Research Topics
Genomes and Genes | U AlbrechtSummaryAffiliation: University of Fribourg Country: Switzerland Publications
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Publications
Circadian expression of the clock gene Per2 is altered in the ruin lizard (Podarcis sicula) when temperature changesMaria Chiara Magnone
Department of Medicine, Division of Biochemistry, University of Fribourg, , 1700 Fribourg, Switzerland
Brain Res Mol Brain Res 133:281-5. 2005..The alteration of the lPer2 expression pattern at low temperature indicates that the activity of the molecular feedback loop is modified under these conditions...
Circadian clocks and mood-related behaviorsUrs Albrecht
Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musee 5, 1700, Fribourg, Switzerland
Handb Exp Pharmacol 217:227-39. 2013..The relationship between metabolism and mood disorders is highlighted followed by a discussion of how mood disorders may be treated by changing the circadian cycle...- Timing to perfection: the biology of central and peripheral circadian clocksUrs Albrecht
Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
Neuron 74:246-60. 2012..This review will highlight the relationship between clocks and metabolism, and describe how cues such as light, food, and reward mediate entrainment of the circadian system... 
Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampusLaurence Borgs
Developmental Neurobiology Unit, Center for Cellular and Molecular Neurobiology, University of Liege, Liege, Belgium
BMC Neurosci 10:30. 2009..Since light/dark variations of the mitotic index and DNA synthesis occur in many tissues, we wanted to unravel the role of the clock-controlled Period2 gene (mPer2) in timing cell cycle kinetics and neurogenesis in the adult DG...- Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCKSonja Langmesser
Department of Medicine, Division of Biochemistry, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
BMC Mol Biol 9:41. 2008.... - Circadian clocks in mood-related behaviorsUrs Albrecht
Department of Medicine, Unit of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Ann Med 42:241-51. 2010..This review will focus on internal and external factors affecting synchronization and function of the circadian system and highlight connections to mood-related behavior... - The mammalian circadian clockUrs Albrecht
Institute of Biochemistry, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
Curr Opin Genet Dev 13:271-7. 2003..Genetic, biochemical and genomic approaches have led to major advances in understanding the molecular and cellular basis of mammalian circadian clock components and mechanisms... - Orchestration of gene expression and physiology by the circadian clockUrs Albrecht
Department of Medicine, Division of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
J Physiol Paris 100:243-51. 2006..In this review, I briefly describe the principle of the clock mechanism, its synchronization to the environment and consequences on health when the circadian clock is disrupted... - Molecular orchestration of the hepatic circadian symphonyUrs Albrecht
Department of Medicine, Division of Biochemistry, University of Fribourg, Rue du Muséee, 1700 Fribourg, Switzerland
Genome Biol 7:234. 2006..A recent study investigating the circadian regulation of liver proteins reveals multiple levels of regulation, including transcriptional, post-transcriptional and post-translational mechanisms... - Circadian rhythms and sleep--the metabolic connectionUrs Albrecht
Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musee 5, 1700, Fribourg, Switzerland
Pflugers Arch 463:23-30. 2012..This suggests that organs other than the brain may "sleep." A hypothetic view on this aspect is presented providing a different perspective on sleep regulation... - Invited review: regulation of mammalian circadian clock genesUrs Albrecht
Institute of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
J Appl Physiol 92:1348-55. 2002..In this mini-review, I will summarize these advances that have led us to begin understanding the mammalian circadian clock at the molecular level... - The circadian clock and behaviorU Albrecht
Max Planck Institute for Experimental Endocrinology, Feodor Lynen Strasse 7, 30625 Hannover, Germany
Behav Brain Res 125:89-91. 2001..In the following, we describe how daily or circadian activity is measured in mice, and what such activity measurements can tell us about the state of the animal... - Circadian rhythms: a fine c(l)ocktail!U Albrecht
Institute of Biochemistry, University of Fribourg, Rue du Musee 5, CH 1700, Fribourg, Switzerland
Curr Biol 11:R517-9. 2001..Recent studies shed light on the integration of these individual cellular rhythms and on novel genetic determinants that have been found to influence circadian behavior... - Human molecular chronotyping in sight?Urs Albrecht
Department of Medicine, Division of Biochemistry, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
Genome Biol 5:246. 2004..How feasible will it be to create a molecular timetable that allows determination of individual body time from tissue harvested at a single time point?.. - Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant miceHenrik Oster
Max Planck Institute for Experimental Endocrinology, 30625 Hannover, Germany
Genes Dev 16:2633-8. 2002..In marked contrast, inactivation of mCry1 in mPer2 mutant mice does not restore circadian rhythmicity but instead results in complete behavioral arrhythmicity in DD, indicating different effects of mCry1 and mCry2 in the clock mechanism.. - Daily variation of clock output gene activation in behaviorally arrhythmic mPer/mCry triple mutant miceHenrik Oster
Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland
Chronobiol Int 20:683-95. 2003.... - Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant miceHenrik Oster
Department of Medicine, Division of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Genes Dev 17:1366-79. 2003.... - Circadian rhythms in murine pups develop in absence of a functional maternal circadian clockCorinne Jud
Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland
J Biol Rhythms 21:149-54. 2006..These findings indicate that development of circadian rhythms does not depend on a functional circadian clock in maternal tissue, extending previous findings obtained from pups born to SCN-lesioned mothers... - Regulation of monoamine oxidase A by circadian-clock components implies clock influence on moodGabriele Hampp
Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland
Curr Biol 18:678-83. 2008..These findings suggest a role of circadian-clock components in dopamine metabolism highlighting a role of the clock in regulating mood-related behaviors... - The circadian clock as a molecular calendarHenrik Oster
Institute of Biochemistry, University of Fribourg, Switzerland
Chronobiol Int 19:507-16. 2002..However, not every aspect of photoperiodism is covered by this theory and majoradjustments will need tobe made toestablish a widely acceptable uniform model of circadian/circannual timekeeping... - The role of clock genes and rhythmicity in the liverI Schmutz
Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg, Switzerland
Mol Cell Endocrinol 349:38-44. 2012..Here we will focus on the input and output pathways of the hepatic circadian oscillator and discuss the recently found flexibility of its circadian transcriptional networks... - The multiple facets of Per2U Albrecht
Department of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
Cold Spring Harb Symp Quant Biol 72:95-104. 2007..This might provide new views about Per2 function and help to better understand diseases that are rooted in the circadian system... - cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clockHenrik Oster
Department of Medicine, Division of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Curr Biol 13:725-33. 2003..The major stimulus for adjustment (resetting) of the clock is nocturnal light. It evokes activation of signaling pathways in the SCN that ultimately lead to expression of mPer1 and mPer2 genes conveying adjustment of the clock... - Mutation of the circadian clock gene Per2 alters vascular endothelial functionHema Viswambharan
Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
Circulation 115:2188-95. 2007..The circadian clock regulates biological processes including cardiovascular function and metabolism. In the present study, we investigated the role of the circadian clock gene Period2 (Per2) in endothelial function in a mouse model... - MPer1 and mper2 are essential for normal resetting of the circadian clockU Albrecht
Max Planck Institute for Experimental Endocrinology, Hannover, Germany
J Biol Rhythms 16:100-4. 2001..They conclude that the mammalian Per genes are not only light-responsive components of the circadian oscillator but also are involved in resetting of the circadian clock... - Placing ocular mutants into a functional context: a chronobiological approachUrs Albrecht
Division of Biochemistry, Department of Medicine, University of Fribourg, Rue du Musee 5, Switzerland
Methods 28:465-77. 2002..Such measurements have, and continue to provide, a remarkably powerful assay of how light is detected and transduced to regulate circadian rhythms. The methods used for such measurements in mice are described in the following article... - The mammalian circadian clock: a network of gene expressionUrs Albrecht
Department of Medicine, Division of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Front Biosci 9:48-55. 2004..In this review I will discuss the current understanding of the clock mechanism at the molecular level, how it adjusts to environmental changes and what the implications of a defect in the circadian clock are on mammalian physiology... - The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptorsIsabelle Schmutz
Department of Medicine, Unit of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Genes Dev 24:345-57. 2010..The concept that PER2 may propagate clock information to metabolic pathways via nuclear receptors adds an important facet to the clock-dependent regulation of biological networks... - Lack of calbindin-D28k alters response of the murine circadian clock to lightFrédéric Stadler
Department of Medicine, Unit of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Chronobiol Int 27:68-82. 2010..Period length and circadian rhythmicity were comparable between Calb1(-/-) and wild-type animals. Our findings indicate an involvement of CB in the signaling pathway that modulates the behavioral and molecular response to light... - Age-dependent alterations in human PER2 levels after early morning blue light exposureCorinne Jud
Department of Medicine, University of Fribourg, Switzerland
Chronobiol Int 26:1462-9. 2009..Additionally, our results indicate that the influence of light on clock-gene expression in humans is altered with age... - Life time-circadian clocks, mitochondria and metabolismSonja Langmesser
Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland
Chronobiol Int 23:151-7. 2006..In mitochondria, both metabolic and cellular defense mechanisms are carefully regulated. Abnormal clock function, might influence mitochondrial function, resulting in decreased fitness of an organism... - cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulnessSonja Langmesser
Division of Biochemistry, Department of Medicine, University of Fribourg, Fribourg, Switzerland
PLoS ONE 4:e4238. 2009..Moreover, PRKG1 deficiency results in an aberrant pattern, and consequently a reduced quality, of sleep and wakefulness, possibly due to a decreased wake-promoting output of the circadian system impinging upon sleep... - A switch from diurnal to nocturnal activity in S. ehrenbergi is accompanied by an uncoupling of light input and the circadian clockHenrik Oster
Department of Medicine, Division of Biochemistry, University of Fribourg, 1700, Fribourg, Switzerland
Curr Biol 12:1919-22. 2002..Hence, the strict coupling of light, Per expression, and the circadian clock is lost. This indicates that Spalax can dissociate the light-driven resetting pathway from the central clock oscillator... - Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin D-28k or bothMaria A Farré-Castany
Unit of Anatomy, Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
Behav Brain Res 178:250-61. 2007..In summary, the lack of these calcium-binding proteins yields characteristic, yet distinct phenotypes with respect to locomotor activity and coordination... - Evening exposure to blue light stimulates the expression of the clock gene PER2 in humansChristian Cajochen
Centre for Chronobiology, Psychiatric University Clinics, University of Basel, CH 4025 Basel, Switzerland
Eur J Neurosci 23:1082-6. 2006..The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders... - Fragile X-related proteins regulate mammalian circadian behavioral rhythmsJing Zhang
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Am J Hum Genet 83:43-52. 2008.... - Impaired daily glucocorticoid rhythm in Per1 ( Brd ) miceRobert Dallmann
Institute of Zoology, School of Veterinary Medicine Hannover, Hannover, Germany
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:769-75. 2006..In conclusion, our study presents first evidence for a link between an altered metabolism in Per1 and Per2 deficient mice, which in the case of the Per1 ( Brd ) animals might be due to an impaired corticosterone rhythm... - Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant miceCaroline Kopp
Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
Eur J Neurosci 16:1099-106. 2002..The results provide further evidence for the independence of the circadian and the homeostatic components underlying sleep regulation... - Circadian genes in a blind subterranean mammal II: conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi superspeciesAaron Avivi
Laboratory of Animal Molecular Evolution, Institute of Evolution, University of Haifa, Mount Carmel, Haifa 31905, Israel
Proc Natl Acad Sci U S A 99:11718-23. 2002.... - Spatial and temporal variation of passer Per2 gene expression in two distinct cell groups of the suprachiasmatic hypothalamus in the house sparrow (Passer domesticus)Ute Abraham
Max Planck Research Centre for Ornithology, Von-der-Tann-Str. 7, D-82346 Andechs, Germany
Eur J Neurosci 16:429-36. 2002.... - The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillatorNicolas Preitner
Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
Cell 110:251-60. 2002..While REV-ERBalpha influences the period length and affects the phase-shifting properties of the clock, it is not required for circadian rhythm generation... - Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light, and dynamics of Per1 and Per2 gene expression under long and short photoperiodsStephan Steinlechner
School of Veterinary Medicine of Hannover, Germany
J Biol Rhythms 17:202-9. 2002..Per1 could be part of a morning oscillator tracking dawn, and Per2 could be part of an evening oscillator tracking dusk... - The human PER1 gene is inducible by interleukin-6Dirk Motzkus
IPF PharmaCeuticals GmbH, Hannover, Germany
J Mol Neurosci 18:105-9. 2002..Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters... - Cocaine sensitization and reward are under the influence of circadian genes and rhythmCarolina Abarca
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
Proc Natl Acad Sci U S A 99:9026-30. 2002..In conclusion, we demonstrate that processes involved in cocaine addiction depend on the circadian rhythm and are modulated in an opposing manner by mPer1 and mPer2 genes... - Hypothalamic circadian organization in birds. II. Clock gene expressionUte Abraham
Max-Planck Research Centre for Ornithology, Andechs, Germany
Chronobiol Int 20:657-69. 2003..Certain changes in peak expression levels and the expression phase, however, suggest that the pineal melatonin rhythm affects both the phase and the amplitude of rhythmic hypothalamic pPer2 expression... - Circadian genes in a blind subterranean mammal III: molecular cloning and circadian regulation of cryptochrome genes in the blind subterranean mole rat, Spalax ehrenbergi superspeciesAaron Avivi
Laboratory of Animal Molecular Evolution, Institute of Evolution, University of Haifa, Mount Carmel, Haifa 31905, Israel
J Biol Rhythms 19:22-34. 2004..Once again, the results indicate that the uniquely hypertrophied harderian gland of Spalax plays a key role in its circadian system... - Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2Sowmya V Yelamanchili
AG Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, 10115 Berlin, Germany
J Biol Chem 281:15671-9. 2006..A reduced amount of VGLUT1 per vesicle is probably achieved by means of selective sorting controlled by clock genes... - Restoration of circadian rhythmicity in circadian clock-deficient mice in constant lightDiya Abraham
Max-Planck Institute of Experimental Endocrinology, Hannover, Germany
J Biol Rhythms 21:169-76. 2006.... - The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nucleiMariska J Vansteensel
Department of Neurophysiology, Leiden University Medical Centre, Wassenaarseweg 62, PO Box 9604, 2300 RC Leiden, The Netherlands
Eur J Neurosci 21:2958-66. 2005..This suggests that the pathways regulating addictive behaviour and the circadian clock intersect... - Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant miceTarek Zghoul
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159, Mannheim, Germany
Psychopharmacology (Berl) 190:13-9. 2007..Objective To further complement the mPer2 study, our lab proceeded to assess mPer1's possible role on alcohol intake using operant and free choice two bottle paradigms... - Lack of food anticipation in Per2 mutant miceCeline A Feillet
Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, University Louis Pasteur, Centre National de la Recherche Scientifique, 67084 Strasbourg, France
Curr Biol 16:2016-22. 2006..In conclusion, a mutation in Per2 abolishes anticipation of mealtime, without interfering with peripheral synchronization by feeding cycles... - Per2 has time on its sideUrs Albrecht
Nat Chem Biol 3:139-40. 2007 - "Feeding time" for the brain: a matter of clocksCeline A Feillet
Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, University Louis Pasteur and CNRS, 67084 Strasbourg, France
J Physiol Paris 100:252-60. 2006..We also describe several neurochemical pathways, including orexinergic and noradrenergic, likely to participate in conveying inputs to and outputs from the FEC to control anticipatory processes... - The clock gene Per2 influences the glutamatergic system and modulates alcohol consumptionRainer Spanagel
Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Nat Med 11:35-42. 2005..Collectively, these data establish glutamate as a link between dysfunction of the circadian clock gene Per2 and enhanced alcohol intake... - Phase responses to light pulses in mice lacking functional per or cry genesKamiel Spoelstra
Zoological Laboratory, University of Groningen, The Netherlands
J Biol Rhythms 19:518-29. 2004..In general, mPer2(Brdm1) mutant mice were more accelerated by light compared to mPer1(Brdm1) and wildtype control mice, whereas mCry1(-/-) mice were more delayed by light than were mCry2(-/-) mice... - Forebrain oscillators ticking with different clock handsCeline A Feillet
Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, IFR37, University Louis Pasteur, 67084 Strasbourg, France
Mol Cell Neurosci 37:209-21. 2008..Our results suggest that there is not one single cerebral clock, but a system of multiple brain oscillators ticking with different clock hands and differentially sensitive to nutritional cues... - The period length of fibroblast circadian gene expression varies widely among human individualsSteven A Brown
Department of Molecular Biology, University of Geneva, Geneva, Switzerland
PLoS Biol 3:e338. 2005..Given its robustness, the presented procedure should permit quantitative trait mapping of human period length...