathways of GnRH degradation, different receptor affinities, or even by different types of placental GnRH receptor... - Is cellular fibronectin a biological marker for pre-eclampsia?D Islami
Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211 Geneva, Switzerland
Eur J Obstet Gynecol Reprod Biol 97:40-5. 2001..Our data represent the first longitudinal study showing the increase of cFn values throughout normal and pre-eclamptic pregnancies... - Gelatinase and oncofetal fibronectin secretion is dependent on integrin expression on human cytotrophoblastsP Bischof
Department of Obstetrics and Gynecology, University of Geneva, Switzerland
Hum Reprod 10:734-42. 1995..When expression of the alpha 5 integrin subunit is turned on, their invasive behaviour ceases and they secrete low amounts of gelatinases and high concentrations of fibronectin... - Endocrine, paracrine and autocrine regulation of trophoblastic metalloproteinasesP Bischof
Department Obstetrics and Gynaecology, University of Geneva, Switzerland
Early Pregnancy 5:30-1. 2001.... 
Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cellsM Cohen
Department of Obstetrics and Gynaecology, Laboratory of Hormonology, University of Geneva, Geneva, Switzerland
Hum Reprod 23:2273-81. 2008..METHODS and..- Biochemistry and molecular biology of trophoblast invasionP Bischof
Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
Ann N Y Acad Sci 943:157-62. 2001..This review is not intended to be an exhaustive catalogue of potential regulators of trophoblast invasion but is aimed at summarizing the most important categories of factors affecting trophoblast-endometrium interactions... - Status of p53 in first-trimester cytotrophoblastic cellsM Cohen
Department of Obstetrics and Gynaecology, Maternity, Laboratory of Hormonology, University of Geneva, Geneva, Switzerland
Mol Hum Reprod 13:111-6. 2007..These complexes could prolong the half-life of p53 in the cytoplasm of CTBs. By contrast, in the nuclei of CTBs, p53 seems to be present as a tetramer... - Effects of human chorionic gonadotropin on trophoblast invasionD Islami
Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
Semin Reprod Med 19:49-53. 2001..This article describes some of the regulators of CTB invasion and summarizes and discusses the potential autocrine/paracrine role of hCG in trophoblast invasion... - CA125 production by the peritoneum: in-vitro and in-vivo studiesM Epiney
Department of Obstetrics and Gynaecology WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, Switzerland
Hum Reprod 15:1261-5. 2000..03) after abdominal surgery as compared with extra-abdominal surgery. This is considered as indirect evidence for in-vivo production of CA125 by the peritoneum... - Serum antimüllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroidsIsabelle Streuli
Joint Division of Reproductive Endocrinology and Infertility, University Hospitals of Geneva and Lausanne, Geneva, Switzerland
Fertil Steril 90:395-400. 2008..To investigate whether oral or vaginal administration of contraceptive hormones might affect antimüllerian hormone (AMH) levels... 
Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasionMarie Cohen
Department of Obstetrics and Gynaecology, Maternity, Laboratory of Hormonology, University of Geneva, Boulevard de la Cluse, Geneva 14, Switzerland
J Pept Sci 14:883-7. 2008..The peptide IRAP inhibitors could exert their effect on cytotrophoblastic cell invasiveness by inhibition of its enzymatic activity, and thus increasing half life of the known placental peptide substrate of IRAP, OT...- Renal hemodynamic and tubular responses to salt in women using oral contraceptivesAntoinette Pechere-Bertschi
Policlinique of Medicine and Division of Endocrinology, Reproduction and Chemical Laboratories University Hospital, Geneva, Switzerland
Kidney Int 64:1374-80. 2003..The purpose of the present study was to assess prospectively the systemic and renal hemodynamic and tubular responses to salt in women taking oral contraceptives... - Role of decidua in trophoblastic invasionMarie Cohen
Laboratoire d Hormonologie, Department of Gynaecology and Obstetrics, Geneva, Switzerland
Neuro Endocrinol Lett 31:193-7. 2010..Shallow trophoblast invasion is associated with pathologies including preeclampsia and fetal growth restriction whereas unlimited invasion is associated with hydatidiform moles and choriocarcinomas... - Early and late half-life of human chorionic gonadotropin as a predictor of persistent trophoblast after laparoscopic conservative surgery for tubal pregnancyMarie Helene Billieux
Department of Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland
Acta Obstet Gynecol Scand 82:550-5. 2003..To determine if the early or late half-lives (T0.5) of human chorionic gonadotropin (hCG) can identify patients with persistent trophoblastic activity after conservative surgery for tubal pregnancy... - Trophoblastic p53 is stabilised by a cis-trans isomerisation necessary for the formation of high molecular weight complexes involving the N-terminus of p53M Cohen
Department of Obstetrics and Gynaecology, Maternity, Laboratory of Hormonology, University of Geneva, Boulevard de la Cluse, 1211 Geneva 14, Switzerland
Biochimie 90:855-62. 2008..Moreover, decreasing HMWC or inhibiting Pin1 activity increases p53 activity towards its target genes MMP-9 and MMP-2, thus confirming the role of Pin-1 and these HMWC in the regulation of trophoblast invasiveness... - GRP78 as a marker of pre-eclampsia: an exploratory studyA Laverriere
Laboratoire d Hormonologie, Department of Obstetrics and Gynaecology, Maternity, University of Geneva, 1211 Geneva 14, Switzerland
Mol Hum Reprod 15:569-74. 2009..004) and at term (P < 0.0001). Our findings suggest that circulating C-terminal GRP78 reflect the invasive properties of cells, and could be used as a predictive marker for pre-eclampsia early in pregnancy... - Metalloproteinases and human placental invasivenessM Cohen
Department of Obstetrics and Gynaecology, Maternity, Hormone Laboratory, University of Geneva, 32 Boulevard de la Cluse, 1211 Geneva 14, Switzerland
Placenta 27:783-93. 2006..Then, the enzyme activity is regulated by inhibition or stabilization. In this review, we shall focus on the expression, the role in invasion and the regulation of MMPs in the human placenta... - Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placentaP Petignat
Department of Obstetrics and Gynecology, Hormone Laboratory, University of Geneva, Switzerland
Int J Gynecol Cancer 16:1679-84. 2006..MMP-2 and mutp53 are overexpressed in HM as compared with normal trophoblast and might participate in the invasive behavior of the HM... - Triptorelin acetate administration in early pregnancy: case reports and review of the literatureD Chardonnens
Department of Obstetrics and Gynecology, Clinic of Infertility and Gynecological Endocrinology, WHO Collaborating Center in Human Reproduction, University Hospital of Geneva, Switzerland
Eur J Obstet Gynecol Reprod Biol 80:143-9. 1998..However, long term follow-up of these babies is still lacking and the number of reported cases is too small adequately to rule out the possibility of any detrimental effect related GnRH-a administration in pregnancy... - An exploratory pilot study of acupuncture on the quality of life and reproductive hormone secretion in menopausal womenH Dong
Department of Obstetrics and Gynaecology, University Hospital of Geneva, Switzerland
J Altern Complement Med 7:651-8. 2001..A prospective study with larger sample sizes will be needed to define the role of acupuncture in the management of menopausal symptoms... - Coculture of decidua and trophoblast to study proliferation and invasionMarie Cohen
Laboratoire d Hormonologie, Department of Gynaecology and Obstetrics, Geneva, Switzerland
Methods Mol Biol 550:63-72. 2009.... - Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG)D Islami
Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211, Geneva, Switzerland
Eur J Obstet Gynecol Reprod Biol 110:169-75. 2003..Furthermore, we observe that leptin has a significant stimulatory effect on hCG pulsatility... - Can we improve the diagnosis of rupture of membranes? The value of insulin-like growth factor binding protein-1B Martinez de Tejada
Division of Obstetrics, Department of Obstetrics and Gynaecology, University Hospitals of Geneva, Geneva, Switzerland
BJOG 113:1096-9. 2006..The detection of IGFBP-1 in vaginal secretions has high sensitivity for the diagnosis of ROM... - What do we know about the origin of CA 125?P Bischof
Department of Obstetrics and Gynecology, University of Geneva, Switzerland
Eur J Obstet Gynecol Reprod Biol 49:93-8. 1993.... - Glucose-regulated protein 78: a new partner of p53 in trophoblastSerge Arnaudeau
Bioimaging Core Facility, University Medical Center, Geneva University, Geneva, Switzerland
Proteomics 9:5316-27. 2009..These results suggest that GRP78 is involved in inactivation and stabilization of p53 and in the regulation of trophoblastic invasion... - Factors regulating trophoblast invasionMarie Cohen
Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
Gynecol Obstet Invest 64:126-30. 2007..Factors regulating MMP expression are of maternal and fetal origin... - Undetectable serum anti-Müllerian hormone levels and occurrence of ongoing pregnancyTimothee Fraisse
Unité d Endocrinologie Gynécologique et Médecine de la Reproduction, Hopitaux Universitaires de Geneve, Département de Gynécologie et d Obstétrique, Geneva, Switzerland
Fertil Steril 89:723.e9-11. 2008..To discuss, on the basis of the experience of two clinical cases and extensive literature review, the significance of extremely low levels of anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance, in infertile women... - Identification of BARD1 splice-isoforms involved in human trophoblast invasionLin Li
Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Maternité, 30, Bld de la Cluse, CH 1211 Geneva, Switzerland
Int J Biochem Cell Biol 39:1659-72. 2007.... - Accuracy of single measurements of pregnancy-associated plasma protein-A, human chorionic gonadotropin and progesterone in the diagnosis of early pregnancy failurePatrick Dumps
Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
Eur J Obstet Gynecol Reprod Biol 100:174-80. 2002..The threshold values were 14.3mIU/l, 10,400IU/l and 10.1ng/ml for PAPP-A, hCG and progesterone. CONCLUSION: We confirm the decrease of PAPP-A concentrations in pregnancy failure, but hCG and progesterone remain the best clinical tools... - Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cellsMarie Cohen
Department of Obstetrics and Gynaecology, Maternity, Hormone Laboratory, University of Geneva, Boulevard de la Cluse, Switzerland
Mol Hum Reprod 12:225-32. 2006.... - Matrix metalloproteinases and their specific tissue inhibitors in menstruationJi-Cui Dong
Department of Obstetrics and Gynaecology, University Hospital of Geneva, 1211, Switzerland
Reproduction 123:621-31. 2002..This and other processes, although not fully resolved, serve to illustrate the involvement of matrix metalloproteinases and their tissue inhibitors in the process of menstruation... - First trimester screening for trisomy 21; Do the parameters used detect more pathologies than just Down syndrome?Genc Kabili
Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
Eur J Obstet Gynecol Reprod Biol 114:35-8. 2004..To assess the value of first trimester maternal serum free beta human chorionic gonadotropin (beta hCG), pregnancy-associated plasma protein (PAPP-A) concentrations and nuchal translucency (NT) as predictors of pregnancy complications... - Effect of hydrosalpinx fluid on secretion of trophoblastic matrix metalloproteinasesNicole Jastrow
Infertility and Gynaecological Endocrinology Clinic, WHO Collaborating Centre, University Hospital of Geneva, Geneva, Switzerland
Fertil Steril 77:588-94. 2002..However, the stimulatory effect of hydrosalpinx on the net gelatinolytic activity could partly explain the increased incidence of ectopic pregnancies that have been described in the presence of hydrosalpinx... - Is screening for fetal anomalies reliable in HIV-infected pregnant women? A multicentre studyPhilippe Brossard
Department of Gynaecology and Obstetrics, University of Geneva Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
AIDS 22:2013-7. 2008.... - Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT analyzerReto Stricker
DIANALAB SA, Geneva, Switzerland
Clin Chem Lab Med 44:883-7. 2006..Based on our data, we were able to establish detailed reference values for LH, FSH, estradiol, and progesterone, which should aid in the interpretation of results for these reproductive hormones in a variety of circumstances... - Clinical uses of anti-Müllerian hormone assays: pitfalls and promisesIsabelle Streuli
Joint Division of Reproductive Endocrinology and Infertility, University Hospitals of Geneva and Lausanne, Geneva, Switzerland
Fertil Steril 91:226-30. 2009.... - Effect of leptin on progesterone, human chorionic gonadotropin, and interleukin-6 secretion by human term trophoblast cells in culturePaula Cameo
Instituto de Biología y Medicina Experimental Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Biol Reprod 68:472-7. 2003..Primary cultures of term trophoblast cells expressed leptin mRNA. All these findings suggest a role for leptin in human placental endocrine function... - Localization and cellular distribution of pregnancy-associated plasma protein-a and major basic protein in human ovary and corpora lutea throughout the menstrual cycleAlice Rhoton-Vlasak
Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610, USA
Fertil Steril 79:1149-53. 2003..To assess the expression and cellular distribution of pregnancy-associated plasma protein-A (PAPP-A) and major basic protein (MBP) in human ovarian tissue during the menstrual cycle...