Andrea Banfi

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
    Clare R Ozawa
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    J Clin Invest 113:516-27. 2004
  2. ncbi request reprint Atypical GPI-anchored T-cadherin stimulates angiogenesis in vitro and in vivo
    Maria Philippova
    Cardiovascular Signalling Group, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Arterioscler Thromb Vasc Biol 26:2222-30. 2006
  3. ncbi request reprint Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia
    Georges von Degenfeld
    Baxter Laboratory in Genetic Pharmacology, Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
    FASEB J 20:2657-9. 2006
  4. ncbi request reprint Localization of vascular response to VEGF is not dependent on heparin binding
    Matthew L Springer
    Division of Cardiology, Box 0124, 513 Parnassus Ave, Rm S1136, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    FASEB J 21:2074-85. 2007
  5. ncbi request reprint Angiotensin II induces angiogenesis in the hypoxic adult mouse heart in vitro through an AT2-B2 receptor pathway
    Veronica C Munk
    Department of Research, Laboratory of Vascular Biology, University Hospital, Basel, Switzerland
    Hypertension 49:1178-85. 2007
  6. pmc Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB
    Andrea Banfi
    Baxter Laboratory for Stem Cell Biology, Institute for Regenerative Medicine and Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, California 34305 5175, USA
    FASEB J 26:2486-97. 2012
  7. ncbi request reprint Critical role of microenvironmental factors in angiogenesis
    Andrea Banfi
    Department of Research, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland
    Curr Atheroscler Rep 7:227-34. 2005
  8. pmc Generation of human adult mesenchymal stromal/stem cells expressing defined xenogenic vascular endothelial growth factor levels by optimized transduction and flow cytometry purification
    Uta Helmrich
    Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    Tissue Eng Part C Methods 18:283-92. 2012
  9. doi request reprint FACS-purified myoblasts producing controlled VEGF levels induce safe and stable angiogenesis in chronic hind limb ischemia
    Thomas Wolff
    Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    J Cell Mol Med 16:107-17. 2012
  10. doi request reprint VEGF over-expression in skeletal muscle induces angiogenesis by intussusception rather than sprouting
    Roberto Gianni-Barrera
    Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Switzerland
    Angiogenesis 16:123-36. 2013

Collaborators

Detail Information

Publications21

  1. pmc Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
    Clare R Ozawa
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    J Clin Invest 113:516-27. 2004
    ..Long-term continuous delivery of VEGF, when maintained below a threshold microenvironmental level, can lead to normal angiogenesis without other exogenous growth factors...
  2. ncbi request reprint Atypical GPI-anchored T-cadherin stimulates angiogenesis in vitro and in vivo
    Maria Philippova
    Cardiovascular Signalling Group, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Arterioscler Thromb Vasc Biol 26:2222-30. 2006
    ..In vitro, overexpression and/or homophilic ligation of T-cad on endothelial cells (ECs) facilitates migration, proliferation, and survival. This study investigated T-cad effects on angiogenesis...
  3. ncbi request reprint Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia
    Georges von Degenfeld
    Baxter Laboratory in Genetic Pharmacology, Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
    FASEB J 20:2657-9. 2006
    ..Blood flow was only improved if vessels were increased both in size and in number. Microenvironmental VEGF concentrations determine efficacy and safety in a therapeutic setting...
  4. ncbi request reprint Localization of vascular response to VEGF is not dependent on heparin binding
    Matthew L Springer
    Division of Cardiology, Box 0124, 513 Parnassus Ave, Rm S1136, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    FASEB J 21:2074-85. 2007
    ..These results indicate that heparin binding is not essential for the localization of VEGF in adult tissue and suggest that the preferential delivery of VEGF121 cDNA for clinical applications may not have a physiological basis...
  5. ncbi request reprint Angiotensin II induces angiogenesis in the hypoxic adult mouse heart in vitro through an AT2-B2 receptor pathway
    Veronica C Munk
    Department of Research, Laboratory of Vascular Biology, University Hospital, Basel, Switzerland
    Hypertension 49:1178-85. 2007
    ....
  6. pmc Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB
    Andrea Banfi
    Baxter Laboratory for Stem Cell Biology, Institute for Regenerative Medicine and Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, California 34305 5175, USA
    FASEB J 26:2486-97. 2012
    ..We conclude that coordinated expression of VEGF and PDGF-BB via a single vector constitutes a novel strategy for harnessing the potency of VEGF to induce safe and efficacious angiogenesis...
  7. ncbi request reprint Critical role of microenvironmental factors in angiogenesis
    Andrea Banfi
    Department of Research, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland
    Curr Atheroscler Rep 7:227-34. 2005
    ..To achieve therapeutic angiogenesis, a means of regulating the microenvironmental levels of angiogenic factors will be critical to the generation of effective new treatment strategies...
  8. pmc Generation of human adult mesenchymal stromal/stem cells expressing defined xenogenic vascular endothelial growth factor levels by optimized transduction and flow cytometry purification
    Uta Helmrich
    Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    Tissue Eng Part C Methods 18:283-92. 2012
    ....
  9. doi request reprint FACS-purified myoblasts producing controlled VEGF levels induce safe and stable angiogenesis in chronic hind limb ischemia
    Thomas Wolff
    Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    J Cell Mol Med 16:107-17. 2012
    ..Based on these results, the total number of implanted cells required to achieve efficacy will need to be determined before a clinical application...
  10. doi request reprint VEGF over-expression in skeletal muscle induces angiogenesis by intussusception rather than sprouting
    Roberto Gianni-Barrera
    Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Switzerland
    Angiogenesis 16:123-36. 2013
    ..Our findings indicate that VEGF over-expression, at doses that have been shown to induce functional benefit, induces vascular growth in skeletal muscle by intussusception rather than sprouting...
  11. doi request reprint Controlled angiogenesis in the heart by cell-based expression of specific vascular endothelial growth factor levels
    Ludovic F Melly
    Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital and University of Basel, 4031 Basel, Switzerland
    Hum Gene Ther Methods 23:346-56. 2012
    ..These results suggest that controlled VEGF delivery by FACS-purified ASC may be a promising strategy to achieve safe therapeutic angiogenesis in the heart...
  12. doi request reprint High-throughput flow cytometry purification of transduced progenitors expressing defined levels of vascular endothelial growth factor induces controlled angiogenesis in vivo
    Heidi Misteli
    Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    Stem Cells 28:611-9. 2010
    ....
  13. pmc Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis
    Georges von Degenfeld
    Departments of Molecular Pharmacology and Microbiology and Immunology, Stanford University School of Medicine, 269 Campus Drive, CCSR 4215A, Stanford, CA 94305 5175, USA
    Br J Pharmacol 140:620-6. 2003
    ..Finally, the autologous cell-based approach using transduced myoblasts could be an alternative gene delivery system for therapeutic angiogenesis in patients, avoiding the toxicities seen with some viral vectors...
  14. doi request reprint Osteogenic graft vascularization and bone resorption by VEGF-expressing human mesenchymal progenitors
    Uta Helmrich
    Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital and Basel University, ICFS 407, Hebelstrasse 20, 4031 Basel, Switzerland
    Biomaterials 34:5025-35. 2013
    ....
  15. doi request reprint Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c
    Nunzia Di Maggio
    Departments of Surgery and of Biomedicine, Basel University Hospital, Hebelstrasse 20, Basel, Switzerland
    Stem Cells 30:1455-64. 2012
    ..In conclusion, our data show a niche/progenitor organization in vitro, in which the BM adherent fraction provides a self-renewing microenvironment for primitive NAMP...
  16. doi request reprint Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis
    Silvia Reginato
    Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital, Hebelstrasse 20, Basel, CH 4031, Switzerland
    Biochem Soc Trans 39:1654-8. 2011
    ....
  17. ncbi request reprint Myoblast-mediated gene transfer for therapeutic angiogenesis
    Andrea Banfi
    Department of Molecular Pharmacology, Stanford University School of Medicine, CCSR 4215, Stanford, California 94305, USA
    Methods Enzymol 346:145-57. 2002
  18. doi request reprint To sprout or to split? VEGF, Notch and vascular morphogenesis
    Roberto Gianni-Barrera
    Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital, Hebelstrasse 20, Basel, CH 4031, Switzerland
    Biochem Soc Trans 39:1644-8. 2011
    ....
  19. ncbi request reprint Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle
    Matthew L Springer
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    Mol Ther 7:441-9. 2003
    ..In contrast with the distant arteriogenesis resulting from VEGF delivery described in previous studies, we report here that highly localized arterioles also form adjacent to the site of delivery...
  20. doi request reprint Adipose tissue-derived progenitors for engineering osteogenic and vasculogenic grafts
    Arnaud Scherberich
    Tissue Engineering, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    J Cell Physiol 225:348-53. 2010
    ....
  21. pmc The effect of controlled expression of VEGF by transduced myoblasts in a cardiac patch on vascularization in a mouse model of myocardial infarction
    Anna Marsano
    Columbia University, Department of Biomedical Engineering, New York, NY 10032, USA
    Biomaterials 34:393-401. 2013
    ..We propose that this combined cell-biomaterial approach can be a promising strategy to engineer cardiac patches with intrinsic and extrinsic vascularization potential...