Research Topics
Genomes and Genes | Bärbel StecherSummaryAffiliation: Swiss Federal Institute of Technology Country: Switzerland Publications
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Publications
Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteriaBärbel Stecher
Institute of Microbiology, ETH Zurich, Zurich, Switzerland
PLoS Pathog 6:e1000711. 2010..This might be of relevance for human enteropathogen infections as well as therapeutic use of probiotic commensal bacteria...- Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycinBärbel Stecher
Institute of Microbiology, ETH Zurich, Wolfgang Paulistrasse 10, HCI G413, CH 8093 Zurich, Switzerland
Infect Immun 73:3228-41. 2005..One obvious difference was more pronounced damage and reduced regenerative response of the cecal epithelium in GF mice. Overall, StrSPF mice and GF mice provide similar but not identical models for Salmonella serovar Typhimurium colitis... - Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated miceBärbel Stecher
Institute of Microbiology, ETH Zurich, Schmelzbergstrasse 7, 8092 Zurich, Switzerland
Infect Immun 72:4138-50. 2004..This effect is mostly attributable to chemotaxis. Recognition of flagellar subunits (i.e., flagellin) by innate immune receptors (i.e., Toll-like receptor 5) may be less important... - Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiotaBärbel Stecher
Institute of Microbiology, Swiss Institute of Technology Zurich, Zurich, Switzerland
PLoS Biol 5:2177-89. 2007..Triggering the host's immune defence can shift the balance between the protective microbiota and the pathogen in favour of the pathogen... - Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitisSiegfried Hapfelmeier
Institute of Microbiology, D BIOL, ETH Zurich, CH 8093 Zurich, Switzerland
J Exp Med 205:437-50. 2008..These results establish that pathogen sampling by DCs is a discrete, and MyD88-independent, step during the initiation of a mucosal innate immune response to bacterial infection in vivo... - Bacterial colitis increases susceptibility to oral prion diseaseChristina J Sigurdson
Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
J Infect Dis 199:243-52. 2009..Therefore, moderate intestinal inflammation at the time of prion exposure may constitute one of the elusive risk factors underlying the development of TSE... - The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrheaKathrin Endt
Institute of Microbiology, ETH Zurich, Zurich, Switzerland
PLoS Pathog 6:e1001097. 2010..This has implications for curing S. typhimurium diarrhea and for preventing transmission... - Salmonella transiently reside in luminal neutrophils in the inflamed gutYvonne Loetscher
Institute of Microbiology, ETH Zurich, Zurich, Switzerland
PLoS ONE 7:e34812. 2012..Here, we analyzed the interaction of gut luminal neutrophils with S. enterica serovar Typhimurium (S. Tm) in a mouse colitis model... - O-antigen-negative Salmonella enterica serovar Typhimurium is attenuated in intestinal colonization but elicits colitis in streptomycin-treated miceKarin Ilg
Institut fur Mikrobiologie, Eidgenossische Technische Hochschule, ETH Zurich, Zurich, Switzerland
Infect Immun 77:2568-75. 2009..Our experiments prove that the presence of complete LPS is not essential for in vitro invasion or for triggering acute colitis... - Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infectionPascal Songhet
Institute of Microbiology D BIOL, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
PLoS ONE 6:e22459. 2011..Thus IFN-γR-signaling influences different mucosal responses to infection, including not only pathogen restriction in the lamina propria, but, as shown here, also goblet cell function... - Gut inflammation can boost horizontal gene transfer between pathogenic and commensal EnterobacteriaceaeBärbel Stecher
Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
Proc Natl Acad Sci U S A 109:1269-74. 2012..These blooms may favor reassortment of plasmid-encoded genes between pathogens and commensals fostering the spread of fitness-, virulence-, and antibiotic-resistance determinants... 
The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune responsePatrick Kaiser
Institute of Microbiology, D BIOL, ETH Zurich, Zurich, Switzerland
Immunol Rev 245:56-83. 2012..Finally, we discuss the general need for defined assay conditions when using animal models for enteric infections and the central importance of littermate controls...- Roles of spvB and spvC in S. Typhimurium colitis via the alternative pathwayRina Käppeli
Institute of Microbiology, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
Int J Med Microbiol 301:117-24. 2011..This establishes a novel virulence phenotype for spvB in the alternative pathway of S. Typhimurium colitis... - Self-destructive cooperation mediated by phenotypic noiseMartin Ackermann
Institute of Integrative Biology, ETH Zurich, 8092 Zurich, Switzerland
Nature 454:987-90. 2008.... - Motility allows S. Typhimurium to benefit from the mucosal defenceBärbel Stecher
Institute of Microbiology, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
Cell Microbiol 10:1166-80. 2008..Thus, nutrient availability contributes to enhanced pathogen growth in the inflamed intestine. Strategies interfering with bacterial motility or nutrient availability might offer starting points for therapeutic approaches... - A simple screen to identify promoters conferring high levels of phenotypic noiseNikki E Freed
Institute of Integrative Biology, Eidgenossische Technische Hochschule ETH Zurich, Zurich, Switzerland
PLoS Genet 4:e1000307. 2008..Typhimurium genome. This approach can be applied to many other bacterial and eukaryotic systems as a simple method for identifying genes with noisy expression... - Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated dockingBenjamin Misselwitz
Institute of Microbiology, ETH Zurich, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
Infect Immun 79:330-41. 2011..Typhimurium helper strain. Our data show that binding to HeLa cells is mediated by at least two different mechanisms and that both can lead to invasion if actin rearrangements are triggered... - The role of microbiota in infectious diseaseBärbel Stecher
Institute of Microbiology, Eidgenoessische Technische Hochschule ETH Zürich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
Trends Microbiol 16:107-14. 2008..Thus, some pathogens can benefit from inflammatory defenses. This new paradigm will enable the study of host factors enhancing or inhibiting bacterial growth in health and disease... - Chronic Salmonella enterica serovar Typhimurium-induced colitis and cholangitis in streptomycin-pretreated Nramp1+/+ miceBärbel Stecher
Institute of Microbiology, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
Infect Immun 74:5047-57. 2006..We propose that streptomycin-pretreated 129Sv/Ev mice provide a robust murine model for chronic enteric salmonellosis including complications such as cholangitis...