Michael B Zimmermann

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. ncbi The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Thyroid 12:867-78. 2002
  2. doi Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone
    Jeannine Baumgartner
    Laboratory of Human Nutrition, ETH, Zurich, Switzerland
    J Nutr 142:1463-71. 2012
  3. ncbi Dual fortification of salt with iodine and iron: a randomized, double-blind, controlled trial of micronized ferric pyrophosphate and encapsulated ferrous fumarate in southern India
    Maria Andersson
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 88:1378-87. 2008
  4. ncbi Dual fortification of salt with iodine and micronized ferric pyrophosphate: a randomized, double-blind, controlled trial
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 80:952-9. 2004
  5. ncbi Diet determines features of the metabolic syndrome in 6- to 14-year-old children
    Isabelle Aeberli
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    Int J Vitam Nutr Res 79:14-23. 2009
  6. doi A micronutrient powder with low doses of highly absorbable iron and zinc reduces iron and zinc deficiency and improves weight-for-age Z-scores in South African children
    Barbara Troesch
    Laboratory for Human Nutrition, ETH, Zurich, Switzerland
    J Nutr 141:237-42. 2011
  7. ncbi Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans
    Diego Moretti
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 83:632-8. 2006
  8. doi Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods
    Barbara Troesch
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, ETH, Zurich, Switzerland
    Am J Clin Nutr 89:539-44. 2009
  9. ncbi Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 83:108-14. 2006
  10. ncbi Triple fortification of salt with microcapsules of iodine, iron, and vitamin A
    Michael B Zimmermann
    Human Nutrition Laboratory and the Food Process Engineering Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 80:1283-90. 2004

Detail Information

Publications96

  1. ncbi The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Thyroid 12:867-78. 2002
    ....
  2. doi Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone
    Jeannine Baumgartner
    Laboratory of Human Nutrition, ETH, Zurich, Switzerland
    J Nutr 142:1463-71. 2012
    ..42; P = 0.018). These results suggest that the combined deficiencies of Fe and (n-3) FA disrupt brain monoamine metabolism and produce greater deficits in reference memory than ID or (n-3)FAD alone...
  3. ncbi Dual fortification of salt with iodine and iron: a randomized, double-blind, controlled trial of micronized ferric pyrophosphate and encapsulated ferrous fumarate in southern India
    Maria Andersson
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 88:1378-87. 2008
    ..Dual fortification of salt with iodine and iron could be a sustainable approach to combating iodine and iron deficiencies...
  4. ncbi Dual fortification of salt with iodine and micronized ferric pyrophosphate: a randomized, double-blind, controlled trial
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 80:952-9. 2004
    ..In areas of subsistence farming in rural Africa, salt is one of the few regularly purchased food items and could be a good fortification vehicle for iodine and iron, provided that a stable yet bioavailable iron fortificant is used...
  5. ncbi Diet determines features of the metabolic syndrome in 6- to 14-year-old children
    Isabelle Aeberli
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    Int J Vitam Nutr Res 79:14-23. 2009
    ..Therefore, the objective of this study was to investigate dietary determinants of IR, BP, resistin, adiponectin, and leptin concentrations, as well as the interrelationship among these variables, in normal and overweight children...
  6. doi A micronutrient powder with low doses of highly absorbable iron and zinc reduces iron and zinc deficiency and improves weight-for-age Z-scores in South African children
    Barbara Troesch
    Laboratory for Human Nutrition, ETH, Zurich, Switzerland
    J Nutr 141:237-42. 2011
    ..In addition, the MNP is likely to enhance absorption of the high native iron content of complementary foods based on cereals and/or legumes...
  7. ncbi Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans
    Diego Moretti
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 83:632-8. 2006
    ..Although ferric pyrophosphate is a promising compound for iron fortification of foods, few data are available on the effect of food matrices, processing, and ascorbic acid on its bioavailability...
  8. doi Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods
    Barbara Troesch
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, ETH, Zurich, Switzerland
    Am J Clin Nutr 89:539-44. 2009
    ..However, low iron doses have little nutritional effect, unless iron absorption is high...
  9. ncbi Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 83:108-14. 2006
    ..Although several randomized trials examined the effect of iodine supplementation on cognitive performance in schoolchildren, the results were equivocal...
  10. ncbi Triple fortification of salt with microcapsules of iodine, iron, and vitamin A
    Michael B Zimmermann
    Human Nutrition Laboratory and the Food Process Engineering Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 80:1283-90. 2004
    ..In many developing countries, children are at high risk of goiter, vitamin A deficiency, and iron deficiency anemia...
  11. ncbi Dual fortification of salt with iodine and microencapsulated iron: a randomized, double-blind, controlled trial in Moroccan schoolchildren
    Michael B Zimmermann
    Human Nutrition Laboratory, Instituts of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 77:425-32. 2003
    ..In many developing countries, children are at high risk of both goiter and iron deficiency anemia...
  12. ncbi Fructose intake is a predictor of LDL particle size in overweight schoolchildren
    Isabelle Aeberli
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    Am J Clin Nutr 86:1174-8. 2007
    ..Childhood adiposity is associated with smaller LDL particle size, but the dietary predictors of LDL size in overweight children have not been studied...
  13. doi Iron deficiency up-regulates iron absorption from ferrous sulphate but not ferric pyrophosphate and consequently food fortification with ferrous sulphate has relatively greater efficacy in iron-deficient individuals
    Michael B Zimmermann
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology ETH Zurich, Schmelzbergstrasse 7, LFV E19, CH 8092 Zurich, Switzerland
    Br J Nutr 105:1245-50. 2011
    ....
  14. ncbi Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and reduces the goiter rate
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 86:1040-4. 2007
    ..Vitamin A (VA) deficiency (VAD) and iodine deficiency (ID) often coexist in children in Africa. VAD may affect thyroid function and the response to iodine prophylaxis...
  15. ncbi Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland, and The Ministry of Health, Rabat, Morocco
    Am J Clin Nutr 84:580-6. 2006
    ..The mechanism of these effects is unclear. In vitro and in animal models, vitamin A treatment increases the production of erythropoietin (EPO), a stimulant of erythropoiesis...
  16. pmc Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya
    Tanja Jaeggi
    Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland
    PLoS ONE 8:e57513. 2013
    ..We propose gender-specific reference values for serum hepcidin in iron-replete infants without inflammation...
  17. doi Nonheme-iron absorption in first-degree relatives is highly correlated: a stable-isotope study in mother-child pairs
    Michael B Zimmermann
    Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 91:802-7. 2010
    ..Iron absorption in humans is highly variable even after iron status and dietary components that influence iron absorption are controlled for. Inherited factors may help explain this variance...
  18. doi Fortification iron as ferrous sulfate plus ascorbic acid is more rapidly absorbed than as sodium iron EDTA but neither increases serum nontransferrin-bound iron in women
    Barbara Troesch
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, ETH Zurich, 8092 Zurich, Switzerland
    J Nutr 141:822-7. 2011
    ..Even with the use of a very well absorbed ferrous iron compound, iron fortification in this population does not increase NTBI, suggesting a low risk for adverse health consequences...
  19. ncbi Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin
    Michael B Zimmermann
    Human Nutrition Laboratory, The Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 90:1280-7. 2009
    ..Plasma hepcidin appears to be a major regulator of iron absorption and homeostasis, but there are few data in humans...
  20. ncbi Extruded rice fortified with micronized ground ferric pyrophosphate reduces iron deficiency in Indian schoolchildren: a double-blind randomized controlled trial
    Diego Moretti
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 84:822-9. 2006
    ..Iron fortification of rice could be an effective strategy for reducing iron deficiency anemia in South Asia...
  21. pmc Iron depletion and repletion with ferrous sulfate or electrolytic iron modifies the composition and metabolic activity of the gut microbiota in rats
    Alexandra Dostal
    Institute of Food, Nutrition and Health, Zurich, Switzerland
    J Nutr 142:271-7. 2012
    ..In conclusion, Fe depletion and repletion strongly affect the composition and metabolic activity of rat gut microbiota...
  22. doi Efficacy of wheat-based biscuits fortified with microcapsules containing ferrous sulfate and potassium iodate or a new hydrogen-reduced elemental iron: a randomised, double-blind, controlled trial in Kuwaiti women
    Ralf Biebinger
    The Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    Br J Nutr 102:1362-9. 2009
    ..01). NutraFine RS added at double the amount of Fe as FeSO4 was not efficacious in improving Fe status. The newly developed microcapsules were highly efficacious in improving both Fe stores and iodine status...
  23. doi Iodine treatment in children with subclinical hypothyroidism due to chronic iodine deficiency decreases thyrotropin and C-peptide concentrations and improves the lipid profile
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Thyroid 19:1099-104. 2009
    ..Thus, the study aim was to determine if iodine treatment of children with elevated TSH concentrations due to ID would affect their lipid profile, insulin (C-peptide) levels, and/or subclinical inflammation...
  24. ncbi Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 81:615-23. 2005
    ..Although transferrin receptor (TfR) and zinc protoporphyrin (ZnPP) are often used to define iron status in school-age children in developing countries, the diagnostic cutoffs for this age group are uncertain...
  25. ncbi Dietary intakes of fat and antioxidant vitamins are predictors of subclinical inflammation in overweight Swiss children
    Isabelle Aeberli
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 84:748-55. 2006
    ..Dietary factors, such as fatty acids and antioxidants, potentially modulate the association between adiposity and subclinical inflammation, but few data are available in children...
  26. ncbi Comparison of the efficacy of wheat-based snacks fortified with ferrous sulfate, electrolytic iron, or hydrogen-reduced elemental iron: randomized, double-blind, controlled trial in Thai women
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 82:1276-82. 2005
    ..Although elemental iron powders are widely used to fortify cereal products, little data exist on their efficacy in humans...
  27. ncbi Treatment of iodine deficiency in school-age children increases insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations and improves somatic growth
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, LFV E19, Schmelzbergstrasse 7, CH 8092 Zurich, Switzerland
    J Clin Endocrinol Metab 92:437-42. 2007
    ..Iodine deficiency in utero impairs fetal growth, but the relationship between iodine deficiency and postnatal growth is less clear...
  28. ncbi Iron metabolism in heterozygotes for hemoglobin E (HbE), alpha-thalassemia 1, or beta-thalassemia and in compound heterozygotes for HbE/beta-thalassemia
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 88:1026-31. 2008
    ..Despite large populations carrying traits for thalassemia in countries implementing universal iron fortification, there are few data on the absorption and utilization of iron in these persons...
  29. ncbi Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, LFV E19, Schmelzbergstrasse 7, CH 8092 Zurich, Switzerland
    J Clin Endocrinol Metab 91:4881-7. 2006
    ..Thyroglobulin (Tg) may be a valuable indicator of improving thyroid function in children after salt iodization. A recently developed Tg assay for use on dried whole blood spots (DBS) makes sampling practical, even in remote areas...
  30. doi Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate
    Maria Andersson
    Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 92:1094-104. 2010
    ..Random serial sampling is widely used in population pharmacokinetic studies and may have advantages compared with conventional fixed time-point evaluation of iron fortification...
  31. ncbi Iron status influences the efficacy of iodine prophylaxis in goitrous children in Côte d'Ivoire
    Michael B Zimmermann
    Laboratory for Human Nutrition, Food Science Institute, Swiss Federal Institute of Technology Zurich, Seestrasse 72 P O Box 474, CH 8803 Ruschlikon, Switzerland
    Int J Vitam Nutr Res 72:19-25. 2002
    ..The data suggest that a high prevalence of IDA among children in areas of endemic goiter may reduce the effectiveness of iodine prophylaxis...
  32. doi Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents
    Stefanie B Murer
    Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland
    J Nutr 144:193-201. 2014
    ..The study was registered at clinicaltrials.gov as NCT01316081...
  33. ncbi Introduction of iodized salt to severely iodine-deficient children does not provoke thyroid autoimmunity: a one-year prospective trial in northern Morocco
    Michael B Zimmermann
    The Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Thyroid 13:199-203. 2003
    ..Rapid introduction of iodized salt does not provoke significant thyroid autoimmunity in severely iodine-deficient children followed for 1 year...
  34. ncbi Addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous, iron-deficient children: a randomized, double-blind, controlled trial
    Michael B Zimmermann
    The Human Nutrition Laboratory, Swiss Federal Institute of Technology, Seestrasse 72 PO Box 474, CH 8803 Ruschlikon, Switzerland
    Eur J Endocrinol 147:747-53. 2002
    ..The study aim was to determine if co-fortification of iodized salt with Fe would improve efficacy of the iodine in goitrous children with a high prevalence of anemia...
  35. ncbi Development of a dried whole-blood spot thyroglobulin assay and its evaluation as an indicator of thyroid status in goitrous children receiving iodized salt
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Switzerland
    Am J Clin Nutr 77:1453-8. 2003
    ..Serum thyroglobulin appears to be a sensitive marker of thyroid dysfunction in endemic goiter. However, its value as an indicator of thyroid status in children after the introduction of iodized salt has not been tested...
  36. ncbi Particle size reduction and encapsulation affect the bioavailability of ferric pyrophosphate in rats
    Rita Wegmüller
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Institute of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Nutr 134:3301-4. 2004
    ..Encapsulation of FePP with hydrogenated palm oil at a capsule:substrate ratio of 60:40 decreased RBV. Particle size reduction increases the RBV of FePP and may make this compound more useful for food fortification...
  37. doi Global iodine status in 2011 and trends over the past decade
    Maria Andersson
    Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland
    J Nutr 142:744-50. 2012
    ..Intervention programs need to be extended to reach the nearly one-third of the global population that still has inadequate iodine intakes...
  38. ncbi Rapid relapse of thyroid dysfunction and goiter in school-age children after discontinuation of salt iodization
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Ruschlikon, Switzerland
    Am J Clin Nutr 79:642-5. 2004
    ..In programs to control iodine deficiency disorders (IDD), sustainability is a major concern. IDD has recently recurred in countries where salt iodization programs have lapsed...
  39. pmc Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women
    Colin I Cercamondi
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 92:1385-92. 2010
    ..Iron deficiency anemia (IDA) affects many young women in sub-Saharan Africa. Its etiology is multifactorial, but the major cause is low dietary iron bioavailability exacerbated by parasitic infections such as malaria...
  40. ncbi Iron deficiency due to consumption of a habitual diet low in bioavailable iron: a longitudinal cohort study in Moroccan children
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 81:115-21. 2005
    ..In many developing countries, cereal and legume-based diets contain low amounts of bioavailable iron, which may increase the risk of iron deficiency...
  41. ncbi The influence of iron status on iodine utilization and thyroid function
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zürich CH 8092 Switzerland
    Annu Rev Nutr 26:367-89. 2006
    ..The dual fortification of salt with iodine and iron may prove to be an effective and sustainable method to accomplish these important goals...
  42. doi Iron from nanocompounds containing iron and zinc is highly bioavailable in rats without tissue accumulation
    Florentine M Hilty
    Human Nutrition Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, Zurich, Switzerland
    Nat Nanotechnol 5:374-80. 2010
    ..Nanosizing of poorly water-soluble Fe compounds sharply increases their absorption and nutritional value...
  43. ncbi Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire
    Sonja Y Hess
    Human Nutrition Laboratory, The Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 75:743-8. 2002
    ..In many developing countries, children are at high risk of both goiter and iron deficiency anemia. Iron deficiency adversely affects thyroid metabolism and may reduce the efficacy of iodine prophylaxis in areas of endemic goiter...
  44. doi Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology Zentrum, Zurich, Switzerland
    Am J Clin Nutr 89:668S-72S. 2009
    ..In countries or regions where <90% of households are using iodized salt and the median UI concentration in school-age children is <100 microg/L, the WHO recommends iodine supplementation in pregnancy and infancy...
  45. doi Decrease in the prevalence of paediatric adiposity in Switzerland from 2002 to 2007
    Isabelle Aeberli
    Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    Public Health Nutr 13:806-11. 2010
    ..Since then, many programmes have been introduced in an attempt to control the problem. The aim of the present study was to determine the prevalence of childhood overweight in Switzerland five years later...
  46. ncbi The potential of encapsulated iron compounds in food fortification: a review
    Michael B Zimmermann
    Laboratory for Human Nutrition, Institute for Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Ruschlikon, Switzerland
    Int J Vitam Nutr Res 74:453-61. 2004
    ..Further research is needed to determine which encapsulation technologies are most effective in ensuring iron bioavailability from encapsulated compounds...
  47. ncbi Thyroid size and goiter prevalence after introduction of iodized salt: a 5-y prospective study in schoolchildren in Côte d'Ivoire
    Michael B Zimmermann
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 77:663-7. 2003
    ..Normalization of the goiter rate probably indicates disappearance of iodine deficiency disorders as a public health problem. However, thyroid size may not return to normal for months or years after correction of iodine deficiency...
  48. pmc Low iron availability in continuous in vitro colonic fermentations induces strong dysbiosis of the child gut microbial consortium and a decrease in main metabolites
    Alexandra Dostal
    Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland
    FEMS Microbiol Ecol 83:161-75. 2013
    ..The strong dysbiosis of the gut microbiota together with decrease in main gut microbiota metabolites observed with very low iron conditions could weaken the barrier effect of the microbiota and negatively impact gut health...
  49. doi The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire
    Michael B Zimmermann
    Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 92:1406-15. 2010
    ..Thus, increasing colonic iron could select gut microbiota for humans that are unfavorable to the host...
  50. doi Iodine-deficiency disorders
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Lancet 372:1251-62. 2008
    ..International efforts to control iodine-deficiency disorders are slowing, and reaching the third of the worldwide population that remains deficient poses major challenges...
  51. doi Iodine deficiency
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Schmelzbergstrasse 7, LFV E19, CH 8092 Zurich, Switzerland
    Endocr Rev 30:376-408. 2009
    ....
  52. ncbi Iron deficiency predicts poor maternal thyroid status during pregnancy
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Eidgenössische Technische Hochschule Zürich, Schmelzbergstrasse 7, LFV E 19, CH 8092 Zurich, Switzerland
    J Clin Endocrinol Metab 92:3436-40. 2007
    ..Pregnant women are often iron deficient, and iron deficiency has adverse effects on thyroid metabolism. Impaired maternal thyroid function during pregnancy may cause neurodevelopmental delays in the offspring...
  53. ncbi Overweight and obesity in 6-12 year old children in Switzerland
    Michael B Zimmermann
    Laboratory for Human Nutrition, Institute for Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Swiss Med Wkly 134:523-8. 2004
    ..Our aim was to estimate the national prevalence of overweight and obesity in Swiss primary schoolchildren and to determine if adiposity is increasing in this age group...
  54. ncbi Dietary intake and physical activity of normal weight and overweight 6 to 14 year old Swiss children
    Isabelle Aeberli
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    Swiss Med Wkly 137:424-30. 2007
    ..The aim of the study was therefore to compare nutrient intake, dietary patterns and physical activity in overweight and normal weight children in Switzerland...
  55. doi In male rats with concurrent iron and (n-3) fatty acid deficiency, provision of either iron or (n-3) fatty acids alone alters monoamine metabolism and exacerbates the cognitive deficits associated with combined deficiency
    Jeannine Baumgartner
    Laboratory of Human Nutrition, ETH Zurich, Zurich, Switzerland
    J Nutr 142:1472-8. 2012
    ....
  56. doi The role of iodine in human growth and development
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Semin Cell Dev Biol 22:645-52. 2011
    ..Iodine prophylaxis of deficient populations with periodic monitoring is an extremely cost effective approach to reduce the substantial adverse effects of iodine deficiency throughout the life cycle...
  57. ncbi Nutritional iron deficiency
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Lancet 370:511-20. 2007
    ..Selective plant breeding and genetic engineering are promising new approaches to improve dietary iron nutritional quality...
  58. ncbi Assessing iodine status and monitoring progress of iodized salt programs
    Michael B Zimmermann
    Laboratory for Human Nutrition, Institute for Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, CH 8803 Ruschlikon, Switzerland
    J Nutr 134:1673-7. 2004
    ..A recent cohort study demonstrated the vulnerability of children in IDD-affected areas to even short-term lapses in iodized salt programs...
  59. ncbi Stabilization of the prevalence of childhood obesity in Switzerland
    Isabelle Aeberli
    Institute of Food Science and Nutrition, Human Nutrition Laboratory, ETH Zurich, Zurich, Switzerland
    Swiss Med Wkly 140:w13046. 2010
    ..The prevalence of childhood obesity is increasing rapidly in most industrialised countries, but several countries, including Switzerland, have recently reported a levelling off or even a reversal of this alarming trend...
  60. ncbi Iron fortification reduces blood lead levels in children in Bangalore, India
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Pediatrics 117:2014-21. 2006
    ..Our study objective was to determine if iron fortification reduces blood lead levels in urban, lead-exposed, iron-deficient children in Bangalore, India...
  61. ncbi High thyroid volume in children with excess dietary iodine intakes
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 81:840-4. 2005
    ..There are few data on the adverse effects of chronic exposure to high iodine intakes, particularly in children...
  62. ncbi New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Am J Clin Nutr 79:231-7. 2004
    ..In areas of mild-to-moderate IDDs, measurement of thyroid volume (Tvol) by ultrasound is preferable to palpation for grading goiter, but interpretation requires reference criteria from iodine-sufficient children...
  63. ncbi Measurement of magnesium absorption and retention in type 2 diabetic patients with the use of stable isotopes
    Monika K Wälti
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Am J Clin Nutr 78:448-53. 2003
    ..The etiology of magnesium depletion in diabetes is unclear. Animal studies suggest that diabetes may impair magnesium absorption; however, there are no published data on magnesium absorption in humans with diabetes...
  64. ncbi The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Thyroid 17:829-35. 2007
    ....
  65. doi The effects of iodine deficiency in pregnancy and infancy
    Michael B Zimmermann
    Laboratory for Human Nutrition, Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Paediatr Perinat Epidemiol 26:108-17. 2012
    ..5 points. In nearly all regions affected by iodine deficiency, salt iodisation is the most cost-effective way of delivering iodine and improving maternal and infant health...
  66. ncbi Enhancing the absorption of fortification iron. A SUSTAIN Task Force report
    Richard F Hurrell
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Int J Vitam Nutr Res 74:387-401. 2004
    ..An approach to the calculation of cost using a conservative estimate of the enhancing effects of the innovative technologies discussed in the supplement is given in the final section...
  67. ncbi Severe iodine deficiency in southern Albania
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Int J Vitam Nutr Res 73:347-50. 2003
    ..These findings suggest that regional distribution of oral iodized oil capsules is indicated to control IDD in vulnerable groups until salt iodization is implemented...
  68. doi Nanocompounds of iron and zinc: their potential in nutrition
    Michael B Zimmermann
    Laboratory of Human Nutrition, ETH Zurich, 8092, Zurich, Switzerland
    Nanoscale 3:2390-8. 2011
    ..Thus, these novel compounds show promise as food fortificants or supplements...
  69. doi Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women
    Franziska König
    Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland
    J Nutr 141:2049-54. 2011
    ..However, the large number of repeated urine samples needed to estimate individual iodine status is a major limitation and emphasizes the need for further investigation of more practical biomarkers of individual iodine status...
  70. ncbi Increasing the iodine concentration in the Swiss iodized salt program markedly improved iodine status in pregnant women and children: a 5-y prospective national study
    Michael B Zimmermann
    Laboratory for Human Nutrition, Institute for Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 82:388-92. 2005
    ..In Switzerland, because of declining iodine intakes in children and pregnant women, the iodine concentration in table salt was increased from 15 to 20 mg/kg...
  71. doi Methods to assess iron and iodine status
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Schmelzbergstrasse 7, LFV E 19, CH 8092 Zurich, Switzerland
    Br J Nutr 99:S2-9. 2008
    ..In the absence of inflammation, a sensitive method to assess iron status is to combine the use of serum ferritin as a measure of iron stores and the serum transferrin receptor as a measure of tissue iron deficiency...
  72. ncbi Research on iodine deficiency and goiter in the 19th and early 20th centuries
    Michael B Zimmermann
    The Human Nutrition Laboratory, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland
    J Nutr 138:2060-3. 2008
    ..Switzerland's iodized salt program has been operating uninterrupted since 1922. Today, control of the iodine deficiency disorders is an integral part of most national nutrition strategies...
  73. doi Iodine: it's important in patients that require parenteral nutrition
    Michael B Zimmermann
    Human Nutrition Laboratory, ETH Zurich, Switzerland
    Gastroenterology 137:S36-46. 2009
    ..Adults may be less vulnerable because thyroidal iodine stores may be able to support thyroid hormone production for several months. More studies to clarify this issue would be valuable...
  74. ncbi Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children
    Isabelle Aeberli
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, 8092 Zurich, Switzerland
    J Clin Endocrinol Metab 92:4359-65. 2007
    ..There are few published data on RBP4 levels in overweight children, and most previous studies did not control for vitamin A (VA) status and/or subclinical inflammation...
  75. ncbi Low plasma magnesium in type 2 diabetes
    Monika K Wälti
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Swiss Med Wkly 133:289-92. 2003
    ..The aim of this study was to compare plasma magnesium concentrations of type 2 diabetics and healthy controls in Switzerland...
  76. doi Baseline leptin and leptin reduction predict improvements in metabolic variables and long-term fat loss in obese children and adolescents: a prospective study of an inpatient weight-loss program
    Stefanie B Murer
    Human Nutrition Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Switzerland
    Am J Clin Nutr 93:695-702. 2011
    ..Moreover, whether changes in leptin predict metabolic improvements during weight loss is uncertain...
  77. ncbi Interactions of vitamin A and iodine deficiencies: effects on the pituitary-thyroid axis
    Michael B Zimmermann
    Human Nutrition Laboratory, Institute for Food Science and Nutrition, LFV E19
    Int J Vitam Nutr Res 77:236-40. 2007
    ....
  78. ncbi Mild riboflavin deficiency is highly prevalent in school-age children but does not increase risk for anaemia in Côte d'Ivoire
    Fabian Rohner
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Schmelzbergstrasse 7, 8092 Ziirich, Switzerland
    Br J Nutr 97:970-6. 2007
    ..Riboflavin deficiency did not predict Hb and/or anaemia, but did predict iron deficiency among children free of malaria...
  79. ncbi The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology Zurich, Seestrasse 72 Postfach 474, CH 8803 Ruschlikon, Switzerland
    J Clin Endocrinol Metab 89:5441-7. 2004
    ..This effect could be due to decreased VA-mediated suppression of the pituitary TSHbeta gene. In IDD- and VAD-affected children receiving iodized salt, concurrent VA supplementation improves iodine efficacy...
  80. doi Symposium on 'Geographical and geological influences on nutrition': Iodine deficiency in industrialised countries
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology Zurich, Schmelzbergstrasse 7, LFV E19, CH 8092 Zurich, Switzerland
    Proc Nutr Soc 69:133-43. 2010
    ....
  81. ncbi Effect of concurrent vitamin A and iodine deficiencies on the thyroid-pituitary axis in rats
    Ralf Biebinger
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    Thyroid 16:961-5. 2006
    ..Vitamin A deficiency (VAD) may adversely affect thyroid metabolism. The study aim was to investigate the effects of concurrent vitamin A and iodine deficiencies on the thyroid-pituitary axis in rats...
  82. doi Iodine in enteral and parenteral nutrition
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Best Pract Res Clin Endocrinol Metab 24:143-58. 2010
    ..Infants may be particularly vulnerable to ID because of their small thyroidal iodine store. In this review, we describe three recent patients (an infant, a child and an adult) who developed ID and thyroid hypofunction during PN...
  83. ncbi Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size
    Ralf Biebinger
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    J Nutr 137:573-7. 2007
    ..In concurrent VAD and ID, VAS, independent of iodine repletion, reduces thyroid hyperstimulation and size, an effect likely mediated through the effects of VA on pituitary TSHbeta gene expression...
  84. ncbi Improving iron, zinc and vitamin A nutrition through plant biotechnology
    Michael B Zimmermann
    Laboratory of Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, PO Box 474, CH 8803 Ruschlikon, Switzerland
    Curr Opin Biotechnol 13:142-5. 2002
    ..Improving the micronutrient composition of plant foods may become a sustainable strategy to combat deficiencies in human populations, replacing or complementing other strategies such as food fortification or nutrient supplementation...
  85. doi Does obesity increase risk for iron deficiency? A review of the literature and the potential mechanisms
    Ana C Cepeda-Lopez
    Human Nutrition Division, Wageningen University, Wageningen, The Netherlands, and Health Sciences Division, Universidad de Monterrey, Mexico
    Int J Vitam Nutr Res 80:263-70. 2010
    ..In this review, we focus on subclinical inflammation in obesity, and its effect on hepcidin levels, as the most plausible explanation for the link between iron deficiency and obesity...
  86. ncbi Comparison of manual and automated ELISA methods for serum ferritin analysis
    Fabian Rohner
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Clin Lab Anal 19:196-8. 2005
    ..We conclude that the automated assay has several potential advantages compared to the manual method, including better precision, less operator dependence, and faster sample through-put...
  87. ncbi Detection of overweight and obesity in a national sample of 6-12-y-old Swiss children: accuracy and validity of reference values for body mass index from the US Centers for Disease Control and Prevention and the International Obesity Task Force
    Michael B Zimmermann
    Laboratory for Human Nutrition, Institute for Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, PO Box 474, Seestrasse 72, CH 8803 Ruschlikon, Switzerland
    Am J Clin Nutr 79:838-43. 2004
    ..However, these 2 sets of reference criteria differ, and their accuracy in classifying adiposity has not yet been validated in most countries...
  88. ncbi Iron deficiency anemia reduces thyroid peroxidase activity in rats
    Sonja Y Hess
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Nutr 132:1951-5. 2002
    ..05). These data indicate that Fe deficiency sharply reduces TPO activity and suggest that decreased TPO activity contributes to the adverse effects of IDA on thyroid metabolism...
  89. doi The impact of iodised salt or iodine supplements on iodine status during pregnancy, lactation and infancy
    Michael B Zimmermann
    Swiss Federal Institute of Technology Zurich, ETH Zentrum, Schmelzbergstrasse 7, LFV E19, CH 8092 Zurich, Switzerland
    Public Health Nutr 10:1584-95. 2007
    ....
  90. ncbi Iodine requirements and the risks and benefits of correcting iodine deficiency in populations
    Michael B Zimmermann
    The Human Nutrition Laboratory, ETH Zurich, Switzerland
    J Trace Elem Med Biol 22:81-92. 2008
    ..Although more data on the epidemiology of thyroid disorders caused by differences in iodine intake are needed, overall, the relatively small risks of iodine excess are far outweighed by the substantial risks of iodine deficiency...
  91. ncbi Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire
    Rita Wegmüller
    Programme National de Nutrition, Abidjan, Cote d Ivoire
    J Nutr 136:1814-20. 2006
    ..Iron utilization may have been impaired by the high prevalence of malaria and concurrent nutrient deficiencies...
  92. doi Reference values for spot urinary iodine concentrations in iodine-sufficient newborns using a new pad collection method
    Corine M Dorey
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Thyroid 18:347-52. 2008
    ....
  93. ncbi The effect of micronutrient deficiencies on iodine nutrition and thyroid metabolism
    Sonja Y Hess
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, Seestrasse 72, PO Box 474, CH 8803 Ruschlikon, Switzerland
    Int J Vitam Nutr Res 74:103-15. 2004
  94. ncbi Synthesis, characterization, and bioavailability in rats of ferric phosphate nanoparticles
    Fabian Rohner
    Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    J Nutr 137:614-9. 2007
    ..In conclusion, nanoparticles of FePO(4) have a solubility and RBV not significantly different from FeSO(4). Reducing poorly soluble Fe compounds to nanoscale may increase their value for human nutrition...
  95. ncbi FLOTAC: a new sensitive technique for the diagnosis of hookworm infections in humans
    Jurg Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Trans R Soc Trop Med Hyg 102:84-90. 2008
    ..7 EPG) and ether concentration (5.7 EPG) methods. The FLOTAC method shows promise as an important new tool for individual hookworm diagnosis and for rigorous monitoring of helminth control programmes. [Clinical Trial No. ISRCTN21782274]...
  96. ncbi Salt as a carrier of iodine in iodine deficient areas
    Hans Burgi
    Fluorine Iodine Commission, Swiss Academy of Medical Sciences
    Schweiz Monatsschr Zahnmed 115:648-50. 2005
    ..However, the advantages of salt as a carrier largely outweigh its drawbacks, and today iodized salt is available to over one billion people...