Lukas Sommer

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells
    Lars M Ittner
    Research Laboratory for Calcium Metabolism, Orthopedic University Hospital Balgrist, Ch 8008 Zurich, Switzerland
    J Biol 4:11. 2005
  2. ncbi request reprint Neural stem cells and regulation of cell number
    Lukas Sommer
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Hoenggerberg HPM E38, CH 8093 Zurich, Switzerland
    Prog Neurobiol 66:1-18. 2002
  3. ncbi request reprint Checkpoints of melanocyte stem cell development
    Lukas Sommer
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Hoenggerberg HPM E38, CH 8093 Zurich, Switzerland
    Sci STKE 2005:pe42. 2005
  4. ncbi request reprint Growth factors regulating neural crest cell fate decisions
    Lukas Sommer
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Hoenggerberg, Zurich, Switzerland
    Adv Exp Med Biol 589:197-205. 2006
  5. ncbi request reprint Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells
    Hye Youn Lee
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 303:1020-3. 2004
  6. pmc Lineage-specific requirements of beta-catenin in neural crest development
    Lisette Hari
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Cell Biol 159:867-80. 2002
  7. doi request reprint Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
  8. pmc Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
    Christine E Wong
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 175:1005-15. 2006
  9. pmc Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling
    Maurice Kléber
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    J Cell Biol 169:309-20. 2005
  10. pmc Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome
    Heiko Wurdak
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, CH 8093, Switzerland
    Genes Dev 19:530-5. 2005

Collaborators

Detail Information

Publications34

  1. pmc Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells
    Lars M Ittner
    Research Laboratory for Calcium Metabolism, Orthopedic University Hospital Balgrist, Ch 8008 Zurich, Switzerland
    J Biol 4:11. 2005
    ....
  2. ncbi request reprint Neural stem cells and regulation of cell number
    Lukas Sommer
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Hoenggerberg HPM E38, CH 8093 Zurich, Switzerland
    Prog Neurobiol 66:1-18. 2002
    ....
  3. ncbi request reprint Checkpoints of melanocyte stem cell development
    Lukas Sommer
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Hoenggerberg HPM E38, CH 8093 Zurich, Switzerland
    Sci STKE 2005:pe42. 2005
    ..It will be intriguing to identify these signals and to elucidate whether and how neighboring epithelial stem cells influence the balance between melanocyte stem cell maintenance and differentiation...
  4. ncbi request reprint Growth factors regulating neural crest cell fate decisions
    Lukas Sommer
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Hoenggerberg, Zurich, Switzerland
    Adv Exp Med Biol 589:197-205. 2006
    ..It will be important to determine how such signaling networks are established and how they elicit multiple signaling responses in neural crest cells to activate appropriate genetic programs...
  5. ncbi request reprint Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells
    Hye Youn Lee
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 303:1020-3. 2004
    ..Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a beta-catenin-dependent manner. Thus, the role of Wnt/beta-catenin in stem cells is cell-type dependent...
  6. pmc Lineage-specific requirements of beta-catenin in neural crest development
    Lisette Hari
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Cell Biol 159:867-80. 2002
    ..We propose that the requirement of beta-catenin for the specification of melanocytes and sensory neuronal lineages reflects roles of beta-catenin both in Wnt signaling and in mediating cell-cell interactions...
  7. doi request reprint Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
    ..Thus, TGF-beta signaling controls the size of a specific brain area, the dorsal midbrain, by antagonizing canonical Wnt signaling and negatively regulating self-renewal of neuroepithelial stem cells...
  8. pmc Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
    Christine E Wong
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 175:1005-15. 2006
    ..These findings are relevant for the design of therapeutic strategies because the potential of stem and progenitor cells in vivo likely depends on their nature and origin...
  9. pmc Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling
    Maurice Kléber
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    J Cell Biol 169:309-20. 2005
    ..Thus, stem cell development is regulated by combinatorial growth factor activities that interact with changing cell-intrinsic cues...
  10. pmc Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome
    Heiko Wurdak
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, CH 8093, Switzerland
    Genes Dev 19:530-5. 2005
    ..Thus, TGFbeta signal modulation in neural crest differentiation might play a crucial role in the etiology of DiGeorge syndrome...
  11. ncbi request reprint The protooncogene Ski controls Schwann cell proliferation and myelination
    Suzana Atanasoski
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Neuron 43:499-511. 2004
    ..The myelination-regulating transcription factor Oct6 is involved in a complex modulatory relationship with Ski. We conclude that Ski is a crucial signal in Schwann cell development and myelination...
  12. ncbi request reprint Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord
    Fabian Ille
    Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    Dev Biol 304:394-408. 2007
    ..A model emerges in which dorsal Wnt/BMP signal integration links growth and patterning, thereby maintaining undifferentiated and slow-cycling neural progenitors that form the dorsal confines of the developing spinal cord...
  13. ncbi request reprint Efficient isolation and gene expression profiling of small numbers of neural crest stem cells and developing Schwann cells
    Johanna Buchstaller
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Neurosci 24:2357-65. 2004
    ..The combination of methods applied in this study should be generally useful for isolating and profiling other stem cell and difficult to isolate cell populations...
  14. doi request reprint Transforming growth factor β-mediated Sox10 suppression controls mesenchymal progenitor generation in neural crest stem cells
    Nessy John
    Division of Cell and Developmental Biology, Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Stem Cells 29:689-99. 2011
    ..Thus, negative regulation of Sox10 by TGFβ signaling promotes the generation of mesenchymal progenitors from NCSCs. Our study might lay the grounds for future applications demanding defined populations of MSCs for regenerative medicine...
  15. ncbi request reprint The role of the Ets domain transcription factor Erm in modulating differentiation of neural crest stem cells
    Christian Paratore
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Dev Biol 250:168-80. 2002
    ..Moreover, our data point to multiple, lineage-specific roles of Erm in neural crest stem cells and their derivatives, suggesting that Erm function is dependent on the cell intrinsic and extrinsic context...
  16. ncbi request reprint Distinct disease mechanisms in peripheral neuropathies due to altered peripheral myelin protein 22 gene dosage or a Pmp22 point mutation
    Guya Giambonini-Brugnoli
    Institute for Cell Biology, Department of Biology, ETH Honggerberg, Swiss Federal Institute of Technology, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Neurobiol Dis 18:656-68. 2005
    ..Finally, we have identified a number of candidate genes that may play important roles in the disease process or in myelination per se...
  17. ncbi request reprint Cell-intrinsic and cell-extrinsic cues regulating lineage decisions in multipotent neural crest-derived progenitor cells
    Christian Paratore
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    Int J Dev Biol 46:193-200. 2002
    ..This approach appears promising given the identification of multipotent progenitor cells from the mouse PNS and the availability of genetics in the mouse system...
  18. ncbi request reprint Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease
    Christian Paratore
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Hum Mol Genet 11:3075-85. 2002
    ..Thus, the cells that normally colonize the hindgut are depleted in the Sox10 mutant, causing the distal bowel to become aganglionic...
  19. doi request reprint Generation of melanocytes from neural crest cells
    Lukas Sommer
    Cell and Developmental Biology, Institute of Anatomy, University of Zurich, Winterthurerstrasse, Zurich, Switzerland
    Pigment Cell Melanoma Res 24:411-21. 2011
    ..Here, we summarize the current view of how melanocytes are specified from the neural crest and put this process into the context of spatiotemporal lineage decisions in neural crest cells...
  20. ncbi request reprint Wnt signaling and the regulation of stem cell function
    Maurice Kléber
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Curr Opin Cell Biol 16:681-7. 2004
    ..How a stem cell integrates Wnt and other signals and how such signaling networks regulate stem cell function on the molecular level remains to be elucidated...
  21. pmc Tumor cell plasticity and angiogenesis in human melanomas
    Daniela Mihic-Probst
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 7:e33571. 2012
    ..0001). We suggest that the hypoxic microenvironment in metastases contributes to a phenotype switch allowing melanoma cells to physically contribute to blood vessel formation...
  22. ncbi request reprint The neural crest: understanding stem cell function in development and disease
    Sebastian Fuchs
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Neurodegener Dis 4:6-12. 2007
    ..Using the neural crest as a model system helps us not only to understand the role of stem cells in development but might also lead to new aspects for the cure of stem cell-related diseases...
  23. doi request reprint Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells
    Elisa A Casanova
    Institute of Laboratory Animal Science, University of Zurich, Zurich, Switzerland
    Stem Cells 29:474-85. 2011
    ..Thus, Pramel7 represents a central and essential factor in the signaling network regulating pluripotency and self-renewal in ESCs...
  24. ncbi request reprint DiGeorge syndrome and pharyngeal apparatus development
    Heiko Wurdak
    Institute of Cell Biology, Department of Biology, ETH Zurich, ETH Honggerberg, Zurich, Switzerland
    Bioessays 28:1078-86. 2006
    ..Intriguingly, these mouse models reveal that interference with either of two distinct phases of pharyngeal apparatus development can contribute to the aetiology of DiGeorge syndrome...
  25. ncbi request reprint The genetic basis of craniofacial and dental abnormalities
    Thaleia Kouskoura
    University of Zurich, Institute of Oral Biology, Zurich, Switzerland
    Schweiz Monatsschr Zahnmed 121:636-46. 2011
    ..The development of novel clinical therapies for orofacial and dental pathological conditions depends very much on a detailed knowledge of the molecular and cellular processes that are involved in head formation...
  26. ncbi request reprint Membrane-bound neuregulin1 type III actively promotes Schwann cell differentiation of multipotent Progenitor cells
    Rainer Leimeroth
    Institute of Cell Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    Dev Biol 246:245-58. 2002
    ..Thus, axon-bound NRG1 might actively promote both Schwann cell survival and differentiation...
  27. ncbi request reprint Multiple roles of canonical Wnt signaling in cell cycle progression and cell lineage specification in neural development
    Lukas Sommer
    Institute of Cell Biology, Department of Biology, ETH Honggerberg, Zurich, Switzerland
    Cell Cycle 3:701-3. 2004
    ..The molecular basis for the functional diversity of Wnt in different stem cell types remains to be elucidated...
  28. ncbi request reprint Guidance of neural crest cell migration: the inhibitory function of the chondroitin sulfate proteoglycan, versican
    Shilpee Dutt
    Laboratory of Molecular Biology, Department of Pathology, University Hospital, Zurich, Switzerland
    ScientificWorldJournal 6:1114-7. 2006
    ....
  29. doi request reprint Engineering melanoma progression in a humanized environment in vivo
    Gregor Kiowski
    Cell and Developmental Biology, Institute of Anatomy, University of Zurich, Zurich, Switzerland
    J Invest Dermatol 132:144-53. 2012
    ..Therefore, in one defined model system, tumor cell-autonomous and non-autonomous pathways regulating human disease progression can be investigated in a humanized, clinically relevant context...
  30. ncbi request reprint Versican V0 and V1 guide migratory neural crest cells
    Shilpee Dutt
    Laboratory of Molecular Biology, Department of Pathology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Biol Chem 281:12123-31. 2006
    ....
  31. doi request reprint Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells
    Dilek Colak
    Helmhotz Center Munich, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 28:434-46. 2008
    ..Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis...
  32. ncbi request reprint Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis
    Ariel Rinon
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 134:3065-75. 2007
    ..We suggest that CNC cells control craniofacial development by regulating positional interactions with mesoderm-derived muscle progenitors that together shape the cranial musculoskeletal architecture in vertebrate embryos...
  33. ncbi request reprint Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis
    Jochen Maurer
    Department of Developmental Pathology, Institute for Pathology, University of Bonn Medical School, Sigmund Freud Strasse 25 53127 Bonn, Germany
    Differentiation 75:580-91. 2007
    ....
  34. ncbi request reprint Cortical development: the art of generating cell diversity
    Magdalena Gotz
    GSF, National Research Centre for Environment and Health, Institute for Stem Cell Research, Neuherberg Munich, Germany
    Development 132:3327-32. 2005
    ..What emerged from this meeting is an equally fascinating answer, namely that precursor diversity at rather early stages of development anticipates later cell type diversity...