M Baggiolini

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint Human chemokines: an update
    M Baggiolini
    Theodor Kocher Institute, University of Bern, Switzerland
    Annu Rev Immunol 15:675-705. 1997
  2. ncbi request reprint CKbeta8, a novel CC chemokine that predominantly acts on monocytes
    U Forssmann
    Theodor Kocher Institute, University of Bern, Switzerland
    FEBS Lett 408:211-6. 1997
  3. ncbi request reprint Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2
    M Wolf
    Theodor Kocher Institute, University of Bern, Switzerland
    Eur J Immunol 28:164-70. 1998
  4. ncbi request reprint The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3
    P Loetscher
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Biol Chem 276:2986-91. 2001
  5. pmc B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    D F Legler
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 187:655-60. 1998
  6. pmc Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
    M Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 184:963-9. 1996
  7. ncbi request reprint Identification of CCR8, the receptor for the human CC chemokine I-309
    R S Roos
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Biol Chem 272:17251-4. 1997
  8. ncbi request reprint The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4
    M D'Apuzzo
    Theodor Kocher Institute, University of Bern, Switzerland
    Eur J Immunol 27:1788-93. 1997
  9. ncbi request reprint Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes
    M B Delgado
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 31:699-707. 2001
  10. pmc Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes
    U Forssmann
    Theodor Kocher Institute, University of Bern, CH 3000 Bern, Switzerland
    J Exp Med 185:2171-6. 1997

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Human chemokines: an update
    M Baggiolini
    Theodor Kocher Institute, University of Bern, Switzerland
    Annu Rev Immunol 15:675-705. 1997
    ..Of considerable interest is the recent discovery that some chemokines function as HIV-suppressive factors by interacting with chemokine receptors which, together with CD4, were recognized as the binding sites for HIV-1...
  2. ncbi request reprint CKbeta8, a novel CC chemokine that predominantly acts on monocytes
    U Forssmann
    Theodor Kocher Institute, University of Bern, Switzerland
    FEBS Lett 408:211-6. 1997
    ....
  3. ncbi request reprint Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2
    M Wolf
    Theodor Kocher Institute, University of Bern, Switzerland
    Eur J Immunol 28:164-70. 1998
    ..Activation of CXCR1 appears to depend significantly on the presence of a basic binding determinant close to the second cysteine...
  4. ncbi request reprint The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3
    P Loetscher
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Biol Chem 276:2986-91. 2001
    ..These results suggest that chemokines that attract Th1 cells via CXCR3 can concomitantly block the migration of Th2 cells in response to CCR3 ligands, thus enhancing the polarization of T cell recruitment...
  5. pmc B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    D F Legler
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 187:655-60. 1998
    ....
  6. pmc Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
    M Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 184:963-9. 1996
    ..g., MCP-1, MCP-2, MCP-3, MIP-1 alpha, MIP-1 beta, and RANTES, are also found in monocytes and granulocytes. The present observations suggest that the IP10/Mig receptor is involved in the selective recruitment of effector T cells...
  7. ncbi request reprint Identification of CCR8, the receptor for the human CC chemokine I-309
    R S Roos
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Biol Chem 272:17251-4. 1997
    ..Identification of the receptor for I-309 represents a significant progress in determining the function of I-309 in inflammation and disease...
  8. ncbi request reprint The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4
    M D'Apuzzo
    Theodor Kocher Institute, University of Bern, Switzerland
    Eur J Immunol 27:1788-93. 1997
    ....
  9. ncbi request reprint Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes
    M B Delgado
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 31:699-707. 2001
    ..Owing to its availability on the surface of SDF-1-responsive cells and its rapid effect, cathepsin G is likely to play a significant role in down-regulating SDF-1 activity...
  10. pmc Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes
    U Forssmann
    Theodor Kocher Institute, University of Bern, CH 3000 Bern, Switzerland
    J Exp Med 185:2171-6. 1997
    ....
  11. pmc Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin
    M Uguccioni
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 183:2379-84. 1996
    ..This suggests that the 75-residue form with the characteristic NH2 terminus of an MCP is the biologically relevant species...
  12. pmc The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils
    C A Dahinden
    Institute of Clinical Immunology, University of Bern, Switzerland
    J Exp Med 170:1787-92. 1989
    ..In the presence of IL-3, NAF/NAP-1 functions like a "histamine-releasing factor" and may therefore not only induce cellular infiltration but also provoke symptoms of hypersensitivity reactions...
  13. ncbi request reprint Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Berne, Switzerland and Serono Pharmaceutical Research Institute SA, Geneva, Switzerland
    Blood 96:4046-54. 2000
    ..These platelet receptors may be involved in inflammatory or allergic responses or in platelet activation in human immunodeficiency virus infection...
  14. ncbi request reprint The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC
    G Bardi
    Theodor-Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 31:3291-7. 2001
    ..These findings could explain how T lymphocytes that enter lymphoid tissues in response to SLC produced by high-endothelial venules can subsequently migrate in response to SLC and ELC expressed within the T cell areas...
  15. pmc Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis
    M Uguccioni
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Am J Pathol 155:331-6. 1999
    ..No expression of MIP-1alpha was found in controls and UC. IP-10 was also markedly expressed in the mucosa of control biopsies and therefore could have a role in activated T lymphocytes' recruitment into the healthy mucosa...
  16. ncbi request reprint Functional inhibition of CCR3-dependent responses by peptides derived from phage libraries
    M Houimel
    Institute of Pathology, University of Bern, Bern, Switzerland
    Eur J Immunol 31:3535-45. 2001
    ..Specificity was affirmed using other CCR3 ligands. This is the first de novo identification of chemokine antagonists by direct screening on target proteins...
  17. pmc Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors
    A Granelli-Piperno
    Theodor Kocher Institute, Bern, Switzerland
    J Exp Med 184:2433-8. 1996
    ..DCs express more CCR5 and CXCR4 mRNA than T cells. Therefore, while HIV-1 does not replicate efficiently in mature DCs, viral entry can be active and can be blocked by chemokines that act on known receptors for M- and T-tropic virus...
  18. ncbi request reprint Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes
    M Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    J Biol Chem 269:232-7. 1994
    ....
  19. ncbi request reprint Chemokines in inflammation and immunity
    M Baggiolini
    Theodor Kocher Institute, University of Bern, 3000 Bern, Switzerland
    Immunol Today 21:418-20. 2000
    ..Originally, they were considered as inducible mediators of inflammation, but in recent years, several chemokines have been identified that are expressed constitutively and function in the physiological traffic and homing of leukocytes...
  20. pmc Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation
    L Barella
    Theodor Kocher Institute, University of Bern, Switzerland
    Biochem J 309:773-9. 1995
    ..Alternative transcript formation affecting the 5'-terminal part of the coding region may be a way to modify ligand-binding selectivity...
  21. ncbi request reprint Chemokines in pathology and medicine
    M Baggiolini
    Theodor Kocher Institute, University of Bern, and Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Intern Med 250:91-104. 2001
    ....
  22. ncbi request reprint Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines
    R M Borzi
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 43:1734-41. 2000
    ..We investigated whether human chondrocytes also have chemokine receptors and examined the effects of chemokines on chondrocyte activity...
  23. ncbi request reprint Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5
    P Ogilvie
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 97:1920-4. 2001
    ..The present findings suggest a role of eotaxin in the fine-tuning of cellular responses occurring at sites of allergic inflammation, in which both MCP-1 and eotaxin are produced. (Blood. 2001;97:1920-1924)..
  24. pmc Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity
    P Romagnani
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
    J Clin Invest 107:53-63. 2001
    ..These data provide definitive evidence of CXCR3 expression by HMVEC and open new avenues for therapeutic interventions in all conditions in which an angiostatic effect may be beneficial...
  25. ncbi request reprint The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
    E Oberlin
    Unite d Immunologie Virale, Institut Pasteur, Paris, France
    Nature 382:833-5. 1996
    ....
  26. ncbi request reprint [The role of chemokines in nasal polyps]
    M Caversaccio
    Universitätsklinik für HNO, Hals und Kopfchirurgie, Inselspital Bern
    Schweiz Med Wochenschr . 2000
    ..The increased levels of eosinophil-stimulating chemokines, such as Eotaxin and Eotaxin-2 in nasal polyps suggest that they may be important regulators of eosinophil recruitment in this inflammatory disease...
  27. pmc Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1
    M P Crump
    Protein Engineering Network of Centers of Excellence PENCE and Department of Biochemistry, 713 Heritage Medical Research Center, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    EMBO J 16:6996-7007. 1997
    ..Activation of the receptor is not required for HIV-1 inhibition...
  28. ncbi request reprint Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo
    B Moepps
    Department of Pharmacology and Toxicology, University of Ulm, Germany
    Eur J Immunol 27:2102-12. 1997
    ....
  29. pmc HCC-1, a novel chemokine from human plasma
    P Schulz-Knappe
    Lower Saxony Institute for Peptide Research IPF, Hannover, Germany
    J Exp Med 183:295-9. 1996
    ..In addition, HCC-1 enhanced the proliferation of CD34+ myeloid progenitor cells. It was as effective as MIP-1 alpha, but about 100-fold less potent...
  30. ncbi request reprint The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein
    S Gustincich
    Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie CIB, Area Science Park, Padriciano 99, Trieste, 34012, Italy
    Genomics 57:120-9. 1999
    ..SDPR is homologous to two genes in the databank, one of which, srbc, is similarly regulated during growth arrest and encodes a phosphatidylserine-binding protein that is a substrate of PKC...
  31. pmc HCC-2, a human chemokine: gene structure, expression pattern, and biological activity
    A Pardigol
    Lower Saxony Institute for Peptide Research, D 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 95:6308-13. 1998
    ..It is a potent chemoattractant and inducer of enzyme release in monocytes and a moderately active attractant for eosinophils. Desensitization studies indicate that HCC-2 acts mainly via CC chemokine receptor CCR1...
  32. ncbi request reprint TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function
    M Loetscher
    Theodor Kocher Institute University of Bern P O Box 99, CH 3000 Bern 9, Switzerland
    Curr Biol 7:652-60. 1997
    ..Here, we describe the isolation of a novel, putative chemokine receptor...
  33. pmc Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant
    M Weber
    Institute of Immunology and Allergology, University Hospital, Bern, Switzerland
    J Exp Med 183:681-5. 1996
    ....
  34. ncbi request reprint A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils
    A Walz
    Theodor Kocher Institut, University of Bern, Switzerland
    Biochem Biophys Res Commun 159:969-75. 1989
    ..NAP-2 is homologous to NAF/NAP-1. When aligned on the basis of their two first cysteines, 13 out of 20 amino-terminal residues are identical. The overall homology between the two peptides is 46%...
  35. pmc Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases
    A Walz
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 171:449-54. 1990
    ..The monocyte-conditioned medium was found to cleave purified CTAP-III into NAP-2 through proteinases that were highly sensitive to PMSF, moderately sensitive to leupeptin and insensitive to EDTA...
  36. pmc Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets
    R Burgener
    Theodor Kocher Institut, Universitat Bern, Switzerland
    Biochem J 269:729-34. 1990
    ..Platelets appear to be the only blood cells containing PS-p68, which was not detected in neutrophils, monocytes and lymphocytes...
  37. ncbi request reprint Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide
    I Clark-Lewis
    Biomedical Research Centre, University of British Columbia, Vancouver
    Biochemistry 30:3128-35. 1991
    ..The results indicate that by chemical synthesis these cytokines can be obtained in purity and quantities suitable for further structural analysis, as well as functional studies both in vivo and in vitro.(ABSTRACT TRUNCATED AT 250 WORDS)..
  38. pmc Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8
    A Walz
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 174:1355-62. 1991
    ..Cross-desensitization experiments indicate that ENA-78 acts through the same type of receptors as IL-8, NAP-2, and GRO alpha...