K M Wegner

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. doi request reprint Massive parallel MHC genotyping: titanium that shines
    K Mathias Wegner
    Institute of Integrative Biology IBZ, Experimental Ecology, ETH Zurich, Zurich, Switzerland
    Mol Ecol 18:1818-20. 2009
  2. doi request reprint Host genetic architecture in single and multiple infections
    K M Wegner
    Experimental Ecology, Institute of Integrative Biology, ETH Zürich Universitätstrasse, Zurich, Switzerland
    J Evol Biol 22:396-404. 2009
  3. pmc Clustering of Drosophila melanogaster immune genes in interplay with recombination rate
    K Mathias Wegner
    Institute for Integrative Biology, Experimental Ecology, ETH Zurich, Zurich, Switzerland
    PLoS ONE 3:e2835. 2008
  4. doi request reprint Nonadditive genetic components in resistance of the red flour beetle Tribolium castanaeum against parasite infection
    K Mathias Wegner
    Experimental Ecology, Institute of Integrative Biology, ETH Zurich, Switzerland
    Evolution 62:2381-92. 2008
  5. pmc Mortality selection during the 2003 European heat wave in three-spined sticklebacks: effects of parasites and MHC genotype
    K Mathias Wegner
    Department of Integrative Biology IBZ, Experimental Ecology, ETH Zurich, Universitatstrasse 16, CH 8092 Zurich, Switzerland
    BMC Evol Biol 8:124. 2008
  6. ncbi request reprint Genetic variation in MHC class II expression and interactions with MHC sequence polymorphism in three-spined sticklebacks
    K M Wegner
    Max Planck Institute of Limnology, Department of Evolutionary Ecology, August Thienemann Str 2, 24306 Plön, Germany
    Mol Ecol 15:1153-64. 2006
  7. ncbi request reprint Rapid genetic divergence in postglacial populations of threespine stickleback (Gasterosteus aculeatus): the role of habitat type, drainage and geographical proximity
    T B Reusch
    Max Planck Institut für Limnologie, Abt Evolutions Okologie, August Thienemann Str 2, 24306 Plön, Germany
    Mol Ecol 10:2435-45. 2001
  8. doi request reprint Experimental coevolution leads to a decrease in parasite-induced host mortality
    C Berenos
    Institute of Integrative Biology, Experimental Ecology, ETH Zürich Universitätstrasse, Zurich, Switzerland
    J Evol Biol 24:1777-82. 2011
  9. ncbi request reprint Multiple parasites are driving major histocompatibility complex polymorphism in the wild
    K M Wegner
    Max Planck Institute of Limnology, Department of Evolutionary Ecology, Plon, Germany
    J Evol Biol 16:224-32. 2003
  10. pmc Mate choice decisions of stickleback females predictably modified by MHC peptide ligands
    Manfred Milinski
    Department of Evolutionary Ecology, Max Planck Institute of Limnology, 24306 Plön, Germany
    Proc Natl Acad Sci U S A 102:4414-8. 2005

Detail Information

Publications16

  1. doi request reprint Massive parallel MHC genotyping: titanium that shines
    K Mathias Wegner
    Institute of Integrative Biology IBZ, Experimental Ecology, ETH Zurich, Zurich, Switzerland
    Mol Ecol 18:1818-20. 2009
    ..1). Their approach can be useful for many researchers working with complex multiallelic templates and large sample sizes...
  2. doi request reprint Host genetic architecture in single and multiple infections
    K M Wegner
    Experimental Ecology, Institute of Integrative Biology, ETH Zürich Universitätstrasse, Zurich, Switzerland
    J Evol Biol 22:396-404. 2009
    ..These findings may suggest that specificity of host-parasite interactions are mediated by genetic and especially epistatic components whereas maternal effects constitute a more general form of resistance...
  3. pmc Clustering of Drosophila melanogaster immune genes in interplay with recombination rate
    K Mathias Wegner
    Institute for Integrative Biology, Experimental Ecology, ETH Zurich, Zurich, Switzerland
    PLoS ONE 3:e2835. 2008
    ..To identify patterns left by the intimate interaction between hosts and parasites, I analysed the genomic parameters of the immune genes from 24 gene families/groups of Drosophila melanogaster...
  4. doi request reprint Nonadditive genetic components in resistance of the red flour beetle Tribolium castanaeum against parasite infection
    K Mathias Wegner
    Experimental Ecology, Institute of Integrative Biology, ETH Zurich, Switzerland
    Evolution 62:2381-92. 2008
    ..castanaeum can be understood as a multi peaked fitness landscape with epistasis contributing substantially to phenotypic differentiation in resistance...
  5. pmc Mortality selection during the 2003 European heat wave in three-spined sticklebacks: effects of parasites and MHC genotype
    K Mathias Wegner
    Department of Integrative Biology IBZ, Experimental Ecology, ETH Zurich, Universitatstrasse 16, CH 8092 Zurich, Switzerland
    BMC Evol Biol 8:124. 2008
    ....
  6. ncbi request reprint Genetic variation in MHC class II expression and interactions with MHC sequence polymorphism in three-spined sticklebacks
    K M Wegner
    Max Planck Institute of Limnology, Department of Evolutionary Ecology, August Thienemann Str 2, 24306 Plön, Germany
    Mol Ecol 15:1153-64. 2006
    ..The observed differences among families and the negative correlation with individual sequence diversity imply that MHC expression is evolutionary relevant for the onset and control of the immune response in natural populations...
  7. ncbi request reprint Rapid genetic divergence in postglacial populations of threespine stickleback (Gasterosteus aculeatus): the role of habitat type, drainage and geographical proximity
    T B Reusch
    Max Planck Institut für Limnologie, Abt Evolutions Okologie, August Thienemann Str 2, 24306 Plön, Germany
    Mol Ecol 10:2435-45. 2001
    ..This demonstrates both the utility of hypervariable microsatellites for detecting recent population divergences and the danger of operating at temporal or spatial scales which are beyond their resolution...
  8. doi request reprint Experimental coevolution leads to a decrease in parasite-induced host mortality
    C Berenos
    Institute of Integrative Biology, Experimental Ecology, ETH Zürich Universitätstrasse, Zurich, Switzerland
    J Evol Biol 24:1777-82. 2011
    ....
  9. ncbi request reprint Multiple parasites are driving major histocompatibility complex polymorphism in the wild
    K M Wegner
    Max Planck Institute of Limnology, Department of Evolutionary Ecology, Plon, Germany
    J Evol Biol 16:224-32. 2003
    ..We thus present correlative evidence supporting the 'allele counting' strategy for optimizing the immunocompetence in stickleback offspring...
  10. pmc Mate choice decisions of stickleback females predictably modified by MHC peptide ligands
    Manfred Milinski
    Department of Evolutionary Ecology, Max Planck Institute of Limnology, 24306 Plön, Germany
    Proc Natl Acad Sci U S A 102:4414-8. 2005
    ..Our results suggest that female sticklebacks use evolutionarily conserved structural features of MHC peptide ligands to evaluate MHC diversity of their prospective mating partners...
  11. ncbi request reprint Contrasting mode of evolution between the MHC class I genomic region and class II region in the three-spined stickleback (Gasterosteus aculeatus L.; Gasterosteidae: Teleostei)
    Helmut Schaschl
    Department of Evolutionary Ecology, Max Planck Institute for Limnology, Ploen, Germany
    Immunogenetics 59:295-304. 2007
    ..In humans, however, homologues of Oct-2 beta and ATPasealpha3 lie outside the MHC region, which indicates that the concentration of immune genes found in mammalian genomes is a derived state...
  12. ncbi request reprint Parasites and individual major histocompatibility complex diversity--an optimal choice?
    K Mathias Wegner
    Department of Evolutionary Ecology, Max Planck Institute of Limnology, August Thienemann Street 2, 24306 Plön, Germany
    Microbes Infect 6:1110-6. 2004
    ..Here, we review recent studies suggesting that due to the dominant nature of MHC-mediated resistance, a heterozygote advantage is most likely to be detected in multiple pathogen challenges...
  13. pmc Major histocompatibility complex diversity influences parasite resistance and innate immunity in sticklebacks
    Joachim Kurtz
    Department of Evolutionary Ecology, Max Planck Institute of Limnology, August Thienemann Strasse 2, 24306 Plön, Germany
    Proc Biol Sci 271:197-204. 2004
    ..Such a pattern is consistent with theoretical expectations of an optimal balance between the number of recognizable antigens and self-tolerance...
  14. ncbi request reprint Parasite selection for immunogenetic optimality
    K Mathias Wegner
    Max Planck Institute for Limnology, Department of Evolutionary Ecology, August Thienemann Str 2, 24306 Plön, Germany
    Science 301:1343. 2003
  15. pmc MHC genes and oxidative stress in sticklebacks: an immuno-ecological approach
    Joachim Kurtz
    Department of Evolutionary Ecology, Max Planck Institute of Limnology, August Thienemann Strasse 2, 24306 Plön, Germany
    Proc Biol Sci 273:1407-14. 2006
    ..They could, thus, also be relevant in the broader context of the evolution of sexually selected signals that are based on carotenoids and are, thus supposed to reflect oxidative stress resistance...
  16. ncbi request reprint Recent duplication and inter-locus gene conversion in major histocompatibility class II genes in a teleost, the three-spined stickleback
    Thorsten B H Reusch
    Max Planck Institut für Limnologie, August Thienemann Strasse 2, 24306 Plön, Germany
    Immunogenetics 56:427-37. 2004
    ..007). In accordance, we found a 10- to 20-fold higher frequency of CpG-islands on the MH class II segment compared to other species, a feature that may be conducive for inter-locus recombination...