M Beghetti

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint [Pulmonary hypertension associated with congenital heart disease]
    M Beghetti
    Unité de Cardiologie Pédiatrique, Departement de Pediatrie, Hopital des Enfants, Hopitaux Universitaires de Geneve, Suisse
    Rev Mal Respir 23:13S49-59; quiz 13S157, 13S159. 2006
  2. pmc Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study
    Maurice Beghetti
    Children s Hospital, Department of Paediatrics, University of Geneva, Geneva, Switzerland
    Br J Clin Pharmacol 68:948-55. 2009
  3. pmc Review of inhaled iloprost for the control of pulmonary artery hypertension in children
    Cecile Tissot
    Department of the Child and Adolescent, Pediatric Cardiology Unit, University Hospital of Geneva, Switzerland
    Vasc Health Risk Manag 5:325-31. 2009
  4. doi request reprint Diagnostic evaluation of paediatric pulmonary hypertension in current clinical practice
    Maurice Beghetti
    Paediatric Cardiology Unit, University Hospital, Geneva, Switzerland
    Eur Respir J 42:689-700. 2013
  5. pmc Prevention of airway hyperresponsiveness induced by left ventricular dysfunction in rats
    Ferenc Petak
    Department of Medical Physics and Informatics, University of Szeged, 9 Koranyi fasor, H 6720, Szeged, Hungary
    Respir Res 13:114. 2012
  6. doi request reprint Can "inoperable" congenital heart defects become operable in patients with pulmonary arterial hypertension? Dream or reality?
    Maurice Beghetti
    Pediatric Cardiology Unit, Department of the Child and Adolescent, Children s University Hospital, 6 Rue Willy Donze, Geneva, Switzerland
    Congenit Heart Dis 7:3-11. 2012
  7. pmc The role of endothelin-1 in hyperoxia-induced lung injury in mice
    Walid Habre
    Pediatric Anesthesia Unit, Geneva Children s Hospital, University Hospitals of Geneva, 6, rue Willy Donze, CH 1205, Geneva, Switzerland
    Respir Res 7:45. 2006
  8. doi request reprint Pulmonary arterial hypertension in congenital heart diseases
    Maurice Beghetti
    Pediatric Cardiology Unit, Department of the Child and Adolescent, Children s University Hospital, 1211 Geneva, 14 Switzerland
    Semin Respir Crit Care Med 30:421-8. 2009
  9. ncbi request reprint Endothelin-1 in congenital heart disease
    Maurice Beghetti
    Pediatric Cardiology Unit, Department of Pediatrics, Children s University Hospital, Geneva, Switzerland
    Pediatr Res 57:16R-20R. 2005
  10. ncbi request reprint Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan
    M Beghetti
    Paediatric Cardiology Unit, Children s Hospital, Geneva, Switzerland
    Eur J Clin Invest 36:16-24. 2006

Detail Information

Publications94

  1. ncbi request reprint [Pulmonary hypertension associated with congenital heart disease]
    M Beghetti
    Unité de Cardiologie Pédiatrique, Departement de Pediatrie, Hopital des Enfants, Hopitaux Universitaires de Geneve, Suisse
    Rev Mal Respir 23:13S49-59; quiz 13S157, 13S159. 2006
    ..The most common forms are congenital cardiac shunts (i.e.: ventricular septal defects, atrial septal defects, patent ductus arteriosus) that account for almost 60% of the malformations...
  2. pmc Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study
    Maurice Beghetti
    Children s Hospital, Department of Paediatrics, University of Geneva, Geneva, Switzerland
    Br J Clin Pharmacol 68:948-55. 2009
    ..In healthy adult subjects, bosentan pharmacokinetics are less than dose-proportional at doses of >or=500 mg...
  3. pmc Review of inhaled iloprost for the control of pulmonary artery hypertension in children
    Cecile Tissot
    Department of the Child and Adolescent, Pediatric Cardiology Unit, University Hospital of Geneva, Switzerland
    Vasc Health Risk Manag 5:325-31. 2009
    ..In this review we will discuss the role of inhaled iloprost in acute and chronic pulmonary hypertension in children...
  4. doi request reprint Diagnostic evaluation of paediatric pulmonary hypertension in current clinical practice
    Maurice Beghetti
    Paediatric Cardiology Unit, University Hospital, Geneva, Switzerland
    Eur Respir J 42:689-700. 2013
    ..Most children did not undergo the diagnostic workup currently recommended for adults, which highlights either incomplete awareness of current guidelines and/or challenges their appropriateness for children. ..
  5. pmc Prevention of airway hyperresponsiveness induced by left ventricular dysfunction in rats
    Ferenc Petak
    Department of Medical Physics and Informatics, University of Szeged, 9 Koranyi fasor, H 6720, Szeged, Hungary
    Respir Res 13:114. 2012
    ....
  6. doi request reprint Can "inoperable" congenital heart defects become operable in patients with pulmonary arterial hypertension? Dream or reality?
    Maurice Beghetti
    Pediatric Cardiology Unit, Department of the Child and Adolescent, Children s University Hospital, 6 Rue Willy Donze, Geneva, Switzerland
    Congenit Heart Dis 7:3-11. 2012
    ....
  7. pmc The role of endothelin-1 in hyperoxia-induced lung injury in mice
    Walid Habre
    Pediatric Anesthesia Unit, Geneva Children s Hospital, University Hospitals of Geneva, 6, rue Willy Donze, CH 1205, Geneva, Switzerland
    Respir Res 7:45. 2006
    ..As prolonged hyperoxia induces extensive lung tissue damage, we set out to investigate the involvement of endothelin-1 (ET-1) receptors in these adverse changes...
  8. doi request reprint Pulmonary arterial hypertension in congenital heart diseases
    Maurice Beghetti
    Pediatric Cardiology Unit, Department of the Child and Adolescent, Children s University Hospital, 1211 Geneva, 14 Switzerland
    Semin Respir Crit Care Med 30:421-8. 2009
    ..This review summarizes the current knowledge on pulmonary hypertension associated with CHD, focusing on the pathophysiology and treatment of ES...
  9. ncbi request reprint Endothelin-1 in congenital heart disease
    Maurice Beghetti
    Pediatric Cardiology Unit, Department of Pediatrics, Children s University Hospital, Geneva, Switzerland
    Pediatr Res 57:16R-20R. 2005
    ..In addition, therapeutic implications for the use of novel ET receptor antagonists will be emphasized...
  10. ncbi request reprint Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan
    M Beghetti
    Paediatric Cardiology Unit, Children s Hospital, Geneva, Switzerland
    Eur J Clin Invest 36:16-24. 2006
    ..Recent experience with bosentan in paediatric patients with PAH indicates that the results obtained in adult patients may be extrapolated to children, thus offering a safe and effective therapy that is easy to administer...
  11. ncbi request reprint [Pulmonary arterial hypertension in children: new therapeutic approaches]
    M Beghetti
    Unité de Cardiologie Pédiatrique, Departement de Pediatrie, Hopital des Enfants, Hopitaux Universitaires de Geneve, Geneve, Switzerland
    Ann Fr Anesth Reanim 26:570-5. 2007
    ..This short review will discuss these new therapeutic approaches and refers to several large reviews recently published for a more comprehensive description...
  12. doi request reprint Safety experience with bosentan in 146 children 2-11 years old with pulmonary arterial hypertension: results from the European Postmarketing Surveillance program
    Maurice Beghetti
    Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
    Pediatr Res 64:200-4. 2008
    ..They also suggest that Tracleer may be better tolerated in children than in adults. This observation confirms the value of monthly monitoring of liver function for the duration of bosentan treatment...
  13. doi request reprint [Treatment of idiopathic pulmonary arterial hypertension in pediatrics]
    M Beghetti
    Unité de Cardiologie Pédiatrique, Département de l enfant et l adolescent, Hopital des Enfants, 6, rrue Willy Donzé, 1211 Geneve 14, Suisse
    Arch Pediatr 15:702-4. 2008
  14. doi request reprint Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension
    Maurice Beghetti
    University Hospital of Geneva, Switzerland
    J Am Coll Cardiol 53:733-40. 2009
    ..The authors of future studies may seek to investigate whether the pulmonary vascular remodeling in ES can be targeted and reversed...
  15. ncbi request reprint Bosentan in pediatric patients with pulmonary arterial hypertension
    Maurice Beghetti
    Hopital des Enfants, Geneva, Switzerland
    Curr Vasc Pharmacol 7:225-33. 2009
    ..In order to provide an overview of current knowledge, the literature was systematically examined for clinical studies, which evaluate the safety and effectiveness of bosentan in pediatric pulmonary arterial hypertension (PAH)...
  16. doi request reprint Fontan and the pulmonary circulation: a potential role for new pulmonary hypertension therapies
    Maurice Beghetti
    Unité de Cardiologie Pédiatrique, Département de l enfant et de l adolescent, Hopital des Enfants, 6 Rue Willy Donze, Geneva, Switzerland
    Heart 96:911-6. 2010
    ..Recent evidence suggests that therapies approved for pulmonary arterial hypertension may provide benefits in this increasingly important patient population...
  17. ncbi request reprint Pulmonary hypertension in congenital shunts
    Maurice Beghetti
    Unidad de Cardiología Pediátrica, Hospital Universitario Infantil de Ginebra, Ginebra, Suiza
    Rev Esp Cardiol 63:1179-93. 2010
    ..This article reviews pulmonary hypertension associated with congenital shunts and discusses a number of the specific problems encountered...
  18. doi request reprint Paediatric pulmonary hypertension: monitoring progress and identifying unmet needs
    M Beghetti
    Hopital des Enfants, Geneva, Switzerland
    Eur Respir Rev 18:18-23. 2009
    ..Dedicated childhood pulmonary hypertension services would optimise the diagnosis and management of this life-threatening disease...
  19. pmc New combined treatments avoided transplantation in a child with severe pulmonary hypertension
    M Beghetti
    Heart 90:154. 2004
  20. ncbi request reprint Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension
    Maurice Beghetti
    Cardiology Unit, University of Geneva Hospital, Geneva, Switzerland
    Med Sci Monit 9:BR193-8. 2003
    ....
  21. ncbi request reprint Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation
    M Beghetti
    Cardiology Unit, Hopital des Enfants, Dept of Paediatrics, Geneva, Switzerland
    Eur Respir J 19:518-24. 2002
    ..Platelet aggregation inhibition may be one of the mechanisms which explains the beneficial effect of repeated inhalation of iloprost in pulmonary hypertension...
  22. pmc Long term inhalation of iloprost in a child with primary pulmonary hypertension: an alternative to continuous infusion
    M Beghetti
    Cardiology Unit, Hopital des Enfants, Department of Paediatrics, University Hospital of Geneva, 1211 Geneve 14, Switzerland
    Heart 86:E10. 2001
    ..This treatment may offer an alternative to continuous intravenous prostacyclin infusion and obviates the need for a permanent central venous catheter...
  23. ncbi request reprint Kinetics of procalcitonin, interleukin 6 and C-reactive protein after cardiopulmonary-bypass in children
    Maurice Beghetti
    Cardiology Unit, University Hospital Geneva, Switzerland
    Cardiol Young 13:161-7. 2003
    ....
  24. ncbi request reprint Inhaled nitric oxide versus aerosolized iloprost in secondary pulmonary hypertension in children with congenital heart disease: vasodilator capacity and cellular mechanisms
    P C Rimensberger
    Pediatric and Neonatal Critical Care Division, , University Hospital of Geneva, Switzerland
    Circulation 103:544-8. 2001
    ..Aerosolized iloprost might be an alternative to iNO for early testing of vascular reactivity and for the postoperative treatment of acute PHT...
  25. doi request reprint Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure
    Yacine Aggoun
    Paediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, 6, rue Willy Donze, 1211 Geneva 14, Switzerland
    Eur Heart J 29:792-9. 2008
    ....
  26. ncbi request reprint [Follow-up of patients treated by conduits between the right ventricle and the pulmonary artery]
    S Chraibi
    , , , Suisse
    Arch Mal Coeur Vaiss 93:527-32. 2000
    ..Homografts have a slightly longer life compared with valved Dacron conduits but the difference is not statistically significant...
  27. ncbi request reprint Right ventricular outflow tract reconstruction: what conduit to use? Homograft or Contegra?
    Jorge Sierra
    Division of Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    Ann Thorac Surg 84:606-10; discussion 610-1. 2007
    ..Both types of conduits have their pros and cons vividly described in the literature, but so far only a few comparative studies have been presented...
  28. doi request reprint Associations among obesity, blood pressure, and left ventricular mass
    Albane B R Maggio
    Pediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, Switzerland
    J Pediatr 152:489-93. 2008
    ..To measure resting and ambulatory systemic blood pressure (BP) and left ventricular mass (LVM) in prepubertal obese and lean children and to determine their relationships...
  29. doi request reprint Preclinical noninvasive markers of atherosclerosis in children and adolescents with type 1 diabetes are influenced by physical activity
    Béatrice Trigona
    Pediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland
    J Pediatr 157:533-9. 2010
    ..To measure preclinical noninvasive markers of atherosclerosis in youth with type 1 diabetes (T1DM), and to determine their associations between physical activity level and cardiorespiratory fitness (maximal oxygen consumption [VO2max])...
  30. ncbi request reprint Novel approach to mitral valve repair in childhood dilated cardiomyopathy
    P Myers
    Division of Cardiovascular Surgery, Geneva University Hospital, Geneva, Switzerland
    Minerva Chir 66:119-21. 2011
    ....
  31. ncbi request reprint Systemic pulmonary artery shunt using a bovine mesenteric venous graft in newborns
    A Kalangos
    Clinic for Cardiovascular Surgery, Division of Pediatric Cardiology, University Hospital of Geneva, Switzerland
    J Card Surg 15:239-43. 2000
    ....
  32. ncbi request reprint Truncus arteriosus repair with double aortic homograft
    J Sierra
    Clinic for Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    J Card Surg 19:252-3. 2004
    ..Even if they present structural deterioration with time, they represent an attractive alternative to prosthetic valves in infants and children who would anyhow need reoperation because of the outgrowth of valvular or conduit substitutes...
  33. ncbi request reprint Preoperative pulmonary hemodynamics determines changes in airway and tissue mechanics following surgical repair of congenital heart diseases
    W Habre
    Pediatric Anesthesia Unit, Geneva Children s Hospital, Geneva, Switzerland
    Pediatr Pulmonol 38:470-6. 2004
    ..The adverse effects of surgery, mechanical ventilation, and/or cardiopulmonary bypass may be responsible for the increased stiffness of the respiratory system observed in both groups of children...
  34. ncbi request reprint Anterior mitral leaflet prolapse as a primary cause of pure rheumatic mitral insufficiency
    A Kalangos
    Clinic for Cardiovascular Surgery, Department of Pathology, University Cantonal Hospital of Geneva, Switzerland
    Ann Thorac Surg 69:755-61. 2000
    ..This study was designed to revise the mechanisms and repair techniques of anterior mitral leaflet prolapse observed during the correction of pure rheumatic mitral regurgitation in children...
  35. ncbi request reprint Morphologic and functional evaluation of congenital heart disease by magnetic resonance imaging
    D Didier
    Départements de Radiologie et Cardiologie Pédiatrique, Hopital Cantonal Universitaire de Geneve, 1211 Geneva 14, Switzerland
    J Magn Reson Imaging 10:639-55. 1999
    ..This review describes the various techniques used in the evaluation of CHD with emphasis on recent developments as well as recognized clinical applications. J. Magn. Reson. Imaging 1999;10:639-655...
  36. ncbi request reprint Ascending aortic aneurysm associated with aortic insufficiency due to Takayasu's arteritis
    A Kalangos
    Clinic for Cardiovascular Surgery, and Clinic for Pediatric Cardiology, University Cantonal Hospital of Geneva, Switzerland
    Ann Thorac Surg 68:248-50. 1999
    ..This unusual clinical problem in the young population is discussed with regard to other eventual pathologies that should be taken into account in the differential diagnosis...
  37. ncbi request reprint Time course of appearance of markers of arrhythmia in patients with tetralogy of Fallot before and after surgery
    Rim Al Balkhi
    Paediatric Cardiac Unit, Hopital des Enfants, Hopitaux Universitaires, Geneva, Switzerland
    Cardiol Young 14:360-6. 2004
    ..Long-term follow-up is needed to assess the significance of these findings...
  38. ncbi request reprint [Early detection and treatment of pulmonary arterial hypertension]
    Frédéric Lador
    Service de Pneumologie, HUG, 1211 Geneve 14
    Rev Med Suisse 5:2317-21. 2009
    ..The challenge of this early detection is to allow the establishment of a specific treatment which aims to improve the prognosis of patients by limiting the progression of the vasculopathy...
  39. ncbi request reprint Tricuspid valve replacement with a mitral homograft in children with rheumatic tricuspid valvulopathy
    Afksendiyos Kalangos
    Clinic for Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    J Thorac Cardiovasc Surg 127:1682-7. 2004
    ..The objective of this study was to examine the midterm clinical outcomes of tricuspid valve replacement with a mitral homograft in 8 children with unreparable rheumatic tricuspid valve involvement...
  40. ncbi request reprint Congenital heart disease and pulmonary hypertension
    Maurice Beghetti
    Pediatric Cardiology Unit, Children s University Hospital, Geneva, Switzerland
    Rev Port Cardiol 23:273-81. 2004
  41. doi request reprint Pneumonia and pericarditis in a child with HRV-C infection: a case report
    Caroline Tapparel
    Laboratory of Virology, University of Geneva Hospitals, Geneva, Switzerland
    J Clin Virol 45:157-60. 2009
    ..This observation highlights the need for adapted diagnostic tools and the potential for the new rhinovirus species C to cause complications, including pericarditis...
  42. doi request reprint Mitral valve repair for rheumatic valve disease in children: midterm results and impact of the use of a biodegradable mitral ring
    Afksendiyos Kalangos
    Division of Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    Ann Thorac Surg 86:161-8; discussion 168-9. 2008
    ..A mitral valve ring is frequently used in the repair. A recently introduced biodegradable ring has shown promising results and allows for growth of the native annulus...
  43. ncbi request reprint Blood group incompatibility and accelerated homograft fibrocalcifications
    Jan T Christenson
    Clinic for Cardiovascular Surgery, University Hospital of Geneva, Switzerland
    J Thorac Cardiovasc Surg 127:242-50. 2004
    ..Aortic homografts have been frequently used in pulmonary position, but accelerated aortic homograft fibrocalcification may occur. Blood group incompatibility between receiver and homograft donor may play a central role in this context...
  44. ncbi request reprint Value and limitations of the von Reyn, Duke, and modified Duke criteria for the diagnosis of infective endocarditis in children
    Pierre Tissieres
    Pediatric Cardiology, Department of Pediatrics, University Children s Hospital, Geneva, Switzerland
    Pediatrics 112:e467. 2003
    ..To compare the sensitivity of 3 different criteria-von Reyn, Duke, and modified Duke-in diagnosing infective endocarditis (IE) in children...
  45. doi request reprint Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children
    Nathalie J Farpour-Lambert
    Pediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, 6 Rue Willy Donze, 1211 Geneva 14, Switzerland
    J Am Coll Cardiol 54:2396-406. 2009
    ..The aim of this study was to determine the effects of physical activity on systemic blood pressure (BP) and early markers of atherosclerosis in pre-pubertal obese children...
  46. doi request reprint Homografts and xenografts for right ventricular outflow tract reconstruction: long-term results
    Jan T Christenson
    Division of Cardiovascular Surgery, University Hospital of Geneva, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Ann Thorac Surg 90:1287-93. 2010
    ..This study determined long-term results of homografts and midterm results of Contegra grafts, with special emphasis on reoperation rate...
  47. ncbi request reprint Long-term outcome after surgical intervention and interventional procedures for the management of Takayasu's arteritis in children
    Afksendiyos Kalangos
    Clinic for Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    J Thorac Cardiovasc Surg 132:656-64. 2006
    ..There is little information available on the results of reconstructive arterial surgery for Takayasu's arteritis in children. This study evaluates midterm to long-term outcome after surgical, as well as interventional, procedures...
  48. ncbi request reprint Aerosolized iloprost as a bridge to lung transplantation in a patient with cystic fibrosis and pulmonary hypertension
    Pierre Tissieres
    Unit of Pediatric Cardiology, University Children s Hospital, Geneva, Switzerland
    Ann Thorac Surg 78:e48-50. 2004
    ..Inhaled iloprost may be an efficient and selective approach to treat pulmonary hypertension related to end-stage obstructive pulmonary disease...
  49. ncbi request reprint Gaseous microemboluses after replacement of the mitral valve with a mechanical prosthesis in a child
    Pierre Tissieres
    Pediatric Cardiology Unit, Department of Pediatrics, University Children s Hospital, Geneva, Switzerland
    Cardiol Young 14:569. 2004
  50. ncbi request reprint Extratracheal biodegradable splint to treat life-threatening tracheomalacia
    Philippe Bugmann
    Clinic of Pediatric Surgery, Hopital des Enfants, Geneva, Switzerland
    Ann Thorac Surg 78:1446-8. 2004
    ..Thereafter, the child recovered normal respiratory function. Follow-up bronchoscopy showed a posterior dip at the splint level and an asymptomatic persistent posterior compression of the right main bronchus...
  51. ncbi request reprint Repair of aortic coarctation using temporary ascending to descending aortic bypass in children with poor collateral circulation
    Jan T Christenson
    Department of Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    Cardiol Young 14:39-45. 2004
    ..The use of a temporary bypass can possibly eliminate the risk of neurological sequels following direct repair of coarctation in children with poorly developed collateral circulation. The temporary bypass is both easy to apply and safe...
  52. ncbi request reprint Advances in therapies for pediatric pulmonary arterial hypertension
    Cecile Tissot
    The Children s University Hospital of Geneva, Pediatric Cardiology Unit, 6 Rue Willy Donze, 1211 Geneva 14, Switzerland
    Expert Rev Respir Med 3:265-82. 2009
    ..We review the current understanding of pediatric pulmonary hypertension, classification, diagnostic evaluation and available treatment. A description of targeted pharmacological therapy and new treatments in children is outlined...
  53. doi request reprint Reduced physical activity level and cardiorespiratory fitness in children with chronic diseases
    Albane B R Maggio
    Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland
    Eur J Pediatr 169:1187-93. 2010
    ..As the benefits of PA on health have been well demonstrated during growth, it should be encouraged in those children to prevent a reduction of cardiorespiratory fitness and the development of comorbidities...
  54. doi request reprint Central venous hypoxemia is a determinant of human atrial ATP-sensitive potassium channel expression: evidence for a novel hypoxia-inducible factor 1alpha-Forkhead box class O signaling pathway
    Véronique Raeis
    Department of Neuroscience, University of Geneva, 1211 Geneve 4, Switzerland
    Hypertension 55:1186-92. 2010
    ..1 gene via activation of HIF-1alpha-FOXO1. Because increased SUR2A/B/Kir6.1 has known survival benefits, this pathway offers novel therapeutic targets for children with heart disease...
  55. ncbi request reprint Transcatheter occlusion of the patent ductus arteriosus with a single device technique: comparison between the Cook detachable coil and the Rashkind umbrella device
    E T Jaeggi
    Paediatric Cardiology, University Children s Hospital of Geneva, 6 Rue Willy Donze, 1211, Geneva, Switzerland
    Int J Cardiol 79:71-6. 2001
    ..A primary multiple coil approach is advocated if the postcoil aortogram shows residual ductal shunting and if there is persistence of a ductal murmur on auscultation...
  56. ncbi request reprint First intention high-frequency oscillation with early lung volume optimization improves pulmonary outcome in very low birth weight infants with respiratory distress syndrome
    P C Rimensberger
    Pediatric and Neonatal Intensive Care Unit, Hopital des Enfants, University Hospital of Geneva, Geneva, Switzerland
    Pediatrics 105:1202-8. 2000
    ..We used a new ventilatory strategy in very low birth weight (VLBW) infants, by initiating HFO immediately after intubation and attempting early lung volume optimization before surfactant was administered...
  57. ncbi request reprint Early-onset familial dilatation of the ascending aorta
    M Beghetti
    Cardiology Unit, Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
    Cardiology 92:68-70. 1999
    ..This provides further evidence that genetic factors are involved in the etiology of aortic aneurysms and calls for screening first-degree family members, including children, of young adult patients diagnosed with this condition...
  58. ncbi request reprint Treatment of a persistent postoperative chylothorax with somatostatin
    P C Rimensberger
    Department of Pediatrics, Hopital des Enfants, University Hospital of Geneva, Switzerland
    Ann Thorac Surg 66:253-4. 1998
    ..Thereafter, continuous somatostatin infusion for 14 days led to the reduction and finally cessation of chyle production. This treatment allowed early enteral feeding and avoided further surgical intervention...
  59. doi request reprint Precapillary pulmonary hypertension leads to reversible bronchial hyperreactivity in rats
    Britta S von Ungern-Sternberg
    Pediatric Anesthesia Unit, Geneva Children s Hospital, Geneva, Switzerland
    Exp Lung Res 36:129-39. 2010
    ..This may be consequent to the altered mechanical interdependence between the pulmonary vasculature and the respiratory tract...
  60. ncbi request reprint Comparison of classifications for heart failure in children undergoing valvular surgery
    Pierre Tissieres
    Cardiology Unit, Children s Hospital of Geneva, Geneva, Switzerland
    J Pediatr 149:210-5. 2006
    ..To characterize correlations between clinical classifications of heart failure and diagnostic workup...
  61. ncbi request reprint How to diminish reoperation rates after initial repair of tetralogy of Fallot?
    Bernard Faidutti
    Clinic for Cardiovascular Surgery, University Hospital, Geneva, Switzerland
    Ann Thorac Surg 73:96-101. 2002
    ..The present study evaluated the efficacy of reoperation following complete correction of tetralogy of Fallot, the sites of recurrences and impact of techniques used at first operation...
  62. ncbi request reprint Somato-sympathetic vasoconstriction to intranasal fluid administration with consecutive decrease in nasal nitric oxide
    B N Landis
    ENT Department, University Hospital of Geneva, Switzerland
    Acta Physiol Scand 177:507-15. 2003
    ..Patients suffering from non-allergic chronic rhinosinusitis (NACRS) increasingly use intranasal saline sprays. They report better nasal comfort...
  63. ncbi request reprint Coarctation of the aorta: pre and postoperative evaluation with MRI and MR angiography; correlation with echocardiography and surgery
    D Didier
    Department of Radiology, University Hospital of Geneva, Geneva, Switzerland
    Int J Cardiovasc Imaging 22:457-75. 2006
    ..To compare MRI and MRA with Doppler-echocardiography (DE) in native and postoperative aortic coarctation, define the best MR protocol for its evaluation, compare MR with surgical findings in native coarctation...
  64. ncbi request reprint [Non-surgical approach in congenital cardiopathy]
    M Beghetti
    , , , , , Suisse
    Rev Med Suisse Romande 121:223-7. 2001
    ..It is necessary to maintain careful indications and compare the results with conventional surgery in order to assess the risks and benefits of these new techniques...
  65. ncbi request reprint [False aneurysm complicating ligation of patent ductus arteriosus operated on successfully]
    S Chraibi
    Unité de Cardiologie Pédiatrique, hôpital Cautonal de Genève, Suisse
    Ann Cardiol Angeiol (Paris) 52:188-90. 2003
    ..Through bilateral thoracotomy, an anevrismorraphy and aortic repair was carried out without problem. The postoperative course was unremarkable...
  66. ncbi request reprint Management of preterm infants with intracardiac thrombi: use of thrombolytic agents
    P C Rimensberger
    Unit of Neonatal Intensive Care, Hematology Oncology and Cardiology, Department of Pediatrics, Children s Hospital, University of Geneva, rue Willy Donze, Geneva, 6, CH 1211, 14, Switzerland
    Paediatr Drugs 3:883-98. 2001
    ..e. hereditary thrombophilia or central venous catheter still in place) are present. Furthermore, it is recommended that any neonate with thrombosis should be evaluated for hereditary thrombophilia later in life...
  67. ncbi request reprint [Short and long term results of pulmonary balloon valvuloplasty in children]
    M Beghetti
    Departement de Pediatrie, Hopital des Enfants, Hopital Cantonal Universitaire, Geneve
    Schweiz Med Wochenschr 128:491-6. 1998
    ..Failure is attributed to very dysplastic valves and these patients may require, in a second stage, a surgical approach (patch enlargement and/or valvulectomy)...
  68. ncbi request reprint Tricuspidalization of a bicuspid aortic valve with severe aortic valve insufficiency
    Afksendiyos Kalangos
    Department of Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    J Thorac Cardiovasc Surg 125:964-6. 2003
  69. pmc Corrective surgery for idiopathic scoliosis after heart transplantation
    D Ceroni
    Paediatric Orthopaedic Unit, Children s Hospital, University Hospital Geneva, Switzerland
    Eur Spine J 10:454-7. 2001
    ..We report on a 15-year-old patient who underwent successful corrective surgery for idiopathic scoliosis 14 months after heart transplant...
  70. doi request reprint Biodegradable mitral annuloplasty for congenital ischemic mitral regurgitation
    P O Myers
    Division of Cardiovascular Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland
    Thorac Cardiovasc Surg 57:363-4. 2009
    ..It could represent a novel tool for mitral valve repair in ALCAPA-associated ischemic mitral regurgitation...
  71. ncbi request reprint [New treatments of pediatric pulmonary hypertension]
    Julie Wacker
    Unité de Cardiologie Pédiatrique, Département de l enfant et de I adolescent, HUG, 1211 Geneve 14
    Rev Med Suisse 8:423-7. 2012
    ..Various new molecules are being currently tested in children or in development, offering hope to further improve the prognosis of pulmonary arterial hypertension...
  72. ncbi request reprint Decreased bone turnover in children and adolescents with well controlled type 1 diabetes
    A B R Maggio
    Pediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland
    J Pediatr Endocrinol Metab 23:697-707. 2010
    ..Osteoporosis is a common long-term complication of type 1 diabetes (T1DM). We aimed to determine whether bone mineral density (BMD) and turnover are already altered during childhood...
  73. ncbi request reprint Tissue plasminogen activator for a left atrial thrombus after Senning repair
    Cecile Tissot
    Pediatric Cardiology Unit, Department of Pediatrics, Children s University Hospital of Geneva, Geneva, Switzerland
    Pediatr Crit Care Med 8:279-81. 2007
    ..To avoid the surgical removal of an obstructive thrombus in a Senning baffle by the administration of recombinant tissue-type plasminogen activator...
  74. ncbi request reprint Cardiac rhythm and left ventricular function of infants at 1 MAC sevoflurane and halothane
    Sonja Saudan
    Paediatric Anaesthesia Unit, Geneva Children s University Hospital, Geneva, Switzerland
    Paediatr Anaesth 17:540-6. 2007
    ..Thus, we compared cardiac rhythm and left ventricular function at 1 MAC sevoflurane and halothane anesthesia and investigated the potential benefit effect of atropine...
  75. ncbi request reprint Cavo-pulmonary shunt for left ventricular outflow tract obstruction after senning
    Stephane Reverdin
    Department of Surgery, Cardiovascular Surgery Unit, University Hospital of Geneva, Geneva, Switzerland
    J Card Surg 20:478-80. 2005
    ..A cavo-pulmonary shunt (CPS) was performed, with considerable subsequent improvement. We consider the use of CPS as a valuable option in patients with persisting, significant dynamic LVOTO after atrial switch...
  76. ncbi request reprint Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: a potential new drug for rescue therapy
    Alessandro Motti
    Service of Pediatric and Neonatal Intensive Care, Department of Pediatrics, Geneva Children s University Hospital, Switzerland
    Pediatr Crit Care Med 7:380-2. 2006
    ....
  77. doi request reprint Surfactant use based on the oxygenation response to lung recruitment during HFOV in VLBW infants
    Pierre Tissieres
    Division of Pediatric and Neonatal Intensive Care, Department of Pediatrics, University Hospital of Geneva, 6, rue Willy Donze, 1211, Geneva 14, Switzerland
    Intensive Care Med 36:1164-70. 2010
    ..We report our first experience from such a selective early rescue use of surfactant in VLBW infants on HFOV...
  78. ncbi request reprint Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study
    Nazzareno Galie
    Istituto di Cardiologia, Universita di Bologna, Via Massarenti, 9 IT 40138, Bologna, Italy
    Circulation 114:48-54. 2006
    ..Theoretically, interventions that have some effect on the systemic vascular bed could worsen the shunt and increase hypoxemia...
  79. ncbi request reprint 11-year follow-up of two Gianturco Z stents placed in the airways of an infant: a prospective analysis of stent damage
    Philippe Bugmann
    J Vasc Interv Radiol 14:818-9. 2003
  80. pmc Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension
    D Dunbar Ivy
    The Pulmonary Hypertension Program and Pediatric Heart Lung Center, Department of Pediatrics, The University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80045, USA
    J Am Coll Cardiol 51:161-9. 2008
    ..This study investigated the short- and long-term outcome of children with pulmonary arterial hypertension (PAH) treated with inhaled iloprost...
  81. ncbi request reprint Early clinical results of the telemetric adjustable pulmonary artery banding FloWatch-PAB
    Damien Bonnet
    Pediatric Cardiology, Hopital Necker Enfants Malades, Paris, France, EU
    Circulation 110:II158-63. 2004
    ..Adjustment of pulmonary artery banding (PAB) may be a challenging procedure in complex congenital heart defects. Whatever the technique used, subsequent re-operations are frequently needed to control the pulmonary blood flow or pressures...
  82. ncbi request reprint Inhaled NO inhibits platelet aggregation and elevates plasma but not intraplatelet cGMP in healthy human volunteers
    Maurice Beghetti
    Division of Cardiology, Department of Critical Care Medicine, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5J 1X8
    Am J Physiol Heart Circ Physiol 285:H637-42. 2003
    ..43 to 9.99 +/- 5.57 pmol/ml (P < 0.005), intraplatelet cGMP levels were unchanged (means +/- SD: 1.96 +/- 0.58 vs. 2.71 +/- 1.67 pmol/109 platelets; P > 0.05). Inhaled NO inhibits platelet aggregation via a cGMP independent mechanism...
  83. ncbi request reprint The Swiss registry for pulmonary arterial hypertension: the paediatric experience
    Margrit Suzanne Fasnacht
    University Children s Hospital Zurich, Zurich
    Swiss Med Wkly 137:510-3. 2007
    ..A registry was recently developed in order to collect epidemiological data on patients with pulmonary arterial hypertension (PAH) in Switzerland. This is the first description of the paediatric data...
  84. ncbi request reprint Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: results of the BREATHE-5 open-label extension study
    Michael A Gatzoulis
    Royal Brompton Hospital and the National Heart and Lung Institute, Imperial College, London, UK
    Int J Cardiol 127:27-32. 2008
    ..This study investigated the efficacy and safety of bosentan up to 40 weeks in these patients...
  85. ncbi request reprint The Lecompte maneuver as an alternative to reduction pulmonary arterioplasty for relief of airway compression in absent pulmonary valve syndrome
    Cecile Tissot
    Ann Thorac Surg 83:727; author reply 727-8. 2007
  86. ncbi request reprint Nitric oxide precursors and congenital cardiac surgery: a randomized controlled trial of oral citrulline. Definition of pulmonary hypertension in Fontan circulation?
    Maurice Beghetti
    J Thorac Cardiovasc Surg 132:1501-2. 2006
  87. ncbi request reprint Initial experience with Bosentan therapy in patients with the Eisenmenger syndrome: Tetralogy of Fallot?
    Maurice Beghetti
    Am J Cardiol 95:435-6; author reply 436. 2005
  88. doi request reprint Classifying pulmonary hypertension in the setting of the congenitally malformed heart--cleaning up a dog's dinner
    Ingram Schulze-Neick
    National UK Service for Pulmonary Hypertension in Children, Cardiac Unit, Great Ormond Street Hospital, London, United Kingdom
    Cardiol Young 18:22-5. 2008
  89. ncbi request reprint Re: Systematic placement of left-sided pacing leads as an appealing option for cardiac resynchronization as treatment of congestive cardiac failure in children dependent on chronic cardiac pacing
    Eduardo Da Cruz
    Cardiol Young 17:234-5. 2007
  90. ncbi request reprint Clinical classification of pulmonary hypertension
    Gerald Simonneau
    Department of Pulmonary and Critical Medicine, University of Paris Sud, Paris, France
    J Am Coll Cardiol 43:5S-12S. 2004
    ....
  91. ncbi request reprint A neonate with isolated combined aortic and pulmonary valvar stenosis
    Eduardo Da Cruz
    Int J Cardiol 116:e13-4. 2007
    ..Our patient required an urgent and successful percutaneous pulmonary valvuloplasty due to poorly tolerated right ventricular hypertension and dilatation compressing the left ventricle...
  92. ncbi request reprint Fatal coronary artery anomaly presenting as bronchiolitis
    Eduardo Da Cruz
    Eur J Pediatr 165:505; author reply 506. 2006