Research Topics
Genomes and Genes | Mubeccel AkdisSummaryAffiliation: University of Zurich Country: Switzerland Publications
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Publications
Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitisM Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
J Immunol 163:466-75. 1999..These results indicate that in addition to the CD4+ subset, the CD8+CLA+ memory/effector T cells are capable of responding to superantigenic stimulation and play an important role in the pathogenesis of AD...- Healthy immune response to allergens: T regulatory cells and moreMubeccel Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
Curr Opin Immunol 18:738-44. 2006.... - T cells and effector mechanisms in the pathogenesis of atopic dermatitisMubeccel Akdis
Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
Curr Allergy Asthma Rep 2:1-3. 2002 - T regulatory cells in allergyMubeccel Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Chem Immunol Allergy 91:159-73. 2006..It is associated with regulation of antibody isotypes and effector cells to the direction of a healthy immune response and opens a window for novel therapies of allergic diseases... - T-cell tolerance to inhaled allergens: mechanisms and therapeutic approachesMubeccel Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
Expert Opin Biol Ther 8:769-77. 2008..Specific immune response to allergens is decisive in the development of clinically healthy or allergic states... - Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergensC A Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Int Arch Allergy Immunol 124:180-2. 2001.... - Expression of cutaneous lymphocyte-associated antigen on human CD4(+) and CD8(+) Th2 cellsM Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Eur J Immunol 30:3533-41. 2000..In addition, CLA could be re-induced on T cells that had lost CLA expression upon resting. These results suggest that skin-selective homing is not restricted to functional and phenotypic T cell subsets... - Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cellsMubeccel Akdis
Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
J Exp Med 199:1567-75. 2004..These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy... - T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cellsMubeccel Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
FASEB J 17:1026-35. 2003..These results define a novel mechanism for peripheral Th2 response in atopic diseases... - Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopesFariba Karamloo
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Eur J Immunol 35:3268-76. 2005.... - IL-10 suppresses CD2-mediated T cell activation via SHP-1Alison Taylor
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Mol Immunol 46:622-9. 2009..In conclusion, SHP-1-mediated inhibition of CD2 signaling represents a novel mechanism for direct T cell suppression by IL-10... - In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposureFlurina Meiler
Swiss Institute of Allergy and Asthma Research, University of Zurich, 7270 Davos, Switzerland
J Exp Med 205:2887-98. 2008..Thus, rapid switch and expansion of IL-10-producing Tr1 cells and the use of multiple suppressive factors represent essential mechanisms in immune tolerance to a high dose of allergens in nonallergic individuals... - Are regulatory T cells the target of venom immunotherapy?Marek Jutel
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
Curr Opin Allergy Clin Immunol 5:365-9. 2005..T-regulatory (TReg) cells are involved in preventing sensitization to allergens and represent a major target for venom- or other allergen-specific immunotherapy... - Human NK1 and NK2 subsets determined by purification of IFN-gamma-secreting and IFN-gamma-nonsecreting NK cellsGunnur Deniz
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Eur J Immunol 32:879-84. 2002..These results demonstrate that circulating NK cells retain effector subsets in humans with distinct cytokine profiles and may display different inflammatory properties... - Role of Treg in immune regulation of allergic diseasesOscar Palomares
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
Eur J Immunol 40:1232-40. 2010..The identification of the molecules involved in these processes will contribute to the development of more efficient and safer treatment modalities... - Inhibition of angiogenesis by IL-32: possible role in asthmaNorbert Meyer
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
J Allergy Clin Immunol 129:964-73.e7. 2012..Chronic airway inflammation in asthmatic patients results in structural airway changes, including angiogenesis. Vascular endothelial growth factor (VEGF) is a key inducer of angiogenesis in the airways of asthmatic patients... - Mechanisms of immune tolerance to allergensHiroyuki Fujita
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
Chem Immunol Allergy 96:30-8. 2012..Knowledge of this molecular basis is crucial to understanding the regulation of the immune response and their possible therapeutic applications for allergic diseases... - IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapyMarek Jutel
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Eur J Immunol 33:1205-14. 2003..Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens... - A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapyFatimah Kussebi
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
J Allergy Clin Immunol 115:323-9. 2005..Differences between epitopes of IgE that recognize the 3-dimensional structure of allergens and T cells that recognize linear amino acid sequences provide a suitable tool for novel vaccine development for specific immunotherapy... - Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjectsHiroyuki Fujita
Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 127:1612-21.e8. 2011..Tight junction (TJ) proteins, which are expressed in endothelial and epithelial cells and affect tissue integrity, might exist in other types of cells and display additional functions in the asthmatic lung... - Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseasesTunc Akkoc
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
J Allergy Clin Immunol 121:652-658.e1. 2008..Increased activation and massive infiltration of T cells in the dermis without any evidence for the expansion of their numbers in peripheral blood characterize atopic dermatitis... - Mechanisms of allergen-specific immunotherapyCezmi A Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Chem Immunol Allergy 91:195-203. 2006..By the application of the recent knowledge in mechanisms of allergen-SIT, more rational and safer approaches are awaiting in the future for the prevention and cure of allergic diseases... - IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1Alison Taylor
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
J Allergy Clin Immunol 120:76-83. 2007..Specific T-cell activation requires T-cell receptor stimulation and the generation of costimulatory signals. Major costimulatory signals are delivered to T cells by the interaction of CD28 and inducible costimulator (ICOS)... - A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis inSven Klunker
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
J Immunol 171:1078-84. 2003..Keratinocytes undergoing apoptosis in acute eczematous lesions release chemokines that attract more T cells toward the epidermis, which may further augment the inflammation and keratinocyte apoptosis... - Regulatory effects of histamine and histamine receptor expression in human allergic immune responsesCezmi A Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Chem Immunol Allergy 94:67-82. 2008..In addition, differences in affinities of these receptors for histamine are highly decisive for the biological effects of histamine and drugs that target histamine receptors... - Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseasesMubeccel Akdis
Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 127:701-21.e1-70. 2011..We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections... - Mechanisms and treatment of allergic disease in the big picture of regulatory T cellsCezmi A Akdis
Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009..Current strategies for drug development and allergen-specific immunotherapy exploit these observations, with the potential for preventive therapies and cure for allergic diseases... - Therapeutic manipulation of immune tolerance in allergic diseaseMubeccel Akdis
Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos Platz, Switzerland
Nat Rev Drug Discov 8:645-60. 2009..This Review highlights current knowledge of immunomodulatory therapies for the manipulation of immune tolerance and highlights recent approaches to improve allergen-specific immunotherapy for the treatment of allergic diseases... - Novel immunotherapeutic approaches for allergy and asthmaLiam O'Mahony
Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
Autoimmunity 43:493-503. 2010..This review will discuss novel approaches to the management of allergy and asthma by targeting the T regulatory cell via modulation of the commensal microbiota and allergen-SIT... - TH17 cells in the big picture of immunologyCarsten B Schmidt-Weber
Swiss Institute of Allergy and Asthma Research, Switzerland
J Allergy Clin Immunol 120:247-54. 2007..This review summarizes the recent developments on T(H) cell subsets and integrates these findings into existing concepts of immunopathologic mechanisms... - Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral toleranceOscar Palomares
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 129:510-20, 520.e1-9. 2012..Tonsillectomy removes only the palatine tonsils and sometimes adenoids. Lingual tonsil is anatomically big and remains lifelong intact... - Apoptosis and loss of adhesion of bronchial epithelial cells in asthmaAxel Trautmann
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Int Arch Allergy Immunol 138:142-50. 2005..Since EC shedding is a histologic hallmark of asthma, the intercellular junction of EC may be a target of pro-inflammatory cytokines... - IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitisNorbert Meyer
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland High altitude Clinic of Davos, Davos Wolfgang, Switzerland
J Allergy Clin Immunol 125:858-865.e10. 2010..IL-32 is a proinflammatory cytokine that is involved in the inflammatory processes of rheumatoid arthritis, chronic obstructive pulmonary disease, and Crohn disease. Recently, it was shown that upregulation of IL-32 induces apoptosis... - Absence of T-regulatory cell expression and function in atopic dermatitis skinJohan Verhagen
Swiss Institute of Allergy and Asthma Research, Davos Platz, Switzerland
J Allergy Clin Immunol 117:176-83. 2006.... - T regulatory cells in allergy and health: a question of allergen specificity and balanceAlison Taylor
Swiss Institute of Allergy and Asthma Research (SIAF, Obere Strasse 22, CH-7270 Davos, Switzerland
Int Arch Allergy Immunol 135:73-82. 2004..In conclusion, induction of antigen-specific T(Reg) cells may redirect an inappropriate immune response against allergen or autoantigens with the help of a broad range of suppressor mechanisms... - Mechanisms of allergen-specific immunotherapyMubeccel Akdis
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
J Allergy Clin Immunol 119:780-91. 2007..Current understanding of mechanisms of allergen-SIT, particularly the role of Treg cells in peripheral tolerance, may enable novel treatment strategies... - Immune tolerance in allergyMubeccel Akdis
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Obere Strasse 22, CH 7270 Davos Platz, Switzerland
Curr Opin Immunol 21:700-7. 2009..This review focuses on current knowledge of immune tolerance to allergens in healthy immune response to allergens and allergen-SIT... - Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cellsAlison Taylor
Swiss Institute of Allergy and Asthma Research (SIAF, Davos, Switzerland
Immunology 117:433-42. 2006..Induction of antigen-specific Tr1 cells can thus re-direct an inappropriate immune response against allergens or auto-antigens using a broad range of suppressor mechanisms... - Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus ReportCezmi A Akdis
Swiss Institute of Allergy and Asthma Research, Davos
J Allergy Clin Immunol 118:152-69. 2006..The consensus report is part of the PRACTALL initiative, which is endorsed by both academies... - Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptidesCezmi A Akdis
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
Eur J Immunol 33:2717-26. 2003..These results demonstrate that stimulation of TLR-2 by lipopeptides represents a novel way for possible treatment of allergy and asthma by regulating the disrupted cytokine balance... - Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitisAna Rebane
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 129:1297-306. 2012..Enhanced apoptosis of keratinocytes is the main cause of eczema and spongiosis in patients with the common inflammatory skin disease atopic dermatitis (AD)... - T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseasesMubeccel Akdis
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
J Allergy Clin Immunol 116:961-8; quiz 969. 2005..Current strategies for drug development and allergen-specific immunotherapy exploit these observations with the potential to provide cure for allergic diseases... - The cellular orchestra in skin allergy; are differences to lung and nose relevant?Mubeccel Akdis
2Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Curr Opin Allergy Clin Immunol 10:443-51. 2010.... - Immune regulation by histamineMarek Jutel
Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
Curr Opin Immunol 14:735-40. 2002..Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals... - Regulation of the immune response and inflammation by histamine and histamine receptorsLiam O'Mahony
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 128:1153-62. 2011.... - T regulatory cells and allergyAlison Taylor
Swiss Institute of Allergy and Asthma Research (SIAF, Davos, Switzerland
Microbes Infect 7:1049-55. 2005..By utilizing multiple secreted cytokines and surface molecules, antigen-specific T(Reg) cells may re-direct an inappropriate immune response against allergens or auto-antigens... - T regulatory cells in allergen-specific immunotherapyJohan Verhagen
Swiss Institute of Allergy and Asthma Research (SIAF, Davos, Switzerland
Int Rev Immunol 24:533-48. 2005..Mechanisms underlying allergen-SIT and in particular the role of regulatory T cells will be discussed in this review, based on recent findings and current concepts... - Apoptosis in tissue inflammation and allergic diseaseCezmi A Akdis
Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH-7270 Davos, Switzerland
Curr Opin Immunol 16:717-23. 2004..In individuals with non-atopic monoallergic disease, by contrast, a disturbed balance towards allergen-specific Th2 cells instead of T regulatory type 1 (Tr1) cells characterizes the T cell response... - TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protectionMubeccel Akdis
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 129:1438-49; quiz1450-1. 2012.... - Mechanisms of allergen-specific immunotherapyHiroyuki Fujita
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
Clin Transl Allergy 2:2. 2012..Knowledge of these molecular basis is crucial in the understanding the regulation of immune responses and their possible therapeutic targets in allergic diseases... - Mechanisms of allergen-specific immunotherapyCezmi A Akdis
Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 127:18-27; quiz 28-9. 2011..New strategies for immune intervention will likely include targeting of the molecular mechanisms of allergen tolerance and reciprocal regulation of effector and Treg cell subsets... - Mechanisms of allergen-specific immunotherapy: T-regulatory cells and moreJohan Verhagen
Swiss Institute of Allergy and Asthma Research (SIAF, Obere Strasse 22, CH-7270 Davos, Switzerland
Immunol Allergy Clin North Am 26:207-31, vi. 2006..The application of current knowledge of Treg cells and related mechanisms of peripheral tolerance may soon lead to more rational and safer approaches to the prevention and cure of allergic disease... - Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthmaChristian Karagiannidis
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
J Allergy Clin Immunol 114:1425-33. 2004..Strategies that convert transient glucocorticoid-induced T reg activity into a stable phenotype might improve allergy and asthma therapy... - T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthmaAxel Trautmann
Swiss Institute of Allergy and Asthma Research (SIAF, Davos, Switzerland
J Allergy Clin Immunol 109:329-37. 2002..Furthermore, we demonstrated in situ apoptotic features of ECs in bronchial biopsy specimens of asthmatic patients. CONCLUSION: T cell- and eosinophil-induced apoptosis represents a key pathogenic event leading to EC shedding in asthma... - Advances in allergen-specific immunotherapyJohan Verhagen
Swiss Institute of Allergy and Asthma Research (SIAF, CH-7270 Davos, Switzerland
Expert Opin Biol Ther 5:537-44. 2005.... - Targets in allergy-directed immunotherapyJohan Verhagen
Swiss Institute of Allergy and Asthma Research, CH-7270 Davos, Switzerland
Expert Opin Ther Targets 9:217-24. 2005..Recent advances in our knowledge of immunological mechanisms have created several options to comply with these demands. This article will focus on some of the most promising new developments...