Research Topics
| Stephen TooveySummaryCountry: Switzerland Publications
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Detail Information
Publications
Rheumatoid arthritis and the incidence of influenza and influenza-related complications: a retrospective cohort studyWilliam A Blumentals
Hoffmann La Roche, Inc, Nutley, NJ, USA
BMC Musculoskelet Disord 13:158. 2012..Patients with rheumatoid arthritis (RA) are known to be at increased risk of infection, particularly if they are taking drugs with immunomodulatory effects. There is a need for more information on the risk of influenza in patients with RA...
Post-marketing assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: an updated reviewStephen Toovey
F Hoffmann La Roche Ltd, PBMT Bldg 74 3O Z01 05, CH 4070, Basel, Switzerland
Adv Ther 29:826-48. 2012..Evidence suggests that influenza-related encephalopathies are caused by influenza-induced inflammatory responses, but more work is needed to confirm the underlying mechanisms.Supplementary material is available on SpringerLink.com...
A new inactivated Japanese encephalitis vaccine for adult travelersStephen Toovey
Travel Med Infect Dis 7:301-4. 2009..In development trials the new JE vaccine was as well tolerated as placebo. A review of existing guidelines for JE vaccine use in travelers should be considered...
Mefloquine neurotoxicity: a literature reviewStephen Toovey
Academic Centre for Travel Medicine and Vaccines, and the WHO Collaborating Centre for Reference, Research and Training in Travel Medicine, University College London Medical School, Royal Free Campus, London, UK
Travel Med Infect Dis 7:2-6. 2009..It may be prudent to avoid mefloquine in females and low BMI individuals, and in combination with other potentially neurotoxic agents such as the artemisinin antimalarials...
Assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: a comprehensive reviewStephen Toovey
F Hoffmann La Roche Ltd, Basel, Switzerland
Drug Saf 31:1097-114. 2008....
Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum calcium adenosine triphosphatase activityStephen Toovey
Academic Centre for Travel Medicine and Vaccines, WHO Collaborating Centre for Travel Medicine, Royal Free and University College Medical School, London, UK
Basic Clin Pharmacol Toxicol 103:209-13. 2008..Candidate antimalarials should be screened pre-clinically for SERCA inhibition...
Special infectious disease risks of expatriates and long-term travelers in tropical countries. Part II: infections other than malariaStephen Toovey
Royal Free Hospital Medical School, London, UK
J Travel Med 14:50-60. 2007..Many infections are chronic or asymptomatic, and appropriate screening is recommended on return or after prolonged exposure...
Body mass index and the incidence of influenza-associated pneumonia in a UK primary care cohortWilliam A Blumentals
Hoffmann La Roche, Inc, Nutley, NJ 07110, USA
Influenza Other Respi Viruses 6:28-36. 2012..Accumulating data suggest an association between increased BMI/obesity and morbidity in patients with pandemic (H1N1) 2009 influenza. Information on metabolic status and prognosis in seasonal influenza is lacking, however...
The use of antiviral agents for the management of severe influenzaJames R Smith
F Hoffmann La Roche Ltd, Basel, Switzerland
Crit Care Med 38:e43-51. 2010..Very little resistance to oseltamivir has been found to date...
Effects of weight, age, and time on artemether-lumefantrine associated ototoxicity and evidence of irreversibilityStephen Toovey
Burggartenstrasse 32, Basel, Bottmingen, Switzerland
Travel Med Infect Dis 4:71-6. 2006..Ototoxicity is common to many antimalarials and the elucidation of a common antiparasitic and ototoxic pathway will assist in the design of safer new antimalarials...
Special infectious disease risks of expatriates and long-term travelers in tropical countries. Part I: malariaStephen Toovey
Royal Free and University College Medical School, London, UK
J Travel Med 14:42-9. 2007..Choice of strategies will depend upon assessment of actual risk and likely compliance, with a combination of measures usually appropriate...
Are currently deployed artemisinins neurotoxic?Stephen Toovey
Royal Free and University College Medical School, London, UK Travel Clinic, Cape Town, South Africa
Toxicol Lett 166:95-104. 2006..Uncertainty remains over the neurotoxicity of currently deployed artemisinins, and their safety profile should be reviewed, especially in pediatric use. The development of non-neurotoxic artemisinins is possible and should be encouraged...
Influenza-associated central nervous system dysfunction: a literature reviewStephen Toovey
F Hoffmann La Roche Ltd, Basel, Switzerland
Travel Med Infect Dis 6:114-24. 2008..Influenza is a viral pathogen that imposes an under-recognized burden of central nervous system (CNS) disease...
