Charaf Benarafa

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice
    Tiziana P Cremona
    Theodor Kocher Institute, Univ of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Am J Physiol Lung Cell Mol Physiol 305:L981-9. 2013
  2. pmc SerpinB1 protects the mature neutrophil reserve in the bone marrow
    Charaf Benarafa
    Theodor Kocher Institute, Freiestrasse 1, 3006 Bern, Switzerland
    J Leukoc Biol 90:21-9. 2011
  3. pmc SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G
    Mathias Baumann
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Blood 121:3900-7, S1-6. 2013
  4. doi request reprint The SerpinB1 knockout mouse a model for studying neutrophil protease regulation in homeostasis and inflammation
    Charaf Benarafa
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Methods Enzymol 499:135-48. 2011

Collaborators

Detail Information

Publications4

  1. ncbi request reprint SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice
    Tiziana P Cremona
    Theodor Kocher Institute, Univ of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Am J Physiol Lung Cell Mol Physiol 305:L981-9. 2013
    ..In conclusion, we showed that, although AAT and serpinB1 are similarly potent inhibitors of neutrophil proteases, serpinB1 deficiency is not associated with more severe emphysema. ..
  2. pmc SerpinB1 protects the mature neutrophil reserve in the bone marrow
    Charaf Benarafa
    Theodor Kocher Institute, Freiestrasse 1, 3006 Bern, Switzerland
    J Leukoc Biol 90:21-9. 2011
    ..Collectively, these findings demonstrate that serpinB1 sustains a healthy neutrophil reserve that is required in acute immune responses...
  3. pmc SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G
    Mathias Baumann
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Blood 121:3900-7, S1-6. 2013
    ..In conclusion, we have unveiled a new cytotoxic function for the serine protease CG and showed that serpinB1 is critical for maintaining PMN survival by antagonizing intracellular CG activity...
  4. doi request reprint The SerpinB1 knockout mouse a model for studying neutrophil protease regulation in homeostasis and inflammation
    Charaf Benarafa
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Methods Enzymol 499:135-48. 2011
    ..SerpinB1-knockout mice provide a model to dissect the pathogenesis of inflammatory disease characterized by protease:antiprotease imbalance and may be used to assess the efficacy of therapeutic compounds...