Research Topics
Genomes and Genes
| M BaggioliniSummaryAffiliation: University of Bern Country: Switzerland Publications
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Detail Information
Publications
Human chemokines: an updateM Baggiolini
Theodor Kocher Institute, University of Bern, Switzerland
Annu Rev Immunol 15:675-705. 1997..Of considerable interest is the recent discovery that some chemokines function as HIV-suppressive factors by interacting with chemokine receptors which, together with CD4, were recognized as the binding sites for HIV-1...- CKbeta8, a novel CC chemokine that predominantly acts on monocytesU Forssmann
Theodor Kocher Institute, University of Bern, Switzerland
FEBS Lett 408:211-6. 1997.... - Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2M Wolf
Theodor Kocher Institute, University of Bern, Switzerland
Eur J Immunol 28:164-70. 1998..Activation of CXCR1 appears to depend significantly on the presence of a basic binding determinant close to the second cysteine... - The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3P Loetscher
Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
J Biol Chem 276:2986-91. 2001..These results suggest that chemokines that attract Th1 cells via CXCR3 can concomitantly block the migration of Th2 cells in response to CCR3 ligands, thus enhancing the polarization of T cell recruitment... 
B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5D F Legler
Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
J Exp Med 187:655-60. 1998....- Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytesM Loetscher
Theodor Kocher Institute, University of Bern, Switzerland
J Exp Med 184:963-9. 1996..g., MCP-1, MCP-2, MCP-3, MIP-1 alpha, MIP-1 beta, and RANTES, are also found in monocytes and granulocytes. The present observations suggest that the IP10/Mig receptor is involved in the selective recruitment of effector T cells... - Identification of CCR8, the receptor for the human CC chemokine I-309R S Roos
Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
J Biol Chem 272:17251-4. 1997..Identification of the receptor for I-309 represents a significant progress in determining the function of I-309 in inflammation and disease... - The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4M D'Apuzzo
Theodor Kocher Institute, University of Bern, Switzerland
Eur J Immunol 27:1788-93. 1997.... - Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytesM B Delgado
Theodor Kocher Institute, University of Bern, Bern, Switzerland
Eur J Immunol 31:699-707. 2001..Owing to its availability on the surface of SDF-1-responsive cells and its rapid effect, cathepsin G is likely to play a significant role in down-regulating SDF-1 activity... - Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytesU Forssmann
Theodor Kocher Institute, University of Bern, CH 3000 Bern, Switzerland
J Exp Med 185:2171-6. 1997.... - Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxinM Uguccioni
Theodor Kocher Institute, University of Bern, Switzerland
J Exp Med 183:2379-84. 1996..This suggests that the 75-residue form with the characteristic NH2 terminus of an MCP is the biologically relevant species... - The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophilsC A Dahinden
Institute of Clinical Immunology, University of Bern, Switzerland
J Exp Med 170:1787-92. 1989..In the presence of IL-3, NAF/NAP-1 functions like a "histamine-releasing factor" and may therefore not only induce cellular infiltration but also provoke symptoms of hypersensitivity reactions... - Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human plateletsK J Clemetson
Theodor Kocher Institute, University of Berne, Berne, Switzerland and Serono Pharmaceutical Research Institute SA, Geneva, Switzerland
Blood 96:4046-54. 2000..These platelet receptors may be involved in inflammatory or allergic responses or in platelet activation in human immunodeficiency virus infection... - The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLCG Bardi
Theodor-Kocher Institute, University of Bern, Bern, Switzerland
Eur J Immunol 31:3291-7. 2001..These findings could explain how T lymphocytes that enter lymphoid tissues in response to SLC produced by high-endothelial venules can subsequently migrate in response to SLC and ELC expressed within the T cell areas... - Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitisM Uguccioni
Theodor Kocher Institute, University of Bern, Bern, Switzerland
Am J Pathol 155:331-6. 1999..No expression of MIP-1alpha was found in controls and UC. IP-10 was also markedly expressed in the mucosa of control biopsies and therefore could have a role in activated T lymphocytes' recruitment into the healthy mucosa... - Functional inhibition of CCR3-dependent responses by peptides derived from phage librariesM Houimel
Institute of Pathology, University of Bern, Bern, Switzerland
Eur J Immunol 31:3535-45. 2001..Specificity was affirmed using other CCR3 ligands. This is the first de novo identification of chemokine antagonists by direct screening on target proteins... - Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptorsA Granelli-Piperno
Theodor Kocher Institute, Bern, Switzerland
J Exp Med 184:2433-8. 1996..DCs express more CCR5 and CXCR4 mRNA than T cells. Therefore, while HIV-1 does not replicate efficiently in mature DCs, viral entry can be active and can be blocked by chemokines that act on known receptors for M- and T-tropic virus... - Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytesM Loetscher
Theodor Kocher Institute, University of Bern, Switzerland
J Biol Chem 269:232-7. 1994.... - Chemokines in inflammation and immunityM Baggiolini
Theodor Kocher Institute, University of Bern, 3000 Bern, Switzerland
Immunol Today 21:418-20. 2000..Originally, they were considered as inducible mediators of inflammation, but in recent years, several chemokines have been identified that are expressed constitutively and function in the physiological traffic and homing of leukocytes... - Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formationL Barella
Theodor Kocher Institute, University of Bern, Switzerland
Biochem J 309:773-9. 1995..Alternative transcript formation affecting the 5'-terminal part of the coding region may be a way to modify ligand-binding selectivity... - Chemokines in pathology and medicineM Baggiolini
Theodor Kocher Institute, University of Bern, and Institute for Research in Biomedicine, Bellinzona, Switzerland
J Intern Med 250:91-104. 2001.... - Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokinesR M Borzi
Istituti Ortopedici Rizzoli, Bologna, Italy
Arthritis Rheum 43:1734-41. 2000..We investigated whether human chondrocytes also have chemokine receptors and examined the effects of chemokines on chondrocyte activity... - Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5P Ogilvie
Institute for Research in Biomedicine, Bellinzona, Switzerland
Blood 97:1920-4. 2001..The present findings suggest a role of eotaxin in the fine-tuning of cellular responses occurring at sites of allergic inflammation, in which both MCP-1 and eotaxin are produced. (Blood. 2001;97:1920-1924).. - Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activityP Romagnani
Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
J Clin Invest 107:53-63. 2001..These data provide definitive evidence of CXCR3 expression by HMVEC and open new avenues for therapeutic interventions in all conditions in which an angiostatic effect may be beneficial... - The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1E Oberlin
Unite d Immunologie Virale, Institut Pasteur, Paris, France
Nature 382:833-5. 1996.... - [The role of chemokines in nasal polyps]M Caversaccio
Universitätsklinik für HNO, Hals und Kopfchirurgie, Inselspital Bern
Schweiz Med Wochenschr . 2000..The increased levels of eosinophil-stimulating chemokines, such as Eotaxin and Eotaxin-2 in nasal polyps suggest that they may be important regulators of eosinophil recruitment in this inflammatory disease... - Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1M P Crump
Protein Engineering Network of Centers of Excellence PENCE and Department of Biochemistry, 713 Heritage Medical Research Center, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
EMBO J 16:6996-7007. 1997..Activation of the receptor is not required for HIV-1 inhibition... - Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivoB Moepps
Department of Pharmacology and Toxicology, University of Ulm, Germany
Eur J Immunol 27:2102-12. 1997.... - HCC-1, a novel chemokine from human plasmaP Schulz-Knappe
Lower Saxony Institute for Peptide Research IPF, Hannover, Germany
J Exp Med 183:295-9. 1996..In addition, HCC-1 enhanced the proliferation of CD34+ myeloid progenitor cells. It was as effective as MIP-1 alpha, but about 100-fold less potent... - The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding proteinS Gustincich
Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie CIB, Area Science Park, Padriciano 99, Trieste, 34012, Italy
Genomics 57:120-9. 1999..SDPR is homologous to two genes in the databank, one of which, srbc, is similarly regulated during growth arrest and encodes a phosphatidylserine-binding protein that is a substrate of PKC... - HCC-2, a human chemokine: gene structure, expression pattern, and biological activityA Pardigol
Lower Saxony Institute for Peptide Research, D 30625 Hannover, Germany
Proc Natl Acad Sci U S A 95:6308-13. 1998..It is a potent chemoattractant and inducer of enzyme release in monocytes and a moderately active attractant for eosinophils. Desensitization studies indicate that HCC-2 acts mainly via CC chemokine receptor CCR1... - TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor functionM Loetscher
Theodor Kocher Institute University of Bern P O Box 99, CH 3000 Bern 9, Switzerland
Curr Biol 7:652-60. 1997..Here, we describe the isolation of a novel, putative chemokine receptor... - Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractantM Weber
Institute of Immunology and Allergology, University Hospital, Bern, Switzerland
J Exp Med 183:681-5. 1996.... - A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophilsA Walz
Theodor Kocher Institut, University of Bern, Switzerland
Biochem Biophys Res Commun 159:969-75. 1989..NAP-2 is homologous to NAF/NAP-1. When aligned on the basis of their two first cysteines, 13 out of 20 amino-terminal residues are identical. The overall homology between the two peptides is 46%... - Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteasesA Walz
Theodor Kocher Institute, University of Bern, Switzerland
J Exp Med 171:449-54. 1990..The monocyte-conditioned medium was found to cleave purified CTAP-III into NAP-2 through proteinases that were highly sensitive to PMSF, moderately sensitive to leupeptin and insensitive to EDTA... - Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human plateletsR Burgener
Theodor Kocher Institut, Universitat Bern, Switzerland
Biochem J 269:729-34. 1990..Platelets appear to be the only blood cells containing PS-p68, which was not detected in neutrophils, monocytes and lymphocytes... - Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptideI Clark-Lewis
Biomedical Research Centre, University of British Columbia, Vancouver
Biochemistry 30:3128-35. 1991..The results indicate that by chemical synthesis these cytokines can be obtained in purity and quantities suitable for further structural analysis, as well as functional studies both in vivo and in vitro.(ABSTRACT TRUNCATED AT 250 WORDS).. - Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8A Walz
Theodor Kocher Institute, University of Bern, Switzerland
J Exp Med 174:1355-62. 1991..Cross-desensitization experiments indicate that ENA-78 acts through the same type of receptors as IL-8, NAP-2, and GRO alpha...