Manfred Kopf

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. Bretscher P, Egger J, Shamshiev A, Trötzmüller M, Köfeler H, Carreira E, et al. Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2. EMBO Mol Med. 2015;7:593-607 pubmed publisher
    ..These findings provide a molecular basis for the negative regulation of inflammation by lipid peroxidation products and propose a novel class of highly bioactive compounds for the treatment of inflammatory diseases. ..
  2. Kisielow J, Obermair F, Kopf M. Deciphering CD4+ T cell specificity using novel MHC-TCR chimeric receptors. Nat Immunol. 2019;20:652-662 pubmed publisher
    ..Thus, the MCR technology holds promise for basic research and clinical applications, allowing the personalized identification of T cell-specific neo-antigens in patients. ..
  3. Tortola L, Pawelski H, Sonar S, Ampenberger F, Kurrer M, Kopf M. IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3+ regulatory T cells. J Allergy Clin Immunol. 2019;: pubmed publisher
    ..IL-21 directly promotes apoptosis of Treg cells and therefore indirectly sustains generation of inflammatory TH cells and related effector responses. ..
  4. Nobs S, Kayhan M, Kopf M. GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation. J Allergy Clin Immunol. 2019;143:1513-1524.e2 pubmed publisher
    ..GM-CSF intrinsically promotes eosinophil accumulation in the setting of pulmonary allergic inflammation. ..
  5. Muri J, Heer S, Matsushita M, Pohlmeier L, Tortola L, Fuhrer T, et al. The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation. Nat Commun. 2018;9:1851 pubmed publisher
    ..These results uncover a pivotal function of the Trx1 system in metabolic reprogramming of thymic and peripheral T cells and provide a rationale for targeting Txnrd1 in T-cell leukemia. ..
  6. Schneider C, Kopf M. tEMPting Fate MaYBe the Solution. Immunity. 2015;42:597-9 pubmed publisher
    ..2015) reconcile a controversy by demonstrating that a distinct wave of yolk-sac-derived erythro-myeloid progenitors (EMPs) differentiate to fetal monocytes in the liver and further to adult macrophages in the majority of tissues. ..
  7. Nobs S, Schneider C, Dietrich M, Brocker T, Rolink A, Hirsch E, et al. PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development. Immunity. 2015;43:674-89 pubmed publisher
    ..Thus we identified PI3Kγ as an essential organ-specific regulator of lung DC development and discovered a signaling network regulating tissue-specific DC development mediated by FLT3. ..
  8. Schmitz N, Kurrer M, Bachmann M, Kopf M. Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol. 2005;79:6441-8 pubmed
    ..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection. ..
  9. Matsushita M, Freigang S, Schneider C, Conrad M, Bornkamm G, Kopf M. T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med. 2015;212:555-68 pubmed publisher
    ..Ex vivo, Gpx4-deficient T cells rapidly accumulated membrane lipid peroxides and concomitantly underwent cell death driven by ferroptosis but not necroptosis. These studies unveil an essential role of Gpx4 for T cell immunity. ..

More Information

Publications11

  1. Schneider C, Nobs S, Heer A, Hirsch E, Penninger J, Siggs O, et al. Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection. J Leukoc Biol. 2017;101:367-376 pubmed publisher
  2. Nobs S, Natali S, Pohlmeier L, Okreglicka K, Schneider C, Kurrer M, et al. PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation. J Exp Med. 2017;214:3015-3035 pubmed publisher
    ..Thus, we uncover a surprising proinflammatory role for PPARγ and establish it as a novel, important mediator of DC-T cell interactions in type-2 immunity. ..