Hugo Stocker

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. ncbi The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction
    Isabel Almudi
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, Zurich 8093, Switzerland
    Cell Commun Signal 11:26. 2013
  2. ncbi Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
  3. ncbi Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
    Federica Parisi
    Department of Biology, City College of City University of New York, New York, USA
    BMC Biol 9:65. 2011
  4. ncbi Growth control: Myc and Yorkie get connected
    Hugo Stocker
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, CH 8093 Zurich, Switzerland
    Curr Biol 21:R37-9. 2011
  5. ncbi The WW domain protein Kibra acts upstream of Hippo in Drosophila
    Roland Baumgartner
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Dev Cell 18:309-16. 2010
  6. ncbi Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation
    Ingrid Poernbacher
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Curr Biol 22:389-96. 2012
  7. ncbi Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila
    Silvia Gluderer
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    J Biol 9:9. 2010
  8. ncbi The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
    Christian Werz
    Institute of Molecular Systems Biology, Zurich, Switzerland
    PLoS Genet 5:e1000596. 2009
  9. ncbi Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
    Timo Glatter
    Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Mol Syst Biol 7:547. 2011
  10. ncbi MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress
    Gerhard Seisenbacher
    Institute of Molecular Systems Biology, Swiss Federal Institute of Technology Zurich ETH Zurich, Zurich, Switzerland
    PLoS Genet 7:e1002168. 2011

Collaborators

  • Silvia Gluderer
  • Ernst Hafen
  • Laurel A Raftery
  • Ruedi Aebersold
  • Peter Gallant
  • Sean Oldham
  • Erich Brunner
  • Xiaodong Wu
  • Ingrid Poernbacher
  • Roland Baumgartner
  • Katja Kohler
  • Isabel Almudi
  • Gerhard Seisenbacher
  • Federica Parisi
  • Timo Glatter
  • Christian Werz
  • Basil Honegger
  • Suresh K Marada
  • Kevin Edwards
  • Daniela Grifoni
  • Katarzyna Roguska
  • Martin A Jünger
  • Nandini Kundu
  • Margaret Daniel
  • Sara Riccardo
  • Annalisa Pession
  • Alexey I Nesvizhskii
  • Alexander Wepf
  • Paola Bellosta
  • Oliver Rinner
  • Esteban Tabak
  • Alexander Schmidt
  • Ralf B Schittenhelm
  • Irena Jevtov
  • Matthias Gstaiger
  • Mahesh Saqcena
  • Hyungwon Choi
  • Nathalie Buser
  • Milos Galic
  • Walter Brogiolo
  • Franz Wittwer

Detail Information

Publications12

  1. ncbi The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction
    Isabel Almudi
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, Zurich 8093, Switzerland
    Cell Commun Signal 11:26. 2013
    ..The adaptor molecule Lnk/SH2B has been implicated in IIS but the mechanism by which it promotes IIS activity has remained enigmatic...
  2. ncbi Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    ..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
  3. ncbi Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
    Federica Parisi
    Department of Biology, City College of City University of New York, New York, USA
    BMC Biol 9:65. 2011
    ..Using biochemical and genetic approaches we tried to identify novel mechanisms that control Myc activity upon activation of insulin and TOR signaling pathways...
  4. ncbi Growth control: Myc and Yorkie get connected
    Hugo Stocker
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, CH 8093 Zurich, Switzerland
    Curr Biol 21:R37-9. 2011
    ..In turn, Myc keeps the concentration of Yorkie in check via negative feedback regulation...
  5. ncbi The WW domain protein Kibra acts upstream of Hippo in Drosophila
    Roland Baumgartner
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Dev Cell 18:309-16. 2010
    ..Kibra acts synergistically with Expanded, and it physically interacts with Merlin. Thus, Kibra predominantly acts in the Merlin branch upstream of the core kinase cascade to regulate Hippo signaling...
  6. ncbi Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation
    Ingrid Poernbacher
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Curr Biol 22:389-96. 2012
    ..Thus, Pez displays a tissue-specific requirement and functions as a negative upstream regulator of Yki in the regulation of ISC proliferation...
  7. ncbi Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila
    Silvia Gluderer
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    J Biol 9:9. 2010
    ..In Drosophila, the long isoform Bunched A (BunA) acts as a growth promoter, but how BunA controls growth has remained obscure...
  8. ncbi The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
    Christian Werz
    Institute of Molecular Systems Biology, Zurich, Switzerland
    PLoS Genet 5:e1000596. 2009
    ..Furthermore, chico; lnk double mutants are synthetically lethal, suggesting that Chico and Lnk fulfill independent but partially redundant functions in the activation of PI3K upon InR stimulation...
  9. ncbi Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
    Timo Glatter
    Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Mol Syst Biol 7:547. 2011
    ..Subsequent genetic studies in flies suggest a role for dTTT in controlling cell growth via a dTORC1- and dTORC2-dependent mechanism...
  10. ncbi MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress
    Gerhard Seisenbacher
    Institute of Molecular Systems Biology, Swiss Federal Institute of Technology Zurich ETH Zurich, Zurich, Switzerland
    PLoS Genet 7:e1002168. 2011
    ..Thus, the p38/MK2 complex ensures homeostasis of the hindgut epithelium by counteracting JNK-mediated apoptosis of the enterocytes upon chronic stress...
  11. ncbi Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth
    Silvia Gluderer
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Str, 16, 8093 Zurich, Switzerland
    BMC Dev Biol 8:10. 2008
    ..Possible redundancy among the members of the TSC-22/Dip/Bun protein family complicates a genetic analysis. In Drosophila, all proteins homologous to the TSC-22/Dip/Bun family members are derived from a single locus called bunched (bun)...
  12. ncbi Getting started : an overview on raising and handling Drosophila
    Hugo Stocker
    Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Methods Mol Biol 420:27-44. 2008
    ..It briefly introduces the biological properties of fruit flies, describes the minimal equipment required for working with flies, and offers some basic advice for maintaining fly lines and setting up and analyzing experiments...