M Affolter

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis
    M Affolter
    Biozentrum, Universitat Basel, Switzerland
    Development 120:3105-17. 1994
  2. pmc Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation
    Valerie Petit
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Mol Cell Biol 24:3769-81. 2004
  3. ncbi request reprint A simple molecular complex mediates widespread BMP-induced repression during Drosophila development
    George Pyrowolakis
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056, Switzerland
    Dev Cell 7:229-40. 2004
  4. pmc Enhancer blocking and transvection at the Drosophila apterous locus
    Daryl Gohl
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Genetics 178:127-43. 2008
  5. ncbi request reprint Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture
    Markus Affolter
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 135:2055-64. 2008
  6. ncbi request reprint Tissue remodelling through branching morphogenesis
    Markus Affolter
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Nat Rev Mol Cell Biol 10:831-42. 2009
  7. ncbi request reprint Tube or not tube: remodeling epithelial tissues by branching morphogenesis
    Markus Affolter
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056, Basel, Switzerland
    Dev Cell 4:11-8. 2003
  8. pmc Nuclear interpretation of Dpp signaling in Drosophila
    M Affolter
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4026 Basel, Switzerland
    EMBO J 20:3298-305. 2001
  9. ncbi request reprint The Decapentaplegic morphogen gradient: from pattern formation to growth regulation
    Markus Affolter
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Rev Genet 8:663-74. 2007
  10. doi request reprint Signal-induced repression: the exception or the rule in developmental signaling?
    Markus Affolter
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 15:11-22. 2008

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis
    M Affolter
    Biozentrum, Universitat Basel, Switzerland
    Development 120:3105-17. 1994
    ..The requirements for tkv in dorsal closure, visceral mesoderm and trachea development assign novel functions to dpp or a closely related member of the TGF beta superfamily...
  2. pmc Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation
    Valerie Petit
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Mol Cell Biol 24:3769-81. 2004
    ..Additional proteins binding either to the FGFRs, to Dof, or to Csw appear to be crucial for a chemotactic response...
  3. ncbi request reprint A simple molecular complex mediates widespread BMP-induced repression during Drosophila development
    George Pyrowolakis
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056, Switzerland
    Dev Cell 7:229-40. 2004
    ....
  4. pmc Enhancer blocking and transvection at the Drosophila apterous locus
    Daryl Gohl
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Genetics 178:127-43. 2008
    ..We demonstrate that this is unlikely to be due to insulator bypass. The transvection effects described here may provide insight into the role that boundary element pairing plays in enhancer blocking both in cis and in trans...
  5. ncbi request reprint Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture
    Markus Affolter
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 135:2055-64. 2008
    ..We also discuss the similarities and differences between flies and vertebrates in branched organ formation that are becoming apparent from these studies...
  6. ncbi request reprint Tissue remodelling through branching morphogenesis
    Markus Affolter
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Nat Rev Mol Cell Biol 10:831-42. 2009
    ..Recent experiments suggest that cell competition and cell rearrangements might be conserved key features in branch formation and might be controlled by local cell signalling...
  7. ncbi request reprint Tube or not tube: remodeling epithelial tissues by branching morphogenesis
    Markus Affolter
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056, Basel, Switzerland
    Dev Cell 4:11-8. 2003
    ....
  8. pmc Nuclear interpretation of Dpp signaling in Drosophila
    M Affolter
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4026 Basel, Switzerland
    EMBO J 20:3298-305. 2001
    ..It remains to be seen whether similar molecular mechanisms operate in the nucleus in vertebrate systems...
  9. ncbi request reprint The Decapentaplegic morphogen gradient: from pattern formation to growth regulation
    Markus Affolter
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Rev Genet 8:663-74. 2007
    ..Continued efforts to elucidate the role of DPP in D. melanogaster is likely to shed light on this fundamental question in the near future...
  10. doi request reprint Signal-induced repression: the exception or the rule in developmental signaling?
    Markus Affolter
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 15:11-22. 2008
    ..These new findings raise the interesting possibility that this repressive mode of action is shared by many or most developmental signaling pathways...
  11. pmc Hyped-up for Hox in Hyderabad. Workshop on upstream and downstream of Hox genes
    Markus Affolter
    Department Biozentrum, Unviersity of Basel, Basel, Switzerland
    EMBO Rep 7:674-8. 2006
  12. ncbi request reprint Self-renewal in the fly kidney
    Markus Affolter
    Biozentrum der Universitat Basel, Kingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 13:321-2. 2007
    ..In the latest issue of Cell Stem Cell, Singh et al. (2007) demonstrate that, in the adult fly, epithelial cells exist that are neither in niches nor in small numbers, divide at high rates, and are multipotent...
  13. doi request reprint A lexicon for homeodomain-DNA recognition
    Markus Affolter
    Growth and Development, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Cell 133:1133-5. 2008
    ..2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in many transcription factors. The data underscore the complexity of determining target specificities in vivo...
  14. ncbi request reprint Development. Legs, eyes, or wings--selectors and signals make the difference
    M Affolter
    Biozentrum der Universitat Basel, Abteilung Zellbiologie, Basel CH 4056, Switzerland
    Science 292:1080-1. 2001
  15. ncbi request reprint DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo
    S Vincent
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Switzerland
    Development 124:2741-50. 1997
    ..It is required to control the dorsal expression of the BNL ligand; in addition, the DPP signal recruits groups of dorsal and ventral tracheal cells and programs them to migrate in dorsal and ventral directions...
  16. ncbi request reprint A HOX complex, a repressor element and a 50 bp sequence confer regional specificity to a DPP-responsive enhancer
    T Marty
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 128:2833-45. 2001
    ....
  17. ncbi request reprint Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1
    N C Grieder
    Biozentrum, Universitat Basel, Switzerland
    Cell 81:791-800. 1995
    ..The shn protein might therefore act as a nuclear target in the dpp signaling pathway directly regulating the expression of dpp-responsive genes...
  18. ncbi request reprint Genetic control of branching morphogenesis during Drosophila tracheal development
    M Affolter
    Biozentrum, Abteilung Zellbiologie, Klingelbergstrasse 70, 4056, Basel, Switzerland
    Curr Opin Cell Biol 12:731-5. 2000
    ..More than 30 genes have been identified and ordered into sequential steps controlling branching morphogenesis. These studies have revealed a number of important principles that might be conserved in other systems...
  19. ncbi request reprint Schnurri mediates Dpp-dependent repression of brinker transcription
    T Marty
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Cell Biol 2:745-9. 2000
    ..The existence of several Shn-like proteins in vertebrates and the observation that Brk functions in BMP signalling in Xenopus indicates that a similar regulatory cascade may be conserved in higher organisms...
  20. ncbi request reprint Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development
    U Nussbaumer
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Mech Dev 96:27-36. 2000
    ..Hence, each of the three characterized enhancers constitutes a molecular link between a specific territory induced by a morphogen signal and the localized expression of a gene required for the final differentiation of this territory...
  21. ncbi request reprint Specificity of FGF signaling in cell migration in Drosophila
    C Dossenbach
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Development 128:4563-72. 2001
    ..We discuss our findings in the light of the recent findings that RTKs generate a generic signal that is interpreted in responding cells according to their developmental history...
  22. ncbi request reprint Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Development 117:1199-210. 1993
    ....
  23. ncbi request reprint The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered
    J Montagne
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 122:2589-97. 1996
    ..We propose that DSRF acts at a key step between regulatory genes that define the early positional values in the developing wing disc and the subsequent localized expression of intervein-specific structural genes...
  24. pmc Isolation and sequence-specific DNA binding of the Antennapedia homeodomain
    M Muller
    Biozentrum der Universitat Basel, Switzerland
    EMBO J 7:4299-304. 1988
    ..It selectively binds to the same sites as a longer Antp polypeptide and a full-length fushi tarazu (ftz) protein. Therefore, the homeodomain represents the DNA-binding domain of the homeotic proteins...
  25. pmc Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling
    N C Grieder
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    EMBO J 16:7402-10. 1997
    ..Our results illustrate how a tissue-specific response to DPP can be generated through synergistic effects on an enhancer carrying both DPP- and HOX-responsive sequences...
  26. pmc DNA binding properties of the purified Antennapedia homeodomain
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 87:4093-7. 1990
    ..The DNA binding properties of the Antp HD and prokaryotic DNA binding domains that share a helix-turn-helix motif are compared...
  27. ncbi request reprint Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated
    L Pick
    Department of Cell Biology, University of Basel, Switzerland
    Genes Dev 4:1224-39. 1990
    ..We suggest that ftz protein acts in combination with germ layer-restricted transcription factors directly and positively to regulate the transcription of its own gene...
  28. ncbi request reprint The structure of the homeodomain and its functional implications
    W J Gehring
    University of Basel, Switzerland
    Trends Genet 6:323-9. 1990
    ..Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution...
  29. ncbi request reprint The Drosophila protein Dof is specifically required for FGF signaling
    S Vincent
    Biozentrum, Universität Basel Abt Zellbiologie, Switzerland
    Mol Cell 2:515-25. 1998
    ..Dof is needed in these cells for activation of the MAPK cascade via FGF signaling, but not for activation via other RTK ligands. Dof therefore appears to be committed exclusively to FGFR-mediated signal transduction...
  30. ncbi request reprint The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen
    Y Yamamoto
    Biozentrum, University of Basel, Switzerland
    Development 124:3385-94. 1997
    ..Together, our data suggest that these two proteins are involved in a common regulatory pathway and highlight possible interactions between Pc-G-mediated silencing and DNA replication in Drosophila...
  31. ncbi request reprint Homeodomain proteins in development and therapy
    A Dorn
    Pharma Division, Preclinical Research, F Hoffmann La Roche Ltd, Basel, Switzerland
    Pharmacol Ther 61:155-84. 1994
    ..It has been demonstrated that chimeric peptide molecules encompassing pAntp are also captured by cultured neurons and conveyed to their nuclei. This may be of enormous interest for the internalization of drugs...
  32. pmc The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells
    Samir Merabet
    Biozentrum der Universitat Basel, Switzerland
    EMBO Rep 6:762-8. 2005
    ..These findings provide a hitherto unknown and interesting link between combinatorial inputs of transcription factors, cell-specific ligand expression and organ morphogenesis...
  33. pmc The interaction with DNA of wild-type and mutant fushi tarazu homeodomains
    A Percival-Smith
    University of Basel, Department of Cell Biology, Switzerland
    EMBO J 9:3967-74. 1990
    ..These three points of contact allowed us to propose a crude orientation of the ftz HD within the protein-DNA complex. We find that the ftz HD and the Antp HD peptides contact DNA in a similar way...
  34. ncbi request reprint Homeodomain proteins and the regulation of gene expression
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Curr Opin Cell Biol 2:485-95. 1990
  35. ncbi request reprint Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4
    J Groppe
    Department of Cell Biology, University of Basel, CH 4056 Basel, Switzerland
    J Biol Chem 273:29052-65. 1998
    ....
  36. ncbi request reprint The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development
    M Affolter
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 120:743-53. 1994
    ..Thus, the DSRF gene might play a role in the proper formation and maintenance of the trachea...
  37. ncbi request reprint Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ
    Andreas Ebner
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Gene 287:55-66. 2002
    ..We also identified a Sulfotransferase and a Multiple Inositol Polyphosphate phosphatase that are strongly upregulated in tracheal cells and discuss their possible involvement in tracheal development...
  38. ncbi request reprint Genetic control of cell intercalation during tracheal morphogenesis in Drosophila
    Carlos Ribeiro
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Curr Biol 14:2197-207. 2004
    ..Branching is controlled by several signaling pathways, but the molecular consequences of these pathways in the responding cells are poorly understood...
  39. ncbi request reprint Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis
    Alain C Jung
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Curr Biol 16:1224-31. 2006
    ..Our study suggests that MAGUK proteins might play important roles during AJ remodeling in epithelial morphogenesis...
  40. ncbi request reprint Signaling systems, guided cell migration, and organogenesis: insights from genetic studies in Drosophila
    Carlos Ribeiro
    Biozentrum der Universitat Basel, Department of Cell Biology, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Biol 260:1-8. 2003
    ....
  41. ncbi request reprint Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila
    Clemens Cabernard
    Department of Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 9:831-42. 2005
    ..Ras and the Mapk pathway are also needed for Egf-regulated cell division/survival, but Pointed is dispensable...
  42. ncbi request reprint In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis
    Carlos Ribeiro
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 2:677-83. 2002
    ..Bnl/FGF signaling affects the formation of dynamic filopodia, possibly controlling cytoskeletal activity and motility as such, and Dpp controls cellular functions allowing branch morphogenesis and outgrowth...
  43. pmc Distamycin-induced inhibition of homeodomain-DNA complexes
    A Dorn
    Pharma Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    EMBO J 11:279-86. 1992
    ....
  44. ncbi request reprint Balancing import and export in development
    M Affolter
    Biocenter, University of Basel, CH 4056 Basel, Switzerland
    Genes Dev 13:913-5. 1999
  45. ncbi request reprint Cellular and molecular mechanisms involved in branching morphogenesis of the Drosophila tracheal system
    Clemens Cabernard
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    J Appl Physiol 97:2347-53. 2004
    ..Clearly, both striking similarities and important differences are apparent, but it might still be too early to conclude whether the former or the latter prevail...
  46. ncbi request reprint DNA recognition by the brinker repressor--an extreme case of coupling between binding and folding
    Florence Cordier
    Division of Structural Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Mol Biol 361:659-72. 2006
    ..The transition from a highly flexible, completely unfolded conformation in the absence of DNA to a well-formed structure in the complex presents a very extreme case of the "coupling of binding and folding" phenomenon...
  47. ncbi request reprint Renal tubule development in Drosophila: a closer look at the cellular level
    Alain C Jung
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Am Soc Nephrol 16:322-8. 2005
    ..The molecular similarities between these two cases is reviewed here...
  48. ncbi request reprint Confronting morphogen gradients: how important are they for growth?
    Fisun Hamaratoglu
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Sci Signal 2:pe67. 2009
    ..In the developing fly wing, graded distributions of the morphogens Decapentaplegic and Wingless are essential for tissue patterning, but when it comes to growth, evidence suggests that it may not be so...
  49. ncbi request reprint Regulation of cell migration during tracheal development in Drosophila melanogaster
    Valerie Petit
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Switzerland
    Int J Dev Biol 46:125-32. 2002
    ..We try to link these in vivo studies and the movement of cells over two dimensional substrates and elaborate on important questions which remain to be addressed in the future...
  50. doi request reprint Spalt major controls the development of the notum and of wing hinge primordia of the Drosophila melanogaster wing imaginal disc
    Nicole C Grieder
    Biozentrum der Universtät Basel, Abteilung Zellbiologie, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Dev Biol 329:315-26. 2009
    ..We also find that salm activity is down-regulated by its own product and by that of the Pax gene eyegone...
  51. ncbi request reprint Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein
    Anna Jazwinska
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Switzerland
    Nat Cell Biol 5:895-901. 2003
    ..Our results suggest that a similar structural role might be attributed to other ZP-domain proteins in the formation of different branched organs...
  52. doi request reprint Tip-cell migration controls stalk-cell intercalation during Drosophila tracheal tube elongation
    Emmanuel Caussinus
    Growth and Development, Biozentrum der Universiät Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Curr Biol 18:1727-34. 2008
    ....
  53. ncbi request reprint Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex
    Andreas Ebner
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 132:1591-600. 2005
    ..Thus Lab, and most probably other Hox proteins, selects different DNA sequences in regulating downstream target genes. These observations have implications with regard to the current model of Hox-binding selectivity...
  54. pmc gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster
    Nicole C Grieder
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Basel, Switzerland
    PLoS ONE 3:e3241. 2008
    ..To identify the functions of COPI coatomer-mediated membrane trafficking in Drosophila development, we were aiming to create loss-of-function mutations in the gammaCOP gene, which encodes a subunit of the COPI coatomer complex...
  55. ncbi request reprint A family of genes encoding zona pellucida (ZP) domain proteins is expressed in various epithelial tissues during Drosophila embryogenesis
    Anna Jazwinska
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Gene Expr Patterns 4:413-21. 2004
    ..Five genes are expressed during oogenesis; two of them are transcribed in the follicular epithelium, but not in the germ line cells...
  56. ncbi request reprint A conserved activation element in BMP signaling during Drosophila development
    Alexander Weiss
    Biozentrum der Universitat Basel, Basel, Switzerland
    Nat Struct Mol Biol 17:69-76. 2010
    ..The AE allows the identification of hitherto unknown direct Dpp targets and is functionally conserved in vertebrates...
  57. pmc Remodelling epithelial tubes through cell rearrangements: from cells to molecules
    Marc Neumann
    Biozentrum der Universitat Basel, Switzerland
    EMBO Rep 7:36-40. 2006
    ..In this review, we describe recent progress in understanding cell rearrangements during epithelial tube remodelling and discuss several models that might account for the developmental control of the spatial dynamics of AJs...
  58. doi request reprint Vascular morphogenesis in the zebrafish embryo
    Elin Ellertsdottir
    Department of Cell Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Biol 341:56-65. 2010
    ..We discuss the diversity of morphogenetic mechanisms that contribute to vessel assembly, angiogenic sprouting and tube formation in different blood vessels and how some of these complex cell behaviors are regulated by molecular pathways...
  59. doi request reprint Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo
    Yannick Blum
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Biol 316:312-22. 2008
    ....
  60. pmc A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis
    Hélène Chanut-Delalande
    Institut fur Genetik, Universitat zu Koln, D 50674 Köln, Germany
    Genetics 176:2177-87. 2007
    ..Three of the mutants were mapped to either the Mhc or the stam complementation groups. Further experiments confirmed that these genes are required for cell migration in the tracheal air sac primordium...
  61. ncbi request reprint Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient
    Bruno Muller
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Cell 113:221-33. 2003
    ..Together, our results provide the molecular framework for a mechanism by which the extracellular Dpp/BMP morphogen establishes a finely tuned, graded read-out of transcriptional repression...
  62. ncbi request reprint Drosophila gastrulation: identification of a missing link
    Maria Leptin
    Institute of Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    Curr Biol 14:R480-2. 2004
    ..The ligand of the FGF receptor Heartless, which is involved in mesoderm movement, has now been isolated and shown to be a link between a morphogen gradient and cell behavior...
  63. ncbi request reprint Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13
    Adrian Streit
    Department of Biology, University of Fribourg, Perolles, Fribourg, CH 1700, Switzerland
    Dev Biol 242:96-108. 2002
    ..The second regulatory sequence is sufficient to drive correct early embryonic expression of ceh-13. Interestingly, this enhancer fragment acts as a response element of the Wnt/WG signaling pathway in Drosophila embryos...
  64. ncbi request reprint Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein
    Jay Groppe
    Salk Institute, La Jolla, CA 92037, USA
    J Bone Joint Surg Am 85:52-8. 2003
    ..Toward that end, we have determined the crystal structure of the antagonist Noggin bound to BMP-7...
  65. pmc A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax
    Samir Merabet
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 104:16946-51. 2007
    ....
  66. ncbi request reprint eIF4A goes beyond translation
    Markus Affolter
    Nat Cell Biol 8:1319-21. 2006
  67. ncbi request reprint Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
    Jay Groppe
    Structural Biology, Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 420:636-42. 2002
    ..The scaffold of Noggin contains a cystine (the oxidized form of cysteine) knot topology similar to that of BMPs; thus, ligand and antagonist seem to have evolved from a common ancestral gene...
  68. ncbi request reprint Signaling to cytoskeletal dynamics during chemotaxis
    Markus Affolter
    Department of Cell Biology, Biozentrum University of Basel, Klingelbergstr 70, CH 4056 Basel, Switzerland
    Dev Cell 9:19-34. 2005
    ..We compare and contrast these insights with our current understanding of pathways controlling chemotactic movements in more-complex multicellular developmental contexts...
  69. ncbi request reprint It takes guts to make a single lumen
    Heinz Georg Belting
    Nat Cell Biol 9:880-1. 2007