Manfred Kopf

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. doi request reprint Averting inflammation by targeting the cytokine environment
    Manfred Kopf
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    Nat Rev Drug Discov 9:703-18. 2010
  2. pmc Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection
    Nicole Schmitz
    Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    J Virol 79:6441-8. 2005
  3. ncbi request reprint TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    J Immunol 178:3466-73. 2007
  4. pmc GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival
    Ivo Sonderegger
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, 8952 Zurich, Switzerland
    J Exp Med 205:2281-94. 2008
  5. pmc CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells
    Giandomenica Iezzi
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:876-81. 2009
  6. doi request reprint Effective T-cell immune responses in the absence of the serine/threonine kinase RIP2
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    Microbes Infect 10:522-30. 2008
  7. ncbi request reprint CD4+ and CD8+ T cells exhibit differential requirements for CCR7-mediated antigen transport during influenza infection
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 181:6984-94. 2008
  8. ncbi request reprint Strong TCR signaling, TLR ligands, and cytokine redundancies ensure robust development of type 1 effector T cells
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 176:7180-8. 2006
  9. pmc Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity
    Abdijapar T Shamshiev
    Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology Zurich, 8952 Zurich, Switzerland
    J Exp Med 204:441-52. 2007
  10. doi request reprint IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    Anja Fröhlich
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Switzerland
    Science 324:1576-80. 2009

Detail Information

Publications69

  1. doi request reprint Averting inflammation by targeting the cytokine environment
    Manfred Kopf
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    Nat Rev Drug Discov 9:703-18. 2010
    ..Recent advances in our understanding of cytokine networks, as well as technical progress in blocking cytokines in vivo, are likely to be a source for new drugs that can control chronic inflammatory diseases...
  2. pmc Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection
    Nicole Schmitz
    Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    J Virol 79:6441-8. 2005
    ..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection...
  3. ncbi request reprint TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    J Immunol 178:3466-73. 2007
    ....
  4. pmc GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival
    Ivo Sonderegger
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, 8952 Zurich, Switzerland
    J Exp Med 205:2281-94. 2008
    ..These results suggest a novel role for GM-CSF in promoting generation and maintenance of Th17 cells by regulation of IL-6 and IL-23 in vivo...
  5. pmc CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells
    Giandomenica Iezzi
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:876-81. 2009
    ..Our data demonstrate that CD40-CD40L cross-talk is important for Th17 development by translating strong T cell receptor and microbial stimuli into IL-6 production...
  6. doi request reprint Effective T-cell immune responses in the absence of the serine/threonine kinase RIP2
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    Microbes Infect 10:522-30. 2008
    ..Thus contrary to early reports, our data show that RIP2 is not an essential component of the TCR signaling machinery...
  7. ncbi request reprint CD4+ and CD8+ T cells exhibit differential requirements for CCR7-mediated antigen transport during influenza infection
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 181:6984-94. 2008
    ..Overall, our data show that CCR7-mediated active Ag transport is differentially required for CD4(+) and CD8(+) T cell expansion during influenza infection...
  8. ncbi request reprint Strong TCR signaling, TLR ligands, and cytokine redundancies ensure robust development of type 1 effector T cells
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 176:7180-8. 2006
    ..Our findings clarify the hierarchical requirements of the major IFN-gamma inducing pathways and highlight the important role TLR ligand-activated DCs have to preserve them...
  9. pmc Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity
    Abdijapar T Shamshiev
    Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology Zurich, 8952 Zurich, Switzerland
    J Exp Med 204:441-52. 2007
    ..These results show that a dyslipidemic microenvironment can directly interfere with DC responses to pathogen-derived signals and skew the development of T cell-mediated immunity...
  10. doi request reprint IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    Anja Fröhlich
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Switzerland
    Science 324:1576-80. 2009
    ..These data suggest that IL-21R signaling is required for the maintenance of polyfunctional T cells during chronic viral infections and have implications for understanding the immune response to other persisting antigens, such as tumors...
  11. pmc Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
    Proc Natl Acad Sci U S A 102:14374-9. 2005
    ..Our data show that increased activation signals delivered in vivo by highly activated dendritic cells, as present during viral infections, overcome the requirement for PKC- during CD8(+) T cell antiviral responses...
  12. doi request reprint Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    Eur J Immunol 38:479-88. 2008
    ..Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema...
  13. pmc Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk
    Luigi Tortola
    Institute of Molecular Health Sciences, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
    J Clin Invest 122:3965-76. 2012
    ..These results highlight a central and unique IL-1-independent role for IL-36 in control of the IL-23/IL-17/IL-22 pathway and development of psoriasiform dermatitis...
  14. ncbi request reprint The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model
    Nicole Schmitz
    Molecular Biomedicine, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Eur J Immunol 33:991-1000. 2003
    ..These results suggest a critical role of IL-1/IL-1R1 for development of allergic Th2 responses, but its requirement can be overcome by using alum as adjuvant for sensitization...
  15. doi request reprint IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
    Ivo Sonderegger
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 38:1833-8. 2008
    ..IL-6 induced Th17 differentiation independent of and much more potently than IL-21 in vitro. These data suggest that IL-6 is sufficient to drive Th17 development and associated autoimmunity in vivo in the absence of IL-21 or IL-21R...
  16. ncbi request reprint TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 178:2182-91. 2007
    ..Taken together, these data reveal that TLR signaling is not required for anti-influenza T cell responses, but through both direct and indirect means orchestrates appropriate anti-influenza B cell responses...
  17. doi request reprint T-cell fate and function: PKC-theta and beyond
    Benjamin J Marsland
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH, CH 8952 Zurich, Switzerland
    Trends Immunol 29:179-85. 2008
    ..In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function...
  18. pmc The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, CH 8952 Zurich, Switzerland
    J Biol Chem 284:19183-8. 2009
    ..Our results highlight the central role that Rip2 kinase activity plays in conferring stability to the protein and thus in the preservation of Nod1- and Nod2-mediated innate immune responses...
  19. pmc IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection
    Iwana Schmitz
    Molecular Biomedicine, Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 9:e1003362. 2013
    ....
  20. ncbi request reprint Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis
    Ivo Sonderegger
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
    Eur J Immunol 36:2849-56. 2006
    ..Thus, targeting of IL-23 and IL-17 by passive and active vaccination strategies holds promise as a therapeutic approach to treat patients at risk for development of dilated cardiomyopathy...
  21. doi request reprint IL-21 induces death of marginal zone B cells during chronic inflammation
    Luigi Tortola
    Institute of Integrative Biology, Molecular Biomedicine, Eidgenossische Technische Hochschule Zurich, Schlieren, Switzerland
    Blood 116:5200-7. 2010
    ..Our results highlight key roles of IL-2 in inhibiting IL-21 production by CD4(+) T cells and of IL-21 in negatively regulating MZ B-cell survival and antibody production...
  22. doi request reprint Evidence for the divergence of innate and adaptive T-cell precursors before commitment to the αβ and γδ lineages
    Jan Kisielow
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, Zurich Schlieren, Switzerland
    Blood 118:6591-600. 2011
    ..These results suggest that innate and adaptive T-cell lineages do not develop from the same pool of precursors and potentially diverge before αβ/γδ lineage commitment...
  23. doi request reprint Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
    Stefan Freigang
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Schlieren, Switzerland
    Eur J Immunol 41:2040-51. 2011
    ..These findings suggest a common pathway through which oxidative stress and metabolic danger signals converge and mutually perpetuate the chronic vascular inflammation that drives atherosclerosis...
  24. doi request reprint IL-17-producing T cells in lung immunity and inflammation
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, ETH, Zurich, Switzerland
    J Allergy Clin Immunol 123:986-94; quiz 995-6. 2009
    ..This review will summarize T(H)17 cell differentiation and discuss the host beneficial and detrimental function of IL-17A and related cytokines produced by different subpopulations of T cells...
  25. ncbi request reprint IL-4Ralpha signaling is important for CD8+ T cell cytotoxicity in the absence of CD4+ T cell help
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    Eur J Immunol 35:1391-8. 2005
    ..Taken together, this work reveals previously unrecognized in vivo redundancies between IL-4, IL-13 and IL-2 during immune responses against influenza virus...
  26. doi request reprint Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism
    Chiara Nembrini
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
    Thorax 66:755-63. 2011
    ..Airborne microbial products have been reported to promote immune responses that suppress asthma, yet how these beneficial effects take place remains controversial and poorly understood...
  27. ncbi request reprint IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
    Anja Fröhlich
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Switzerland
    Blood 109:2023-31. 2007
    ..Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses...
  28. ncbi request reprint The osteopontin - CD44 pathway is superfluous for the development of autoimmune myocarditis
    Brian Abel
    Molecular Biomedicine, ETH Zurich, Zurich Schlieren, Switzerland
    Eur J Immunol 36:494-9. 2006
    ..Thus, OPN and CD44v6/v7 are merely spectators rather than protagonists in autoimmune myocarditis...
  29. ncbi request reprint Role of IgM antibodies versus B cells in influenza virus-specific immunity
    Manfred Kopf
    Swiss Federal Institute of Technology Zurich, Molecular Biomedicine, Department of Environmental Sciences, Zurich Schlieren, Switzerland
    Eur J Immunol 32:2229-36. 2002
    ..Taken together, our data suggest a role for B cells to promote effector T cell responses and a role of both IgM and IgG antibodies in the defense against acute influenza virus infection...
  30. ncbi request reprint Lymph node resident rather than skin-derived dendritic cells initiate specific T cell responses after Leishmania major infection
    Giandomenica Iezzi
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, 8952 Zurich Schlieren, Switzerland
    J Immunol 177:1250-6. 2006
    ..Furthermore, prevention of migration through early removal of the infection site did not affect Ag presentation by CD11c(high) CD11b(high) DCs and activation of Leishmania major-specific naive CD4+ T cells in vivo...
  31. pmc Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistr 27, CH8952 Zurich Schlieren, Switzerland
    J Exp Med 200:181-9. 2004
    ..Taken together, our results reveal a central role for PKC-theta signaling during Th2 responses...
  32. ncbi request reprint SCART scavenger receptors identify a novel subset of adult gammadelta T cells
    Jan Kisielow
    Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology ETH, Zurich Schlieren, Switzerland
    J Immunol 181:1710-6. 2008
    ..Characterization of SCART2 positive immature and peripheral gammadelta T cells suggests that they undergo lineage specification in the thymus and belong to a new IL-17-producing subset with distinct homing capabilities...
  33. pmc HVEM signalling promotes colitis
    Corinne Schaer
    Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    PLoS ONE 6:e18495. 2011
    ..Several members of the TNFSF are closely associated with inflammatory bowel disease (IBD). Thus, they represent interesting new targets for therapeutic treatment of IBD...
  34. ncbi request reprint Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection
    Manfred Kopf
    Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Nat Med 8:373-8. 2002
    ..Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses...
  35. ncbi request reprint CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells
    Benjamin J Marsland
    Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Immunity 22:493-505. 2005
    ....
  36. pmc IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium
    Pascal Songhet
    Institute of Microbiology, D BIOL, ETH Zurich, Zurich, Switzerland
    PLoS ONE 5:e13804. 2010
    ..Future work will have to address whether this is attributable to redundancy in the cytokine signaling network...
  37. ncbi request reprint Toll-like receptors: paving the path to T cell-driven autoimmunity?
    Benjamin J Marsland
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Wagistr 27, 8952, Zurich, Switzerland
    Curr Opin Immunol 19:611-4. 2007
    ..This apparent mechanism of immune homeostasis may break tolerance or anergy upon pathogen infection and promote the development of immune responses against self-antigens...
  38. pmc Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells
    Benjamin J Marsland
    Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand
    Proc Natl Acad Sci U S A 101:6116-21. 2004
    ....
  39. doi request reprint siRNA Screen of Early Poxvirus Genes Identifies the AAA+ ATPase D5 as the Virus Genome-Uncoating Factor
    Samuel Kilcher
    Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland
    Cell Host Microbe 15:103-12. 2014
    ..These results demonstrate the use of virus-targeting RNAi libraries to investigate viral gene function and suggest therapeutic avenues. ..
  40. doi request reprint The origin and fate of γδT cell subsets
    Jan Kisielow
    Institute of Molecular Health Sciences, ETH Zurich, Switzerland
    Curr Opin Immunol 25:181-8. 2013
    ..Here we discuss recent advances in the understanding of γδT cell subset development, with particular focus on IL-17-producing γδT cells and their beneficial and pathogenic roles in immunity...
  41. doi request reprint Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    ..Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI...
  42. ncbi request reprint IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Eur J Immunol 37:2695-706. 2007
    ..As IL-23-driven inflammation promotes infection and impairs antifungal resistance, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi...
  43. ncbi request reprint Tick saliva inhibits dendritic cell migration, maturation, and function while promoting development of Th2 responses
    Anna Skallová
    Institute of Parasitology, Biology Centre AS CR, Branisovska 31, Ceske Budejovice, Czech Republic
    J Immunol 180:6186-92. 2008
    ..Given the role of DCs as the key instigators of adaptive immune responses, alteration of their function might represent a major mechanism of tick-mediated immune evasion...
  44. ncbi request reprint Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity
    Carsten Wiethe
    Department of Dermatology, University Hospital, Erlangen, Germany
    J Immunol 178:4908-16. 2007
    ....
  45. ncbi request reprint Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key
    Martin F Bachmann
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    Eur J Immunol 34:317-26. 2004
    ..See accompanying article http://dx.doi.org/10.1002/eji.200324844..
  46. ncbi request reprint Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity
    Urs Eriksson
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Nat Med 9:1484-90. 2003
    ..DC-induced myocarditis provides a unifying theory as to how tissue damage and activation of TLRs during infection can induce autoimmunity, relapses and cardiomyopathy...
  47. ncbi request reprint A role for antibodies in the generation of memory antifungal immunity
    Claudia Montagnoli
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Eur J Immunol 33:1193-204. 2003
    ....
  48. pmc Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis
    Urs Eriksson
    Medicine A, University Hospital, CH 4031 Basel, Switzerland
    J Exp Med 197:323-31. 2003
    ..Thus, IL-1R1 triggering is required for efficient activation of dendritic cells, which is in turn a prerequisite for induction of autoreactive CD4(+) T cells and autoimmunity...
  49. ncbi request reprint Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3
    Urs Eriksson
    Department of Internal Medicine, Medical ICU, University Hospital, Basel, Switzerland
    Circulation 107:320-5. 2003
    ..Interleukin (IL)-6 regulates various aspects of the immune response. In the context of heart diseases, it has been recognized as a prognostic factor for dilated cardiomyopathy, which often results from myocarditis...
  50. ncbi request reprint CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis
    Antonella Mencacci
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
    J Immunol 169:3180-90. 2002
    ..These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections...
  51. ncbi request reprint Balancing protective immunity and immunopathology
    Martin F Bachmann
    Cytos Biotechnology AG, Wagistrasse 25, Zurich, Schlieren Zürich, Switzerland
    Curr Opin Immunol 14:413-9. 2002
    ..In order to counterbalance overshooting immune responses, T cells and APCs secrete anti-inflammatory cytokines that are key for maintaining a healthy balance between protection and immunopathology...
  52. ncbi request reprint The role of IL-12 in maintaining resistance to Leishmania major
    Audrey Y Park
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Immunol 168:5771-7. 2002
    ....
  53. pmc Role of interleukin-1 in prion disease-associated astrocyte activation
    Julia Schultz
    Project Neurodegenerative Diseases, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Am J Pathol 165:671-8. 2004
    ....
  54. ncbi request reprint Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis
    Luisa Camoglio
    Department of Experimental Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 32:261-9. 2002
    ..These results demonstrate that IL-12p40, in contrast to IL-12p70, inhibits TNBS-induced colitis and IL-18 expression independent of IFN-gamma...
  55. ncbi request reprint TLR9 signaling in B cells determines class switch recombination to IgG2a
    Andrea Jegerlehner
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    J Immunol 178:2415-20. 2007
    ..Thus, TLR9 can regulate isotype switching to IgG2a directly by interacting with B cells rather than indirectly by inducing Th1 responses...
  56. pmc VSIG4, a B7 family-related protein, is a negative regulator of T cell activation
    Lorenz Vogt
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    J Clin Invest 116:2817-26. 2006
    ..The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues...
  57. pmc Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells
    Simona Stager
    Immunology and Infection Unit, Hull York Medical School and Department of Biology, University of York, York, UK
    Eur J Immunol 36:1764-71. 2006
    ..Breadth of cytokine production is thus an important factor when considering strategies for DC-based interventions...
  58. ncbi request reprint Aberrant acute-phase response in aged interleukin-6 knockout mice
    Christian R Gomez
    Department of Cell Biology, Neurobiology, and Anatomy, The Burn and Shock Trauma Institute, Alcohol Research Program, and Immunology and Aging Program, Loyola University Medical Center, Maywood, IL 60130, USA
    Shock 25:581-5. 2006
    ..We conclude that the absence of IL-6, a cytokine that contributes to the elevated basal proinflammatory state observed in aging, can improve the ability of aged mice to withstand an otherwise lethal challenge of bacterial endotoxin...
  59. pmc Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1
    Dominique Gatto
    Cytos Biotechnology, Swiss Federal Institute of Technology, Zurich Schlieren 8952, Switzerland
    J Exp Med 201:993-1005. 2005
    ..These results suggest that complement receptors maintain antibody responses by delivery of differentiation and survival signals to precursors of bone marrow plasma cells...
  60. ncbi request reprint Osteopontin is not required for the development of Th1 responses and viral immunity
    Brian Abel
    Molecular Biomedicine, Swiss Federal Institute of Technology, and
    J Immunol 175:6006-13. 2005
    ..Contrary to a previous report, we found that OPN-/- mice mounted a normal immune response to Listeria monocytogenes. In conclusion, OPN is dispensable for antiviral immune responses against influenza virus and vaccinia virus...
  61. ncbi request reprint Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis
    Robert Paul
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Brain 126:1873-82. 2003
    ..These findings suggest that the migration of leukocytes across the BBB and the increase in vascular permeability are two independent processes during bacterial meningitis...
  62. pmc Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
    David Robbe
    Actions Concertées Incitatives Jeunes Chercheurs Plasticité Synaptique et Toxicomanie, Centre National de la Recherche Scientifique, Unité Propre de Recherche 9023, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    Proc Natl Acad Sci U S A 99:8384-8. 2002
    ..These findings unveil the role of the eCB system in activity-dependent long-term synaptic plasticity and identify a mechanism by which marijuana can alter synaptic functions in the endogenous brain reward system...
  63. ncbi request reprint Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis
    Till A Röhn
    Cytos Biotechnology AG, Immunodrugs, Zurich, Switzerland
    Eur J Immunol 36:2857-67. 2006
    ..Active immunization against IL-17 therefore represents a novel therapeutic approach for the treatment of chronic inflammatory diseases...
  64. ncbi request reprint IL-6 is required for glioma development in a mouse model
    Jakob Weissenberger
    Division of Neuropathology, Institute of Pathology, University of Bern, Murtenstrasse 31, Bern CH 3010, Switzerland
    Oncogene 23:3308-16. 2004
    ..Together with the observation that STAT3 activation increases with malignancy, these findings indicate an important role for IL-6 in the development and malignant progression of astrocytomas...
  65. ncbi request reprint Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia
    Anne Remaury
    Department of Molecular and Functional Genomics, Sanofi Synthelabo Recherche, Innopole, 31676 Labège Cedex, France
    Brain Res 953:63-72. 2002
    ..This analysis of NT-1R-deficient mice shows that the NT-1R does not play a role in NT-induced analgesia, but that it is clearly implicated in thermal and feeding regulation, weight control, and NT-induced hypolocomotion...
  66. ncbi request reprint Chemokines: more than just road signs
    Martin F Bachmann
    Cytos Biotechnology AG, Wagistrasse 25, 8952 Zurich Schlieren, Switzerland
    Nat Rev Immunol 6:159-64. 2006
    ..Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming...
  67. ncbi request reprint Cytokines that regulate autoimmune myocarditis
    Michael O Kurrer
    Department of Pathology, University Hospital, Zurich, Switzerland
    Swiss Med Wkly 132:408-13. 2002
    ....
  68. pmc Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6
    Hirokazu Ohtaki
    Department of Anatomy, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
    Proc Natl Acad Sci U S A 103:7488-93. 2006
    ..These results suggest that PACAP prevents neuronal cell death after ischemia via a signaling mechanism involving IL-6...
  69. ncbi request reprint Viral infection and allergy
    Benjamin J Marsland
    Nat Immunol 5:865; author reply 865-6. 2004