Affiliation: Swiss Federal Institute of Technology
Jevtov I, Zacharogianni M, van Oorschot M, van Zadelhoff G, Aguilera Gomez A, Vuillez I, et al
. TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules. J Cell Sci. 2015;128:2497-508 pubmed publisher
..We propose that TORC2 mediates heat resistance in Drosophila by promoting the cell autonomous formation of stress granules. ..
Stocker H. Stress Relief Downstream of TOR. Dev Cell. 2015;33:245-6 pubmed publisher
..In this issue of Developmental Cell, Tiebe et al. (2015) identify a transcriptional regulator complex repressed by TORC1 and responsible for a vast majority of the observed transcriptional changes in Drosophila. ..
Stocker H. Growth control: Myc and Yorkie get connected. Curr Biol. 2011;21:R37-9 pubmed publisher
..In turn, Myc keeps the concentration of Yorkie in check via negative feedback regulation. ..
Almudi I, Poernbacher I, Hafen E, Stocker H. The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction. Cell Commun Signal. 2013;11:26 pubmed publisher
..Furthermore, Lnk is able to recruit an intracellular InR fragment to the membrane. Thus, by acting as a scaffolding molecule that ensures InR and Chico enrichment at the membrane, Lnk provides a fail-safe mechanism for IIS activation. ..
Stocker H. Patchy Growth Control. Dev Cell. 2017;42:311-313 pubmed publisher
..Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled pattern of TORC1 activation in Drosophila imaginal discs. ..
Gluderer S, Oldham S, Rintelen F, Sulzer A, Schütt C, Wu X, et al
. Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth. BMC Dev Biol. 2008;8:10 pubmed publisher
Parisi F, Riccardo S, Daniel M, Saqcena M, Kundu N, Pession A, et al
. Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. BMC Biol. 2011;9:65 pubmed publisher