Research Topics
Species | B J MarslandSummaryAffiliation: Swiss Federal Institute of Technology Country: Switzerland Publications
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Detail Information
Publications
Effective T-cell immune responses in the absence of the serine/threonine kinase RIP2Chiara Nembrini
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
Microbes Infect 10:522-30. 2008..Thus contrary to early reports, our data show that RIP2 is not an essential component of the TCR signaling machinery...
Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responsesBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
Proc Natl Acad Sci U S A 102:14374-9. 2005..Our data show that increased activation signals delivered in vivo by highly activated dendritic cells, as present during viral infections, overcome the requirement for PKC- during CD8(+) T cell antiviral responses...- Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cellsBenjamin J Marsland
Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand
Proc Natl Acad Sci U S A 101:6116-21. 2004.... 
Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cellsB J Marsland
Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand
Clin Exp Allergy 34:1299-306. 2004..Respiratory viral infections are a leading cause of the hospitalization of asthmatics, however, the cellular immunological interactions which underlie these two diseases remain elusive...- T-cell fate and function: PKC-theta and beyondBenjamin J Marsland
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH, CH 8952 Zurich, Switzerland
Trends Immunol 29:179-85. 2008..In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function... 
Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunityAbdijapar T Shamshiev
Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology Zurich, 8952 Zurich, Switzerland
J Exp Med 204:441-52. 2007..These results show that a dyslipidemic microenvironment can directly interfere with DC responses to pathogen-derived signals and skew the development of T cell-mediated immunity...- TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responsesAlex K Heer
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
J Immunol 178:2182-91. 2007..Taken together, these data reveal that TLR signaling is not required for anti-influenza T cell responses, but through both direct and indirect means orchestrates appropriate anti-influenza B cell responses... - Strong TCR signaling, TLR ligands, and cytokine redundancies ensure robust development of type 1 effector T cellsChiara Nembrini
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
J Immunol 176:7180-8. 2006..Our findings clarify the hierarchical requirements of the major IFN-gamma inducing pathways and highlight the important role TLR ligand-activated DCs have to preserve them... - Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophagesBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
Eur J Immunol 38:479-88. 2008..Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema... - Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisationNicola L Harris
Malaghan Institute of Medical Research, Central Services Building, Victoria University, Wellington, New Zealand
Microbes Infect 8:232-7. 2006..These findings indicate that the activation status and tissue microenvironment of effector CD4+ T cells can determine their requirement for NFAT-mediated transcription... - CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cellsBenjamin J Marsland
Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
Immunity 22:493-505. 2005.... - IL-4Ralpha signaling is important for CD8+ T cell cytotoxicity in the absence of CD4+ T cell helpBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
Eur J Immunol 35:1391-8. 2005..Taken together, this work reveals previously unrecognized in vivo redundancies between IL-4, IL-13 and IL-2 during immune responses against influenza virus... - Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory responseBenjamin J Marsland
Malaghan Institute of Medical Research, Wellington School of Medicine, University of Otago, Wellington, New Zealand
Immunol Cell Biol 83:40-7. 2005..This disease is characteristic of atopic asthma and can be induced within 11 days, thus providing a platform for the rapid analysis of allergic disease and high throughput testing of immunomodulatory factors... - Viral infection and allergyBenjamin J Marsland
Nat Immunol 5:865; author reply 865-6. 2004 - Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responsesBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistr 27, CH8952 Zurich Schlieren, Switzerland
J Exp Med 200:181-9. 2004..Taken together, our results reveal a central role for PKC-theta signaling during Th2 responses... - CD8+ T cells and immunoregulatory networks in asthmaBenjamin J Marsland
Malaghan Institute of Medical Research, Wellington, New Zealand
Springer Semin Immunopathol 25:311-23. 2004..The mechanistic principles underlying this form of immunomodulation should be taken into consideration when developing future forms of therapy and rational vaccine design... - TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditisBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
J Immunol 178:3466-73. 2007.... - Toll-like receptors: paving the path to T cell-driven autoimmunity?Benjamin J Marsland
Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Wagistr 27, 8952, Zurich, Switzerland
Curr Opin Immunol 19:611-4. 2007..This apparent mechanism of immune homeostasis may break tolerance or anergy upon pathogen infection and promote the development of immune responses against self-antigens... - IL-21 receptor signaling is integral to the development of Th2 effector responses in vivoAnja Fröhlich
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Switzerland
Blood 109:2023-31. 2007..Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses... - Natural IgE production in the absence of MHC Class II cognate helpKathy D McCoy
Institute of Experimental Immunology, Department of Pathology, Universitatsspital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Immunity 24:329-39. 2006..The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals... - Chemokines: more than just road signsMartin F Bachmann
Cytos Biotechnology AG, Wagistrasse 25, 8952 Zurich Schlieren, Switzerland
Nat Rev Immunol 6:159-64. 2006..Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming... - The role of the cytokine milieu in protecting us from allergyBenjamin J Marsland
Malaghan Institute of Medical Research, Wellington
N Z Med J 115:76-7. 2002