Alessandro Bianchi

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Early replication of short telomeres in budding yeast
    Alessandro Bianchi
    Department of Molecular Biology and NCCR Frontiers in Genetics Program, University of Geneva, Geneva, Switzerland
    Cell 128:1051-62. 2007
  2. pmc Increased association of telomerase with short telomeres in yeast
    Alessandro Bianchi
    Department of Molecular Biology and National Centre of Competence in Research NCCR Frontiers in Genetics Program, University of Geneva, Sciences III, CH 1211 Geneva 4, Switzerland
    Genes Dev 21:1726-30. 2007
  3. pmc Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition
    Andrea Puglisi
    Department of Molecular Biology and NCCR Program Frontiers in Genetics, University of Geneva, Geneva, Switzerland
    EMBO J 27:2328-39. 2008
  4. doi request reprint How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex
    Alessandro Bianchi
    Department of Molecular Biology and NCCR Frontiers in Genetics Program, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Geneva, Switzerland
    Mol Cell 31:153-65. 2008
  5. pmc Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase
    David Shore
    Department of Molecular Biology and NCCR Program Frontiers in Genetics, University of Geneva, Sciences III, Geneva, Switzerland
    EMBO J 28:2309-22. 2009
  6. doi request reprint Molecular biology. Refined view of the ends
    Alessandro Bianchi
    Department of Molecular Biology and the National Centres of Competence in Research Frontiers in Genetics Program, University of Geneva, CH 1211 Geneva 4, Geneva, Switzerland
    Science 320:1301-2. 2008
  7. ncbi request reprint The KEOPS complex: a rosetta stone for telomere regulation?
    Alessandro Bianchi
    Department of Molecular Biology and NCCR Program Frontiers in Genetics, University of Geneva, Sciences III, 30, Quai Ernest Ansermet, CH 1211, Geneva 4, Switzerland
    Cell 124:1125-8. 2006
  8. ncbi request reprint Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1
    Alessandro Bianchi
    Department of Molecular Biology and NCCR Frontiers in Genetics Program, University of Geneva, Sciences III, 30, Quai Ernest Ansermet, CH 1211, Geneva 4, Switzerland
    Mol Cell 16:139-46. 2004
  9. pmc DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation
    Simona Negrini
    Department of Molecular Biology, National Center for Competence in Research NCCR Program Frontiers in Genetics, University of Geneva, Geneva 4, 1211 Switzerland
    Genes Dev 21:292-302. 2007
  10. ncbi request reprint Distinct DNA elements contribute to Rap1p affinity for its binding sites
    Valerio Del Vescovo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita La Sapienza di Roma, Rome, Italy
    J Mol Biol 338:877-93. 2004

Collaborators

  • D Shore
  • Veronica De Sanctis
  • Andrea Puglisi
  • Simona Negrini
  • Valerio Del Vescovo
  • Ernesto Di Mauro
  • Rodolfo Negri
  • Pascal Damay
  • Laure Lemmens
  • Virginie Ribaud
  • Luciano Burderi
  • Sabrina La Terra

Detail Information

Publications11

  1. ncbi request reprint Early replication of short telomeres in budding yeast
    Alessandro Bianchi
    Department of Molecular Biology and NCCR Frontiers in Genetics Program, University of Geneva, Geneva, Switzerland
    Cell 128:1051-62. 2007
    ..These data reveal an epigenetic effect of telomere length on the activity of nearby replication origins and an unanticipated link between telomere replication timing and telomerase action...
  2. pmc Increased association of telomerase with short telomeres in yeast
    Alessandro Bianchi
    Department of Molecular Biology and National Centre of Competence in Research NCCR Frontiers in Genetics Program, University of Geneva, Sciences III, CH 1211 Geneva 4, Switzerland
    Genes Dev 21:1726-30. 2007
    ..In addition, we provide support for a molecular mechanism by which this key step of telomerase recruitment is regulated by TG tract length...
  3. pmc Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition
    Andrea Puglisi
    Department of Molecular Biology and NCCR Program Frontiers in Genetics, University of Geneva, Geneva, Switzerland
    EMBO J 27:2328-39. 2008
    ..These data provide new insights into the coordination of telomere capping and telomerase regulation...
  4. doi request reprint How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex
    Alessandro Bianchi
    Department of Molecular Biology and NCCR Frontiers in Genetics Program, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Geneva, Switzerland
    Mol Cell 31:153-65. 2008
    ..We discuss recent advances on the mechanism of telomerase regulation at chromosome ends in both yeast and mammalian systems...
  5. pmc Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase
    David Shore
    Department of Molecular Biology and NCCR Program Frontiers in Genetics, University of Geneva, Sciences III, Geneva, Switzerland
    EMBO J 28:2309-22. 2009
    ..The emerging picture is that of a complex interplay between the conventional DNA replication machinery, DNA damage response factors, and a specialized set of proteins that help to recruit and regulate the telomerase enzyme...
  6. doi request reprint Molecular biology. Refined view of the ends
    Alessandro Bianchi
    Department of Molecular Biology and the National Centres of Competence in Research Frontiers in Genetics Program, University of Geneva, CH 1211 Geneva 4, Geneva, Switzerland
    Science 320:1301-2. 2008
  7. ncbi request reprint The KEOPS complex: a rosetta stone for telomere regulation?
    Alessandro Bianchi
    Department of Molecular Biology and NCCR Program Frontiers in Genetics, University of Geneva, Sciences III, 30, Quai Ernest Ansermet, CH 1211, Geneva 4, Switzerland
    Cell 124:1125-8. 2006
    ..In this issue of Cell, the surprising identification of a new complex, called KEOPS, which promotes both telomere uncapping and elongation is presented...
  8. ncbi request reprint Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1
    Alessandro Bianchi
    Department of Molecular Biology and NCCR Frontiers in Genetics Program, University of Geneva, Sciences III, 30, Quai Ernest Ansermet, CH 1211, Geneva 4, Switzerland
    Mol Cell 16:139-46. 2004
    ..These data demonstrate a critical role for Est1 in recruiting telomerase to its site of action, in cooperation with the telomere binding protein Cdc13...
  9. pmc DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation
    Simona Negrini
    Department of Molecular Biology, National Center for Competence in Research NCCR Program Frontiers in Genetics, University of Geneva, Geneva 4, 1211 Switzerland
    Genes Dev 21:292-302. 2007
    ..Rap1 binding is required for end concealment at long tracts, but Rif proteins, yKu, and Cdc13 are not. These results shed light on the nature of the telomere cap and mechanisms that regulate telomerase access at chromosome ends...
  10. ncbi request reprint Distinct DNA elements contribute to Rap1p affinity for its binding sites
    Valerio Del Vescovo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita La Sapienza di Roma, Rome, Italy
    J Mol Biol 338:877-93. 2004
    ..These findings may explain the observed in vivo binding properties of Rap1p at many promoters that lack canonical binding sites...
  11. ncbi request reprint In vivo topography of Rap1p-DNA complex at Saccharomyces cerevisiae TEF2 UAS(RPG) during transcriptional regulation
    Veronica De Sanctis
    Fondazione Istituto Pasteur Fondazione Cenci Bolognetti, c o Dipartimento di Genetica e Biologia Molecolare, Universita di Roma, La Sapienza, Rome, Italy
    J Mol Biol 318:333-49. 2002
    ..The implications of these results for the mechanism of Rap1p action are discussed...