Kristin Schirmer

Summary

Affiliation: Swiss Federal Institute of Aquatic Science and Technology
Country: Switzerland

Publications

  1. pmc Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure
    Jacob J Michaelson
    Cellular Networks and Systems Biology, Biotechnology Center, TU Dresden, Dresden, Germany
    BMC Genomics 12:502. 2011
  2. pmc Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
    Wibke Busch
    UFZ Helmholtz Centre for Environmental Research Leipzig, Department of Bioanalytical Ecotoxicology, 04318 Leipzig, Germany
    BMC Genomics 11:65. 2010
  3. doi request reprint Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
    Kristin Schirmer
    Eawag Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, 8600 Dubendorf, Switzerland
    Aquat Toxicol 90:128-37. 2008
  4. pmc Transcriptomics in ecotoxicology
    Kristin Schirmer
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Anal Bioanal Chem 397:917-23. 2010
  5. doi request reprint Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis
    Melanie Knöbel
    Eawag Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:9690-700. 2012
  6. doi request reprint Predicting fish acute toxicity using a fish gill cell line-based toxicity assay
    Katrin Tanneberger
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 47:1110-9. 2013
  7. pmc The insecticide imidacloprid causes mortality of the freshwater amphipod Gammarus pulex by interfering with feeding behavior
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    PLoS ONE 8:e62472. 2013
  8. pmc Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600, Dubendorf, Switzerland
    Ecotoxicology 21:1828-40. 2012
  9. pmc Predicting concentrations of organic chemicals in fish by using toxicokinetic models
    Julita Stadnicka
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:3273-80. 2012
  10. doi request reprint Effects of solvents and dosing procedure on chemical toxicity in cell-based in vitro assays
    Katrin Tanneberger
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Environ Sci Technol 44:4775-81. 2010

Collaborators

Detail Information

Publications12

  1. pmc Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure
    Jacob J Michaelson
    Cellular Networks and Systems Biology, Biotechnology Center, TU Dresden, Dresden, Germany
    BMC Genomics 12:502. 2011
    ..Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals...
  2. pmc Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
    Wibke Busch
    UFZ Helmholtz Centre for Environmental Research Leipzig, Department of Bioanalytical Ecotoxicology, 04318 Leipzig, Germany
    BMC Genomics 11:65. 2010
    ..Therefore, we investigated the impact of these particles, compared to cobalt ions applied as CoCl(2), on the global gene expression level in human keratinocytes (HaCaT) in vitro...
  3. doi request reprint Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
    Kristin Schirmer
    Eawag Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, 8600 Dubendorf, Switzerland
    Aquat Toxicol 90:128-37. 2008
    ..One example would be the use of this list to validate structure-activity prediction models, which in turn would benefit from a continuous extension of this list with regard to physico-chemical and toxicological data...
  4. pmc Transcriptomics in ecotoxicology
    Kristin Schirmer
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Anal Bioanal Chem 397:917-23. 2010
    ..This in turn allows one to deduce how organisms respond to changes in the external environment. In this article we explore how transcriptomics is currently applied in ecotoxicology and highlight challenges and trends...
  5. doi request reprint Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis
    Melanie Knöbel
    Eawag Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:9690-700. 2012
    ..Yet, two types of compounds were less lethal to embryos than to adult fish: a neurotoxic compound acting via sodium channels (permethrin) and a compound requiring metabolic activation (allyl alcohol)...
  6. doi request reprint Predicting fish acute toxicity using a fish gill cell line-based toxicity assay
    Katrin Tanneberger
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 47:1110-9. 2013
    ..We discuss further developments of this assay and suggest its use beyond predicting acute toxicity to fish, for example, as part of adverse outcome pathways to replace, reduce, or refine chronic fish tests...
  7. pmc The insecticide imidacloprid causes mortality of the freshwater amphipod Gammarus pulex by interfering with feeding behavior
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    PLoS ONE 8:e62472. 2013
    ..Using a multiple stressor toxicokinetic-toxicodynamic modeling approach, we showed that both starvation and other toxic effects of imidacloprid play a role for determining mortality in constant exposure to the insecticide...
  8. pmc Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600, Dubendorf, Switzerland
    Ecotoxicology 21:1828-40. 2012
    ..e. the time-weighted average concentration was equal. We studied mode of toxic action of propiconazole and it likely acts as a baseline toxicant in G. pulex during 10-days of exposure for the endpoint survival...
  9. pmc Predicting concentrations of organic chemicals in fish by using toxicokinetic models
    Julita Stadnicka
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:3273-80. 2012
    ..All the models can be used to predict concentrations in different fish species without additional experiments. However, further development of TK models is required for polar, ionizable, and easily biotransformed compounds...
  10. doi request reprint Effects of solvents and dosing procedure on chemical toxicity in cell-based in vitro assays
    Katrin Tanneberger
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Environ Sci Technol 44:4775-81. 2010
    ....
  11. doi request reprint Testing nanomaterial toxicity in unicellular eukaryotic algae and fish cell lines
    Alexandra Kroll
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Methods Mol Biol 1028:165-95. 2013
    ..Furthermore, different types of dose metrics, which is still a strongly debated issue in nanotoxicology, are highlighted. We also consider laboratory safety regarding NM handling and disposal...
  12. doi request reprint Multiple-endpoint assay provides a detailed mechanistic view of responses to herbicide exposure in Chlamydomonas reinhardtii
    Holger Nestler
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, 8600 Duebendorf, Switzerland
    Aquat Toxicol 110:214-24. 2012
    ..Overall, the presented multiple-endpoint assay constitutes a promising basis for investigating stressor and toxicant effects in green algae...