Mubeccel Akdis

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    Flurina Meiler
    Swiss Institute of Allergy and Asthma Research, University of Zurich, 7270 Davos, Switzerland
    J Exp Med 205:2887-98. 2008
  2. ncbi T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Expert Opin Biol Ther 8:769-77. 2008
  3. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
  4. ncbi T regulatory cells in allergy
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:159-73. 2006
  5. ncbi T cells and effector mechanisms in the pathogenesis of atopic dermatitis
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Allergy Asthma Rep 2:1-3. 2002
  6. ncbi Healthy immune response to allergens: T regulatory cells and more
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 18:738-44. 2006
  7. ncbi Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergens
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 124:180-2. 2001
  8. ncbi Expression of cutaneous lymphocyte-associated antigen on human CD4(+) and CD8(+) Th2 cells
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 30:3533-41. 2000
  9. ncbi Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Immunol 163:466-75. 1999
  10. ncbi T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 109:329-37. 2002

Detail Information

Publications60

  1. pmc In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    Flurina Meiler
    Swiss Institute of Allergy and Asthma Research, University of Zurich, 7270 Davos, Switzerland
    J Exp Med 205:2887-98. 2008
    ..Thus, rapid switch and expansion of IL-10-producing Tr1 cells and the use of multiple suppressive factors represent essential mechanisms in immune tolerance to a high dose of allergens in nonallergic individuals...
  2. ncbi T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Expert Opin Biol Ther 8:769-77. 2008
    ..Specific immune response to allergens is decisive in the development of clinically healthy or allergic states...
  3. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
    ..These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy...
  4. ncbi T regulatory cells in allergy
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:159-73. 2006
    ..It is associated with regulation of antibody isotypes and effector cells to the direction of a healthy immune response and opens a window for novel therapies of allergic diseases...
  5. ncbi T cells and effector mechanisms in the pathogenesis of atopic dermatitis
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Allergy Asthma Rep 2:1-3. 2002
  6. ncbi Healthy immune response to allergens: T regulatory cells and more
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 18:738-44. 2006
    ....
  7. ncbi Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergens
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 124:180-2. 2001
    ....
  8. ncbi Expression of cutaneous lymphocyte-associated antigen on human CD4(+) and CD8(+) Th2 cells
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 30:3533-41. 2000
    ..In addition, CLA could be re-induced on T cells that had lost CLA expression upon resting. These results suggest that skin-selective homing is not restricted to functional and phenotypic T cell subsets...
  9. ncbi Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Immunol 163:466-75. 1999
    ..These results indicate that in addition to the CD4+ subset, the CD8+CLA+ memory/effector T cells are capable of responding to superantigenic stimulation and play an important role in the pathogenesis of AD...
  10. ncbi T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 109:329-37. 2002
    ..Asthma is an inflammatory airway disease associated with an infiltration of T cells and eosinophils, increased levels of pro-inflammatory cytokines, and shedding of bronchial epithelial cells (ECs)...
  11. ncbi Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes
    Fariba Karamloo
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 35:3268-76. 2005
    ....
  12. ncbi T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    FASEB J 17:1026-35. 2003
    ..These results define a novel mechanism for peripheral Th2 response in atopic diseases...
  13. doi Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood
    Umut Can Kucuksezer
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 131:875-85. 2013
    ..Breaking of peripheral T-cell tolerance to allergens can lead to the development of allergies, but the mechanisms are not completely understood...
  14. doi IL-10 suppresses CD2-mediated T cell activation via SHP-1
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Mol Immunol 46:622-9. 2009
    ..In conclusion, SHP-1-mediated inhibition of CD2 signaling represents a novel mechanism for direct T cell suppression by IL-10...
  15. ncbi Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    Christian Karagiannidis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 114:1425-33. 2004
    ..The loss of peripheral tolerance against allergens causes diseases that can be therapeutically controlled with glucocorticoids...
  16. doi Role of Treg in immune regulation of allergic diseases
    Oscar Palomares
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Eur J Immunol 40:1232-40. 2010
    ..The identification of the molecules involved in these processes will contribute to the development of more efficient and safer treatment modalities...
  17. ncbi Absence of T-regulatory cell expression and function in atopic dermatitis skin
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research, Davos Platz, Switzerland
    J Allergy Clin Immunol 117:176-83. 2006
    ..Increasing the number and activity of regulatory T cells in affected organs has been suggested as a remedy in various inflammatory diseases, including allergy...
  18. ncbi Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Eur J Immunol 33:2717-26. 2003
    ..These results demonstrate that stimulation of TLR-2 by lipopeptides represents a novel way for possible treatment of allergy and asthma by regulating the disrupted cytokine balance...
  19. doi Inhibition of angiogenesis by IL-32: possible role in asthma
    Norbert Meyer
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 129:964-73.e7. 2012
    ..Chronic airway inflammation in asthmatic patients results in structural airway changes, including angiogenesis. Vascular endothelial growth factor (VEGF) is a key inducer of angiogenesis in the airways of asthmatic patients...
  20. pmc Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Immunology 117:433-42. 2006
    ..Induction of antigen-specific Tr1 cells can thus re-direct an inappropriate immune response against allergens or auto-antigens using a broad range of suppressor mechanisms...
  21. ncbi T regulatory cells in allergy and health: a question of allergen specificity and balance
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Int Arch Allergy Immunol 135:73-82. 2004
    ..In conclusion, induction of antigen-specific T(Reg) cells may redirect an inappropriate immune response against allergen or autoantigens with the help of a broad range of suppressor mechanisms...
  22. ncbi Are regulatory T cells the target of venom immunotherapy?
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Curr Opin Allergy Clin Immunol 5:365-9. 2005
    ..T-regulatory (TReg) cells are involved in preventing sensitization to allergens and represent a major target for venom- or other allergen-specific immunotherapy...
  23. ncbi Human NK1 and NK2 subsets determined by purification of IFN-gamma-secreting and IFN-gamma-nonsecreting NK cells
    Gunnur Deniz
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 32:879-84. 2002
    ..These results demonstrate that circulating NK cells retain effector subsets in humans with distinct cytokine profiles and may display different inflammatory properties...
  24. doi Mechanisms of immune tolerance to allergens
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Chem Immunol Allergy 96:30-8. 2012
    ..Knowledge of this molecular basis is crucial to understanding the regulation of the immune response and their possible therapeutic applications for allergic diseases...
  25. ncbi A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy
    Fatimah Kussebi
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 115:323-9. 2005
    ..Differences between epitopes of IgE that recognize the 3-dimensional structure of allergens and T cells that recognize linear amino acid sequences provide a suitable tool for novel vaccine development for specific immunotherapy...
  26. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    ..Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens...
  27. doi Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases
    Tunc Akkoc
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 121:652-658.e1. 2008
    ..Increased activation and massive infiltration of T cells in the dermis without any evidence for the expansion of their numbers in peripheral blood characterize atopic dermatitis...
  28. ncbi A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in
    Sven Klunker
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Immunol 171:1078-84. 2003
    ..Keratinocytes undergoing apoptosis in acute eczematous lesions release chemokines that attract more T cells toward the epidermis, which may further augment the inflammation and keratinocyte apoptosis...
  29. doi Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:1612-21.e8. 2011
    ..Tight junction (TJ) proteins, which are expressed in endothelial and epithelial cells and affect tissue integrity, might exist in other types of cells and display additional functions in the asthmatic lung...
  30. ncbi Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos
    J Allergy Clin Immunol 118:152-69. 2006
    ..The consensus report is part of the PRACTALL initiative, which is endorsed by both academies...
  31. ncbi T regulatory cells in allergen-specific immunotherapy
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Rev Immunol 24:533-48. 2005
    ..Mechanisms underlying allergen-SIT and in particular the role of regulatory T cells will be discussed in this review, based on recent findings and current concepts...
  32. ncbi T regulatory cells and allergy
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Microbes Infect 7:1049-55. 2005
    ..By utilizing multiple secreted cytokines and surface molecules, antigen-specific T(Reg) cells may re-direct an inappropriate immune response against allergens or auto-antigens...
  33. ncbi Mechanisms of allergen-specific immunotherapy
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:195-203. 2006
    ..By the application of the recent knowledge in mechanisms of allergen-SIT, more rational and safer approaches are awaiting in the future for the prevention and cure of allergic diseases...
  34. ncbi IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 120:76-83. 2007
    ..Specific T-cell activation requires T-cell receptor stimulation and the generation of costimulatory signals. Major costimulatory signals are delivered to T cells by the interaction of CD28 and inducible costimulator (ICOS)...
  35. ncbi Apoptosis in tissue inflammation and allergic disease
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 16:717-23. 2004
    ..In individuals with non-atopic monoallergic disease, by contrast, a disturbed balance towards allergen-specific Th2 cells instead of T regulatory type 1 (Tr1) cells characterizes the T cell response...
  36. doi IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses
    Willem Van De Veen
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 131:1204-12. 2013
    ..IgG4 is a blocking antibody isotype with anti-inflammatory potential that is induced in human high-dose antigen tolerance models...
  37. doi Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:701-21.e1-70. 2011
    ..We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections...
  38. doi Regulatory effects of histamine and histamine receptor expression in human allergic immune responses
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 94:67-82. 2008
    ..In addition, differences in affinities of these receptors for histamine are highly decisive for the biological effects of histamine and drugs that target histamine receptors...
  39. doi IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis
    Norbert Meyer
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland High altitude Clinic of Davos, Davos Wolfgang, Switzerland
    J Allergy Clin Immunol 125:858-865.e10. 2010
    ..IL-32 is a proinflammatory cytokine that is involved in the inflammatory processes of rheumatoid arthritis, chronic obstructive pulmonary disease, and Crohn disease. Recently, it was shown that upregulation of IL-32 induces apoptosis...
  40. pmc Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
    Sven Klunker
    Swiss Institute of Allergy and Asthma Research Davos, University of Zurich, CH 7270 Davos Platz, Switzerland
    J Exp Med 206:2701-15. 2009
    ..Furthermore, FOXP3 and RUNX3 were colocalized in human tonsil T reg cells. These data demonstrate Runx transcription factors as a molecular link in TGF-beta-induced Foxp3 expression in iT reg cell differentiation and function...
  41. doi Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland Electronic address
    J Allergy Clin Immunol 133:621-31. 2014
    ....
  42. ncbi Mechanisms of allergen-specific immunotherapy: T-regulatory cells and more
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunol Allergy Clin North Am 26:207-31, vi. 2006
    ..The application of current knowledge of Treg cells and related mechanisms of peripheral tolerance may soon lead to more rational and safer approaches to the prevention and cure of allergic disease...
  43. ncbi Advances in allergen-specific immunotherapy
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research SIAF, CH 7270 Davos, Switzerland
    Expert Opin Biol Ther 5:537-44. 2005
    ....
  44. ncbi Targets in allergy-directed immunotherapy
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research, CH 7270 Davos, Switzerland
    Expert Opin Ther Targets 9:217-24. 2005
    ..Recent advances in our knowledge of immunological mechanisms have created several options to comply with these demands. This article will focus on some of the most promising new developments...
  45. doi TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protection
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 129:1438-49; quiz1450-1. 2012
    ....
  46. ncbi Therapeutic manipulation of immune tolerance in allergic disease
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos Platz, Switzerland
    Nat Rev Drug Discov 8:645-60. 2009
    ..This Review highlights current knowledge of immunomodulatory therapies for the manipulation of immune tolerance and highlights recent approaches to improve allergen-specific immunotherapy for the treatment of allergic diseases...
  47. ncbi TH17 cells in the big picture of immunology
    Carsten B Schmidt-Weber
    Swiss Institute of Allergy and Asthma Research, Switzerland
    J Allergy Clin Immunol 120:247-54. 2007
    ..This review summarizes the recent developments on T(H) cell subsets and integrates these findings into existing concepts of immunopathologic mechanisms...
  48. doi Novel immunotherapeutic approaches for allergy and asthma
    Liam O'Mahony
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Autoimmunity 43:493-503. 2010
    ..This review will discuss novel approaches to the management of allergy and asthma by targeting the T regulatory cell via modulation of the commensal microbiota and allergen-SIT...
  49. doi Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009
    ..Current strategies for drug development and allergen-specific immunotherapy exploit these observations, with the potential for preventive therapies and cure for allergic diseases...
  50. doi Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance
    Oscar Palomares
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 129:510-20, 520.e1-9. 2012
    ..Tonsillectomy removes only the palatine tonsils and sometimes adenoids. Lingual tonsil is anatomically big and remains lifelong intact...
  51. ncbi Apoptosis and loss of adhesion of bronchial epithelial cells in asthma
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 138:142-50. 2005
    ..Since EC shedding is a histologic hallmark of asthma, the intercellular junction of EC may be a target of pro-inflammatory cytokines...
  52. ncbi Immune regulation by histamine
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 14:735-40. 2002
    ..Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals...
  53. ncbi Mechanisms of allergen-specific immunotherapy
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 119:780-91. 2007
    ..Current understanding of mechanisms of allergen-SIT, particularly the role of Treg cells in peripheral tolerance, may enable novel treatment strategies...
  54. doi Immune tolerance in allergy
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Obere Strasse 22, CH 7270 Davos Platz, Switzerland
    Curr Opin Immunol 21:700-7. 2009
    ..This review focuses on current knowledge of immune tolerance to allergens in healthy immune response to allergens and allergen-SIT...
  55. doi Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis
    Ana Rebane
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 129:1297-306. 2012
    ..Enhanced apoptosis of keratinocytes is the main cause of eczema and spongiosis in patients with the common inflammatory skin disease atopic dermatitis (AD)...
  56. ncbi T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 116:961-8; quiz 969. 2005
    ..Current strategies for drug development and allergen-specific immunotherapy exploit these observations with the potential to provide cure for allergic diseases...
  57. doi The cellular orchestra in skin allergy; are differences to lung and nose relevant?
    Mubeccel Akdis
    2Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Curr Opin Allergy Clin Immunol 10:443-51. 2010
    ....
  58. doi Regulation of the immune response and inflammation by histamine and histamine receptors
    Liam O'Mahony
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 128:1153-62. 2011
    ....
  59. pmc Mechanisms of allergen-specific immunotherapy
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Clin Transl Allergy 2:2. 2012
    ..Knowledge of these molecular basis is crucial in the understanding the regulation of immune responses and their possible therapeutic targets in allergic diseases...
  60. doi Mechanisms of allergen-specific immunotherapy
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:18-27; quiz 28-9. 2011
    ..New strategies for immune intervention will likely include targeting of the molecular mechanisms of allergen tolerance and reciprocal regulation of effector and Treg cell subsets...