P Bischof

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Apoptosis in the first trimester human placenta: the role in maintaining immune privilege at the maternal-foetal interface and in the trophoblast remodelling
    Malgorzata Jerzak
    Laboratory of Reproductive Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R Weigl St, 53 114, Wroclaw, Poland
    Eur J Obstet Gynecol Reprod Biol 100:138-42. 2002
  2. ncbi The human cytotrophoblastic cell, a mononuclear chameleon
    Paul Bischof
    Hormone Laboratory, Department of Obstetrics and Gynecology, University of Geneva, Maternity, 1211 Geneva 14, Switzerland
    Int J Biochem Cell Biol 37:1-16. 2005
  3. ncbi Regulation of trophoblastic gelatinases by proto-oncogenes
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Box 232 Addenbrooke s Hospital, Maternité, Switzerland
    Placenta 24:155-63. 2003
  4. ncbi Implantation of the human embryo: research lines and models. From the implantation research network 'Fruitful'
    P Bischof
    University of Geneva, Geneva, Switzerland
    Gynecol Obstet Invest 62:206-16. 2006
  5. ncbi Control of MMP-9 expression at the maternal-fetal interface
    Paul Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
    J Reprod Immunol 55:3-10. 2002
  6. ncbi Effects of decidua-conditioned medium and insulin-like growth factor binding protein-1 on trophoblastic matrix metalloproteinases and their inhibitors
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
    Placenta 19:457-64. 1998
  7. ncbi A putative role for oncogenes in trophoblast invasion?
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
    Hum Reprod 15:51-8. 2000
  8. ncbi Comparison of the effects of GnRH-I and GnRH-II on HCG synthesis and secretion by first trimester trophoblast
    D Islami
    Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211 Geneva, Switzerland
    Mol Hum Reprod 7:3-9. 2001
  9. ncbi Is cellular fibronectin a biological marker for pre-eclampsia?
    D Islami
    Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211 Geneva, Switzerland
    Eur J Obstet Gynecol Reprod Biol 97:40-5. 2001
  10. ncbi Gelatinase and oncofetal fibronectin secretion is dependent on integrin expression on human cytotrophoblasts
    P Bischof
    Department of Obstetrics and Gynecology, University of Geneva, Switzerland
    Hum Reprod 10:734-42. 1995

Collaborators

Detail Information

Publications46

  1. ncbi Apoptosis in the first trimester human placenta: the role in maintaining immune privilege at the maternal-foetal interface and in the trophoblast remodelling
    Malgorzata Jerzak
    Laboratory of Reproductive Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R Weigl St, 53 114, Wroclaw, Poland
    Eur J Obstet Gynecol Reprod Biol 100:138-42. 2002
    ..In addition, in this review contribution of programmed cell death to placental cell turnover and remodelling during first trimester of pregnancy is also discussed...
  2. ncbi The human cytotrophoblastic cell, a mononuclear chameleon
    Paul Bischof
    Hormone Laboratory, Department of Obstetrics and Gynecology, University of Geneva, Maternity, 1211 Geneva 14, Switzerland
    Int J Biochem Cell Biol 37:1-16. 2005
    ..This review is intended to stimulate investigators not acquainted with the field of placental biology to use CTB as a model to study important biological functions in vitro, such as cell fusion, cell invasion and cell transformation...
  3. ncbi Regulation of trophoblastic gelatinases by proto-oncogenes
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Box 232 Addenbrooke s Hospital, Maternité, Switzerland
    Placenta 24:155-63. 2003
    ..We conclude that AP-1 is necessary but may not be sufficient for transactivation of the MMP-9 gene in human CTB...
  4. ncbi Implantation of the human embryo: research lines and models. From the implantation research network 'Fruitful'
    P Bischof
    University of Geneva, Geneva, Switzerland
    Gynecol Obstet Invest 62:206-16. 2006
    ..The 'Fruitful' research network was created to encourage collaborations within the consortium and to describe our different research potentials to granting agencies or private sponsors...
  5. ncbi Control of MMP-9 expression at the maternal-fetal interface
    Paul Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
    J Reprod Immunol 55:3-10. 2002
    ..This review is not intended to be an exhaustive catalogue of potential regulators of trophoblastic MMP-9 secretion but is aimed at summarising the most important signalling pathways involved in MMP-9 regulation...
  6. ncbi Effects of decidua-conditioned medium and insulin-like growth factor binding protein-1 on trophoblastic matrix metalloproteinases and their inhibitors
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
    Placenta 19:457-64. 1998
    ..The possibility of an integrin-mediated effect of IGFBP-1 on CTB is discussed...
  7. ncbi A putative role for oncogenes in trophoblast invasion?
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
    Hum Reprod 15:51-8. 2000
    ....
  8. ncbi Comparison of the effects of GnRH-I and GnRH-II on HCG synthesis and secretion by first trimester trophoblast
    D Islami
    Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211 Geneva, Switzerland
    Mol Hum Reprod 7:3-9. 2001
    ..This difference could be explained by different pathways of GnRH degradation, different receptor affinities, or even by different types of placental GnRH receptor...
  9. ncbi Is cellular fibronectin a biological marker for pre-eclampsia?
    D Islami
    Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211 Geneva, Switzerland
    Eur J Obstet Gynecol Reprod Biol 97:40-5. 2001
    ..Our data represent the first longitudinal study showing the increase of cFn values throughout normal and pre-eclamptic pregnancies...
  10. ncbi Gelatinase and oncofetal fibronectin secretion is dependent on integrin expression on human cytotrophoblasts
    P Bischof
    Department of Obstetrics and Gynecology, University of Geneva, Switzerland
    Hum Reprod 10:734-42. 1995
    ..When expression of the alpha 5 integrin subunit is turned on, their invasive behaviour ceases and they secrete low amounts of gelatinases and high concentrations of fibronectin...
  11. ncbi Endocrine, paracrine and autocrine regulation of trophoblastic metalloproteinases
    P Bischof
    Department Obstetrics and Gynaecology, University of Geneva, Switzerland
    Early Pregnancy 5:30-1. 2001
    ....
  12. pmc Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells
    M Cohen
    Department of Obstetrics and Gynaecology, Laboratory of Hormonology, University of Geneva, Geneva, Switzerland
    Hum Reprod 23:2273-81. 2008
    ....
  13. ncbi Biochemistry and molecular biology of trophoblast invasion
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
    Ann N Y Acad Sci 943:157-62. 2001
    ..This review is not intended to be an exhaustive catalogue of potential regulators of trophoblast invasion but is aimed at summarizing the most important categories of factors affecting trophoblast-endometrium interactions...
  14. ncbi Status of p53 in first-trimester cytotrophoblastic cells
    M Cohen
    Department of Obstetrics and Gynaecology, Maternity, Laboratory of Hormonology, University of Geneva, Geneva, Switzerland
    Mol Hum Reprod 13:111-6. 2007
    ..These complexes could prolong the half-life of p53 in the cytoplasm of CTBs. By contrast, in the nuclei of CTBs, p53 seems to be present as a tetramer...
  15. ncbi Effects of human chorionic gonadotropin on trophoblast invasion
    D Islami
    Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
    Semin Reprod Med 19:49-53. 2001
    ..This article describes some of the regulators of CTB invasion and summarizes and discusses the potential autocrine/paracrine role of hCG in trophoblast invasion...
  16. ncbi CA125 production by the peritoneum: in-vitro and in-vivo studies
    M Epiney
    Department of Obstetrics and Gynaecology WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, Switzerland
    Hum Reprod 15:1261-5. 2000
    ..03) after abdominal surgery as compared with extra-abdominal surgery. This is considered as indirect evidence for in-vivo production of CA125 by the peritoneum...
  17. doi Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion
    Marie Cohen
    Department of Obstetrics and Gynaecology, Maternity, Laboratory of Hormonology, University of Geneva, Boulevard de la Cluse, Geneva 14, Switzerland
    J Pept Sci 14:883-7. 2008
    ..The peptide IRAP inhibitors could exert their effect on cytotrophoblastic cell invasiveness by inhibition of its enzymatic activity, and thus increasing half life of the known placental peptide substrate of IRAP, OT...
  18. ncbi Serum antimüllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids
    Isabelle Streuli
    Joint Division of Reproductive Endocrinology and Infertility, University Hospitals of Geneva and Lausanne, Geneva, Switzerland
    Fertil Steril 90:395-400. 2008
    ..To investigate whether oral or vaginal administration of contraceptive hormones might affect antimüllerian hormone (AMH) levels...
  19. ncbi Renal hemodynamic and tubular responses to salt in women using oral contraceptives
    Antoinette Pechere-Bertschi
    Policlinique of Medicine and Division of Endocrinology, Reproduction and Chemical Laboratories University Hospital, Geneva, Switzerland
    Kidney Int 64:1374-80. 2003
    ..The purpose of the present study was to assess prospectively the systemic and renal hemodynamic and tubular responses to salt in women taking oral contraceptives...
  20. ncbi Role of decidua in trophoblastic invasion
    Marie Cohen
    Laboratoire d Hormonologie, Department of Gynaecology and Obstetrics, Geneva, Switzerland
    Neuro Endocrinol Lett 31:193-7. 2010
    ..Shallow trophoblast invasion is associated with pathologies including preeclampsia and fetal growth restriction whereas unlimited invasion is associated with hydatidiform moles and choriocarcinomas...
  21. ncbi Early and late half-life of human chorionic gonadotropin as a predictor of persistent trophoblast after laparoscopic conservative surgery for tubal pregnancy
    Marie Helene Billieux
    Department of Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland
    Acta Obstet Gynecol Scand 82:550-5. 2003
    ..To determine if the early or late half-lives (T0.5) of human chorionic gonadotropin (hCG) can identify patients with persistent trophoblastic activity after conservative surgery for tubal pregnancy...
  22. ncbi Trophoblastic and decidual response to RU486: effects on human chorionic gonadotrophin, human placental lactogen, prolactin and pregnancy-associated plasma protein-A production in vitro
    P Bischof
    Department of Obstetrics and Gynecology, University of Geneva, Switzerland
    Hum Reprod 1:3-6. 1986
    ..These results suggest that PAPP-A is a progesterone-dependent protein and that the abortifacient effect of RU486 in humans could at least partially be due to an inhibition of the production of HCG and/or PAPP-A...
  23. ncbi Trophoblastic p53 is stabilised by a cis-trans isomerisation necessary for the formation of high molecular weight complexes involving the N-terminus of p53
    M Cohen
    Department of Obstetrics and Gynaecology, Maternity, Laboratory of Hormonology, University of Geneva, Boulevard de la Cluse, 1211 Geneva 14, Switzerland
    Biochimie 90:855-62. 2008
    ..Moreover, decreasing HMWC or inhibiting Pin1 activity increases p53 activity towards its target genes MMP-9 and MMP-2, thus confirming the role of Pin-1 and these HMWC in the regulation of trophoblast invasiveness...
  24. ncbi Triptorelin acetate administration in early pregnancy: case reports and review of the literature
    D Chardonnens
    Department of Obstetrics and Gynecology, Clinic of Infertility and Gynecological Endocrinology, WHO Collaborating Center in Human Reproduction, University Hospital of Geneva, Switzerland
    Eur J Obstet Gynecol Reprod Biol 80:143-9. 1998
    ..However, long term follow-up of these babies is still lacking and the number of reported cases is too small adequately to rule out the possibility of any detrimental effect related GnRH-a administration in pregnancy...
  25. ncbi Metalloproteinases and human placental invasiveness
    M Cohen
    Department of Obstetrics and Gynaecology, Maternity, Hormone Laboratory, University of Geneva, 32 Boulevard de la Cluse, 1211 Geneva 14, Switzerland
    Placenta 27:783-93. 2006
    ..Then, the enzyme activity is regulated by inhibition or stabilization. In this review, we shall focus on the expression, the role in invasion and the regulation of MMPs in the human placenta...
  26. ncbi An exploratory pilot study of acupuncture on the quality of life and reproductive hormone secretion in menopausal women
    H Dong
    Department of Obstetrics and Gynaecology, University Hospital of Geneva, Switzerland
    J Altern Complement Med 7:651-8. 2001
    ..A prospective study with larger sample sizes will be needed to define the role of acupuncture in the management of menopausal symptoms...
  27. doi GRP78 as a marker of pre-eclampsia: an exploratory study
    A Laverriere
    Laboratoire d Hormonologie, Department of Obstetrics and Gynaecology, Maternity, University of Geneva, 1211 Geneva 14, Switzerland
    Mol Hum Reprod 15:569-74. 2009
    ..004) and at term (P < 0.0001). Our findings suggest that circulating C-terminal GRP78 reflect the invasive properties of cells, and could be used as a predictive marker for pre-eclampsia early in pregnancy...
  28. ncbi Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta
    P Petignat
    Department of Obstetrics and Gynecology, Hormone Laboratory, University of Geneva, Switzerland
    Int J Gynecol Cancer 16:1679-84. 2006
    ..MMP-2 and mutp53 are overexpressed in HM as compared with normal trophoblast and might participate in the invasive behavior of the HM...
  29. doi Coculture of decidua and trophoblast to study proliferation and invasion
    Marie Cohen
    Laboratoire d Hormonologie, Department of Gynaecology and Obstetrics, Geneva, Switzerland
    Methods Mol Biol 550:63-72. 2009
    ....
  30. ncbi Can we improve the diagnosis of rupture of membranes? The value of insulin-like growth factor binding protein-1
    B Martinez de Tejada
    Division of Obstetrics, Department of Obstetrics and Gynaecology, University Hospitals of Geneva, Geneva, Switzerland
    BJOG 113:1096-9. 2006
    ..The detection of IGFBP-1 in vaginal secretions has high sensitivity for the diagnosis of ROM...
  31. ncbi Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG)
    D Islami
    Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211, Geneva, Switzerland
    Eur J Obstet Gynecol Reprod Biol 110:169-75. 2003
    ..Furthermore, we observe that leptin has a significant stimulatory effect on hCG pulsatility...
  32. ncbi What do we know about the origin of CA 125?
    P Bischof
    Department of Obstetrics and Gynecology, University of Geneva, Switzerland
    Eur J Obstet Gynecol Reprod Biol 49:93-8. 1993
    ....
  33. ncbi Factors regulating trophoblast invasion
    Marie Cohen
    Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
    Gynecol Obstet Invest 64:126-30. 2007
    ..Factors regulating MMP expression are of maternal and fetal origin...
  34. doi Glucose-regulated protein 78: a new partner of p53 in trophoblast
    Serge Arnaudeau
    Bioimaging Core Facility, University Medical Center, Geneva University, Geneva, Switzerland
    Proteomics 9:5316-27. 2009
    ..These results suggest that GRP78 is involved in inactivation and stabilization of p53 and in the regulation of trophoblastic invasion...
  35. ncbi Undetectable serum anti-Müllerian hormone levels and occurrence of ongoing pregnancy
    Timothee Fraisse
    Unité d Endocrinologie Gynécologique et Médecine de la Reproduction, Hopitaux Universitaires de Geneve, Département de Gynécologie et d Obstétrique, Geneva, Switzerland
    Fertil Steril 89:723.e9-11. 2008
    ..To discuss, on the basis of the experience of two clinical cases and extensive literature review, the significance of extremely low levels of anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance, in infertile women...
  36. ncbi Identification of BARD1 splice-isoforms involved in human trophoblast invasion
    Lin Li
    Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Maternité, 30, Bld de la Cluse, CH 1211 Geneva, Switzerland
    Int J Biochem Cell Biol 39:1659-72. 2007
    ....
  37. ncbi Accuracy of single measurements of pregnancy-associated plasma protein-A, human chorionic gonadotropin and progesterone in the diagnosis of early pregnancy failure
    Patrick Dumps
    Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
    Eur J Obstet Gynecol Reprod Biol 100:174-80. 2002
    ..Previously, PAPP-A was measured with polyclonal antibodies which were later shown to recognise also the pro-form of major basic protein (pro-MBP)...
  38. ncbi Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cells
    Marie Cohen
    Department of Obstetrics and Gynaecology, Maternity, Hormone Laboratory, University of Geneva, Boulevard de la Cluse, Switzerland
    Mol Hum Reprod 12:225-32. 2006
    ....
  39. ncbi Matrix metalloproteinases and their specific tissue inhibitors in menstruation
    Ji Cui Dong
    Department of Obstetrics and Gynaecology, University Hospital of Geneva, 1211, Switzerland
    Reproduction 123:621-31. 2002
    ..This and other processes, although not fully resolved, serve to illustrate the involvement of matrix metalloproteinases and their tissue inhibitors in the process of menstruation...
  40. ncbi Effect of hydrosalpinx fluid on secretion of trophoblastic matrix metalloproteinases
    Nicole Jastrow
    Infertility and Gynaecological Endocrinology Clinic, WHO Collaborating Centre, University Hospital of Geneva, Geneva, Switzerland
    Fertil Steril 77:588-94. 2002
    ..To determine if hydrosalpinx fluid affects trophoblastic metalloproteinases (MMPs) secretion...
  41. ncbi First trimester screening for trisomy 21; Do the parameters used detect more pathologies than just Down syndrome?
    Genc Kabili
    Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
    Eur J Obstet Gynecol Reprod Biol 114:35-8. 2004
    ..To assess the value of first trimester maternal serum free beta human chorionic gonadotropin (beta hCG), pregnancy-associated plasma protein (PAPP-A) concentrations and nuchal translucency (NT) as predictors of pregnancy complications...
  42. ncbi Is screening for fetal anomalies reliable in HIV-infected pregnant women? A multicentre study
    Philippe Brossard
    Department of Gynaecology and Obstetrics, University of Geneva Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
    AIDS 22:2013-7. 2008
    ....
  43. ncbi Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT analyzer
    Reto Stricker
    DIANALAB SA, Geneva, Switzerland
    Clin Chem Lab Med 44:883-7. 2006
    ..Based on our data, we were able to establish detailed reference values for LH, FSH, estradiol, and progesterone, which should aid in the interpretation of results for these reproductive hormones in a variety of circumstances...
  44. doi Clinical uses of anti-Müllerian hormone assays: pitfalls and promises
    Isabelle Streuli
    Joint Division of Reproductive Endocrinology and Infertility, University Hospitals of Geneva and Lausanne, Geneva, Switzerland
    Fertil Steril 91:226-30. 2009
    ....
  45. ncbi Effect of leptin on progesterone, human chorionic gonadotropin, and interleukin-6 secretion by human term trophoblast cells in culture
    Paula Cameo
    Instituto de Biología y Medicina Experimental Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biol Reprod 68:472-7. 2003
    ..Primary cultures of term trophoblast cells expressed leptin mRNA. All these findings suggest a role for leptin in human placental endocrine function...
  46. ncbi Localization and cellular distribution of pregnancy-associated plasma protein-a and major basic protein in human ovary and corpora lutea throughout the menstrual cycle
    Alice Rhoton-Vlasak
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610, USA
    Fertil Steril 79:1149-53. 2003
    ..To assess the expression and cellular distribution of pregnancy-associated plasma protein-A (PAPP-A) and major basic protein (MBP) in human ovarian tissue during the menstrual cycle...