Andreas H Zisch
Affiliation: Swiss Federal Institute of Technology
- Biopolymeric delivery matrices for angiogenic growth factorsAndreas H Zisch
Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich ETHZ, Moussonstrasse 18, 8044 Zurich, Switzerland
Cardiovasc Pathol 12:295-310. 2003..Another promising venue to improve angiogenic performance is presented by biomaterials that allow sequential delivery of growth factors with complementary roles in blood vessel initiation and stabilization...
- Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growthAndreas H Zisch
Department of Materials Science and Institute for Biomedical Engineering, Swiss Federal Institute of Technology Zurich and University of Zurich, Switzerland
FASEB J 17:2260-2. 2003....
- Engineered fibrin matrices for functional display of cell membrane-bound growth factor-like activities: study of angiogenic signaling by ephrin-B2Andreas H Zisch
Department of Materials Science, Institute for Biomedical Engineering, ETH Zurich, University of Zurich, Moussonstr 18, 8044 Zurich, Switzerland
Biomaterials 25:3245-57. 2004....
- Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organizationCornelia C Weber
Department of Materials Science, and Institute of Biomedical Engineering, Swiss Federal Institute of Technology Zurich and University of Zurich, Zurich 8044, Switzerland
J Biol Chem 280:22445-53. 2005..Furthermore, we show that the isolated receptor-binding domain of Ang1 is capable of mediating some effects of full-length Ang1 independently of Tie2 phosphorylation, possibly through integrin ligation...
- Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growthMartin Ehrbar
Institute for Biomedical Engineering, and University of Zurich, Zurich, Switzerland
Circ Res 94:1124-32. 2004..In conclusion, cell-demanded release of engineered VEGF121 from fibrin implants may present a therapeutically safe and practical modality to induce local angiogenesis...
- Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activityMartin Ehrbar
Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland
J Control Release 101:93-109. 2005....
- Adult 'endothelial progenitor cells'. Renewing vasculaturePrisca Zammaretti
Institute for Biomedical Engineering, ETH and University of Zurich, Moussonstr. 18, 8044 Zurich, Switzerland
Int J Biochem Cell Biol 37:493-503. 2005..Moreover, endothelial progenitors represent a potential target of strategies to block tumor growth...
- Broad-spectrum protein biosensors for class-specific detection of antibioticsCornelia C Weber
Institute for Biomedical Engineering, Swiss Federal Institute of Technology, ETH Zurich, CH-8044 Zurich, Switzerland
Biotechnol Bioeng 89:9-17. 2005..Binding of biosensor protein to the cognate DNA chemically linked to a solid surface is converted into an immuno-based colorimetric readout correlating with specific antibiotics concentrations...
- pH-controlled recovery of placenta-derived mesenchymal stem cell sheetsOrane Guillaume-Gentil
Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Switzerland
Biomaterials 32:4376-84. 2011..This novel polyelectrolyte multilayer based platform represents a promising, novel approach for the engineering of human stem cell sheets desired for future clinical applications...
- Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanismCara-Lynn E Helm
Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA
Proc Natl Acad Sci U S A 102:15779-84. 2005..This work thus demonstrates a general mechanism of morphogen gradient generation and amplification by small ubiquitous mechanical forces that are known to exist in vivo...
- Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition modelBeat H Walpoth
Clinic of Cardiovascular Surgery, University of Geneva, Switzerland
J Thorac Cardiovasc Surg 133:1163-70. 2007..Vascular endothelial growth factor is a potent stimulus for endothelial growth, and its provision in a fibrin matrix coating at the luminal graft surface may hold a key to spontaneous graft endothelialization and improved graft patency...
- The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesisMartin Ehrbar
Department of Cranio Maxillofacial Surgery, University Hospital Zurich, Switzerland
Biomaterials 29:1720-9. 2008..In the absence of true physiological demand, even stabilized vessels are ultimately regressed...
- The dosage dependence of VEGF stimulation on scaffold neovascularisationNeil Davies
Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Department of Health Sciences, 203 Cape Heart Centre, Anzio Road, Observatory, 7925 Cape Town, South Africa
Biomaterials 29:3531-8. 2008..These results suggest concentration of VEGF plays a critical role in the nature and persistence of vasculature formed in a tissue regenerative scaffold...
- Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) systemWilfried Weber
Institute of Biotechnology, Swiss Federal Institute of Technology Zurich, ETH Hoenggerberg, CH-8093 Zurich, Switzerland
Nucleic Acids Res 31:e69. 2003..Implantation of microencapsulated DT40 cells engineered for TIGR-controlled expression of the human vascular endothelial growth factor A (hVEGF121) provided low-temperature-induced VEGF-mediated vascularization in chicken embryos...
- Tissue engineering of angiogenesis with autologous endothelial progenitor cellsAndreas H Zisch
Department of Obstetrics, University Hospital Zurich, Frauenklinikstr 10, 8091, Switzerland
Curr Opin Biotechnol 15:424-9. 2004..Autologous endothelial progenitor cells can also substitute for native vessel-derived endothelial cells in tissue-engineered vascular autografts...
- MnSOD marks cord blood late outgrowth endothelial cells and accompanies robust resistance to oxidative stressHao Cai
Department of Obstetrics, University Hospital Zurich, Switzerland
Biochem Biophys Res Commun 350:364-9. 2006..Such cytoprotective levels of MnSOD cells could give therapeutic cell transplants a survival advantage in necrotic or ischemic conditions...
- Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineeringMartin Ehrbar
Oral Biology, Section Bioengineering, Department of Cranio Maxillofacial Surgery, University Hospital Zurich, Zurich, Switzerland
Biomaterials 28:3856-66. 2007..The synthetic ease and potential to engineer their physicochemical and bioactive characteristics makes these hybrid networks true alternatives for fibrin as provisional drug delivery platforms in tissue engineering...