Research Topics
Genomes and Genes
| Manfred KopfSummaryAffiliation: Swiss Federal Institute of Technology Country: Switzerland Publications
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Detail Information
Publications
Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infectionNicole Schmitz
Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
J Virol 79:6441-8. 2005..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection...
Averting inflammation by targeting the cytokine environmentManfred Kopf
Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
Nat Rev Drug Discov 9:703-18. 2010..Recent advances in our understanding of cytokine networks, as well as technical progress in blocking cytokines in vivo, are likely to be a source for new drugs that can control chronic inflammatory diseases...- GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survivalIvo Sonderegger
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, 8952 Zurich, Switzerland
J Exp Med 205:2281-94. 2008..These results suggest a novel role for GM-CSF in promoting generation and maintenance of Th17 cells by regulation of IL-6 and IL-23 in vivo... - CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cellsGiandomenica Iezzi
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
Proc Natl Acad Sci U S A 106:876-81. 2009..Our data demonstrate that CD40-CD40L cross-talk is important for Th17 development by translating strong T cell receptor and microbial stimuli into IL-6 production... 
TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditisBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
J Immunol 178:3466-73. 2007....- Effective T-cell immune responses in the absence of the serine/threonine kinase RIP2Chiara Nembrini
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
Microbes Infect 10:522-30. 2008..Thus contrary to early reports, our data show that RIP2 is not an essential component of the TCR signaling machinery... - Strong TCR signaling, TLR ligands, and cytokine redundancies ensure robust development of type 1 effector T cellsChiara Nembrini
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
J Immunol 176:7180-8. 2006..Our findings clarify the hierarchical requirements of the major IFN-gamma inducing pathways and highlight the important role TLR ligand-activated DCs have to preserve them... - CD4+ and CD8+ T cells exhibit differential requirements for CCR7-mediated antigen transport during influenza infectionAlex K Heer
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
J Immunol 181:6984-94. 2008..Overall, our data show that CCR7-mediated active Ag transport is differentially required for CD4(+) and CD8(+) T cell expansion during influenza infection... 
Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunityAbdijapar T Shamshiev
Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology Zurich, 8952 Zurich, Switzerland
J Exp Med 204:441-52. 2007..These results show that a dyslipidemic microenvironment can directly interfere with DC responses to pathogen-derived signals and skew the development of T cell-mediated immunity...- IL-21R on T cells is critical for sustained functionality and control of chronic viral infectionAnja Fröhlich
Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Switzerland
Science 324:1576-80. 2009..These data suggest that IL-21R signaling is required for the maintenance of polyfunctional T cells during chronic viral infections and have implications for understanding the immune response to other persisting antigens, such as tumors... - Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responsesBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH 8952 Zurich Schlieren, Switzerland
Proc Natl Acad Sci U S A 102:14374-9. 2005..Our data show that increased activation signals delivered in vivo by highly activated dendritic cells, as present during viral infections, overcome the requirement for PKC- during CD8(+) T cell antiviral responses... - Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophagesBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
Eur J Immunol 38:479-88. 2008..Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema... - T-cell fate and function: PKC-theta and beyondBenjamin J Marsland
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH, CH 8952 Zurich, Switzerland
Trends Immunol 29:179-85. 2008..In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function... - The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma modelNicole Schmitz
Molecular Biomedicine, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
Eur J Immunol 33:991-1000. 2003..These results suggest a critical role of IL-1/IL-1R1 for development of allergic Th2 responses, but its requirement can be overcome by using alum as adjuvant for sensitization... - The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responsesChiara Nembrini
Institute of Integrative Biology, Molecular Biomedicine, CH 8952 Zurich, Switzerland
J Biol Chem 284:19183-8. 2009..Our results highlight the central role that Rip2 kinase activity plays in conferring stability to the protein and thus in the preservation of Nod1- and Nod2-mediated innate immune responses... - TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responsesAlex K Heer
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
J Immunol 178:2182-91. 2007..Taken together, these data reveal that TLR signaling is not required for anti-influenza T cell responses, but through both direct and indirect means orchestrates appropriate anti-influenza B cell responses... - IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivoIvo Sonderegger
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Zurich, Switzerland
Eur J Immunol 38:1833-8. 2008..IL-6 induced Th17 differentiation independent of and much more potently than IL-21 in vitro. These data suggest that IL-6 is sufficient to drive Th17 development and associated autoimmunity in vivo in the absence of IL-21 or IL-21R... - Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditisIvo Sonderegger
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
Eur J Immunol 36:2849-56. 2006..Thus, targeting of IL-23 and IL-17 by passive and active vaccination strategies holds promise as a therapeutic approach to treat patients at risk for development of dilated cardiomyopathy... - IL-21 induces death of marginal zone B cells during chronic inflammationLuigi Tortola
Institute of Integrative Biology, Molecular Biomedicine, Eidgenossische Technische Hochschule Zurich, Schlieren, Switzerland
Blood 116:5200-7. 2010..Our results highlight key roles of IL-2 in inhibiting IL-21 production by CD4(+) T cells and of IL-21 in negatively regulating MZ B-cell survival and antibody production... - Evidence for the divergence of innate and adaptive T-cell precursors before commitment to the αβ and γδ lineagesJan Kisielow
Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, Zurich Schlieren, Switzerland
Blood 118:6591-600. 2011..These results suggest that innate and adaptive T-cell lineages do not develop from the same pool of precursors and potentially diverge before αβ/γδ lineage commitment... - IL-17-producing T cells in lung immunity and inflammationChiara Nembrini
Institute of Integrative Biology, Molecular Biomedicine, ETH, Zurich, Switzerland
J Allergy Clin Immunol 123:986-94; quiz 995-6. 2009..This review will summarize T(H)17 cell differentiation and discuss the host beneficial and detrimental function of IL-17A and related cytokines produced by different subpopulations of T cells... - Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosisStefan Freigang
Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Schlieren, Switzerland
Eur J Immunol 41:2040-51. 2011..These findings suggest a common pathway through which oxidative stress and metabolic danger signals converge and mutually perpetuate the chronic vascular inflammation that drives atherosclerosis... - Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanismChiara Nembrini
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
Thorax 66:755-63. 2011..Airborne microbial products have been reported to promote immune responses that suppress asthma, yet how these beneficial effects take place remains controversial and poorly understood... - IL-4Ralpha signaling is important for CD8+ T cell cytotoxicity in the absence of CD4+ T cell helpBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
Eur J Immunol 35:1391-8. 2005..Taken together, this work reveals previously unrecognized in vivo redundancies between IL-4, IL-13 and IL-2 during immune responses against influenza virus... - IL-21 receptor signaling is integral to the development of Th2 effector responses in vivoAnja Fröhlich
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Switzerland
Blood 109:2023-31. 2007..Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses... - Lymph node resident rather than skin-derived dendritic cells initiate specific T cell responses after Leishmania major infectionGiandomenica Iezzi
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, 8952 Zurich Schlieren, Switzerland
J Immunol 177:1250-6. 2006..Furthermore, prevention of migration through early removal of the infection site did not affect Ag presentation by CD11c(high) CD11b(high) DCs and activation of Leishmania major-specific naive CD4+ T cells in vivo... - Role of IgM antibodies versus B cells in influenza virus-specific immunityManfred Kopf
Swiss Federal Institute of Technology Zurich, Molecular Biomedicine, Department of Environmental Sciences, , Switzerland
Eur J Immunol 32:2229-36. 2002..Taken together, our data suggest a role for B cells to promote effector T cell responses and a role of both IgM and IgG antibodies in the defense against acute influenza virus infection... - Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responsesBenjamin J Marsland
Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistr 27, CH8952 Zurich Schlieren, Switzerland
J Exp Med 200:181-9. 2004..Taken together, our results reveal a central role for PKC-theta signaling during Th2 responses... - The osteopontin - CD44 pathway is superfluous for the development of autoimmune myocarditisBrian Abel
Molecular Biomedicine, ETH Zurich, Zurich Schlieren, Switzerland
Eur J Immunol 36:494-9. 2006..Thus, OPN and CD44v6/v7 are merely spectators rather than protagonists in autoimmune myocarditis... - Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infectionManfred Kopf
Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
Nat Med 8:373-8. 2002..Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses... - HVEM signalling promotes colitisCorinne Schaer
Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
PLoS ONE 6:e18495. 2011..Several members of the TNFSF are closely associated with inflammatory bowel disease (IBD). Thus, they represent interesting new targets for therapeutic treatment of IBD... - SCART scavenger receptors identify a novel subset of adult gammadelta T cellsJan Kisielow
Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology ETH, Zurich Schlieren, Switzerland
J Immunol 181:1710-6. 2008..Characterization of SCART2 positive immature and peripheral gammadelta T cells suggests that they undergo lineage specification in the thymus and belong to a new IL-17-producing subset with distinct homing capabilities... - CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cellsBenjamin J Marsland
Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
Immunity 22:493-505. 2005.... - Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalkLuigi Tortola
Institute of Molecular Health Sciences, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
J Clin Invest 122:3965-76. 2012..These results highlight a central and unique IL-1-independent role for IL-36 in control of the IL-23/IL-17/IL-22 pathway and development of psoriasiform dermatitis... - IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. TyphimuriumPascal Songhet
Institute of Microbiology, D BIOL, ETH Zurich, Zurich, Switzerland
PLoS ONE 5:e13804. 2010..Future work will have to address whether this is attributable to redundancy in the cytokine signaling network... - Toll-like receptors: paving the path to T cell-driven autoimmunity?Benjamin J Marsland
Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Wagistr 27, 8952, Zurich, Switzerland
Curr Opin Immunol 19:611-4. 2007..This apparent mechanism of immune homeostasis may break tolerance or anergy upon pathogen infection and promote the development of immune responses against self-antigens... - Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cellsBenjamin J Marsland
Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand
Proc Natl Acad Sci U S A 101:6116-21. 2004.... - Tick saliva inhibits dendritic cell migration, maturation, and function while promoting development of Th2 responsesAnna Skallová
Institute of Parasitology, Biology Centre AS CR, Branisovska 31, Ceske Budejovice, Czech Republic
J Immunol 180:6186-92. 2008..Given the role of DCs as the key instigators of adaptive immune responses, alteration of their function might represent a major mechanism of tick-mediated immune evasion... - Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the keyMartin F Bachmann
Cytos Biotechnology AG, Zurich Schlieren, Switzerland
Eur J Immunol 34:317-26. 2004..See accompanying article http://dx.doi.org/10.1002/eji.200324844.. - Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunityUrs Eriksson
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 7, A 1030 Vienna, Austria
Nat Med 9:1484-90. 2003..DC-induced myocarditis provides a unifying theory as to how tissue damage and activation of TLRs during infection can induce autoimmunity, relapses and cardiomyopathy... - A role for antibodies in the generation of memory antifungal immunityClaudia Montagnoli
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Eur J Immunol 33:1193-204. 2003.... - Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditisUrs Eriksson
Medicine A, University Hospital, CH 4031 Basel, Switzerland
J Exp Med 197:323-31. 2003..Thus, IL-1R1 triggering is required for efficient activation of dendritic cells, which is in turn a prerequisite for induction of autoreactive CD4(+) T cells and autoimmunity... - Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3Urs Eriksson
Department of Internal Medicine, Medical ICU, University Hospital, Basel, Switzerland
Circulation 107:320-5. 2003..Interleukin (IL)-6 regulates various aspects of the immune response. In the context of heart diseases, it has been recognized as a prognostic factor for dilated cardiomyopathy, which often results from myocarditis... - CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasisAntonella Mencacci
Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
J Immunol 169:3180-90. 2002..These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections... - Balancing protective immunity and immunopathologyMartin F Bachmann
Cytos Biotechnology AG, Wagistrasse 25, Zurich, Schlieren Zürich, Switzerland
Curr Opin Immunol 14:413-9. 2002..In order to counterbalance overshooting immune responses, T cells and APCs secrete anti-inflammatory cytokines that are key for maintaining a healthy balance between protection and immunopathology... - The role of IL-12 in maintaining resistance to Leishmania majorAudrey Y Park
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104. Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
J Immunol 168:5771-7. 2002.... - Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitisLuisa Camoglio
Department of Experimental Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Eur J Immunol 32:261-9. 2002..These results demonstrate that IL-12p40, in contrast to IL-12p70, inhibits TNBS-induced colitis and IL-18 expression independent of IFN-gamma... - VSIG4, a B7 family-related protein, is a negative regulator of T cell activationLorenz Vogt
Cytos Biotechnology AG, Zurich Schlieren, Switzerland
J Clin Invest 116:2817-26. 2006..The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues... - Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injuryYumiko Imai
IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
Cell 133:235-49. 2008..Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI... - Role of interleukin-1 in prion disease-associated astrocyte activationJulia Schultz
Project Neurodegenerative Diseases, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
Am J Pathol 165:671-8. 2004.... - Aberrant acute-phase response in aged interleukin-6 knockout miceChristian R Gomez
Department of Cell Biology, Neurobiology, and Anatomy, The Burn and Shock Trauma Institute, Alcohol Research Program, and Immunology and Aging Program, Loyola University Medical Center, Maywood, IL 60130, USA
Shock 25:581-5. 2006..We conclude that the absence of IL-6, a cytokine that contributes to the elevated basal proinflammatory state observed in aging, can improve the ability of aged mice to withstand an otherwise lethal challenge of bacterial endotoxin... - Osteopontin is not required for the development of Th1 responses and viral immunityBrian Abel
Molecular Biomedicine, Swiss Federal Institute of Technology, and
J Immunol 175:6006-13. 2005..Contrary to a previous report, we found that OPN-/- mice mounted a normal immune response to Listeria monocytogenes. In conclusion, OPN is dispensable for antiviral immune responses against influenza virus and vaccinia virus... - Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunityCarsten Wiethe
Department of Dermatology, University Hospital, Erlangen, Germany
J Immunol 178:4908-16. 2007.... - IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistanceTeresa Zelante
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Eur J Immunol 37:2695-706. 2007..As IL-23-driven inflammation promotes infection and impairs antifungal resistance, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi... - Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1Dominique Gatto
Cytos Biotechnology, Swiss Federal Institute of Technology, Zurich Schlieren 8952, Switzerland
J Exp Med 201:993-1005. 2005..These results suggest that complement receptors maintain antibody responses by delivery of differentiation and survival signals to precursors of bone marrow plasma cells... - Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cellsSimona Stager
Immunology and Infection Unit, Hull York Medical School and Department of Biology, University of York, York, UK
Eur J Immunol 36:1764-71. 2006..Breadth of cytokine production is thus an important factor when considering strategies for DC-based interventions... - TLR9 signaling in B cells determines class switch recombination to IgG2aAndrea Jegerlehner
Cytos Biotechnology AG, Zurich Schlieren, Switzerland
J Immunol 178:2415-20. 2007..Thus, TLR9 can regulate isotype switching to IgG2a directly by interacting with B cells rather than indirectly by inducing Th1 responses... - Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitisTill A Röhn
Cytos Biotechnology AG, Immunodrugs, Zurich, Switzerland
Eur J Immunol 36:2857-67. 2006..Active immunization against IL-17 therefore represents a novel therapeutic approach for the treatment of chronic inflammatory diseases... - Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbensDavid Robbe
Actions Concertées Incitatives Jeunes Chercheurs Plasticité Synaptique et Toxicomanie, Centre National de la Recherche Scientifique, Unité Propre de Recherche 9023, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
Proc Natl Acad Sci U S A 99:8384-8. 2002..These findings unveil the role of the eCB system in activity-dependent long-term synaptic plasticity and identify a mechanism by which marijuana can alter synaptic functions in the endogenous brain reward system... - Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6Hirokazu Ohtaki
Department of Anatomy, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
Proc Natl Acad Sci U S A 103:7488-93. 2006..These results suggest that PACAP prevents neuronal cell death after ischemia via a signaling mechanism involving IL-6... - Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesiaAnne Remaury
Department of Molecular and Functional Genomics, Sanofi Synthelabo Recherche, Innopole, 31676 Labège Cedex, France
Brain Res 953:63-72. 2002..This analysis of NT-1R-deficient mice shows that the NT-1R does not play a role in NT-induced analgesia, but that it is clearly implicated in thermal and feeding regulation, weight control, and NT-induced hypolocomotion... - Cytokines that regulate autoimmune myocarditisMichael O Kurrer
Department of Pathology, University Hospital, Zurich, Switzerland
Swiss Med Wkly 132:408-13. 2002.... - Chemokines: more than just road signsMartin F Bachmann
Cytos Biotechnology AG, Wagistrasse 25, 8952 Zurich Schlieren, Switzerland
Nat Rev Immunol 6:159-64. 2006..Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming... - Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitisRobert Paul
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Brain 126:1873-82. 2003..These findings suggest that the migration of leukocytes across the BBB and the increase in vascular permeability are two independent processes during bacterial meningitis... - Viral infection and allergyBenjamin J Marsland
Nat Immunol 5:865; author reply 865-6. 2004 - IL-6 is required for glioma development in a mouse modelJakob Weissenberger
Division of Neuropathology, Institute of Pathology, University of Bern, Murtenstrasse 31, Bern CH 3010, Switzerland
Oncogene 23:3308-16. 2004..Together with the observation that STAT3 activation increases with malignancy, these findings indicate an important role for IL-6 in the development and malignant progression of astrocytomas...