Cezmi A Akdis

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis
    Atil Bisgin
    Department of Medical Genetics, Human Gene and Cell Therapy Center of Akdeniz University Hospitals and Clinics, Antalya, Turkey
    BMC Musculoskelet Disord 11:192. 2010
  2. pmc Nature of regulatory T cells in the context of allergic disease
    Cevdet Ozdemir
    Division of Pediatric Allergy and Immunology, Istanbul, Turkey
    Allergy Asthma Clin Immunol 4:106-10. 2008
  3. ncbi Bypassing IgE and targeting T cells for specific immunotherapy of allergy
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, CH 7270 Davos, Switzerland
    Trends Immunol 22:175-8. 2001
  4. doi Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009
  5. ncbi Immune regulation in atopic dermatitis
    C A Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 12:641-6. 2000
  6. ncbi Immune regulation by histamine H4 receptors in skin
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Invest Dermatol 128:1615-6. 2008
  7. doi Regulatory effects of histamine and histamine receptor expression in human allergic immune responses
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 94:67-82. 2008
  8. ncbi Cytokine network and dysregulated apoptosis in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Acta Odontol Scand 59:178-82. 2001
  9. ncbi Role of IL-10 in allergen-specific immunotherapy and normal response to allergens
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, 7270 Davos, Switzerland
    Microbes Infect 3:891-8. 2001
  10. doi Mechanisms of allergen-specific immunotherapy
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:18-27; quiz 28-9. 2011

Detail Information

Publications122 found, 100 shown here

  1. pmc TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis
    Atil Bisgin
    Department of Medical Genetics, Human Gene and Cell Therapy Center of Akdeniz University Hospitals and Clinics, Antalya, Turkey
    BMC Musculoskelet Disord 11:192. 2010
    ....
  2. pmc Nature of regulatory T cells in the context of allergic disease
    Cevdet Ozdemir
    Division of Pediatric Allergy and Immunology, Istanbul, Turkey
    Allergy Asthma Clin Immunol 4:106-10. 2008
    ..Additionally, SIT reduces the number of mast cells and eosinophils in the target tissues and release of mediators from these cells...
  3. ncbi Bypassing IgE and targeting T cells for specific immunotherapy of allergy
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, CH 7270 Davos, Switzerland
    Trends Immunol 22:175-8. 2001
    ..Here, the underlying mechanisms and principles of allergen modification for the future use of SIT in the treatment of allergy are discussed...
  4. doi Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009
    ..Current strategies for drug development and allergen-specific immunotherapy exploit these observations, with the potential for preventive therapies and cure for allergic diseases...
  5. ncbi Immune regulation in atopic dermatitis
    C A Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 12:641-6. 2000
    ..T cell survival is enhanced in the skin by cytokines and extracellular-matrix proteins. These activated T cells induce keratinocyte apoptosis, leading to eczema formation...
  6. ncbi Immune regulation by histamine H4 receptors in skin
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Invest Dermatol 128:1615-6. 2008
    ..In this issue, Dijkstra et al., demonstrate the expression and some of the functions of histamine H(4) receptors on inflammatory dendritic cells in atopic dermatitis skin...
  7. doi Regulatory effects of histamine and histamine receptor expression in human allergic immune responses
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 94:67-82. 2008
    ..In addition, differences in affinities of these receptors for histamine are highly decisive for the biological effects of histamine and drugs that target histamine receptors...
  8. ncbi Cytokine network and dysregulated apoptosis in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Acta Odontol Scand 59:178-82. 2001
    ....
  9. ncbi Role of IL-10 in allergen-specific immunotherapy and normal response to allergens
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, 7270 Davos, Switzerland
    Microbes Infect 3:891-8. 2001
    ..IL-10 elicits anergy in T cells by selective inhibition of the CD28 costimulatory pathway and controls suppression and development of antigen-specific immunity...
  10. doi Mechanisms of allergen-specific immunotherapy
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:18-27; quiz 28-9. 2011
    ..New strategies for immune intervention will likely include targeting of the molecular mechanisms of allergen tolerance and reciprocal regulation of effector and Treg cell subsets...
  11. ncbi Regulation of specific immune responses by chemical and structural modifications of allergens
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 121:261-9. 2000
    ..Moreover, non-IgE-binding short T cell epitope peptides and single-amino-acid-altered peptide ligands represent potential candidates for future SIT...
  12. ncbi T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos
    J Invest Dermatol 113:628-34. 1999
    ..These data suggest, although high numbers of T cells are present in lesional skin of both types, a lack of interleukin-13-induced B cell activation and consequent immunoglobulin E production in nonallergic atopic dermatitis...
  13. ncbi Glucocorticoids inhibit human antigen-specific and enhance total IgE and IgG4 production due to differential effects on T and B cells in vitro
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 27:2351-7. 1997
    ....
  14. ncbi Histamine receptors are hot in immunopharmacology
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Eur J Pharmacol 533:69-76. 2006
    ..This article highlights recent discoveries in histamine immunobiology and discusses their relevance in allergic inflammation...
  15. ncbi Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants
    C A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Eur J Immunol 28:914-25. 1998
    ..These features may enable new applications for safer immunotherapy...
  16. ncbi Future of allergen-specific immunotherapy: better understanding of the mechanisms, novel treatments, and long-term cure
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos Platz, Switzerland
    Immunol Allergy Clin North Am 26:xiii-xxii. 2006
  17. ncbi Mechanisms of allergen-specific immunotherapy
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:195-203. 2006
    ..By the application of the recent knowledge in mechanisms of allergen-SIT, more rational and safer approaches are awaiting in the future for the prevention and cure of allergic diseases...
  18. ncbi IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy
    C A Akdis
    Swiss Institute of Allergy and Asthma Research, CH 7270 Davos, Switzerland
    FASEB J 13:603-9. 1999
    ..Furthermore, knowledge of the mechanisms explaining reasons for success or failure of SIT may enable possible predictive measures of the treatment...
  19. ncbi Regulation of allergic inflammation by skin-homing T cells in allergic eczema
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 118:140-4. 1999
    ..In both atopic dermatitis (AD) and contact dermatitis (CD), T cells specific to skin-related allergens were confined to the CLA+ T cell population. Our research was aimed to further characterize these T cells in AD...
  20. ncbi T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 116:961-8; quiz 969. 2005
    ..Current strategies for drug development and allergen-specific immunotherapy exploit these observations with the potential to provide cure for allergic diseases...
  21. ncbi Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes
    Fariba Karamloo
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 35:3268-76. 2005
    ....
  22. doi RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter
    Simone Burgler
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Immunol 184:6161-9. 2010
    ..Together, this study identifies RORC2 as a polarizing factor in transcriptional cross-regulation and provides novel viewpoints on the control of immune tolerance versus effector immune responses...
  23. ncbi A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy
    Fatimah Kussebi
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 115:323-9. 2005
    ..Differences between epitopes of IgE that recognize the 3-dimensional structure of allergens and T cells that recognize linear amino acid sequences provide a suitable tool for novel vaccine development for specific immunotherapy...
  24. ncbi Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    Christian Karagiannidis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 114:1425-33. 2004
    ..The loss of peripheral tolerance against allergens causes diseases that can be therapeutically controlled with glucocorticoids...
  25. doi Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood
    Umut Can Kucuksezer
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 131:875-85. 2013
    ..Breaking of peripheral T-cell tolerance to allergens can lead to the development of allergies, but the mechanisms are not completely understood...
  26. doi Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells
    Kerstin Siegmund
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Immunol 182:2124-30. 2009
    ..In conclusion, the current study characterizes FOXP3-expressing CD8(+) T cells from human tonsils and shows that in vitro activation leads to FOXP3 expression in CD8(+) T cells and gain of suppressive activity...
  27. ncbi Apoptosis and loss of adhesion of bronchial epithelial cells in asthma
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 138:142-50. 2005
    ..Since EC shedding is a histologic hallmark of asthma, the intercellular junction of EC may be a target of pro-inflammatory cytokines...
  28. ncbi Regulatory NK cells suppress antigen-specific T cell responses
    Gunnur Deniz
    Institute of Experimental Medicine, Department of Immunology, Istanbul University, Istanbul, Turkey
    J Immunol 180:850-7. 2008
    ..These results demonstrate that a distinct small fraction of NK cells display regulatory functions in humans...
  29. doi Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases
    Tunc Akkoc
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 121:652-658.e1. 2008
    ..Increased activation and massive infiltration of T cells in the dermis without any evidence for the expansion of their numbers in peripheral blood characterize atopic dermatitis...
  30. doi IL-10 suppresses CD2-mediated T cell activation via SHP-1
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Mol Immunol 46:622-9. 2009
    ..In conclusion, SHP-1-mediated inhibition of CD2 signaling represents a novel mechanism for direct T cell suppression by IL-10...
  31. doi T-cell response to allergens
    Cevdet Ozdemir
    Division of Pediatric Allergy and Immunology, Marmara University, Istanbul, Turkey
    Chem Immunol Allergy 95:22-44. 2010
    ..This chapter is mainly focused on antigen presentation pathways and allergen-specific T-cell responses...
  32. doi Role of Treg in immune regulation of allergic diseases
    Oscar Palomares
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Eur J Immunol 40:1232-40. 2010
    ..The identification of the molecules involved in these processes will contribute to the development of more efficient and safer treatment modalities...
  33. pmc In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    Flurina Meiler
    Swiss Institute of Allergy and Asthma Research, University of Zurich, 7270 Davos, Switzerland
    J Exp Med 205:2887-98. 2008
    ..Thus, rapid switch and expansion of IL-10-producing Tr1 cells and the use of multiple suppressive factors represent essential mechanisms in immune tolerance to a high dose of allergens in nonallergic individuals...
  34. doi TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis
    Maya Zimmermann
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:200-7, 207.e1-10. 2011
    ....
  35. pmc Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms
    Patrycja Konieczna
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    PLoS ONE 8:e62617. 2013
    ..infantis-fed mice. Thus, CD103(+)RALDH(+) LP dendritic cells are important cellular targets for microbiota-associated effects on mucosal immunoregulation...
  36. pmc Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Immunology 117:433-42. 2006
    ..Induction of antigen-specific Tr1 cells can thus re-direct an inappropriate immune response against allergens or auto-antigens using a broad range of suppressor mechanisms...
  37. doi Histamine receptor 2 modifies dendritic cell responses to microbial ligands
    Remo Frei
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 132:194-204. 2013
    ..The induction of tolerance and protective immunity to microbes is significantly influenced by host- and microbiota-derived metabolites, such as histamine...
  38. ncbi T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    FASEB J 17:1026-35. 2003
    ..These results define a novel mechanism for peripheral Th2 response in atopic diseases...
  39. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
    ..These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy...
  40. ncbi Absence of T-regulatory cell expression and function in atopic dermatitis skin
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research, Davos Platz, Switzerland
    J Allergy Clin Immunol 117:176-83. 2006
    ..Increasing the number and activity of regulatory T cells in affected organs has been suggested as a remedy in various inflammatory diseases, including allergy...
  41. doi Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:1612-21.e8. 2011
    ..Tight junction (TJ) proteins, which are expressed in endothelial and epithelial cells and affect tissue integrity, might exist in other types of cells and display additional functions in the asthmatic lung...
  42. ncbi A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in
    Sven Klunker
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Immunol 171:1078-84. 2003
    ..Keratinocytes undergoing apoptosis in acute eczematous lesions release chemokines that attract more T cells toward the epidermis, which may further augment the inflammation and keratinocyte apoptosis...
  43. ncbi T cell phenotype in allergic asthma and atopic dermatitis
    Jan G Wohlfahrt
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 131:272-82. 2003
    ..In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pathogenesis of allergic diseases...
  44. ncbi Histamine in the immune regulation of allergic inflammation
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos
    J Allergy Clin Immunol 112:15-22. 2003
    ..This article highlights novel discoveries in histamine immunobiology and discusses clinical findings or disease models that indicate immune regulation by histamine...
  45. doi Differentiation and functional analysis of human T(H)17 cells
    Simone Burgler
    Swiss Institute for Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:588-95, 595.e1-7. 2009
    ..Regulatory T (Treg) cells, in contrast, suppress inflammatory and allergen-driven responses. Despite these disparate functions, both T-cell subsets have been shown to be dependent on TGF-beta for their development...
  46. doi Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4
    Michael B Soyka
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 130:1087-1096.e10. 2012
    ..The regulation of epithelial barrier function and TJ expression has not been extensively studied in patients with CRS and in the paranasal sinus epithelium thus far...
  47. doi Mechanisms of immune tolerance to allergens
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Chem Immunol Allergy 96:30-8. 2012
    ..Knowledge of this molecular basis is crucial to understanding the regulation of the immune response and their possible therapeutic applications for allergic diseases...
  48. doi Dual nature of T cell-epithelium interaction in chronic rhinosinusitis
    Tomasz M Basinski
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos 7270, Switzerland
    J Allergy Clin Immunol 124:74-80.e1-8. 2009
    ..T-cell infiltration of submucosa, release of proinflammatory cytokines leading to epithelial activation, and contributions to inflammation are observed in chronic rhinosinusitis (CRS)...
  49. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    ..Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens...
  50. ncbi Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Eur J Immunol 33:2717-26. 2003
    ..These results demonstrate that stimulation of TLR-2 by lipopeptides represents a novel way for possible treatment of allergy and asthma by regulating the disrupted cytokine balance...
  51. doi IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis
    Norbert Meyer
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland High altitude Clinic of Davos, Davos Wolfgang, Switzerland
    J Allergy Clin Immunol 125:858-865.e10. 2010
    ..IL-32 is a proinflammatory cytokine that is involved in the inflammatory processes of rheumatoid arthritis, chronic obstructive pulmonary disease, and Crohn disease. Recently, it was shown that upregulation of IL-32 induces apoptosis...
  52. ncbi T regulatory cells in allergy and health: a question of allergen specificity and balance
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Int Arch Allergy Immunol 135:73-82. 2004
    ..In conclusion, induction of antigen-specific T(Reg) cells may redirect an inappropriate immune response against allergen or autoantigens with the help of a broad range of suppressor mechanisms...
  53. doi Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:701-21.e1-70. 2011
    ..We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections...
  54. ncbi Are regulatory T cells the target of venom immunotherapy?
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Curr Opin Allergy Clin Immunol 5:365-9. 2005
    ..T-regulatory (TReg) cells are involved in preventing sensitization to allergens and represent a major target for venom- or other allergen-specific immunotherapy...
  55. pmc Portrait of an immunoregulatory Bifidobacterium
    Patrycja Konieczna
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos Platz, Switzerland
    Gut Microbes 3:261-6. 2012
    ..In addition, we discuss the potential DC subset-specific mechanisms, which could contribute to DC(REG) and T(REG) programming by specific gut microbes...
  56. doi Specific immunotherapy and turning off the T cell: how does it work?
    Cevdet Ozdemir
    Division of Pediatric Allergy and Immunology, Marmara University, Istanbul, Turkey
    Ann Allergy Asthma Immunol 107:381-92. 2011
    ..To examine T-regulatory (Treg) cell functions in allergic immune responses and their roles during allergen specific immunotherapy based on recent developments and current understanding of immune regulation...
  57. doi New insights into mechanisms of immunoregulation in 2007
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 122:700-9. 2008
    ..This review highlights key advances in immune regulation that were published in the Journal of Allergy and Clinical Immunology...
  58. ncbi IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 120:76-83. 2007
    ..Specific T-cell activation requires T-cell receptor stimulation and the generation of costimulatory signals. Major costimulatory signals are delivered to T cells by the interaction of CD28 and inducible costimulator (ICOS)...
  59. ncbi T regulatory cells in allergen-specific immunotherapy
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Rev Immunol 24:533-48. 2005
    ..Mechanisms underlying allergen-SIT and in particular the role of regulatory T cells will be discussed in this review, based on recent findings and current concepts...
  60. ncbi Immune regulation by histamine
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 14:735-40. 2002
    ..Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals...
  61. ncbi Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis
    A Trautmann
    Swiss Institute of Allergy and Asthma Research (SIAF, Davos, Switzerland
    J Allergy Clin Immunol 108:839-46. 2001
    ..CONCLUSION: These results demonstrate mechanisms of action of current treatment approaches and provide a future for more focused therapeutic applications...
  62. ncbi T cells and effector mechanisms in the pathogenesis of atopic dermatitis
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Allergy Asthma Rep 2:1-3. 2002
  63. doi IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses
    Willem Van De Veen
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 131:1204-12. 2013
    ..IgG4 is a blocking antibody isotype with anti-inflammatory potential that is induced in human high-dose antigen tolerance models...
  64. ncbi TH17 cells in the big picture of immunology
    Carsten B Schmidt-Weber
    Swiss Institute of Allergy and Asthma Research, Switzerland
    J Allergy Clin Immunol 120:247-54. 2007
    ..This review summarizes the recent developments on T(H) cell subsets and integrates these findings into existing concepts of immunopathologic mechanisms...
  65. pmc Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
    Sven Klunker
    Swiss Institute of Allergy and Asthma Research Davos, University of Zurich, CH 7270 Davos Platz, Switzerland
    J Exp Med 206:2701-15. 2009
    ..Furthermore, FOXP3 and RUNX3 were colocalized in human tonsil T reg cells. These data demonstrate Runx transcription factors as a molecular link in TGF-beta-induced Foxp3 expression in iT reg cell differentiation and function...
  66. pmc Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunology 108:305-12. 2003
    ..Therefore, the CD8low population represent a subset of activated CD8 effector T cells, resulting most probably from a continuous and/or balanced immune response to intracellular pathogens...
  67. ncbi Histamine in allergic inflammation and immune modulation
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 137:82-92. 2005
    ..This article highlights the findings leading to a change of perspective in histamine immunobiology...
  68. ncbi T regulatory cells and allergy
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Microbes Infect 7:1049-55. 2005
    ..By utilizing multiple secreted cytokines and surface molecules, antigen-specific T(Reg) cells may re-direct an inappropriate immune response against allergens or auto-antigens...
  69. doi Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells
    Patrycja Konieczna
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Zurich, Switzerland
    Gut 61:354-66. 2012
    ..Intestinal homoeostasis is dependent on immunological tolerance to the microbiota...
  70. doi Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance
    Oscar Palomares
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 129:510-20, 520.e1-9. 2012
    ..Tonsillectomy removes only the palatine tonsils and sometimes adenoids. Lingual tonsil is anatomically big and remains lifelong intact...
  71. ncbi Role of bacillus Calmette-Guérin as an immunomodulator for the prevention and treatment of allergy and asthma
    Isil B Barlan
    Marmara University Hospital, Pediatric Allergy and Immunology Division, Istanbul, Turkey
    Curr Opin Allergy Clin Immunol 5:552-7. 2005
    ..The current status on the causal-effect link of this relationship and the potential use of mycobacterial adjuvants as a preventive or disease-modifying modality in allergic diseases is reviewed in this article...
  72. ncbi Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites
    Nerin N Bahceciler
    Marmara University Hospital, Division of Pediatric Allergy and Immunology, Istanbul, Turkey
    Int Arch Allergy Immunol 136:287-94. 2005
    ....
  73. ncbi Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos
    J Allergy Clin Immunol 118:152-69. 2006
    ..The consensus report is part of the PRACTALL initiative, which is endorsed by both academies...
  74. doi Modular antigen-translocation as a novel vaccine strategy for allergen-specific immunotherapy
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Curr Opin Allergy Clin Immunol 9:568-73. 2009
    ..Special emphasis will be given to the approach based on specific targeting of the major histocompatibility complex (MHC) class-II antigen-presentation pathway...
  75. ncbi Apoptosis in tissue inflammation and allergic disease
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 16:717-23. 2004
    ..In individuals with non-atopic monoallergic disease, by contrast, a disturbed balance towards allergen-specific Th2 cells instead of T regulatory type 1 (Tr1) cells characterizes the T cell response...
  76. doi Novel immunotherapeutic approaches for allergy and asthma
    Liam O'Mahony
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Autoimmunity 43:493-503. 2010
    ..This review will discuss novel approaches to the management of allergy and asthma by targeting the T regulatory cell via modulation of the commensal microbiota and allergen-SIT...
  77. doi Therapeutic manipulation of immune tolerance in allergic disease
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos Platz, Switzerland
    Nat Rev Drug Discov 8:645-60. 2009
    ..This Review highlights current knowledge of immunomodulatory therapies for the manipulation of immune tolerance and highlights recent approaches to improve allergen-specific immunotherapy for the treatment of allergic diseases...
  78. ncbi T regulatory cells in allergy
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:159-73. 2006
    ..It is associated with regulation of antibody isotypes and effector cells to the direction of a healthy immune response and opens a window for novel therapies of allergic diseases...
  79. ncbi Human NK1 and NK2 subsets determined by purification of IFN-gamma-secreting and IFN-gamma-nonsecreting NK cells
    Gunnur Deniz
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 32:879-84. 2002
    ..These results demonstrate that circulating NK cells retain effector subsets in humans with distinct cytokine profiles and may display different inflammatory properties...
  80. ncbi Mechanisms of allergen-specific immunotherapy: T-regulatory cells and more
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunol Allergy Clin North Am 26:207-31, vi. 2006
    ..The application of current knowledge of Treg cells and related mechanisms of peripheral tolerance may soon lead to more rational and safer approaches to the prevention and cure of allergic disease...
  81. doi Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema
    Sabine Zeller
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 124:278-85, 285.e1-7. 2009
    ..Atopic eczema (AE) is the most common chronic inflammatory skin disease. Recent data demonstrate the presence of autoreactive serum IgE antibodies correlating with the severity of the disease...
  82. ncbi Targets in allergy-directed immunotherapy
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research, CH 7270 Davos, Switzerland
    Expert Opin Ther Targets 9:217-24. 2005
    ..Recent advances in our knowledge of immunological mechanisms have created several options to comply with these demands. This article will focus on some of the most promising new developments...
  83. ncbi SARA and Hgs attenuate susceptibility to TGF-beta1-mediated T cell suppression
    S Kunzmann
    Swiss Institute of Allergy and Asthma Research SIAF, CH 7270 Davos, Switzerland
    FASEB J 17:194-202. 2003
    ..Thus, SARA and Hgs are regulators of TGF-beta1 susceptibility in T cells and integrate regulatory signals into the influence of TGF-beta1-mediated suppression of human T cells...
  84. doi Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors
    F Meiler
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Allergy 63:1455-63. 2008
    ..Our aim was to investigate the role of allergen-specific T regulatory type 1 (Tr1) cells and CD4(+)CD25(+) Treg cells and toll-like receptors (TLRs) on IgE, IgG4 and IgA production...
  85. ncbi IL-10 controls Aspergillus fumigatus- and Pseudomonas aeruginosa-specific T-cell response in cystic fibrosis
    Carmen Casaulta
    Department of Pediatrics, University Children s Hospital, Inselspital, Bern, Switzerland
    Pediatr Res 53:313-9. 2003
    ..Together, these data demonstrate an important role of IL-10-mediated peripheral T-cell tolerance to P. aeruginosa and A. fumigatus in the control of the intensity of the inflammatory T-cell response in CF...
  86. ncbi The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells
    Carsten B Schmidt-Weber
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 32:1196-204. 2002
    ..These results demonstrate that PTEN negatively controls costimulatory signals by antagonizing PI3 K activity in the absence of TCR engagement...
  87. ncbi Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities
    A Faith
    Swiss Institute of Allergy and Asthma Research, Davos
    J Immunol 159:53-60. 1997
    ..Together, our results indicate that anergy in Th2 cells is associated with defective transmembrane signaling through the TCR...
  88. ncbi An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling
    A Faith
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Immunol 162:1836-42. 1999
    ..Defective T cell activation appeared to result from alterations in transmembrane signaling through the TCR, specifically to lack of tyrosine phosphorylation of the tyrosine kinase, ZAP-70...
  89. pmc Role of interleukin 10 in specific immunotherapy
    C A Akdis
    Swiss Institute of Allergy and Asthma Research, CH 7270 Davos, Switzerland
    J Clin Invest 102:98-106. 1998
    ..Accordingly, increased IL-10 production by SIT causes specific anergy in peripheral T cells, and regulates specific IgE and IgG4 production toward normal IgG4-related immunity...
  90. ncbi Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA- memory T cells
    M Akdis
    Swiss Institute of Allergy and Asthma Research, Davos
    J Immunol 159:4611-9. 1997
    ..In contrast, the CLA- resting memory T cell population may exert immunoprotective properties toward allergen by high IFN-gamma secretion and induction of IgG4...
  91. ncbi Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Immunol 163:466-75. 1999
    ..These results indicate that in addition to the CD4+ subset, the CD8+CLA+ memory/effector T cells are capable of responding to superantigenic stimulation and play an important role in the pathogenesis of AD...
  92. pmc Mechanisms of interleukin-10-mediated immune suppression
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Immunology 103:131-6. 2001
    ..Together these results demonstrate that IL-10-induced selective inhibition of the CD28 co-stimulatory pathway acts as a decisive mechanism in determining whether a T cell will contribute to an immune response or become anergic...
  93. pmc T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis
    A Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Clin Invest 106:25-35. 2000
    ..Responses of normal human skin and cultured skin equivalents to activated T cells demonstrated that KC apoptosis caused by skin-infiltrating T cells is a key event in the pathogenesis of eczematous dermatitis...
  94. ncbi Expression of cutaneous lymphocyte-associated antigen on human CD4(+) and CD8(+) Th2 cells
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 30:3533-41. 2000
    ..In addition, CLA could be re-induced on T cells that had lost CLA expression upon resting. These results suggest that skin-selective homing is not restricted to functional and phenotypic T cell subsets...
  95. ncbi The differential fate of cadherins during T-cell-induced keratinocyte apoptosis leads to spongiosis in eczematous dermatitis
    A Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Invest Dermatol 117:927-34. 2001
    ..Therefore, induction of keratinocyte apoptosis by skin-infiltrating T cells, subseqent cleavage of E-cadherin, and resisting desmosomal cadherins suggests a mechanism for spongiosis formation in eczematous dermatitis...
  96. ncbi Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergens
    C A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 124:180-2. 2001
    ....
  97. ncbi Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors
    M Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Nature 413:420-5. 2001
    ..These findings account for an important regulatory mechanism in the control of inflammatory functions through effector-cell-derived histamine...
  98. ncbi Future of allergen-specific immunotherapy
    Cezmi A Akdis
    Expert Opin Emerg Drugs 10:1-4. 2005
    ..In addition, current understanding of immunological mechanisms of SIT, particularly the role of regulatory T cells in allergen-specific peripheral tolerance, may enable novel treatment strategies...
  99. ncbi T-cell subsets in the pathogenesis of human asthma
    Flurina Meiler
    Curr Allergy Asthma Rep 6:91-6. 2006
    ..In addition, skewing of allergen-specific effector T cells to T-regulatory cells appears to be an essential event in the control of harmful immune response induced by allergens as a possible means for remedy...
  100. ncbi Histamine receptors in immune regulation and allergen-specific immunotherapy
    Marek Jutel
    Department of Internal Medicine and Allergy, Wroclaw Medical University, Traugutta 57, Wroclaw 50 417, Poland
    Immunol Allergy Clin North Am 26:245-59, vii. 2006
    ....
  101. ncbi Cytokine and antibody responses in birch-pollen-allergic patients treated with genetically modified derivatives of the major birch pollen allergen Bet v 1
    Guro Gafvelin
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute and University Hospital, SE 171 76 Stockholm, Sweden
    Int Arch Allergy Immunol 138:59-66. 2005
    ..The aim of this study was to evaluate the effects of vaccination with aluminium-hydroxide-adsorbed recombinant Bet v 1 derivatives versus placebo on T-cell, cytokine and antibody responses in a subgroup of patients...