B J Marsland

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. doi Effective T-cell immune responses in the absence of the serine/threonine kinase RIP2
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    Microbes Infect 10:522-30. 2008
  2. pmc Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    Proc Natl Acad Sci U S A 102:14374-9. 2005
  3. pmc Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells
    Benjamin J Marsland
    Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand
    Proc Natl Acad Sci U S A 101:6116-21. 2004
  4. ncbi Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cells
    B J Marsland
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand
    Clin Exp Allergy 34:1299-306. 2004
  5. doi T-cell fate and function: PKC-theta and beyond
    Benjamin J Marsland
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH, CH 8952 Zurich, Switzerland
    Trends Immunol 29:179-85. 2008
  6. pmc Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity
    Abdijapar T Shamshiev
    Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology Zurich, 8952 Zurich, Switzerland
    J Exp Med 204:441-52. 2007
  7. ncbi TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 178:2182-91. 2007
  8. ncbi Strong TCR signaling, TLR ligands, and cytokine redundancies ensure robust development of type 1 effector T cells
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 176:7180-8. 2006
  9. doi Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    Eur J Immunol 38:479-88. 2008
  10. ncbi Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation
    Nicola L Harris
    Malaghan Institute of Medical Research, Central Services Building, Victoria University, Wellington, New Zealand
    Microbes Infect 8:232-7. 2006

Collaborators

Detail Information

Publications22

  1. doi Effective T-cell immune responses in the absence of the serine/threonine kinase RIP2
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    Microbes Infect 10:522-30. 2008
    ..Thus contrary to early reports, our data show that RIP2 is not an essential component of the TCR signaling machinery...
  2. pmc Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    Proc Natl Acad Sci U S A 102:14374-9. 2005
    ..Our data show that increased activation signals delivered in vivo by highly activated dendritic cells, as present during viral infections, overcome the requirement for PKC- during CD8(+) T cell antiviral responses...
  3. pmc Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells
    Benjamin J Marsland
    Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand
    Proc Natl Acad Sci U S A 101:6116-21. 2004
    ....
  4. ncbi Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cells
    B J Marsland
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand
    Clin Exp Allergy 34:1299-306. 2004
    ..Respiratory viral infections are a leading cause of the hospitalization of asthmatics, however, the cellular immunological interactions which underlie these two diseases remain elusive...
  5. doi T-cell fate and function: PKC-theta and beyond
    Benjamin J Marsland
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH, CH 8952 Zurich, Switzerland
    Trends Immunol 29:179-85. 2008
    ..In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function...
  6. pmc Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity
    Abdijapar T Shamshiev
    Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology Zurich, 8952 Zurich, Switzerland
    J Exp Med 204:441-52. 2007
    ..These results show that a dyslipidemic microenvironment can directly interfere with DC responses to pathogen-derived signals and skew the development of T cell-mediated immunity...
  7. ncbi TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 178:2182-91. 2007
    ..Taken together, these data reveal that TLR signaling is not required for anti-influenza T cell responses, but through both direct and indirect means orchestrates appropriate anti-influenza B cell responses...
  8. ncbi Strong TCR signaling, TLR ligands, and cytokine redundancies ensure robust development of type 1 effector T cells
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 176:7180-8. 2006
    ..Our findings clarify the hierarchical requirements of the major IFN-gamma inducing pathways and highlight the important role TLR ligand-activated DCs have to preserve them...
  9. doi Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    Eur J Immunol 38:479-88. 2008
    ..Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema...
  10. ncbi Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation
    Nicola L Harris
    Malaghan Institute of Medical Research, Central Services Building, Victoria University, Wellington, New Zealand
    Microbes Infect 8:232-7. 2006
    ..These findings indicate that the activation status and tissue microenvironment of effector CD4+ T cells can determine their requirement for NFAT-mediated transcription...
  11. ncbi CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells
    Benjamin J Marsland
    Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Immunity 22:493-505. 2005
    ....
  12. ncbi IL-4Ralpha signaling is important for CD8+ T cell cytotoxicity in the absence of CD4+ T cell help
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    Eur J Immunol 35:1391-8. 2005
    ..Taken together, this work reveals previously unrecognized in vivo redundancies between IL-4, IL-13 and IL-2 during immune responses against influenza virus...
  13. ncbi Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory response
    Benjamin J Marsland
    Malaghan Institute of Medical Research, Wellington School of Medicine, University of Otago, Wellington, New Zealand
    Immunol Cell Biol 83:40-7. 2005
    ..This disease is characteristic of atopic asthma and can be induced within 11 days, thus providing a platform for the rapid analysis of allergic disease and high throughput testing of immunomodulatory factors...
  14. ncbi Viral infection and allergy
    Benjamin J Marsland
    Nat Immunol 5:865; author reply 865-6. 2004
  15. pmc Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistr 27, CH8952 Zurich Schlieren, Switzerland
    J Exp Med 200:181-9. 2004
    ..Taken together, our results reveal a central role for PKC-theta signaling during Th2 responses...
  16. ncbi CD8+ T cells and immunoregulatory networks in asthma
    Benjamin J Marsland
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Springer Semin Immunopathol 25:311-23. 2004
    ..The mechanistic principles underlying this form of immunomodulation should be taken into consideration when developing future forms of therapy and rational vaccine design...
  17. ncbi TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    J Immunol 178:3466-73. 2007
    ....
  18. ncbi Toll-like receptors: paving the path to T cell-driven autoimmunity?
    Benjamin J Marsland
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Wagistr 27, 8952, Zurich, Switzerland
    Curr Opin Immunol 19:611-4. 2007
    ..This apparent mechanism of immune homeostasis may break tolerance or anergy upon pathogen infection and promote the development of immune responses against self-antigens...
  19. ncbi IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
    Anja Fröhlich
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Switzerland
    Blood 109:2023-31. 2007
    ..Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses...
  20. ncbi Natural IgE production in the absence of MHC Class II cognate help
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Immunity 24:329-39. 2006
    ..The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals...
  21. ncbi Chemokines: more than just road signs
    Martin F Bachmann
    Cytos Biotechnology AG, Wagistrasse 25, 8952 Zurich Schlieren, Switzerland
    Nat Rev Immunol 6:159-64. 2006
    ..Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming...
  22. ncbi The role of the cytokine milieu in protecting us from allergy
    Benjamin J Marsland
    Malaghan Institute of Medical Research, Wellington
    N Z Med J 115:76-7. 2002