J Bernier

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi A multidisciplinary approach to squamous cell carcinomas of the head and neck: an update
    Jacques Bernier
    Department of Radiation Oncology, Genolier Swiss Medical Network, Genolier, Switzerland
    Curr Opin Oncol 20:249-55. 2008
  2. ncbi Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    N Engl J Med 350:1945-52. 2004
  3. ncbi Radiation oncology: a century of achievements
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, CH 6504 Bellinzona, Switzerland
    Nat Rev Cancer 4:737-47. 2004
  4. ncbi Chemoradiation after surgery for high-risk head and neck cancer patients: how strong is the evidence?
    Jacques Bernier
    Department of Radiation Oncology, Oncology Institute of Southern Switzerland, San Giovanni Hospital, CH 6504 Bellinzona, Switzerland
    Oncologist 10:215-24. 2005
  5. ncbi Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)
    Jacques Bernier
    Department of Radiation Oncology, Oncology Institute of Southern Switzerland, CH 6504 Bellinzona, Switzerland
    Head Neck 27:843-50. 2005
  6. ncbi Partial irradiation of the breast: Old challenges, new solutions
    J Bernier
    Department of Radio Oncology and Breast Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Breast 15:466-75. 2006
  7. ncbi Alteration of radiotherapy fractionation and concurrent chemotherapy: a new frontier in head and neck oncology?
    Jacques Bernier
    Department of Radiation Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Nat Clin Pract Oncol 2:305-14. 2005
  8. ncbi Radiotherapy for head and neck cancer: latest developments and future perspectives
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Curr Opin Oncol 18:240-6. 2006
  9. ncbi Adjuvant therapy in patients with resected poor-risk head and neck cancer
    Jacques Bernier
    Clinique de Genolier, Genolier, Switzerland
    J Clin Oncol 24:2629-35. 2006
  10. ncbi Cetuximab combined with radiotherapy: an alternative to chemoradiotherapy for patients with locally advanced squamous cell carcinomas of the head and neck?
    J Bernier
    Radio Oncologie, Clinique de Genolier, Genolier 1272, Switzerland
    Eur J Cancer 43:35-45. 2007

Detail Information

Publications59

  1. ncbi A multidisciplinary approach to squamous cell carcinomas of the head and neck: an update
    Jacques Bernier
    Department of Radiation Oncology, Genolier Swiss Medical Network, Genolier, Switzerland
    Curr Opin Oncol 20:249-55. 2008
    ..Other approaches are being investigated to improve the clinical benefit at an acceptable level of toxicity...
  2. ncbi Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    N Engl J Med 350:1945-52. 2004
    ..We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer...
  3. ncbi Radiation oncology: a century of achievements
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, CH 6504 Bellinzona, Switzerland
    Nat Rev Cancer 4:737-47. 2004
    ....
  4. ncbi Chemoradiation after surgery for high-risk head and neck cancer patients: how strong is the evidence?
    Jacques Bernier
    Department of Radiation Oncology, Oncology Institute of Southern Switzerland, San Giovanni Hospital, CH 6504 Bellinzona, Switzerland
    Oncologist 10:215-24. 2005
    ....
  5. ncbi Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)
    Jacques Bernier
    Department of Radiation Oncology, Oncology Institute of Southern Switzerland, CH 6504 Bellinzona, Switzerland
    Head Neck 27:843-50. 2005
    ..However, additional studies were needed to identify precisely which patients were most suitable for such intense treatment...
  6. ncbi Partial irradiation of the breast: Old challenges, new solutions
    J Bernier
    Department of Radio Oncology and Breast Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Breast 15:466-75. 2006
    ....
  7. ncbi Alteration of radiotherapy fractionation and concurrent chemotherapy: a new frontier in head and neck oncology?
    Jacques Bernier
    Department of Radiation Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Nat Clin Pract Oncol 2:305-14. 2005
    ..This review is a critical appraisal of the real opportunities offered by the application of treatments aimed at increasing the dose intensity of radiotherapy delivered concurrently with cytotoxic drugs...
  8. ncbi Radiotherapy for head and neck cancer: latest developments and future perspectives
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Curr Opin Oncol 18:240-6. 2006
    ....
  9. ncbi Adjuvant therapy in patients with resected poor-risk head and neck cancer
    Jacques Bernier
    Clinique de Genolier, Genolier, Switzerland
    J Clin Oncol 24:2629-35. 2006
    ....
  10. ncbi Cetuximab combined with radiotherapy: an alternative to chemoradiotherapy for patients with locally advanced squamous cell carcinomas of the head and neck?
    J Bernier
    Radio Oncologie, Clinique de Genolier, Genolier 1272, Switzerland
    Eur J Cancer 43:35-45. 2007
    ..In this review, we explore the question of the degree to which adding cetuximab improves the efficacy of radiotherapy in locally advanced SCCHN and how the benefits of cetuximab plus radiotherapy compare with those achievable with CRT...
  11. ncbi Cetuximab in the treatment of head and neck cancer
    Jacques Bernier
    Genolier Swiss Medical Network, Department of Radiation Oncology, CH 1272 Genolier, Switzerland
    Expert Rev Anticancer Ther 6:1539-52. 2006
    ..This article presents the rationale for EGFR inhibition in the management of head and neck cancers, and the preclinical and clinical evidence for the use of cetuximab in the treatment of SCCHN...
  12. ncbi Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck
    J Bernier
    Department of Radiation Oncology, Genolier Swiss Medical Network, Genolier, Geneva, Switzerland
    Ann Oncol 19:142-9. 2008
    ..Skin toxicity was categorised according to the National Cancer Institute-Common Terminology Criteria for Adverse Events (version 3) grading...
  13. ncbi Primary mediastinal large B-cell lymphoma: the need for prospective controlled clinical trials
    S Bieri
    Cantonal Department of Radiation Oncology, San Giovanni Hospital, Bellinzona, Switzerland
    Leuk Lymphoma 35:537-44. 1999
    ..Our analyses suggest that the application of radiotherapy in combination regimens and the use of more aggressive chemotherapy in the treatment of this particular type of lymphoma should now be evaluated in prospective randomized trials...
  14. ncbi Concomitant cisplatin significantly improves locoregional control in advanced head and neck cancers treated with hyperfractionated radiotherapy
    Pia Huguenin
    Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland
    J Clin Oncol 22:4665-73. 2004
    ....
  15. ncbi Management of radiation dermatitis in patients receiving cetuximab and radiotherapy for locally advanced squamous cell carcinoma of the head and neck: proposals for a revised grading system and consensus management guidelines
    J Bernier
    Department of Radiation Oncology, University of Geneva, Clinique de Genolier, Genolier, Switzerland
    Ann Oncol 22:2191-200. 2011
    ..Current grading tools were not designed to grade this type of radiation dermatitis; their use may lead to misclassification of reactions and inappropriate management strategies, potentially compromising cancer treatment...
  16. ncbi Altered fractionation and combined radio-chemotherapy approaches: pioneering new opportunities in head and neck oncology
    J Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, San Giovanni Hospital, CH 6504 Bellinzona, Switzerland
    Eur J Cancer 39:560-71. 2003
    ..Finally, a number of avenues for further research are identified...
  17. ncbi Quality assurance in radiotherapy: from radiation physics to patient- and trial-oriented control procedures
    J Bernier
    Ospedale San Giovanni, Rue de l Hopital, CH 6500, Bellinzona, Switzerland
    Eur J Cancer 38:S155-8. 2002
    ....
  18. ncbi Drug Insight: cetuximab in the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck
    Jacques Bernier
    Radio Oncology Division, Genolier Swiss Medical Network, Genolier, Switzerland
    Nat Clin Pract Oncol 5:705-13. 2008
    ..The superior survival observed with cetuximab compared with platinum-based treatment demonstrates that cetuximab is the most active treatment for recurrent and/or metastatic SCCHN, and is of particular clinical significance...
  19. ncbi Critical appraisal of a conformal head and neck cancer irradiation avoiding electron beams and field matching
    A Fogliata
    Ospedale S Giovanni, Radio Oncology Department, Bellinzona, Switzerland
    Int J Radiat Oncol Biol Phys 45:1331-8. 1999
    ..This study compares a conventional treatment approach where two lateral photon beams are combined to direct electron fields, to a conformal radiotherapy based on five photon fields, covering the whole neck...
  20. ncbi Early morbidity after radiotherapy with or without chemotherapy in advanced head and neck cancer. Experience from four nonrandomized studies
    Sabine Bieri
    Department of Radiation Oncology, Regional Hospital of Sion, Switzerland
    Strahlenther Onkol 179:390-5. 2003
    ..Data on early treatment-related morbidity after radiotherapy alone (RT; 217 patients) or combined with chemotherapy (RT + CT; 182 patients) of head and neck squamous cell carcinoma are analyzed...
  21. ncbi Molecular therapy in head and neck oncology
    Jacques Bernier
    Department of Radiation Oncology, Genolier Swiss Medical Network, Genolier, Switzerland
    Nat Rev Clin Oncol 6:266-77. 2009
    ....
  22. ncbi Is adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93
    Olivia Pagani
    Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland
    Breast Cancer Res Treat 116:491-500. 2009
    ..03). Chemotherapy significantly improves disease-free survival for postmenopausal women with endocrine-responsive breast cancer, but the magnitude of the effect is substantially attenuated if ER levels are high...
  23. ncbi Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial
    Abdelkarim S Allal
    Radiation Oncology Service, University Hospital of Geneva, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Cancer J 11:133-9. 2005
    ....
  24. ncbi Adjuvant chemo- and radiotherapy for poor prognosis head and neck squamous cell carcinomas
    Jacques Bernier
    Department of Radiation Oncology, Oncology Institute of Southern Switzerland, San Giovanni Hospital, CH 6504 Bellinzona, Switzerland
    Crit Rev Oncol Hematol 56:353-64. 2005
    ..There is remaining need for further research efforts that would enable scientists and clinicians to improve, in the next decade, the management of this complex entity of diseases...
  25. ncbi Preoperative hyperfractionated radiotherapy for locally advanced rectal cancers: a phase I-II trial
    Abdelkarim S Allal
    Division of Radiation Oncology, University Hospital of Geneva, 24 Michelli du Crest Street, 1211 Geneva 14, Switzerland
    Int J Radiat Oncol Biol Phys 54:1076-81. 2002
    ..To assess the toxicity, pathologic response rates, type of surgery, and oncologic results in a prospective Phase I-II trial using pure hyperfractionated radiotherapy (RT) preoperatively in locally advanced rectal cancer...
  26. ncbi Current state-of-the-art for concurrent chemoradiation
    Jacques Bernier
    Department of Radiation Oncology, Genolier Swiss Medical Network, Clinique de Genolier, Genolier, Switzerland
    Semin Radiat Oncol 19:3-10. 2009
    ..Because therapy is becoming more intense, a careful recording and reporting of treatment-related morbidity is also a crucial element in estimating the therapeutic gain from competing strategies...
  27. ncbi Assessment of quality of life in patients with rectal cancer treated by preoperative radiotherapy: a longitudinal prospective study
    Abdelkarim S Allal
    Radiation Oncology Service, University Hospital of Geneva, 24 Micheli du Crest St, 1211 Geneva 14, Switzerland
    Int J Radiat Oncol Biol Phys 61:1129-35. 2005
    ..To assess prospectively the quality of life (QOL) of patients treated by preoperative radiotherapy (RT) and surgery for locally advanced rectal cancer...
  28. ncbi Docetaxel in the management of patients with head and neck squamous cell carcinoma
    Jacques Bernier
    Genolier Swiss Medical Network, Department of Radio Oncology, CH 1272 Genolier, Switzerland
    Expert Rev Anticancer Ther 8:1023-32. 2008
    ..This review article discusses the current developments of docetaxel-based chemotherapy and the optimal use of this agent in patients with HNSCC...
  29. ncbi Incorporation of molecularly targeted agents in the primary treatment of squamous cell carcinomas of the head and neck
    Jacques Bernier
    Department of Radio Oncology, Genolier Swiss Medical Network, CH 1272 Genolier, Switzerland
    Hematol Oncol Clin North Am 22:1193-208, ix. 2008
    ..Another potentially promising approach is the inhibition of vascular endothelial growth factor, alone or in combination with EGFR inhibition...
  30. ncbi Three-dimensional conformal vs. intensity-modulated radiotherapy in head-and-neck cancer patients: comparative analysis of dosimetric and technical parameters
    Luca Cozzi
    Medical Physics Unit, Oncology Institute of Southern Switzerland, 6504 Bellinzona, Switzerland
    Int J Radiat Oncol Biol Phys 58:617-24. 2004
    ....
  31. ncbi From chemoprevention and organ preservation programmes to postoperative management: major achievements and strategies of the EORTC Head and Neck Cancer Group
    J Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, CH 6504, Bellinzona, Switzerland
    Eur J Cancer 38:S75-81. 2002
    ..The present article will also analyse the strategies developed within the Group in the field of translational research...
  32. ncbi Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933
    R Miralbell
    Hopital Cantonal Universitaire, Geneva, Switzerland
    J Clin Oncol 17:3143-9. 1999
    ....
  33. ncbi Breast irradiation with three conformal photon fields for patients with high lung involvement
    Luca Cozzi
    Medical Physics Unit, Department of Physics Oncology, Institute of Southern Switzerland, University of Milan, Bellinzona, Switzerland
    Acta Oncol 43:558-66. 2004
    ..2+/-1.8% (3F) and 98.8+/-1.6 (2F). A preliminary report on clinical follow up is also included; with a mean follow up of 15.8 months, no pulmonary or cardiac complications were observed...
  34. ncbi Primary mediastinal large B-cell lymphoma (PMLCL): the need for prospective controlled clinical trials
    S Bieri
    Cantonal Department of Radiation Oncology, San Giovanni Hospital, Bellinzona, Switzerland
    Leuk Lymphoma 35:139-46. 1999
    ....
  35. ncbi Clinical experience in breast irradiation with intensity modulated photon beams
    Luca Cozzi
    Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Acta Oncol 44:467-74. 2005
    ..4 months, no pulmonary or cardiac complications were observed. IMRT proved to be technically feasible on a clinical basis for the treatment of the whole breast, including internal mammary chain, or of the thoracic wall after mastectomy...
  36. ncbi Comparative dosimetric evaluation of the simultaneous integrated boost with photon intensity modulation in head and neck cancer patients
    Antonella Fogliata
    Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Radiother Oncol 69:267-75. 2003
    ....
  37. ncbi Radiotherapy in early breast disease: current status and perspectives
    Jacques Bernier
    Radio-Oncology Department, San Giovanni Hospital, Bellinzona, Switzerland
    Curr Probl Cancer 27:17-23. 2003
  38. ncbi Translational breast cancer research: recent advances through the lens of experimental radiotherapy
    Jacques Bernier
    Department of Radio Oncology, Clinique de Genolier, Genolier 4 route du Muids, Switzerland
    Breast 19:23-7. 2010
    ....
  39. ncbi Exploitable mechanisms for combining drugs with radiation: concepts, achievements and future directions
    Søren M Bentzen
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, K4 316 Clinical Sciences Center, Madison, WI 53792, USA
    Nat Clin Pract Oncol 4:172-80. 2007
    ..Further clinical progress in this field will require hypothesis-driven trials to ensure efficient identification of treatments with the most favorable risk:benefit ratio...
  40. ncbi Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer
    Jan B Vermorken
    Department of Medical Oncology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium
    N Engl J Med 357:1695-704. 2007
    ..We compared TPF with PF as induction chemotherapy in patients with locoregionally advanced, unresectable disease...
  41. ncbi [Adjuvant treatment of head and neck cancers: advances and challenges]
    Jacques Bernier
    Service de radio oncologie, Clinique de Genolier, 1272 Genolier, Suisse
    Bull Cancer 94:823-7. 2007
    ..Future adjuvant treatments should anchor to the development of high-precision irradiation techniques, as well as concomitant delivery of radiotherapy with more efficacious cytotoxic drugs and/or targeted therapies...
  42. ncbi Rationale for triage in the postoperative management of head and neck cancers
    Jay S Cooper
    Radiation Oncology, Maimonides Cancer Center, Brooklyn, New York 11220, USA
    Oncology (Williston Park) 19:1011-7; discussion 1018, 1023-4, 1027. 2005
    ..The future will likely demand more complex treatment schemes from physicians but holds a greater prospect of success for patients...
  43. ncbi Postoperative radiotherapy with simultaneous chemotherapy in high-risk squamous cell carcinoma of the head and neck: a novel standard that opens new questions
    Jordi Giralt
    Clin Transl Oncol 7:181-2. 2005
  44. ncbi Compliance to the prescribed dose and overall treatment time in five randomized clinical trials of altered fractionation in radiotherapy for head-and-neck carcinomas
    Azza A Khalil
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, United Kingdom
    Int J Radiat Oncol Biol Phys 55:568-75. 2003
    ..This affects the interpretation of the outcome of these trials...
  45. ncbi Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis
    Jean Bourhis
    Radiation Oncology Department, Institut Gustave Roussy, Villejuif, France
    Lancet 368:843-54. 2006
    ..Comparison of the different types of altered radiotherapy suggests that hyperfractionation has the greatest benefit...
  46. ncbi Advances in translational radiation oncology: from molecular signaling to cancer cure
    Jacques Bernier
    Int J Radiat Oncol Biol Phys 58:305-6. 2004
  47. ncbi Cancer of the nasopharynx
    Lisa Licitra
    START Project and Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Crit Rev Oncol Hematol 45:199-213. 2003
    ..Standard therapeutic option for early stages of NPC is radiation, while an integration of radiation therapy and chemotherapy is indicated in more advanced stages...
  48. ncbi Chemoradiation in locally advanced head and neck cancer: new evidence, new challenges
    Jacques Bernier
    Expert Rev Anticancer Ther 4:335-9. 2004
  49. ncbi [The interpretation of pulmonary tuberculosis in the 18th century]
    Jacques Bernier
    , ,
    Can Bull Med Hist 22:35-56. 2005
    ....
  50. ncbi High conformality radiotherapy in Europe: thirty-one centres participating in the quality assurance programme of the EORTC prostate trial 22991
    Fatma Ataman
    EORTC Data Centre, Radiotherapy Group 83 Avenue Mounier, Bte 11, B 1200 Brussels, Belgium
    Eur J Cancer 40:2411-6. 2004
    ..The technology questionnaire is the first step in the extensive quality assurance programme dedicated to this high-tech radiotherapy trial...
  51. ncbi Head and neck oncology: what the past decade has taught us
    Jacques Bernier
    Expert Rev Anticancer Ther 6:1133-6. 2006
  52. ncbi Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial
    Michel Bolla
    University Hospital, Grenoble, France
    Lancet 360:103-6. 2002
    ..INTERPRETATION: Immediate androgen suppression with an LHRH analogue given during and for 3 years after external irradiation improves disease-free and overall survival of patients with locally advanced prostate cancer...
  53. ncbi Late toxicity following conventional radiotherapy for prostate cancer: analysis of the EORTC trial 22863
    Fatma Ataman
    EORTC Data Center, Radiotherapy Group, Avenue E Mounier 83, Bte 11, B 1200 Brussels, Belgium
    Eur J Cancer 40:1674-81. 2004
    ..Although four treatment-related deaths (1%) occurred, grade 3 or 4 late complications were less than 5%...
  54. ncbi [Medical libraries in Quebec of the 18th and 19th centuries: the example of tuberculosis]
    Jacques Bernier
    ,
    Can Bull Med Hist 23:331-54. 2006
    ..quot; After 1815, there was a broader diversity of opinions. The books on phthisis most widely consulted from 1700 to 1868 are almost completely unknown today...
  55. ncbi Bridging gaps in translational radiation oncology
    Jacques Bernier
    Radiother Oncol 80:109-11. 2006
  56. ncbi Effects of probucol versus aspirin and versus brachytherapy on restenosis after femoropopliteal angioplasty: the PAB randomized multicenter trial
    Augusto Gallino
    Division of Vascular Medicine, Ospedale San Giovanni, Bellinzona, Switzerland
    J Endovasc Ther 11:595-604. 2004
    ..To evaluate the effect of probucol and/or of endovascular brachytherapy (EVBT) on restenosis after percutaneous transluminal angioplasty (PTA) of femoropopliteal arteries...