T Binzoni

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi Non-standard O(2) consumption-temperature curves during rest and isometric exercise in human skeletal muscle
    Tiziano Binzoni
    Department of Radiology, University of Geneva, Geneva, Switzerland
    Comp Biochem Physiol A Mol Integr Physiol 132:27-32. 2002
  2. ncbi Non-invasive laser Doppler perfusion measurements of large tissue volumes and human skeletal muscle blood RMS velocity
    T Binzoni
    Department of Radiology, Faculty of Medicine, University of Geneva, Switzerland
    Phys Med Biol 48:2527-49. 2003
  3. ncbi The use of the Henyey-Greenstein phase function in Monte Carlo simulations in biomedical optics
    T Binzoni
    Département des Neurosciences Fondamentales, Centre Medical Universitaire, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Phys Med Biol 51:N313-22. 2006
  4. ncbi Mapping human skeletal muscle perforator vessels using a quantum well infrared photodetector (QWIP) might explain the variability of NIRS and LDF measurements
    T Binzoni
    Department of Radiology, Faculty of Medicine, University of Geneva, Switzerland
    Phys Med Biol 49:N165-73. 2004
  5. ncbi Metabolic studies of human skeletal muscle by near infrared spectroscopy: possible applications in space research
    T Binzoni
    University of Geneva, Department of Radiology, Switzerland
    Int J Sports Med 18:S312-4. 1997
  6. ncbi Energy metabolism and interstitial fluid displacement in human gastrocnemius during short ischemic cycles
    T Binzoni
    Departments of Physiology and Radiology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Appl Physiol (1985) 85:1244-51. 1998
  7. ncbi Muscle O(2) consumption by NIRS: a theoretical model
    T Binzoni
    Departments of Physiology and Radiology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Appl Physiol (1985) 87:683-8. 1999
  8. ncbi Human calf microvascular compliance measured by near-infrared spectroscopy
    T Binzoni
    Departments of Physiology and Radiology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Appl Physiol (1985) 88:369-72. 2000
  9. ncbi Human skeletal muscle energy metabolism: when a physiological model promotes the search for new technologies
    Tiziano Binzoni
    Dept of Radiology, Departement de Physiologie, Centre Medical Universitaire, Rue Michel Servet 1, 1211 Geneve 4, Geneva, Switzerland
    Eur J Appl Physiol 90:260-9. 2003
  10. ncbi Human tibia bone marrow: defining a model for the study of haemodynamics as a function of age by near infrared spectroscopy
    Tiziano Binzoni
    Department of Radiology, Geneva University Hospital, Switzerland
    J Physiol Anthropol Appl Human Sci 22:211-8. 2003

Detail Information

Publications48

  1. ncbi Non-standard O(2) consumption-temperature curves during rest and isometric exercise in human skeletal muscle
    Tiziano Binzoni
    Department of Radiology, University of Geneva, Geneva, Switzerland
    Comp Biochem Physiol A Mol Integr Physiol 132:27-32. 2002
    ..The O(2) value at 28.6 degrees C was significantly higher (P<0.05) than that at 26.8 and 31.9 degrees C. The 'sudden' O(2) change at 28.6 degrees C is compatible with the phenomenon observed at the mitochondrial level...
  2. ncbi Non-invasive laser Doppler perfusion measurements of large tissue volumes and human skeletal muscle blood RMS velocity
    T Binzoni
    Department of Radiology, Faculty of Medicine, University of Geneva, Switzerland
    Phys Med Biol 48:2527-49. 2003
    ..At very large optode spacings or very high moving particle densities, the theory developed here would need to be amended to take into account second-order effects...
  3. ncbi The use of the Henyey-Greenstein phase function in Monte Carlo simulations in biomedical optics
    T Binzoni
    Département des Neurosciences Fondamentales, Centre Medical Universitaire, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Phys Med Biol 51:N313-22. 2006
    ..g. g = 0.98) the two methods give completely different results...
  4. ncbi Mapping human skeletal muscle perforator vessels using a quantum well infrared photodetector (QWIP) might explain the variability of NIRS and LDF measurements
    T Binzoni
    Department of Radiology, Faculty of Medicine, University of Geneva, Switzerland
    Phys Med Biol 49:N165-73. 2004
    ....
  5. ncbi Metabolic studies of human skeletal muscle by near infrared spectroscopy: possible applications in space research
    T Binzoni
    University of Geneva, Department of Radiology, Switzerland
    Int J Sports Med 18:S312-4. 1997
  6. ncbi Energy metabolism and interstitial fluid displacement in human gastrocnemius during short ischemic cycles
    T Binzoni
    Departments of Physiology and Radiology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Appl Physiol (1985) 85:1244-51. 1998
    ..The techniques developed in the present study may be useful in identifying protocols suitable for skeletal muscle preconditioning and to explain the functional basis of this procedure...
  7. ncbi Muscle O(2) consumption by NIRS: a theoretical model
    T Binzoni
    Departments of Physiology and Radiology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Appl Physiol (1985) 87:683-8. 1999
    ..The use of a series of experimental protocols obtained at different levels of mechanical power, rather than repetitions of the same load, appears to be the most suitable procedure...
  8. ncbi Human calf microvascular compliance measured by near-infrared spectroscopy
    T Binzoni
    Departments of Physiology and Radiology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Appl Physiol (1985) 88:369-72. 2000
    ..However, by following the changes in oxy- and deoxyhemoglobin in the P range -16 to 100 mmHg, it appears to be possible to assess the characteristics of the vasomotor response of the arteriolar system...
  9. ncbi Human skeletal muscle energy metabolism: when a physiological model promotes the search for new technologies
    Tiziano Binzoni
    Dept of Radiology, Departement de Physiologie, Centre Medical Universitaire, Rue Michel Servet 1, 1211 Geneve 4, Geneva, Switzerland
    Eur J Appl Physiol 90:260-9. 2003
    ..The present paper wants to present the modern history of the bioenergetic model and is dedicated to Paolo Cerretelli on the occasion of his seventieth birthday...
  10. ncbi Human tibia bone marrow: defining a model for the study of haemodynamics as a function of age by near infrared spectroscopy
    Tiziano Binzoni
    Department of Radiology, Geneva University Hospital, Switzerland
    J Physiol Anthropol Appl Human Sci 22:211-8. 2003
    ..The human tibia bone marrow model presented here and the related measurement technique should enable access to new areas of physiological research...
  11. ncbi Age dependence of human gastrocnemius Mg2+: fitting 31P-NMR spectra using quantum mechanics-based prior knowledge
    T Binzoni
    Departments of Physiology and Radiology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Physiol Anthropol Appl Human Sci 20:275-83. 2001
    ..The hypothesis can be put forward that during aging insufficient intake and/or increased depletion of Mg2+ (e.g., intestinal hypoabsorption or urinary leakage) may affect the musculoskeletal system...
  12. ncbi Human gastrocnemius medialis pennation angle as a function of age: from newborn to the elderly
    T Binzoni
    Department of Radiology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Physiol Anthropol Appl Human Sci 20:293-8. 2001
    ..The present findings indicate that F theta is not a constant parameter but evolves, as is the case for bone length and height, as a function of age...
  13. ncbi Translational and Brownian motion in laser-Doppler flowmetry of large tissue volumes
    T Binzoni
    Department of Physiology, Faculty of Medicine, University of Geneva, Switzerland
    Phys Med Biol 49:5445-58. 2004
    ..A correct way to subtract the biological zero from the LDF data is also proposed. The findings should help in the design of improved LDF instruments and in the interpretation of experimental data...
  14. ncbi Anisotropic photon migration in human skeletal muscle
    T Binzoni
    Département de Neurosciences Fondamentales, University of Geneva, Switzerland
    Phys Med Biol 51:N79-90. 2006
    ..In other words, the observed regional differences might not only be physiological differences but also optical artefacts...
  15. doi Full-field laser-Doppler imaging and its physiological significance for tissue blood perfusion
    T Binzoni
    Département des Neurosciences Fondamentales, University of Geneva, Switzerland
    Phys Med Biol 53:6673-94. 2008
    ..Further improvements on detectors' sampling rate will overcome this limitation...
  16. ncbi Blood volume and haemoglobin oxygen content changes in human bone marrow during orthostatic stress
    Tiziano Binzoni
    Département de Neurosciences Fondamentales, University of Geneva, Switzerland
    J Physiol Anthropol 25:1-6. 2006
    ..No other existing technique currently allows one to obtain the proposed results and this approach might open up a new field of study related to human BM physiology...
  17. ncbi Absorption and scattering coefficient dependence of laser-Doppler flowmetry models for large tissue volumes
    T Binzoni
    Département de Neurosciences Fondamentales, Faculty of Medicine, University of Geneva, Switzerland
    Phys Med Biol 51:311-33. 2006
    ..The simplified model does not need knowledge of the tissue optical parameters and thus should allow the development of very simple and cost-effective LDF hardware...
  18. ncbi Temperature dependence of human gastrocnemius pH and high-energy phosphate concentration by noninvasive techniques
    T Binzoni
    Depts of Radiology and Physiology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Magn Reson Med 43:611-4. 2000
    ..016+/-0.001 pH degrees C(-1)). These findings should be of value when dealing with muscle physiology in extreme environments or clinical applications of hypothermia...
  19. doi Detection limits of multi-spectral optical imaging under the skin surface
    T Binzoni
    Département des Neurosciences Fondamentales, University of Geneva, Switzerland
    Phys Med Biol 53:617-36. 2008
    ..An increase in the concentration of a given molecule may produce different contrast, independently of the depth, depending on the characteristics of the skin layer where this change occurs...
  20. ncbi Light transport in tissue by 3D Monte Carlo: influence of boundary voxelization
    T Binzoni
    Centre Medical Universitaire, 1, r Michel Servet, Département des Neurosciences Fondamentales, University of Geneva, 1211 Geneve 4, Switzerland
    Comput Methods Programs Biomed 89:14-23. 2008
    ....
  21. ncbi Local temperature changes and human skeletal muscle metabolism
    T Binzoni
    Departments of Radiology and Physiology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Physiol Anthropol Appl Human Sci 20:159-74. 2001
    ..A short comment on skeletal muscle temperature measurement techniques, on humans, is also included...
  22. ncbi Determinants of peak muscle power: effects of age and physical conditioning
    G Ferretti
    Departement de Physiologie, Centre Medical Universitaire, Geneva, Switzerland
    Eur J Appl Physiol Occup Physiol 68:111-5. 1994
    ..An important role may be played by hormonal, particularly at puberty, and neural factors...
  23. ncbi Influence of repeated ischaemia/reperfusion cycles (ischaemic preconditioning) on human calf energy metabolism by simultaneous near infrared spectroscopy, 31P-NMR and 23Na-NMR measurements
    T Binzoni
    Department of Physiology, University of Geneva, Switzerland
    Adv Exp Med Biol 428:533-8. 1997
  24. ncbi Maximal lactic capacity at altitude: effect of bicarbonate loading
    B Kayser
    Departement de Physiologie, Centre Medical Universitaire, Geneva, Switzerland
    J Appl Physiol 75:1070-4. 1993
    ..001). [La]max increased from 12.86 +/- 1.45 mM in C to 16.63 +/- 1.76 mM in B (P < 0.01) at sea level and from 6.85 +/- 1.40 mM in C to 7.95 +/- 1.74 mM in B (NS) at altitude.(ABSTRACT TRUNCATED AT 250 WORDS)..
  25. ncbi The contribution of NMR, NIRS and their combination to the functional assessment of human muscle
    P Cerretelli
    Department of Physiology, University of Geneva, Switzerland
    Int J Sports Med 18:S270-9. 1997
    ..The concomitant use of the above techniques is expected to provide a synergic functional picture of the human muscle that is complementary to the structural and ultrastructural microscopic approach...
  26. ncbi Human intramuscular temperature and heat flow transients at rest
    T Binzoni
    Department of Radiology, Hopital Cantonal Universitaire de Geneve, Switzerland
    J Appl Physiol (1985) 79:1736-43. 1995
    ..In conclusion, MRI is indeed a powerful technique, useful to study the determinants of muscle temperature and heat flow changes in space and time...
  27. pmc In vivo human gastrocnemius architecture with changing joint angle at rest and during graded isometric contraction
    M V Narici
    Reparto di Fisiologia Istituto di Tecnologie Biomediche Avanzate, Consiglio Nazionale dell Ricerche, Milano, Italy
    J Physiol 496:287-97. 1996
    ..The extrapolation of muscle architectural data obtained from cadavers to in vivo conditions should be made only for matching muscle lengths...
  28. ncbi Saturation of the lactate clearance mechanisms different from the "lactate shuttle" determines the anaerobic threshold: prediction from the bioenergetic model
    Tiziano Binzoni
    Department of Radiology, Geneva University Hospital, Geneva, Switzerland
    J Physiol Anthropol Appl Human Sci 24:175-82. 2005
    ..bioenergetic model was created during a long historical period, when it was believed that the La production was not present at all for very low exercise levels but, actually, the bioenergetic model predicts exactly the opposite result!..
  29. doi The photo-electric current in laser-Doppler flowmetry by Monte Carlo simulations
    Tiziano Binzoni
    Département des Neurosciences Fondamentales, University of Geneva, Geneva, Switzerland
    Phys Med Biol 54:N303-18. 2009
    ..The proposed method and examples could stimulate new ideas and help the scientific community develop, test and validate new approaches in LDF...
  30. doi A fast time-domain algorithm for the assessment of tissue blood flow in laser-Doppler flowmetry
    Tiziano Binzoni
    Département des Neurosciences Fondamentales, University of Geneva, and Département de l Imagerie et des Sciences de l Information Médicale, University Hospital, Geneva, Switzerland
    Phys Med Biol 55:N383-94. 2010
    ..Moreover, we demonstrate the appropriateness of estimating the zeroth-, first- and second-order moments using Monte Carlo simulations. Finally, we briefly discuss the feasibility of implementing the proposed algorithm in hardware...
  31. doi A new method to measure local oxygen consumption in human skeletal muscle during dynamic exercise using near-infrared spectroscopy
    Tiziano Binzoni
    Département des Neurosciences Fondamentales, University of Geneva, Geneva, Switzerland
    Physiol Meas 31:1257-69. 2010
    ..72 micromol 100 g(-1) min(-1) with the increase in power. The measurements are theoretically exempt from usual NIRS confounders such as myoglobin and adipose tissue and could provide a useful tool for studying human physiology...
  32. ncbi Kinetics of oxygen consumption during maximal exercise at different muscle temperatures
    G Ferretti
    Departement de Physiologie, Centre Medical Universitaire, Geneve, Suisse
    Respir Physiol 102:261-8. 1995
    ....
  33. ncbi Energetics of resting anaerobic frog gastrocnemius at different temperatures by 31P-NMR
    T Binzoni
    Department of Physiology, C M U, Geneva, Switzerland
    Respir Physiol 82:137-47. 1990
    ....
  34. ncbi Autonomic nervous control of heart rate at altitude (5050 m)
    C C Farinelli
    Department of Physiology, University of Geneva, Switzerland
    Eur J Appl Physiol Occup Physiol 69:502-7. 1994
    ..These results corroborate the reported reduced sensitivity of the heart to adrenergic drive in chronic hypoxia, which may, at least in part, explain the decreased maximal heart rate in altitude-acclimatized human subjects...
  35. ncbi Fatigue and exhaustion in chronic hypobaric hypoxia: influence of exercising muscle mass
    B Kayser
    Departement de Physiologie, Centre Medical Universitaire, Geneva, Switzerland
    J Appl Physiol 76:634-40. 1994
    ..By contrast, at HA, for similar t(ex), leg exercise had to be performed at the same relative (i.e., prevailing maximal O2 uptake) but lower absolute load (approximately equal to 80% of SL).(ABSTRACT TRUNCATED AT 250 WORDS)..
  36. ncbi Standardisation of 31phosphorus-nuclear magnetic resonance spectroscopy determinations of high energy phosphates in humans
    L Gariod
    Departement de Physiologie, Centre Medical Universitaire, Geneva, Switzerland
    Eur J Appl Physiol Occup Physiol 68:107-10. 1994
    ..The [ATP] and [PC] were not statistically different in the groups investigated...
  37. ncbi Phosphocreatine hydrolysis by 31P-NMR at the onset of constant-load exercise in humans
    T Binzoni
    Department of Physiology, Centre Medical Universitaire, Geneva, Switzerland
    J Appl Physiol 73:1644-9. 1992
    ....
  38. ncbi Dynamic phosphorus-31 spectroscopy after fructose load in experimental biliary liver cirrhosis
    J P Vallee
    Department of Radiology, University of Geneva, Switzerland
    Acad Radiol 4:26-34. 1997
    ..The authors investigated the usefulness of dynamic phosphorus-31 magnetic resonance (MR) spectroscopy in the assessment of hepatic function by studying the effect of a fructose load on a rat model of liver cirrhosis...
  39. ncbi Human tibia bone marrow blood perfusion by non-invasive near infrared spectroscopy: a new tool for studies on microgravity
    T Binzoni
    Department of Radiology, Geneva University Hospital, Switzerland
    J Gravit Physiol 9:P183-4. 2002
    ..The results define a "normal" baseline and demonstrate the sensitivity of the method to PI changes. The present technique should allow one to investigate physio-pathological effects induced by microgravity on tibia BM blood perfusion...
  40. ncbi Step vs. progressive exercise: the kinetics of phosphocreatine hydrolysis in human muscle
    T Binzoni
    Department of Physiology, University of Geneva, Switzerland
    Acta Physiol Scand 159:209-15. 1997
    ....
  41. ncbi Bioenergetic approach to transfer function of human skeletal muscle
    T Binzoni
    Department of Physiology, University of Geneva, Switzerland
    J Appl Physiol 77:1784-9. 1994
    ..g., skeletal, heart, trained vs. untrained), 5) it allows one to interpret correctly the significance of the oxygen consumption kinetics in the rest-to-work transient at the lung level, and 6) it is conceived for in vivo applications...
  42. ncbi Muscle energetics by 31P-NMRS: recent developments and possible applications in space research
    P Cerretelli
    University of Geneva, Department of Physiology, Switzerland
    Int J Sports Med 18:S306-7. 1997
  43. ncbi Alpha-motoneuron excitability at high altitude
    B Kayser
    Departement de Physiologie, Centre Medical Universitaire, Geneva, Switzerland
    Eur J Appl Physiol Occup Physiol 66:1-4. 1993
    ..The thresholds of both responses and the gain of the M-response were unaltered. The gain of the H-response was significantly higher at altitude when compared to sea level.(ABSTRACT TRUNCATED AT 250 WORDS)..
  44. ncbi The energetic significance of lactate accumulation in blood at altitude
    P Cerretelli
    Department of Physiology, University of Geneva Medical School, Switzerland
    Int J Sports Med 11:S27-30. 1990
    ..Everest base camp (5350 m) were 1.26 and 1.42 liters for acclimatized Caucasians and for Sherpas, respectively. The amount of the measured maximum O2 debt at altitude was somewhat increased by pure O2 breathing (1.53 vs 1.26 l)...
  45. ncbi Muscle 31P-NMR in humans: estimate of bias and qualitative assessment of ATPase activity
    T Binzoni
    Department of Physiology, Centre Medical Universitaire, Geneva, Switzerland
    J Appl Physiol 71:1700-4. 1991
    ..g., during transition from rest to work and vice versa) may represent an index of transient changes of kappa 2...
  46. ncbi A new combined deep-body-temperature/NIRs probe for noninvasive metabolic measurements on human skeletal muscle
    T Binzoni
    Department of Physiology, University of Geneva, Switzerland
    Adv Exp Med Biol 471:623-9. 1999
  47. ncbi A new method of thermoablation with hot water vapour for localized tumours
    E Hiltbrand
    Department of Radiology, School of Medicine, University of Geneva, Micheli du Crest St, 1211 Geneva 4, Switzerland
    Anticancer Res 24:2757-63. 2004
    ..This approach allows tumours, with volume and anatomical positions not accessible to other techniques (cryoablation, radiofrequency ablation, laser ablation) to be treated...
  48. ncbi Venous-arteriolar reflex in human gastrocnemius studied by NIRS
    Tiziano Binzoni
    Depts of Physiology and Radiology, University of Geneva, Switzerland
    Adv Exp Med Biol 530:467-73. 2003
    ....