Research Topics
Genomes and Genes | Theo WallimannSummaryAffiliation: Swiss Federal Institute of Technology Country: Switzerland Publications
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Detail Information
Publications
Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1Olivier Braissant
Clinical Chemistry Laboratory, University Hospital, CH 1011 Lausanne, Switzerland
BMC Dev Biol 5:9. 2005..To investigate the involvement of Cr synthesis and uptake pathways during embryonic development, we determined the spatiotemporal expression of AGAT, GAMT and CT1 during the rat embryogenesis, at the mRNA and protein level...- Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouseZoe Ireland
Department of Physiology, Monash University, Clayton, Australia 3800
BMC Dev Biol 9:39. 2009..Using the spiny mouse as a model of human perinatal development, the purpose of the present study was to comprehensively examine the development of the creatine synthesis and transport systems... 
Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiologyT Wallimann
Institute of Cell Biology, ETH Honggerberg, Zurich, Switzerland
Biofactors 8:229-34. 1998....- The creatine kinase system and pleiotropic effects of creatineTheo Wallimann
Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
Amino Acids 40:1271-96. 2011..This may help to alleviate human starvation and at the same time prevent over-fishing of oceans... - Reduced creatine-stimulated respiration in doxorubicin challenged mitochondria: particular sensitivity of the heartMalgorzata Tokarska-Schlattner
Institute of Cell Biology, ETH Zurich, CH 8093, Zurich, Switzerland
Biochim Biophys Acta 1767:1276-84. 2007..The relevance of these findings for the regulation of mitochondrial energy production in the heart, as well as the obvious differences of DXR action in the heart as compared to brain tissue, is discussed... - Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supplyMalgorzata Tokarska-Schlattner
Institute of Cell Biology, Swiss Federal Institute of Technology, Hönggerberg HPM F23, CH 8093 Zurich, Switzerland
Am J Physiol Heart Circ Physiol 289:H37-47. 2005..These results suggest that an impairment of kinase systems regulating cellular energy homeostasis is involved in the development of DXR cardiotoxicity... - C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinaseUwe Schlattner
Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
J Biol Chem 279:24334-42. 2004..These results are discussed in regard to MtCK microcompartments and evolution... - Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicinMalgorzata Tokarska-Schlattner
Institute of Cell Biology, ETH Zurich, Hönggerberg HPM D24, CH 8093 Zurich, Switzerland
C R Biol 329:657-68. 2006..Here we review doxorubicin-induced detrimental changes in cardiac energetics, with an emphasis on the emerging importance of defects in energy-transferring and -signalling systems, like creatine kinase and AMP-activated protein kinase... - PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysisNabil Djouder
Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
EMBO J 29:469-81. 2010..These results suggest a new mechanism of negative regulation of AMPK activity by PKA that is important for converting a lipolytic signal into an effective lipolytic response... - Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complexDietbert Neumann
ETH Zurich, Institute of Cell Biology, HPM D23, Schafmattstr 18, Zurich, Switzerland
Mol Biotechnol 36:220-31. 2007..Functional mammalian LKB1 complex is constitutively active, and when enriched from bacteria should prove to be a valuable tool for studying its molecular function and regulation... - New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energeticsMalgorzata Tokarska-Schlattner
Institute of Cell Biology, ETH Zurich, Hönggerberg HPM D24, CH 8093 Zurich, Switzerland
J Mol Cell Cardiol 41:389-405. 2006.... - Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helixRoland Scholz
Department of Biology, Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
J Biol Chem 284:27425-37. 2009..Our data suggest a physiological role for the hydrophobic alphaG-helix residues in homo-oligomerization of heterotrimers and cellular interactions, in particular with upstream kinases, indicating an additional level of AMPK regulation... 
Tracking and quantification of 32P-labeled phosphopeptides in liquid chromatography matrix-assisted laser desorption/ionization mass spectrometryRoland D Tuerk
Institute of Cell Biology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland
Anal Biochem 390:141-8. 2009..However, accurate analysis of defined areas within single spots suggests that, rather than such quantitative differences, mainly the manner of matrix crystallization significantly affects ionization of phosphopeptides...- Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinaseMarianne Suter
Institute of Cell Biology, Schafmattstrasse 18, ETH Zurich, 8093 Zurich, Switzerland
J Biol Chem 281:32207-16. 2006..These data shed new light on physiologically important aspects of AMPK regulation... - Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membraneOliver Speer
Swiss Federal Institute of Technology, ETH Zurich, Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
Biochem J 385:445-50. 2005..We conclude that octameric uMtCK induces the formation of mitochondrial contact sites, leading to membrane cross-linking and to an increased stability of the mitochondrial membrane architecture... - Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentationMax Dolder
Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
J Biol Chem 278:17760-6. 2003..These results are of relevance for the design of creatine analogs for cell protection as potential adjuvant therapeutic tools against neurodegenerative diseases... - An automated home-built low-cost fermenter suitable for large-scale bacterial expression of proteins in Escherichia coliUwe Riek
Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
Biotechniques 45:187-9. 2008.... - Effects of N-linked glycosylation on the creatine transporterNadine Straumann
Swiss Federal Institute of Technology, ETH Zurich, Institute of Cell Biology, ETH Honggerberg, 8093 Zurich, Switzerland
Biochem J 393:459-69. 2006..These findings may have relevance for closely related neurotransmitter transporter family members... - Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residuesSilke Wendt
Institute of Cell Biology, Swiss Federal Institute of Technology, Hönggerberg HPM, CH 8093 Zurich, Switzerland
J Biol Chem 278:1125-30. 2003..The results provide a molecular explanation of how oxidative damage can lead to inactivation and decreased octamer/dimer ratio of MtCK, as seen in neurodegenerative diseases and heart pathology, respectively... - New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinasesRoland D Tuerk
Institutes of Cell Biology and Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
J Proteome Res 6:3266-77. 2007..Our data suggests that signaling by AMPK in brain is likely to be involved in the regulation of pathways that have not yet been linked to this kinase... - Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand bindingUwe Riek
Institute of Cell Biology, Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland
J Biol Chem 283:18331-43. 2008.... - Expressing creatine kinase in transgenic tobacco--a first step towards introducing an energy buffering system in plantsJudith Farrés
Institute of Biotechnology, ETH Zurich, Switzerland
Transgenic Res 11:49-59. 2002..Furthermore, the BB-CK expressing tobacco plants and cell suspension cultures were able to convert creatine into phosphocreatine... - Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergeticsBernd Walzel
Swiss Federal Institute of Technology, , Institute of Cell Biology, , CH-8093 Zurich, Switzerland
J Biol Chem 277:37503-11. 2002..Our data suggest that mitochondria, shown here to possess creatine transport activity, may harbor such a creatine/phosphocreatine pool... - Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophaseTanja S Bürklen
Institute of Cell Biology, HPM D24, ETH Zurich, Schafmattstr 18, Zurich 8093, Switzerland
Mol Cell Biochem 297:53-64. 2007..These data may shed new light on BB-CK function for energy provision for Golgi-fragmentation that is initiated by cell signalling cascades in the early phases of mitosis... - Creatine transporters: a reappraisalOliver Speer
, Institute of Cell Biology, , Zurich, Switzerland
Mol Cell Biochem 256:407-24. 2004..This is in line with 14C-Cr-isotope tracer studies and a number of [31P]-NMR magnetization transfer studies, as well as with recent [1H]-NMR spectroscopy data... - Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-proteinThorsten Hornemann
Institute of Cell Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
J Mol Biol 332:877-87. 2003..Our data propose a simple model for the regulation of this dynamic interaction... - Isoenzyme-directed selection and characterization of anti-creatine kinase single chain Fv antibodies from a human phage display libraryUwe Schlattner
Institute of Cell Biology, Swiss Federal Institute of Technology ETH, Hönggerberg HPM, Zurich CH 8093, Switzerland
Biochim Biophys Acta 1579:124-32. 2002..5-9.6 x 10(-7) M, the isolated scFv compare favorably with mouse mAb and may overcome certain of their limitations. Our results demonstrate the advantages of in vitro antibody selection for the generation of isoenzyme-specific antibodies... - Mitochondrial creatine kinase in human health and diseaseUwe Schlattner
Institute of Cell Biology, , , , Switzerland
Biochim Biophys Acta 1762:164-80. 2006.... - Creatine kinase and creatine transporter in normal, wounded, and diseased skinUwe Schlattner
Institute of Cell Biology, Swiss Federal Institute of Technology, Hönggerberg HPM, Zurich, Switzerland
J Invest Dermatol 118:416-23. 2002.... - Multiple interference of anthracyclines with mitochondrial creatine kinases: preferential damage of the cardiac isoenzyme and its implications for drug cardiotoxicityMalgorzata Tokarska-Schlattner
Institute of Cell Biology, Swiss Federal Institute of Technology (ETH, , , Switzerland
Mol Pharmacol 61:516-23. 2002..All anthracycline effects were significantly more pronounced for sMtCK than for uMtCK. These in vitro results suggest that sMtCK damage may play a role in anthracycline cardiotoxicity... - New creatine transporter assay and identification of distinct creatine transporter isoforms in muscleBernd Walzel
Institute of Cell Biology, , , CH-8093 Zurich, Switzerland
Am J Physiol Endocrinol Metab 283:E390-401. 2002.... - Introduction--creatine: cheap ergogenic supplement with great potential for health and diseaseTheo Wallimann
Institute of Cell Biology, ETH Zurich, , Schafmattstrasse 18, CH-8093 Zurich, Switzerland
Subcell Biochem 46:1-16. 2007 - Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis miceSilke Wendt
Institute for Cell Biology, , , Switzerland
Free Radic Biol Med 32:920-6. 2002..Our data provide evidence for oxidative damage to the CK system in ALS, which may contribute to impaired energy metabolism and neurodegeneration... - Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coliDietbert Neumann
Institute of Cell Biology, Swiss Federal Institute of Technology, , , Switzerland
Protein Expr Purif 30:230-7. 2003.... - Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemiaKathryn H Adcock
Neuroradiology and Magnetic Resonance Research, University Children's Hospital, Zurich, Switzerland
Dev Neurosci 24:382-8. 2002..Additional protection by Cr may be related to prevention of calcium overload, prevention of mitochondrial permeability transition pore opening and direct antioxidant effects...