Timothy J Richmond

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. ncbi request reprint Nucleosome arrays reveal the two-start organization of the chromatin fiber
    Benedetta Dorigo
    Eidgenossische Technische Hochschule ETH Zurich, Institute for Molecular Biology and Biophysics, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 306:1571-3. 2004
  2. doi request reprint Nucleosome recognition and spacing by chromatin remodelling factor ISW1a
    Timothy J Richmond
    ETH Zurich, Institute of Molecular Biology and Biophysics, Schafmattstrasse 20, CH 8093 Zurich, Switzerland
    Biochem Soc Trans 40:347-50. 2012
  3. ncbi request reprint The structure of DNA in the nucleosome core
    Timothy J Richmond
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093 Zurich
    Nature 423:145-50. 2003
  4. doi request reprint Structure and mechanism of the chromatin remodelling factor ISW1a
    Kazuhiro Yamada
    ETH Zurich, Institute of Molecular Biology and Biophysics, Schafmattstr 20, CH 8093 Zurich, Switzerland
    Nature 472:448-53. 2011
  5. ncbi request reprint X-ray structure of a tetranucleosome and its implications for the chromatin fibre
    Thomas Schalch
    ETH Zurich, Institute for Molecular Biology and Biophysics, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Nature 436:138-41. 2005
  6. ncbi request reprint Multiprotein expression strategy for structural biology of eukaryotic complexes
    Daniel J Fitzgerald
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Structure 15:275-9. 2007
  7. pmc Reaction cycle of the yeast Isw2 chromatin remodeling complex
    Daniel J Fitzgerald
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Hönggerberg HPK, Zurich, Switzerland
    EMBO J 23:3836-43. 2004
  8. pmc DNA-dependent divalent cation binding in the nucleosome core particle
    Curt A Davey
    Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule Honggerberg, CH 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:11169-74. 2002
  9. ncbi request reprint Crystal structure of Escherichia coli alkanesulfonate monooxygenase SsuD
    Eric Eichhorn
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093, Zurich, Switzerland
    J Mol Biol 324:457-68. 2002
  10. ncbi request reprint Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes
    Michael Bleichenbacher
    ETH Zurich, Institute for Molecular Biology and Biophysics, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Mol Biol 332:783-93. 2003

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Nucleosome arrays reveal the two-start organization of the chromatin fiber
    Benedetta Dorigo
    Eidgenossische Technische Hochschule ETH Zurich, Institute for Molecular Biology and Biophysics, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 306:1571-3. 2004
    ..We analyzed compacted nucleosome arrays stabilized by introduction of disulfide cross-links and show that the chromatin fiber comprises two stacks of nucleosomes in accord with the two-start model...
  2. doi request reprint Nucleosome recognition and spacing by chromatin remodelling factor ISW1a
    Timothy J Richmond
    ETH Zurich, Institute of Molecular Biology and Biophysics, Schafmattstrasse 20, CH 8093 Zurich, Switzerland
    Biochem Soc Trans 40:347-50. 2012
    ..The model suggests how the highly ordered nucleosome arrays observed by mapping nucleosomes in genes and their promoter regions could be generated by a chromatin remodelling factor...
  3. ncbi request reprint The structure of DNA in the nucleosome core
    Timothy J Richmond
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093 Zurich
    Nature 423:145-50. 2003
    ....
  4. doi request reprint Structure and mechanism of the chromatin remodelling factor ISW1a
    Kazuhiro Yamada
    ETH Zurich, Institute of Molecular Biology and Biophysics, Schafmattstr 20, CH 8093 Zurich, Switzerland
    Nature 472:448-53. 2011
    ..Results from a remodelling assay corroborate the dinucleosome model. We show how a chromatin remodelling factor could set the spacing between two adjacent nucleosomes acting as a 'protein ruler'...
  5. ncbi request reprint X-ray structure of a tetranucleosome and its implications for the chromatin fibre
    Thomas Schalch
    ETH Zurich, Institute for Molecular Biology and Biophysics, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Nature 436:138-41. 2005
    ..The resulting models are nearly fully compacted and most closely resemble the previously described crossed-linker model. They suggest that the interfaces between nucleosomes along a single helix start are polymorphic...
  6. ncbi request reprint Multiprotein expression strategy for structural biology of eukaryotic complexes
    Daniel J Fitzgerald
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Structure 15:275-9. 2007
    ..Parallel production of 12 protein complex variants within a period of weeks resulted in specimens of sufficient quantity and homogeneity for structural biology applications...
  7. pmc Reaction cycle of the yeast Isw2 chromatin remodeling complex
    Daniel J Fitzgerald
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Hönggerberg HPK, Zurich, Switzerland
    EMBO J 23:3836-43. 2004
    ..We propose that progression of the DNA-binding site occurs while nucleosome core contacts are maintained and generates a force dissipated by disruption of histone-DNA interactions...
  8. pmc DNA-dependent divalent cation binding in the nucleosome core particle
    Curt A Davey
    Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule Honggerberg, CH 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:11169-74. 2002
    ..The specific location and mode of metal binding is the consequence of unambiguous conformational differences between dinucleotide sites, owing to their sequence context and orientation in the nucleosome core...
  9. ncbi request reprint Crystal structure of Escherichia coli alkanesulfonate monooxygenase SsuD
    Eric Eichhorn
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093, Zurich, Switzerland
    J Mol Biol 324:457-68. 2002
    ..Thus, the structure reported here provides a model for enzymes belonging to this family and suggests that they might all fold as TIM-barrel proteins...
  10. ncbi request reprint Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes
    Michael Bleichenbacher
    ETH Zurich, Institute for Molecular Biology and Biophysics, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Mol Biol 332:783-93. 2003
    ..Of particular interest is a previously unobserved region of TFIIA that extends the binding interface with TBP in the yeast, but not in the human complex, and that further elucidates biochemical and genetic results...
  11. ncbi request reprint Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution
    Curt A Davey
    Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Mol Biol 319:1097-113. 2002
    ..Divalent cations are bound at specific sites in the nucleosome core particle and contribute to histone-histone and histone-DNA interparticle interactions. These interactions may be relevant to nucleosome association in arrays...
  12. ncbi request reprint Chromatin remodeling activities act on UV-damaged nucleosomes and modulate DNA damage accessibility to photolyase
    Hélène Gaillard
    Institut für Zellbiologie and Institut für Molekularbiologie, Departement Biologie, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 278:17655-63. 2003
    ..Similar activities might relieve the inhibitory effect of nucleosomes on DNA repair processes in living cells...
  13. ncbi request reprint Chromatin fiber folding: requirement for the histone H4 N-terminal tail
    Benedetta Dorigo
    ETH Zurich, Institute for Molecular Biology and Biophysics, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Mol Biol 327:85-96. 2003
    ..Fully compacted chromatin fibers are obtained with any one of the histone tails deleted with the exception of the H4 N terminus. The region of the H4 tail, which mediates compaction, resides in the stretch of amino acids 14-19...
  14. ncbi request reprint Protein complex expression by using multigene baculoviral vectors
    Daniel J Fitzgerald
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Nat Methods 3:1021-32. 2006
    ....
  15. ncbi request reprint Direct interaction of Ca2+/calmodulin inhibits histone deacetylase 5 repressor core binding to myocyte enhancer factor 2
    Imre Berger
    ETH Zurich, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 278:17625-35. 2003
    ..Results from real time binding experiments provide evidence for direct interaction of Ca(2+)/calmodulin with HDAC5 inhibiting MEF2a association with this enzyme...
  16. ncbi request reprint DNA stretching and extreme kinking in the nucleosome core
    Michelle S Ong
    Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Mol Biol 368:1067-74. 2007
    ..This suggests that nucleosome position and context within chromatin could promote extreme DNA kinking that may influence genomic processes...
  17. ncbi request reprint Genomics: predictable packaging
    Timothy J Richmond
    Nature 442:750-2. 2006
  18. ncbi request reprint Metal-free MIRAS phasing: structure of apo-S100A3
    Peer R E Mittl
    Institute of Biochemistry, University of Zurich, Winterthurer Strasse 190, 8057 Zurich, Switzerland
    Acta Crystallogr D Biol Crystallogr 58:1255-61. 2002
    ..The C-terminal canonical EF-hand loop shows an extended conformation and a different helix arrangement to other S100/metal complex crystal structures...
  19. ncbi request reprint Comment on Flash-cooling of macromolecular crystals to overcome increased mosaicity by Yao, Yasutake & Tanaka (2004)
    David F Sargent
    Acta Crystallogr D Biol Crystallogr 60:616. 2004