Hans U Lutz

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. doi Natural antibodies in health and disease: an overview of the first international workshop on natural antibodies in health and disease
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, Schafmattstr 18, CH 8093 Zurich, Switzerland
    Autoimmun Rev 7:405-9. 2008
  2. ncbi Homeostatic roles of naturally occurring antibodies: an overview
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, Schafmattstr 18, CH 8093 Zurich, Switzerland
    J Autoimmun 29:287-94. 2007
  3. ncbi Intravenously applied IgG stimulates complement attenuation in a complement-dependent autoimmune disease at the amplifying C3 convertase level
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hönggerberg HPM D 14 1, CH 8093 Zurich, Switzerland
    Blood 103:465-72. 2004
  4. ncbi Opinion paper: Stimulation of complement amplification or activation of the alternative pathway of complement?
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Mol Immunol 44:3862-5. 2007
  5. ncbi Complement amplification revisited
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hoenggerberg, HPM D 14 1, Schafmattstr 18, CH 8093 Zurich, Switzerland
    Mol Immunol 43:2-12. 2006
  6. doi Naturally occurring auto-antibodies in homeostasis and disease
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, CH 8093 Zurich, Switzerland
    Trends Immunol 30:43-51. 2009
  7. ncbi IgG naturally occurring antibodies stabilize and promote the generation of the alternative complement pathway C3 convertase
    Emiliana Jelezarova
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hoenggerberg, HPM D14, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Mol Immunol 42:1393-403. 2005
  8. ncbi Stimulation of complement amplification by F(ab')(2)-containing immune complexes and naturally occurring anti-hinge antibodies, possible role in systemic inflammation
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, Schafmattstr 18, CH 8093 Zurich, Switzerland
    Autoimmun Rev 7:508-13. 2008
  9. doi Human F(ab')2-containing immune complexes together with anti-hinge natural antibodies stimulate complement amplification in vitro and in vivo
    Sandra Fumia
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, Zurich, Switzerland
    Mol Immunol 45:2951-61. 2008
  10. ncbi Naturally occurring autoantibodies in mediating clearance of senescent red blood cells
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Adv Exp Med Biol 750:76-90. 2012

Collaborators

Detail Information

Publications18

  1. doi Natural antibodies in health and disease: an overview of the first international workshop on natural antibodies in health and disease
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, Schafmattstr 18, CH 8093 Zurich, Switzerland
    Autoimmun Rev 7:405-9. 2008
  2. ncbi Homeostatic roles of naturally occurring antibodies: an overview
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, Schafmattstr 18, CH 8093 Zurich, Switzerland
    J Autoimmun 29:287-94. 2007
    ..IgM NAbs to neoepitopes, which are generated by oxidized lipids forming Schiff bases with proteins, are protective and help clear this waste in atherosclerosis, but IgG antibodies (NAbs?) of the same specificity promote disease...
  3. ncbi Intravenously applied IgG stimulates complement attenuation in a complement-dependent autoimmune disease at the amplifying C3 convertase level
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hönggerberg HPM D 14 1, CH 8093 Zurich, Switzerland
    Blood 103:465-72. 2004
    ..Thus, IVIG had an immediate and long-lasting attenuating effect on complement amplification in vivo, despite the fact that it induced classical complement pathway activation...
  4. ncbi Opinion paper: Stimulation of complement amplification or activation of the alternative pathway of complement?
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Mol Immunol 44:3862-5. 2007
    ..Schemes similar to the one drawn may help to better illustrate the interplay of the pathways and convey a clearer comprehension of the mechanics of the complement system...
  5. ncbi Complement amplification revisited
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hoenggerberg, HPM D 14 1, Schafmattstr 18, CH 8093 Zurich, Switzerland
    Mol Immunol 43:2-12. 2006
    ..We illustrate their roles in immune complex solubilization, phagocytosis, immune response, and their ability to initiate devastating effects in ischemia/reperfusion and in aggravating inflammation...
  6. doi Naturally occurring auto-antibodies in homeostasis and disease
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, CH 8093 Zurich, Switzerland
    Trends Immunol 30:43-51. 2009
    ....
  7. ncbi IgG naturally occurring antibodies stabilize and promote the generation of the alternative complement pathway C3 convertase
    Emiliana Jelezarova
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hoenggerberg, HPM D14, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Mol Immunol 42:1393-403. 2005
    ..In conclusion, anti-C3 NAbs associated with framework-specific anti-idiotypic NAbs stabilize C3 convertase and promote its generation but their activity is compensated for in whole IgG...
  8. ncbi Stimulation of complement amplification by F(ab')(2)-containing immune complexes and naturally occurring anti-hinge antibodies, possible role in systemic inflammation
    Hans U Lutz
    Institute of Biochemistry, ETH Zurich, Schafmattstr 18, CH 8093 Zurich, Switzerland
    Autoimmun Rev 7:508-13. 2008
    ....
  9. doi Human F(ab')2-containing immune complexes together with anti-hinge natural antibodies stimulate complement amplification in vitro and in vivo
    Sandra Fumia
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, Zurich, Switzerland
    Mol Immunol 45:2951-61. 2008
    ..The same mechanism may contribute to complement overreaction at the onset of SIRS...
  10. ncbi Naturally occurring autoantibodies in mediating clearance of senescent red blood cells
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Adv Exp Med Biol 750:76-90. 2012
    ..These complexes first bind oligomeric properdin, which enhances their affinity for factor B in assembling an alternative C3 convertase...
  11. ncbi Anti-inflammatory effect of intravenous immunoglobulin mediated through modulation of complement activation
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland
    Clin Rev Allergy Immunol 29:207-12. 2005
    ..We propose that the anti-inflammatory effect of IVIg in a wide range of autoimmune diseases might be explained, at least in part, by attenuation of complement amplification...
  12. ncbi How immune complexes from certain IgG NAbs and any F(ab')₂ can mediate excessive complement activation
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Adv Exp Med Biol 750:186-96. 2012
    ....
  13. pmc Complement factor D, albumin, and immunoglobulin G anti-band 3 protein antibodies mimic serum in promoting rosetting of malaria-infected red blood cells
    Alexander Luginbühl
    ETH Zurich, Institute of Biochemistry, HPM D14, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Infect Immun 75:1771-7. 2007
    ..De novo rosetting experiments showed that naturally occurring anti-band 3 antibodies as well as factor D were effective only when added to pRBC. Factor D appeared to cleave a small fraction of a protein expressed on the surface of pRBC...
  14. ncbi C3b2-IgG complexes retain dimeric C3 fragments at all levels of inactivation
    Emiliana Jelezarova
    Institute of Biochemistry, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Biol Chem 278:51806-12. 2003
    ..Our results suggest that, upon physiological inactivation, C3b2-IgG complexes retain dimeric inactivated C3b and C3dg, which allows bivalent binding to the corresponding complement receptors...
  15. ncbi Splenectomy prolongs in vivo survival of erythrocytes differently in spectrin/ankyrin- and band 3-deficient hereditary spherocytosis
    Ramune Reliene
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hönggerberg HPM D14 2, CH 8093 Zurich, Switzerland
    Blood 100:2208-15. 2002
    ....
  16. doi Therapeutic cleavage of IgG is dangerous in humans
    Hans U Lutz
    Trends Immunol 29:353-4; author reply 355-6. 2008
  17. pmc Alternative complement pathway induction by ANCA
    Hans U Lutz
    Am J Pathol 173:910. 2008
  18. ncbi New approaches to the treatment of dense deposit disease
    Richard J H Smith
    Department of Internal Medicine and Otolaryngology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    J Am Soc Nephrol 18:2447-56. 2007
    ..As the understanding of DDD increases, novel therapies should be integrated into existing protocols for DDD and evaluated using an open-label Bayesian study design...