Kristin Schirmer

Summary

Affiliation: Swiss Federal Institute of Aquatic Science and Technology
Country: Switzerland

Publications

  1. pmc Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos
    Stephan Fischer
    Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, 04318 Leipzig, Germany
    BMC Biol 11:69. 2013
  2. pmc Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro
    Susanne Bastian
    Department of Pediatric Neurology, University Children s Hospital Carl Gustav Carus, University of Technology Dresden, Dresden, Germany
    Environ Health Perspect 117:530-6. 2009
  3. pmc Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
    Wibke Busch
    UFZ Helmholtz Centre for Environmental Research Leipzig, Department of Bioanalytical Ecotoxicology, 04318 Leipzig, Germany
    BMC Genomics 11:65. 2010
  4. doi request reprint Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
    Kristin Schirmer
    Eawag Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, 8600 Dubendorf, Switzerland
    Aquat Toxicol 90:128-37. 2008
  5. pmc Transcriptomics in ecotoxicology
    Kristin Schirmer
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Anal Bioanal Chem 397:917-23. 2010
  6. doi request reprint Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish
    Ksenia J Groh
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland ETH Zürich, Department of Chemistry and Applied Biosciences, 8093 Zurich, Switzerland Electronic address
    Chemosphere 120:778-92. 2015
  7. doi request reprint Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis
    Melanie Knöbel
    Eawag Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:9690-700. 2012
  8. doi request reprint Predicting fish acute toxicity using a fish gill cell line-based toxicity assay
    Katrin Tanneberger
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 47:1110-9. 2013
  9. pmc Linking toxicity and adaptive responses across the transcriptome, proteome, and phenotype of Chlamydomonas reinhardtii exposed to silver
    Smitha Pillai
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Duebendorf, Switzerland
    Proc Natl Acad Sci U S A 111:3490-5. 2014
  10. doi request reprint Critical influence of chloride ions on silver ion-mediated acute toxicity of silver nanoparticles to zebrafish embryos
    Ksenia J Groh
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Nanotoxicology 9:81-91. 2015

Collaborators

Detail Information

Publications25

  1. pmc Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos
    Stephan Fischer
    Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, 04318 Leipzig, Germany
    BMC Biol 11:69. 2013
    ..We tested the hypothesis that an ABCB1 ortholog serves as protection for the sensitive developmental processes in zebrafish embryos against adverse compounds dissolved in the water...
  2. pmc Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro
    Susanne Bastian
    Department of Pediatric Neurology, University Children s Hospital Carl Gustav Carus, University of Technology Dresden, Dresden, Germany
    Environ Health Perspect 117:530-6. 2009
    ..To develop nanoparticles for broad applications, potential risks to human health and the environment should be evaluated and taken into consideration...
  3. pmc Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
    Wibke Busch
    UFZ Helmholtz Centre for Environmental Research Leipzig, Department of Bioanalytical Ecotoxicology, 04318 Leipzig, Germany
    BMC Genomics 11:65. 2010
    ..Therefore, we investigated the impact of these particles, compared to cobalt ions applied as CoCl(2), on the global gene expression level in human keratinocytes (HaCaT) in vitro...
  4. doi request reprint Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
    Kristin Schirmer
    Eawag Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, 8600 Dubendorf, Switzerland
    Aquat Toxicol 90:128-37. 2008
    ..One example would be the use of this list to validate structure-activity prediction models, which in turn would benefit from a continuous extension of this list with regard to physico-chemical and toxicological data...
  5. pmc Transcriptomics in ecotoxicology
    Kristin Schirmer
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Anal Bioanal Chem 397:917-23. 2010
    ..This in turn allows one to deduce how organisms respond to changes in the external environment. In this article we explore how transcriptomics is currently applied in ecotoxicology and highlight challenges and trends...
  6. doi request reprint Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish
    Ksenia J Groh
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland ETH Zürich, Department of Chemistry and Applied Biosciences, 8093 Zurich, Switzerland Electronic address
    Chemosphere 120:778-92. 2015
    ..In conclusion, our work demonstrates how the AOP concept can be used in practice to assess critically the knowledge available for specific chronic toxicity cases and to identify existing knowledge gaps and potential alternative tests. ..
  7. doi request reprint Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis
    Melanie Knöbel
    Eawag Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:9690-700. 2012
    ..Yet, two types of compounds were less lethal to embryos than to adult fish: a neurotoxic compound acting via sodium channels (permethrin) and a compound requiring metabolic activation (allyl alcohol)...
  8. doi request reprint Predicting fish acute toxicity using a fish gill cell line-based toxicity assay
    Katrin Tanneberger
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 47:1110-9. 2013
    ..We discuss further developments of this assay and suggest its use beyond predicting acute toxicity to fish, for example, as part of adverse outcome pathways to replace, reduce, or refine chronic fish tests...
  9. pmc Linking toxicity and adaptive responses across the transcriptome, proteome, and phenotype of Chlamydomonas reinhardtii exposed to silver
    Smitha Pillai
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Duebendorf, Switzerland
    Proc Natl Acad Sci U S A 111:3490-5. 2014
    ..From the analysis of the perturbations of the cell's functions, we derived a detailed mechanistic understanding of temporal dynamics of toxicity and adaptive response pathways for C. reinhardtii exposed to silver. ..
  10. doi request reprint Critical influence of chloride ions on silver ion-mediated acute toxicity of silver nanoparticles to zebrafish embryos
    Ksenia J Groh
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Nanotoxicology 9:81-91. 2015
    ..This consideration should influence the choice of exposure medium to be used when evaluating and comparing AgNP toxicity. ..
  11. doi request reprint Toxicity of silver nanoparticles to a fish gill cell line: Role of medium composition
    Yang Yue
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Toxicology, Dubendorf, Switzerland
    Nanotoxicology 9:54-63. 2015
    ..The newly developed low ionic strength medium, d-L15/ex, which can stabilize cit-AgNP and better mimic the freshwater environment, offers an excellent exposure solution to study cellular and molecular effects of NP to gill cells. ..
  12. doi request reprint LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters
    Adrian A Ammann
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600, Duebendorf, Switzerland
    Anal Bioanal Chem 406:7653-65. 2014
    ..We therefore recommend to include these potentially bioactive metabolites in environmental toxicity assessment...
  13. doi request reprint Physical-chemical characterization of tungsten carbide nanoparticles as a basis for toxicological investigations
    Tobias Meissner
    Fraunhofer Institute for Ceramic Technologies and Systems, Dresden, Germany
    Nanotoxicology 4:196-206. 2010
    ..In the presence of bovine serum albumin (BSA) or serum, the agglomeration process is decelerated or, at the appropriate protein amount, prevented...
  14. pmc The insecticide imidacloprid causes mortality of the freshwater amphipod Gammarus pulex by interfering with feeding behavior
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    PLoS ONE 8:e62472. 2013
    ..Using a multiple stressor toxicokinetic-toxicodynamic modeling approach, we showed that both starvation and other toxic effects of imidacloprid play a role for determining mortality in constant exposure to the insecticide...
  15. doi request reprint Effects of solvents and dosing procedure on chemical toxicity in cell-based in vitro assays
    Katrin Tanneberger
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Environ Sci Technol 44:4775-81. 2010
    ....
  16. doi request reprint Importance of toxicokinetics for interspecies variation in sensitivity to chemicals
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 48:5946-54. 2014
    ..Sensitivity to propiconazole was comparable among all species and, when expressed as internal lethal concentrations, falls in the range of baseline toxicity. ..
  17. pmc Measured and modeled toxicokinetics in cultured fish cells and application to in vitro-in vivo toxicity extrapolation
    Julita Stadnicka-Michalak
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland ETH Zürich, Institute of Biogeochemistry and Pollutant Dynamics, Zurich, Switzerland EPF Lausanne, School of Architecture, Civil and Environmental Engineering, Lausanne, Switzerland
    PLoS ONE 9:e92303. 2014
    ..85, p = 0.0008, F-test). This ratio can be predicted from the log KOW of the chemical (77% of variance explained), comprising a promising model to predict lethal effects on fish based on in vitro data. ..
  18. pmc Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600, Dubendorf, Switzerland
    Ecotoxicology 21:1828-40. 2012
    ..e. the time-weighted average concentration was equal. We studied mode of toxic action of propiconazole and it likely acts as a baseline toxicant in G. pulex during 10-days of exposure for the endpoint survival...
  19. pmc Predicting concentrations of organic chemicals in fish by using toxicokinetic models
    Julita Stadnicka
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:3273-80. 2012
    ..All the models can be used to predict concentrations in different fish species without additional experiments. However, further development of TK models is required for polar, ionizable, and easily biotransformed compounds...
  20. doi request reprint Testing nanomaterial toxicity in unicellular eukaryotic algae and fish cell lines
    Alexandra Kroll
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Methods Mol Biol 1028:165-95. 2013
    ..Furthermore, different types of dose metrics, which is still a strongly debated issue in nanotoxicology, are highlighted. We also consider laboratory safety regarding NM handling and disposal...
  21. doi request reprint Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology
    Ksenia J Groh
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland ETH Zürich, Department of Chemistry and Applied Biosciences, 8093 Zurich, Switzerland Electronic address
    Chemosphere 120:764-77. 2015
    ..This will allow a more efficient application of AOP knowledge for quantitative chemical- and site-specific risk assessment as well as for extrapolation across species in the future. ..
  22. doi request reprint Effect of TiO2 nanoparticles and UV radiation on extracellular enzyme activity of intact heterotrophic biofilms
    Hannah Schug
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 48:11620-8. 2014
    ..Impairment of extracellular enzymes which mediate the uptake of nutrients from water may affect ecosystem function. ..
  23. pmc Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure
    Jacob J Michaelson
    Cellular Networks and Systems Biology, Biotechnology Center, TU Dresden, Dresden, Germany
    BMC Genomics 12:502. 2011
    ..Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals...
  24. doi request reprint Systems toxicology approach to understand the kinetics of benzo(a)pyrene uptake, biotransformation, and DNA adduct formation in a liver cell model
    Danielle J Madureira
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Chem Res Toxicol 27:443-53. 2014
    ..Our study emphasizes the importance of quantifying chemical uptake and fate in cell models to differentiate a stress response from an adverse outcome for better risk assessment...
  25. doi request reprint Multiple-endpoint assay provides a detailed mechanistic view of responses to herbicide exposure in Chlamydomonas reinhardtii
    Holger Nestler
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, 8600 Duebendorf, Switzerland
    Aquat Toxicol 110:214-24. 2012
    ..Overall, the presented multiple-endpoint assay constitutes a promising basis for investigating stressor and toxicant effects in green algae...