Christian Appenzeller-Herzog

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise
    Julia Birk
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel Basel, Switzerland
    Front Genet 4:108. 2013
  2. doi request reprint Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
    Christian Appenzeller-Herzog
    Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Trends Cell Biol 22:274-82. 2012
  3. doi request reprint Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum
    Christian Appenzeller-Herzog
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstr 50, CH 4056 Basel, Switzerland
    J Cell Sci 124:847-55. 2011
  4. doi request reprint Endoplasmic reticulum: reduced and oxidized glutathione revisited
    Julia Birk
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland
    J Cell Sci 126:1604-17. 2013
  5. ncbi request reprint The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function
    Christian Appenzeller-Herzog
    Biozentrum, University of Basel, Switzerland
    J Cell Sci 119:2173-83. 2006
  6. ncbi request reprint GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum
    Thomas Ramming
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland
    Free Radic Biol Med 70:106-16. 2014
  7. pmc Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells
    Denise V Kratschmar
    Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    PLoS ONE 7:e36774. 2012
  8. doi request reprint The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more
    Thomas Ramming
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland
    Antioxid Redox Signal 16:1109-18. 2012
  9. pmc Carbohydrate- and conformation-dependent cargo capture for ER-exit
    Christian Appenzeller-Herzog
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 16:1258-67. 2005
  10. ncbi request reprint pH-induced conversion of the transport lectin ERGIC-53 triggers glycoprotein release
    Christian Appenzeller-Herzog
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 279:12943-50. 2004

Collaborators

Detail Information

Publications13

  1. pmc Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise
    Julia Birk
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel Basel, Switzerland
    Front Genet 4:108. 2013
    ..Advantages and drawbacks of plate-reader and microscopy-based measurements are discussed, and the power of these techniques demonstrated in the context of selected cell culture models for ER stress...
  2. doi request reprint Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
    Christian Appenzeller-Herzog
    Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Trends Cell Biol 22:274-82. 2012
    ..Likewise, chronic ER stress obstructs activation of Akt by mTOR complex 2. This review surveys our knowledge of mTOR-ER stress intersections and highlights potential therapeutic implications...
  3. doi request reprint Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum
    Christian Appenzeller-Herzog
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstr 50, CH 4056 Basel, Switzerland
    J Cell Sci 124:847-55. 2011
    ..Accordingly, the widely held concept that Ero1-mediated over-oxidation in the ER constitutes a common cause of cellular demise is critically re-evaluated...
  4. doi request reprint Endoplasmic reticulum: reduced and oxidized glutathione revisited
    Julia Birk
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland
    J Cell Sci 126:1604-17. 2013
    ..The reported development of ER-localized EGSH sensors will enable more targeted in vivo redox analyses in ER-related disorders...
  5. ncbi request reprint The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function
    Christian Appenzeller-Herzog
    Biozentrum, University of Basel, Switzerland
    J Cell Sci 119:2173-83. 2006
    ..The ERGIC also contributes to the concentration, folding, and quality control of newly synthesized proteins...
  6. ncbi request reprint GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum
    Thomas Ramming
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland
    Free Radic Biol Med 70:106-16. 2014
    ..Along with the induction of GPX8 in ER-stressed cells, these findings question a ubiquitous role of Ero1α as a producer of cytoplasmic ROS under ER stress. ..
  7. pmc Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells
    Denise V Kratschmar
    Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    PLoS ONE 7:e36774. 2012
    ..GR activity is controlled by glucocorticoids, which are synthesized in the adrenal glands and regenerated mainly in the liver from inactive cortisone by 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1)...
  8. doi request reprint The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more
    Thomas Ramming
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland
    Antioxid Redox Signal 16:1109-18. 2012
    ..The conserved, ER-resident endoplasmic oxidoreductin 1 (Ero1) sulfhydryl oxidases that reduce molecular oxygen to generate an active-site disulfide represent one of these pathways. In mammals, two family members exist, Ero1α and Ero1β...
  9. pmc Carbohydrate- and conformation-dependent cargo capture for ER-exit
    Christian Appenzeller-Herzog
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 16:1258-67. 2005
    ..To our knowledge this is the first documentation of an ER-exit signal in soluble cargo in conjunction with its decoding by a transport receptor...
  10. ncbi request reprint pH-induced conversion of the transport lectin ERGIC-53 triggers glycoprotein release
    Christian Appenzeller-Herzog
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 279:12943-50. 2004
    ..The results elucidate the molecular mechanism underlying reversible lectin/cargo interaction and establish the ERGIC as the earliest low pH site of the secretory pathway...