Lionel Pintard

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. ncbi Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family
    Lionel Pintard
    Institute of Biochemistry, ETH Hoenggerberg, Zuerich, Switzerland
    EMBO J 23:1681-7. 2004
  2. ncbi The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase
    Lionel Pintard
    Institute of Biochemistry ETH, Hönggerberg 8093, Zurich, Switzerland
    Nature 425:311-6. 2003
  3. ncbi The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line
    Sarah Luke-Glaser
    Institute of Biochemistry, HPM G8, ETH Honggerberg, 8093 Zurich, Switzerland
    J Cell Sci 120:3179-87. 2007
  4. ncbi CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo
    Sarah Luke-Glaser
    Swiss Federal Institute of Technology, Zurich, Institute of Biochemistry, Zurich, Switzerland
    Mol Cell Biol 27:4526-40. 2007
  5. ncbi An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases
    Michael Hans Olma
    Swiss Federal Institute of Technology Zurich ETH, Institute of Biochemistry, 8093 Zurich, Switzerland
    J Cell Sci 122:1035-44. 2009
  6. ncbi Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans
    Lionel Pintard
    Institute of Biochemistry, HPM G 10 1, ETH Honggerberg, 8093 Zurich, Switzerland
    Curr Biol 13:911-21. 2003
  7. ncbi The BTB protein MEL-26 promotes cytokinesis in C. elegans by a CUL-3-independent mechanism
    Sarah Luke-Glaser
    Institute of Biochemistry, HPM G 8 0, ETH Honggerberg, 8093 Zurich, Switzerland
    Curr Biol 15:1605-15. 2005
  8. ncbi The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites
    Brian Luke
    Swiss Federal Institute of Technology Zurich ETH, Institute of Biochemistry, ETH Hoenggerberg HPM G 10 0, Switzerland
    Curr Biol 16:786-92. 2006
  9. ncbi Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway
    Thimo Kurz
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Science 295:1294-8. 2002
  10. ncbi Cdc34: cycling on and off the SCF
    Lionel Pintard
    Nat Cell Biol 5:856-7. 2003

Collaborators

Detail Information

Publications12

  1. ncbi Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family
    Lionel Pintard
    Institute of Biochemistry, ETH Hoenggerberg, Zuerich, Switzerland
    EMBO J 23:1681-7. 2004
    ..In this review, we present these new findings and compare the composition of Cul3-based ligases to the well-defined SCF and ECS ligases...
  2. ncbi The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase
    Lionel Pintard
    Institute of Biochemistry ETH, Hönggerberg 8093, Zurich, Switzerland
    Nature 425:311-6. 2003
    ..Our results suggest that BTB-containing proteins may generally function as substrate-specific adaptors in Cul3-based E3-ubiquitin ligases...
  3. ncbi The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line
    Sarah Luke-Glaser
    Institute of Biochemistry, HPM G8, ETH Honggerberg, 8093 Zurich, Switzerland
    J Cell Sci 120:3179-87. 2007
    ..We conclude that degradation of FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis...
  4. ncbi CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo
    Sarah Luke-Glaser
    Swiss Federal Institute of Technology, Zurich, Institute of Biochemistry, Zurich, Switzerland
    Mol Cell Biol 27:4526-40. 2007
    ..F and inactivation of cif-1 impairs translation in vivo. Taken together, our results indicate that CIF-1 is a shared subunit of the CSN and eIF3 complexes and may therefore link protein translation and degradation...
  5. ncbi An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases
    Michael Hans Olma
    Swiss Federal Institute of Technology Zurich ETH, Institute of Biochemistry, 8093 Zurich, Switzerland
    J Cell Sci 122:1035-44. 2009
    ..This analysis identifies new components of the CRL family of E3 ligases and elaborates new connections between the CRL and CSN complexes...
  6. ncbi Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans
    Lionel Pintard
    Institute of Biochemistry, HPM G 10 1, ETH Honggerberg, 8093 Zurich, Switzerland
    Curr Biol 13:911-21. 2003
    ..Counteracting the Nedd8 pathway, the COP9/signalosome has been shown to promote deneddylation of the cullin subunit. However, little is known about the role of neddylation and deneddylation for E3 ligase activity in vivo...
  7. ncbi The BTB protein MEL-26 promotes cytokinesis in C. elegans by a CUL-3-independent mechanism
    Sarah Luke-Glaser
    Institute of Biochemistry, HPM G 8 0, ETH Honggerberg, 8093 Zurich, Switzerland
    Curr Biol 15:1605-15. 2005
    ..Previous studies in C. elegans embryos revealed that inactivation of the CUL-3-based E3 ligase activator rfl-1 results in an aberrant microtubule network, ectopic furrowing during pronuclear migration, and defects during cytokinesis...
  8. ncbi The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites
    Brian Luke
    Swiss Federal Institute of Technology Zurich ETH, Institute of Biochemistry, ETH Hoenggerberg HPM G 10 0, Switzerland
    Curr Biol 16:786-92. 2006
    ..We therefore propose that the cullin Rtt101p promotes fork progression through obstacles such as DNA lesions or tightly bound protein-DNA complexes via a new mechanism involving ubiquitin-conjugation...
  9. ncbi Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway
    Thimo Kurz
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Science 295:1294-8. 2002
    ..We propose that Nedd8-modified cullin, as part of an E3 ubiquitin ligase complex, targets katanin for degradation during the transition from meiosis to mitosis...
  10. ncbi Cdc34: cycling on and off the SCF
    Lionel Pintard
    Nat Cell Biol 5:856-7. 2003
  11. ncbi Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop
    Lionel Pintard
    Centre de Recherche de Biochimie Macromoleculaire du CNRS, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    EMBO J 21:1811-20. 2002
    ..We propose that each eukaryotic enzyme is located in a different cell compartment, in which it would methylate a different RNA that can adopt a very similar secondary structure...
  12. ncbi MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase
    Lionel Pintard
    Centre de Recherche de Biochimie Macromoleculaire, CNRS, Montpellier, France
    EMBO J 21:1139-47. 2002
    ..Our data suggest that this universally conserved modified nucleotide plays an important function in vivo, possibly by inducing conformational rearrangement of the peptidyl transferase centre...