Simon Spycher

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. doi request reprint Toward a class-independent quantitative structure--activity relationship model for uncouplers of oxidative phosphorylation
    Simon Spycher
    Department of Environmental Toxicology, UTOX, Swiss Federal Institute of Aquatic Science and Technology, Eawag, CH 8600 Dubendorf, Switzerland
    Chem Res Toxicol 21:911-27. 2008
  2. doi request reprint Mode of action-based classification and prediction of activity of uncouplers for the screening of chemical inventories
    S Spycher
    Department of Environmental Toxicology, UTOX, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    SAR QSAR Environ Res 19:433-63. 2008
  3. ncbi request reprint A quantitative structure--activity relationship model for the intrinsic activity of uncouplers of oxidative phosphorylation
    Simon Spycher
    Computer Chemie Centrum and Institute of Organic Chemistry, University of Erlangen Nurnberg, Nagelsbachstrasse 25, D 91052 Erlangen, Germany
    Chem Res Toxicol 18:1858-67. 2005
  4. doi request reprint COSMOmic: a mechanistic approach to the calculation of membrane-water partition coefficients and internal distributions within membranes and micelles
    Andreas Klamt
    COSMOlogic GmbH and COKG, Burscheider Strasse 515, 51381 Leverkusen, Germany
    J Phys Chem B 112:12148-57. 2008

Collaborators

Detail Information

Publications4

  1. doi request reprint Toward a class-independent quantitative structure--activity relationship model for uncouplers of oxidative phosphorylation
    Simon Spycher
    Department of Environmental Toxicology, UTOX, Swiss Federal Institute of Aquatic Science and Technology, Eawag, CH 8600 Dubendorf, Switzerland
    Chem Res Toxicol 21:911-27. 2008
    ..The applicability domain, limitations of the model, and ideas for future research are critically discussed...
  2. doi request reprint Mode of action-based classification and prediction of activity of uncouplers for the screening of chemical inventories
    S Spycher
    Department of Environmental Toxicology, UTOX, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    SAR QSAR Environ Res 19:433-63. 2008
    ..Nevertheless, uncoupling can be an important mode of action as highlighted with several examples ranging from pesticide metabolites to persistent organic compounds...
  3. ncbi request reprint A quantitative structure--activity relationship model for the intrinsic activity of uncouplers of oxidative phosphorylation
    Simon Spycher
    Computer Chemie Centrum and Institute of Organic Chemistry, University of Erlangen Nurnberg, Nagelsbachstrasse 25, D 91052 Erlangen, Germany
    Chem Res Toxicol 18:1858-67. 2005
    ..The properties of these different measures of lipophilicity were critically discussed...
  4. doi request reprint COSMOmic: a mechanistic approach to the calculation of membrane-water partition coefficients and internal distributions within membranes and micelles
    Andreas Klamt
    COSMOlogic GmbH and COKG, Burscheider Strasse 515, 51381 Leverkusen, Germany
    J Phys Chem B 112:12148-57. 2008
    ..The novel COSMOmic method allows for the efficient prediction of the distribution of molecules in micellar systems...