Theo Wallimann

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1
    Olivier Braissant
    Clinical Chemistry Laboratory, University Hospital, CH 1011 Lausanne, Switzerland
    BMC Dev Biol 5:9. 2005
  2. pmc Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse
    Zoe Ireland
    Department of Physiology, Monash University, Clayton, Australia 3800
    BMC Dev Biol 9:39. 2009
  3. ncbi Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology
    T Wallimann
    Institute of Cell Biology, ETH Honggerberg, Zurich, Switzerland
    Biofactors 8:229-34. 1998
  4. pmc The creatine kinase system and pleiotropic effects of creatine
    Theo Wallimann
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    Amino Acids 40:1271-96. 2011
  5. ncbi Reduced creatine-stimulated respiration in doxorubicin challenged mitochondria: particular sensitivity of the heart
    Malgorzata Tokarska-Schlattner
    Institute of Cell Biology, ETH Zurich, CH 8093, Zurich, Switzerland
    Biochim Biophys Acta 1767:1276-84. 2007
  6. ncbi Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply
    Malgorzata Tokarska-Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology, Hönggerberg HPM F23, CH 8093 Zurich, Switzerland
    Am J Physiol Heart Circ Physiol 289:H37-47. 2005
  7. ncbi C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase
    Uwe Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 279:24334-42. 2004
  8. ncbi Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin
    Malgorzata Tokarska-Schlattner
    Institute of Cell Biology, ETH Zurich, Hönggerberg HPM D24, CH 8093 Zurich, Switzerland
    C R Biol 329:657-68. 2006
  9. ncbi Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex
    Dietbert Neumann
    ETH Zurich, Institute of Cell Biology, HPM D23, Schafmattstr 18, Zurich, Switzerland
    Mol Biotechnol 36:220-31. 2007
  10. pmc PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis
    Nabil Djouder
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 29:469-81. 2010

Collaborators

Detail Information

Publications36

  1. pmc Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1
    Olivier Braissant
    Clinical Chemistry Laboratory, University Hospital, CH 1011 Lausanne, Switzerland
    BMC Dev Biol 5:9. 2005
    ..To investigate the involvement of Cr synthesis and uptake pathways during embryonic development, we determined the spatiotemporal expression of AGAT, GAMT and CT1 during the rat embryogenesis, at the mRNA and protein level...
  2. pmc Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse
    Zoe Ireland
    Department of Physiology, Monash University, Clayton, Australia 3800
    BMC Dev Biol 9:39. 2009
    ..Using the spiny mouse as a model of human perinatal development, the purpose of the present study was to comprehensively examine the development of the creatine synthesis and transport systems...
  3. ncbi Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology
    T Wallimann
    Institute of Cell Biology, ETH Honggerberg, Zurich, Switzerland
    Biofactors 8:229-34. 1998
    ....
  4. pmc The creatine kinase system and pleiotropic effects of creatine
    Theo Wallimann
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    Amino Acids 40:1271-96. 2011
    ..This may help to alleviate human starvation and at the same time prevent over-fishing of oceans...
  5. ncbi Reduced creatine-stimulated respiration in doxorubicin challenged mitochondria: particular sensitivity of the heart
    Malgorzata Tokarska-Schlattner
    Institute of Cell Biology, ETH Zurich, CH 8093, Zurich, Switzerland
    Biochim Biophys Acta 1767:1276-84. 2007
    ..The relevance of these findings for the regulation of mitochondrial energy production in the heart, as well as the obvious differences of DXR action in the heart as compared to brain tissue, is discussed...
  6. ncbi Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply
    Malgorzata Tokarska-Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology, Hönggerberg HPM F23, CH 8093 Zurich, Switzerland
    Am J Physiol Heart Circ Physiol 289:H37-47. 2005
    ..These results suggest that an impairment of kinase systems regulating cellular energy homeostasis is involved in the development of DXR cardiotoxicity...
  7. ncbi C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase
    Uwe Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 279:24334-42. 2004
    ..These results are discussed in regard to MtCK microcompartments and evolution...
  8. ncbi Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin
    Malgorzata Tokarska-Schlattner
    Institute of Cell Biology, ETH Zurich, Hönggerberg HPM D24, CH 8093 Zurich, Switzerland
    C R Biol 329:657-68. 2006
    ..Here we review doxorubicin-induced detrimental changes in cardiac energetics, with an emphasis on the emerging importance of defects in energy-transferring and -signalling systems, like creatine kinase and AMP-activated protein kinase...
  9. ncbi Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex
    Dietbert Neumann
    ETH Zurich, Institute of Cell Biology, HPM D23, Schafmattstr 18, Zurich, Switzerland
    Mol Biotechnol 36:220-31. 2007
    ..Functional mammalian LKB1 complex is constitutively active, and when enriched from bacteria should prove to be a valuable tool for studying its molecular function and regulation...
  10. pmc PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis
    Nabil Djouder
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 29:469-81. 2010
    ..These results suggest a new mechanism of negative regulation of AMPK activity by PKA that is important for converting a lipolytic signal into an effective lipolytic response...
  11. ncbi Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation
    Max Dolder
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 278:17760-6. 2003
    ..These results are of relevance for the design of creatine analogs for cell protection as potential adjuvant therapeutic tools against neurodegenerative diseases...
  12. pmc Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix
    Roland Scholz
    Department of Biology, Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    J Biol Chem 284:27425-37. 2009
    ..Our data suggest a physiological role for the hydrophobic alphaG-helix residues in homo-oligomerization of heterotrimers and cellular interactions, in particular with upstream kinases, indicating an additional level of AMPK regulation...
  13. ncbi New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics
    Malgorzata Tokarska-Schlattner
    Institute of Cell Biology, ETH Zurich, Hönggerberg HPM D24, CH 8093 Zurich, Switzerland
    J Mol Cell Cardiol 41:389-405. 2006
    ....
  14. doi Tracking and quantification of 32P-labeled phosphopeptides in liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry
    Roland D Tuerk
    Institute of Cell Biology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland
    Anal Biochem 390:141-8. 2009
    ..However, accurate analysis of defined areas within single spots suggests that, rather than such quantitative differences, mainly the manner of matrix crystallization significantly affects ionization of phosphopeptides...
  15. ncbi Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
    Marianne Suter
    Institute of Cell Biology, Schafmattstrasse 18, ETH Zurich, 8093 Zurich, Switzerland
    J Biol Chem 281:32207-16. 2006
    ..These data shed new light on physiologically important aspects of AMPK regulation...
  16. pmc Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membrane
    Oliver Speer
    Swiss Federal Institute of Technology, ETH Zurich, Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Biochem J 385:445-50. 2005
    ..We conclude that octameric uMtCK induces the formation of mitochondrial contact sites, leading to membrane cross-linking and to an increased stability of the mitochondrial membrane architecture...
  17. ncbi Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues
    Silke Wendt
    Institute of Cell Biology, Swiss Federal Institute of Technology, Hönggerberg HPM, CH 8093 Zurich, Switzerland
    J Biol Chem 278:1125-30. 2003
    ..The results provide a molecular explanation of how oxidative damage can lead to inactivation and decreased octamer/dimer ratio of MtCK, as seen in neurodegenerative diseases and heart pathology, respectively...
  18. doi An automated home-built low-cost fermenter suitable for large-scale bacterial expression of proteins in Escherichia coli
    Uwe Riek
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    Biotechniques 45:187-9. 2008
    ....
  19. pmc Effects of N-linked glycosylation on the creatine transporter
    Nadine Straumann
    Swiss Federal Institute of Technology, ETH Zurich, Institute of Cell Biology, ETH Honggerberg, 8093 Zurich, Switzerland
    Biochem J 393:459-69. 2006
    ..These findings may have relevance for closely related neurotransmitter transporter family members...
  20. ncbi Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein
    Thorsten Hornemann
    Institute of Cell Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Mol Biol 332:877-87. 2003
    ..Our data propose a simple model for the regulation of this dynamic interaction...
  21. ncbi New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinases
    Roland D Tuerk
    Institutes of Cell Biology and Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    J Proteome Res 6:3266-77. 2007
    ..Our data suggests that signaling by AMPK in brain is likely to be involved in the regulation of pathways that have not yet been linked to this kinase...
  22. doi Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding
    Uwe Riek
    Institute of Cell Biology, Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland
    J Biol Chem 283:18331-43. 2008
    ....
  23. ncbi Expressing creatine kinase in transgenic tobacco--a first step towards introducing an energy buffering system in plants
    Judith Farrés
    Institute of Biotechnology, ETH Zurich, Switzerland
    Transgenic Res 11:49-59. 2002
    ..Furthermore, the BB-CK expressing tobacco plants and cell suspension cultures were able to convert creatine into phosphocreatine...
  24. ncbi Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase
    Tanja S Bürklen
    Institute of Cell Biology, HPM D24, ETH Zurich, Schafmattstr 18, Zurich 8093, Switzerland
    Mol Cell Biochem 297:53-64. 2007
    ..These data may shed new light on BB-CK function for energy provision for Golgi-fragmentation that is initiated by cell signalling cascades in the early phases of mitosis...
  25. ncbi Creatine transporters: a reappraisal
    Oliver Speer
    ETH Zurich, Institute of Cell Biology, ETH Honggerberg, Zurich, Switzerland
    Mol Cell Biochem 256:407-24. 2004
    ..This is in line with 14C-Cr-isotope tracer studies and a number of [31P]-NMR magnetization transfer studies, as well as with recent [1H]-NMR spectroscopy data...
  26. ncbi Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergetics
    Bernd Walzel
    Swiss Federal Institute of Technology, ETH Zurich, Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 277:37503-11. 2002
    ..Our data suggest that mitochondria, shown here to possess creatine transport activity, may harbor such a creatine/phosphocreatine pool...
  27. ncbi New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle
    Bernd Walzel
    Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Am J Physiol Endocrinol Metab 283:E390-401. 2002
    ....
  28. ncbi Introduction--creatine: cheap ergogenic supplement with great potential for health and disease
    Theo Wallimann
    Institute of Cell Biology, ETH Zurich, Hönggerberg HPM D24 1, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Subcell Biochem 46:1-16. 2007
  29. ncbi Mitochondrial creatine kinase in human health and disease
    Uwe Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, Hönggerberg HPM, CH 8093 Zurich, Switzerland
    Biochim Biophys Acta 1762:164-80. 2006
    ....
  30. ncbi Isoenzyme-directed selection and characterization of anti-creatine kinase single chain Fv antibodies from a human phage display library
    Uwe Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH, Hönggerberg HPM, Zurich CH 8093, Switzerland
    Biochim Biophys Acta 1579:124-32. 2002
    ..5-9.6 x 10(-7) M, the isolated scFv compare favorably with mouse mAb and may overcome certain of their limitations. Our results demonstrate the advantages of in vitro antibody selection for the generation of isoenzyme-specific antibodies...
  31. ncbi Multiple interference of anthracyclines with mitochondrial creatine kinases: preferential damage of the cardiac isoenzyme and its implications for drug cardiotoxicity
    Malgorzata Tokarska-Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology ETH, Honggerberg, Zurich, Switzerland
    Mol Pharmacol 61:516-23. 2002
    ..All anthracycline effects were significantly more pronounced for sMtCK than for uMtCK. These in vitro results suggest that sMtCK damage may play a role in anthracycline cardiotoxicity...
  32. ncbi Creatine kinase and creatine transporter in normal, wounded, and diseased skin
    Uwe Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology, Hönggerberg HPM, Zurich, Switzerland
    J Invest Dermatol 118:416-23. 2002
    ....
  33. ncbi Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice
    Silke Wendt
    Institute for Cell Biology, ETH Honggerberg, Zurich, Switzerland
    Free Radic Biol Med 32:920-6. 2002
    ..Our data provide evidence for oxidative damage to the CK system in ALS, which may contribute to impaired energy metabolism and neurodegeneration...
  34. ncbi Functional expression of arginine kinase improves recovery from pH stress of Escherichia coli
    Fabrizio Canonaco
    Institute of Biotechnology, ETH Zurich, CH 8093 Zurich, Switzerland
    Biotechnol Lett 25:1013-7. 2003
    ..This effect is presumably caused by the physiological function of arginine kinase as a short term energy buffer in the form of phosphoarginine, but a pH-buffering effect cannot be excluded...
  35. ncbi Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli
    Dietbert Neumann
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Protein Expr Purif 30:230-7. 2003
    ....
  36. ncbi Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia
    Kathryn H Adcock
    Neuroradiology and Magnetic Resonance Research, University Children s Hospital, Zurich, Switzerland
    Dev Neurosci 24:382-8. 2002
    ..Additional protection by Cr may be related to prevention of calcium overload, prevention of mitochondrial permeability transition pore opening and direct antioxidant effects...