Hugo Stocker

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction
    Isabel Almudi
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, Zurich 8093, Switzerland
    Cell Commun Signal 11:26. 2013
  2. pmc Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
  3. pmc Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
    Federica Parisi
    Department of Biology, City College of City University of New York, New York, USA
    BMC Biol 9:65. 2011
  4. doi request reprint Growth control: Myc and Yorkie get connected
    Hugo Stocker
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, CH 8093 Zurich, Switzerland
    Curr Biol 21:R37-9. 2011
  5. doi request reprint Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation
    Ingrid Poernbacher
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Curr Biol 22:389-96. 2012
  6. pmc Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
    Timo Glatter
    Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Mol Syst Biol 7:547. 2011
  7. doi request reprint The WW domain protein Kibra acts upstream of Hippo in Drosophila
    Roland Baumgartner
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Dev Cell 18:309-16. 2010
  8. pmc Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila
    Silvia Gluderer
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    J Biol 9:9. 2010
  9. doi request reprint Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions
    Ladan Sarraf-Zadeh
    Institute for Molecular Systems Biology IMSB, ETH Zurich, Zurich 8093, Switzerland
    Dev Biol 381:97-106. 2013
  10. pmc The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster
    Roland Baumgartner
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse, Zurich, Switzerland
    PLoS Genet 9:e1003598. 2013

Collaborators

Detail Information

Publications14

  1. pmc The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction
    Isabel Almudi
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, Zurich 8093, Switzerland
    Cell Commun Signal 11:26. 2013
    ..The adaptor molecule Lnk/SH2B has been implicated in IIS but the mechanism by which it promotes IIS activity has remained enigmatic...
  2. pmc Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    ..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
  3. pmc Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
    Federica Parisi
    Department of Biology, City College of City University of New York, New York, USA
    BMC Biol 9:65. 2011
    ..Using biochemical and genetic approaches we tried to identify novel mechanisms that control Myc activity upon activation of insulin and TOR signaling pathways...
  4. doi request reprint Growth control: Myc and Yorkie get connected
    Hugo Stocker
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, CH 8093 Zurich, Switzerland
    Curr Biol 21:R37-9. 2011
    ..In turn, Myc keeps the concentration of Yorkie in check via negative feedback regulation...
  5. doi request reprint Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation
    Ingrid Poernbacher
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Curr Biol 22:389-96. 2012
    ..Thus, Pez displays a tissue-specific requirement and functions as a negative upstream regulator of Yki in the regulation of ISC proliferation...
  6. pmc Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
    Timo Glatter
    Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Mol Syst Biol 7:547. 2011
    ..Subsequent genetic studies in flies suggest a role for dTTT in controlling cell growth via a dTORC1- and dTORC2-dependent mechanism...
  7. doi request reprint The WW domain protein Kibra acts upstream of Hippo in Drosophila
    Roland Baumgartner
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Dev Cell 18:309-16. 2010
    ..Kibra acts synergistically with Expanded, and it physically interacts with Merlin. Thus, Kibra predominantly acts in the Merlin branch upstream of the core kinase cascade to regulate Hippo signaling...
  8. pmc Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila
    Silvia Gluderer
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    J Biol 9:9. 2010
    ..In Drosophila, the long isoform Bunched A (BunA) acts as a growth promoter, but how BunA controls growth has remained obscure...
  9. doi request reprint Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions
    Ladan Sarraf-Zadeh
    Institute for Molecular Systems Biology IMSB, ETH Zurich, Zurich 8093, Switzerland
    Dev Biol 381:97-106. 2013
    ..Taken together our results suggest that Imp-L2-expressing neurons sense the nutritional state of Drosophila larvae and coordinate dietary information and ecdysone production to adjust developmental timing under starvation conditions...
  10. pmc The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster
    Roland Baumgartner
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse, Zurich, Switzerland
    PLoS Genet 9:e1003598. 2013
    ..Thus, Lig regulates cell proliferation during development in concert with Rin, Capr and FMR1. ..
  11. pmc The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
    Christian Werz
    Institute of Molecular Systems Biology, Zurich, Switzerland
    PLoS Genet 5:e1000596. 2009
    ..Furthermore, chico; lnk double mutants are synthetically lethal, suggesting that Chico and Lnk fulfill independent but partially redundant functions in the activation of PI3K upon InR stimulation...
  12. pmc MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress
    Gerhard Seisenbacher
    Institute of Molecular Systems Biology, Swiss Federal Institute of Technology Zurich ETH Zurich, Zurich, Switzerland
    PLoS Genet 7:e1002168. 2011
    ..Thus, the p38/MK2 complex ensures homeostasis of the hindgut epithelium by counteracting JNK-mediated apoptosis of the enterocytes upon chronic stress...
  13. pmc Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth
    Silvia Gluderer
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Str, 16, 8093 Zurich, Switzerland
    BMC Dev Biol 8:10. 2008
    ..Possible redundancy among the members of the TSC-22/Dip/Bun protein family complicates a genetic analysis. In Drosophila, all proteins homologous to the TSC-22/Dip/Bun family members are derived from a single locus called bunched (bun)...
  14. doi request reprint Getting started : an overview on raising and handling Drosophila
    Hugo Stocker
    Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Methods Mol Biol 420:27-44. 2008
    ..It briefly introduces the biological properties of fruit flies, describes the minimal equipment required for working with flies, and offers some basic advice for maintaining fly lines and setting up and analyzing experiments...