- Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
Trends Cell Biol 22:274-82. 2012
..Likewise, chronic ER stress obstructs activation of Akt by mTOR complex 2. This review surveys our knowledge of mTOR-ER stress intersections and highlights potential therapeutic implications...
- Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum
Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstr 50, CH 4056 Basel, Switzerland
J Cell Sci 124:847-55. 2011
..Accordingly, the widely held concept that Ero1-mediated over-oxidation in the ER constitutes a common cause of cellular demise is critically re-evaluated...
- The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function
Biozentrum, University of Basel, Switzerland
J Cell Sci 119:2173-83. 2006
..The ERGIC also contributes to the concentration, folding, and quality control of newly synthesized proteins...
- Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise
Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel Basel, Switzerland
Front Genet 4:108. 2013
..Advantages and drawbacks of plate-reader and microscopy-based measurements are discussed, and the power of these techniques demonstrated in the context of selected cell culture models for ER stress...
- The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more
Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland
Antioxid Redox Signal 16:1109-18. 2012
..The conserved, ER-resident endoplasmic oxidoreductin 1 (Ero1) sulfhydryl oxidases that reduce molecular oxygen to generate an active-site disulfide represent one of these pathways. In mammals, two family members exist, Ero1α and Ero1β...
- pH-induced conversion of the transport lectin ERGIC-53 triggers glycoprotein release
Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
J Biol Chem 279:12943-50. 2004
..The results elucidate the molecular mechanism underlying reversible lectin/cargo interaction and establish the ERGIC as the earliest low pH site of the secretory pathway...
- Carbohydrate- and conformation-dependent cargo capture for ER-exit
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Mol Biol Cell 16:1258-67. 2005
..To our knowledge this is the first documentation of an ER-exit signal in soluble cargo in conjunction with its decoding by a transport receptor...