Jerome Badaut

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi Distribution and possible roles of aquaporin 9 in the brain
    J Badaut
    Department of Neurosurgery, CHUV BH19 208, 1011 Lausanne, Switzerland
    Neuroscience 129:971-81. 2004
  2. ncbi Aquaporins in brain: distribution, physiology, and pathophysiology
    Jerome Badaut
    Departement de Neurochirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Cereb Blood Flow Metab 22:367-78. 2002
  3. ncbi Distribution of Aquaporin 9 in the adult rat brain: preferential expression in catecholaminergic neurons and in glial cells
    J Badaut
    Departement de Neurochirurgie, CHUV BH19 208, 1011 Lausanne, Switzerland
    Neuroscience 128:27-38. 2004
  4. ncbi Thrombin in ischemic neuronal death
    Marlise de Castro Ribeiro
    Neurology Service, BH 19 208, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Exp Neurol 198:199-203. 2006
  5. ncbi Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase
    Cristina Granziera
    Service de Neurologie, CHUV, Lausanne, Switzerland
    Brain Res 1148:217-25. 2007
  6. doi Activation of c-Jun in the nuclei of neurons of the CA-1 in thrombin preconditioning occurs via PAR-1
    Melanie Price
    Neurology Service, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Neurosci Res 88:1338-47. 2010
  7. ncbi Hypoxia/hypoglycemia preconditioning prevents the loss of functional electrical activity in organotypic slice cultures
    Jerome Badaut
    Neurosurgery Research Group, Centre Hospitalier Universitaire Vaudois CHUV, Pavillon 3 Beaumont, 1011 Lausanne, Switzerland
    Brain Res 1051:117-22. 2005
  8. doi Protective role of early aquaporin 4 induction against postischemic edema formation
    Lorenz Hirt
    Neurology Department, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 29:423-33. 2009
  9. ncbi Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke
    Jerome Badaut
    Neurosurgery Research Group, Centre Hospitalier Universitaire Vaudois, Pavilion 3 Beaumont, 1011 Lausanne, Switzerland
    Pediatr Res 62:248-54. 2007
  10. ncbi Time course of aquaporin expression after transient focal cerebral ischemia in mice
    Marlise de Castro Ribeiro
    Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Neurosci Res 83:1231-40. 2006

Collaborators

Detail Information

Publications17

  1. ncbi Distribution and possible roles of aquaporin 9 in the brain
    J Badaut
    Department of Neurosurgery, CHUV BH19 208, 1011 Lausanne, Switzerland
    Neuroscience 129:971-81. 2004
    ..These hypotheses concerning the function of brain AQP9 are still speculative and open new areas of investigation...
  2. ncbi Aquaporins in brain: distribution, physiology, and pathophysiology
    Jerome Badaut
    Departement de Neurochirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Cereb Blood Flow Metab 22:367-78. 2002
    ..Facilitation of these movements may contribute to the development of edema formation after acute cerebral insults such as ischemia or traumatic injury...
  3. ncbi Distribution of Aquaporin 9 in the adult rat brain: preferential expression in catecholaminergic neurons and in glial cells
    J Badaut
    Departement de Neurochirurgie, CHUV BH19 208, 1011 Lausanne, Switzerland
    Neuroscience 128:27-38. 2004
    ....
  4. ncbi Thrombin in ischemic neuronal death
    Marlise de Castro Ribeiro
    Neurology Service, BH 19 208, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Exp Neurol 198:199-203. 2006
    ..After 24 h, there was a marked increase in thrombin immunoreactivity on Western blots. Thrombin therefore contributes to ischemic damage in neural tissue in vitro...
  5. ncbi Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase
    Cristina Granziera
    Service de Neurologie, CHUV, Lausanne, Switzerland
    Brain Res 1148:217-25. 2007
    ..These results, from two different TPC models and with two distinct JNK inhibitors, show that JNK is likely to be involved in TPC...
  6. doi Activation of c-Jun in the nuclei of neurons of the CA-1 in thrombin preconditioning occurs via PAR-1
    Melanie Price
    Neurology Service, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Neurosci Res 88:1338-47. 2010
    ..By using an antibody against the Ser 73 phosphorylation site of c-Jun, we identify possible additional TPC substrates...
  7. ncbi Hypoxia/hypoglycemia preconditioning prevents the loss of functional electrical activity in organotypic slice cultures
    Jerome Badaut
    Neurosurgery Research Group, Centre Hospitalier Universitaire Vaudois CHUV, Pavillon 3 Beaumont, 1011 Lausanne, Switzerland
    Brain Res 1051:117-22. 2005
    ..The major interest and advantage of this system over both the acute slice preparation and primary cell cultures is the ability to simultaneously measure the delayed neuronal damage and neuronal function...
  8. doi Protective role of early aquaporin 4 induction against postischemic edema formation
    Lorenz Hirt
    Neurology Department, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 29:423-33. 2009
    ....
  9. ncbi Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke
    Jerome Badaut
    Neurosurgery Research Group, Centre Hospitalier Universitaire Vaudois, Pavilion 3 Beaumont, 1011 Lausanne, Switzerland
    Pediatr Res 62:248-54. 2007
    ..Finally, induction of AQP4 on astrocyte end-feet could participate in tissue preservation after ischemia in the immature rat brain...
  10. ncbi Time course of aquaporin expression after transient focal cerebral ischemia in mice
    Marlise de Castro Ribeiro
    Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Neurosci Res 83:1231-40. 2006
    ..The expression of AQP1 remained unchanged. These results suggest that AQP4, but not AQP1 or AQP9, may play an important role in water movement associated with the pathophysiology of edema after transient cerebral ischemia in the mouse...
  11. ncbi [Roles of aquaporins in the brain]
    Céline F Guérin
    Groupe de recherche neurochirurgicale, Centre Hospitalier Universitaire Vaudois, Pavillon 3, Beaumont, 1011 Lausanne, Switzerland
    Med Sci (Paris) 21:747-52. 2005
    ..This new result strengthens the hypothesis that the AQPs are not only water channels, but that some AQPs may play a role in energy metabolism as metabolite channels...
  12. ncbi Aquaporins in the brain: from aqueduct to "multi-duct"
    Jerome Badaut
    Department of Neurosurgery, CHUV UNIL, 1011, Lausanne, Switzerland
    Metab Brain Dis 22:251-63. 2007
    ..These recent exciting results suggest that AQPs may not only be involved in water homeostasis in the brain but could also participate in other important physiological functions...
  13. ncbi Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats
    J Badaut
    Neurosurgery Research Group, CHUV UNIL, Lausanne, Switzerland
    Brain Res 1188:17-24. 2008
    ..These results show that the level of expression of brain AQP9 is affected by variations of the concentration of insulin in a diabetic model and in vitro...
  14. ncbi D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia
    Lorenz Hirt
    Service de Neurologie, CHUV, Lausanne, Switzerland
    Stroke 35:1738-43. 2004
    ..In 2 models of severe ischemic injury, we have evaluated the neuroprotective action of D-JNKI1, a cell-penetrating and protease-resistant peptide selectively inhibiting the c-Jun-N-terminal kinase (JNK)...
  15. ncbi Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia
    J Badaut
    Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Cereb Blood Flow Metab 21:477-82. 2001
    ....
  16. ncbi Aquaporin 1 and aquaporin 4 expression in human brain after subarachnoid hemorrhage and in peritumoral tissue
    J Badaut
    Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Acta Neurochir Suppl 86:495-8. 2003
    ..These results reinforce the hypothesis that AQPs may be involved in the dynamics of brain edema formation or resolution. Further studies are needed to understand their functional role...
  17. doi Cell locations for AQP1, AQP4 and 9 in the non-human primate brain
    I I Arciénega
    Neurosurgery Research Group, Lausanne Hospital University CHUV, Pavillon 3, 1011 Lausanne, Switzerland
    Neuroscience 167:1103-14. 2010
    ..This relevant species differences have to be considered carefully to assess potential drugs acting on AQPs non-human primate models before entering human clinical trials...