Annette Audigé

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint HIV-1 does not provoke alteration of cytokine gene expression in lymphoid tissue after acute infection ex vivo
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, Institute of Clinical Immunology, and Clinic of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    J Immunol 172:2687-96. 2004
  2. doi request reprint Evaluation of the immunomodulatory and antiviral effects of the cytokine combination IFN-α and IL-7 in the lymphocytic choriomeningitis virus and Friend retrovirus mouse infection models
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University of Zurich, Zurich, Switzerland
    Viral Immunol 24:375-85. 2011
  3. ncbi request reprint Anti-HIV state but not apoptosis depends on IFN signature in CD4+ T cells
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    J Immunol 177:6227-37. 2006
  4. doi request reprint HIV interferes with SOCS-1 and -3 expression levels driving immune activation
    Regina C Miller
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    Eur J Immunol 41:1058-69. 2011
  5. doi request reprint Low postseroconversion CD4 count and rapid decrease of CD4 density identify HIV+ fast progressors
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    AIDS Res Hum Retroviruses 26:997-1005. 2010
  6. pmc Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1
    Marc Nischang
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e38853. 2012
  7. ncbi request reprint B cells from HIV-infected patients with primary central nervous system lymphoma display an activated phenotype and have a blunted TNF-α response to TLR9 triggering
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    AIDS Res Hum Retroviruses 26:1063-74. 2010
  8. doi request reprint Modeling HIV infection and therapies in humanized mice
    Marc Nischang
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Switzerland
    Swiss Med Wkly 142:w13618. 2012
  9. ncbi request reprint Uncoupled anti-HIV and immune-enhancing effects when combining IFN-alpha and IL-7
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    J Immunol 175:3724-36. 2005
  10. pmc CpG oligodeoxynucleotides block human immunodeficiency virus type 1 replication in human lymphoid tissue infected ex vivo
    Erika Schlaepfer
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    J Virol 78:12344-54. 2004

Detail Information

Publications11

  1. ncbi request reprint HIV-1 does not provoke alteration of cytokine gene expression in lymphoid tissue after acute infection ex vivo
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, Institute of Clinical Immunology, and Clinic of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    J Immunol 172:2687-96. 2004
    ..These results also indicate that different molecular mechanisms govern HIV replication in tissue blocks and HLAC. Prevention of effective cytokine responses may be an important mechanism that HIV uses during acute infection...
  2. doi request reprint Evaluation of the immunomodulatory and antiviral effects of the cytokine combination IFN-α and IL-7 in the lymphocytic choriomeningitis virus and Friend retrovirus mouse infection models
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University of Zurich, Zurich, Switzerland
    Viral Immunol 24:375-85. 2011
    ..e., beyond day 34 pi). Finally, IFN-α/IL-7 may inhibit the replication of other viruses. Thus it might be worth testing these cytokines in other in vivo models of chronic viral infections...
  3. ncbi request reprint Anti-HIV state but not apoptosis depends on IFN signature in CD4+ T cells
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    J Immunol 177:6227-37. 2006
    ..We conclude that acute HIV infection of lymphoid tissue results in up-regulation of ISGs in CD4(+) T cells, which induces an anti-HIV state but not apoptosis...
  4. doi request reprint HIV interferes with SOCS-1 and -3 expression levels driving immune activation
    Regina C Miller
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    Eur J Immunol 41:1058-69. 2011
    ..We speculate that regulating SOCS may be a potential way to counteract immune activation in HIV disease...
  5. doi request reprint Low postseroconversion CD4 count and rapid decrease of CD4 density identify HIV+ fast progressors
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    AIDS Res Hum Retroviruses 26:997-1005. 2010
    ..The lack of an effect of ART on CD4 density implies a persistent dysfunctional immune response by uncontrolled HIV infection...
  6. pmc Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1
    Marc Nischang
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e38853. 2012
    ..Furthermore, they should disclose whether viral breakthrough and emergence of resistance occurs similar as in HIV-infected patients when ART is insufficient...
  7. ncbi request reprint B cells from HIV-infected patients with primary central nervous system lymphoma display an activated phenotype and have a blunted TNF-α response to TLR9 triggering
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    AIDS Res Hum Retroviruses 26:1063-74. 2010
    ..Finally, since increased IL-6 expression is linked to EBV-associated Hodgkin’s lymphoma, the enhanced baseline expression of IL-6 might be important in the pathogenesis of PCNSL in HIV-infected patients...
  8. doi request reprint Modeling HIV infection and therapies in humanized mice
    Marc Nischang
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Switzerland
    Swiss Med Wkly 142:w13618. 2012
    ..Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection...
  9. ncbi request reprint Uncoupled anti-HIV and immune-enhancing effects when combining IFN-alpha and IL-7
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    J Immunol 175:3724-36. 2005
    ..In this scenario, the known reactivation of latent HIV by IL-7 may be advantageous...
  10. pmc CpG oligodeoxynucleotides block human immunodeficiency virus type 1 replication in human lymphoid tissue infected ex vivo
    Erika Schlaepfer
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    J Virol 78:12344-54. 2004
    ....
  11. ncbi request reprint TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection
    Erika Schlaepfer
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland
    J Immunol 176:2888-95. 2006
    ..Compounds triggering TLR7/8 may be attractive drug candidates to purge latent HIV while preventing new infections...