Sebastian Jessberger

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activity
    Benedikt Römer
    Genomics of Regeneration, Center for Regenerative Therapies Dresden Dresden, Germany
    Front Neurosci 5:107. 2011
  2. pmc Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: II. Genetic Covariation and Identification of Nos1 as Linking Candidate Gene
    Julia Krebs
    Genomics of Regeneration, Center for Regenerative Therapies Dresden Dresden, Germany
    Front Neurosci 5:106. 2011
  3. pmc Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS Biol 6:e272. 2008
  4. pmc Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use
    Sebastian Jessberger
    Institute of Cell Biology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland
    Trends Pharmacol Sci 30:61-5. 2009
  5. pmc Directed differentiation of hippocampal stem/progenitor cells in the adult brain
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 11:888-93. 2008
  6. pmc Making a neuron: Cdk5 in embryonic and adult neurogenesis
    Sebastian Jessberger
    Institute of Cell Biology, Department of Biology, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland
    Trends Neurosci 32:575-82. 2009
  7. pmc Stem-cell-associated structural and functional plasticity in the aging hippocampus
    Sebastian Jessberger
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Psychol Aging 23:684-91. 2008
  8. doi request reprint Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus
    Helena Mira
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Stem Cell 7:78-89. 2010
  9. ncbi request reprint Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:9400-7. 2007
  10. pmc Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis
    Oliver Bracko
    Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Neurosci 32:3376-87. 2012

Collaborators

Detail Information

Publications28

  1. pmc Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activity
    Benedikt Römer
    Genomics of Regeneration, Center for Regenerative Therapies Dresden Dresden, Germany
    Front Neurosci 5:107. 2011
    ..In a second part of this study, published separately (Krebs et al., 2011) we have addressed the question of whether there is a shared genetics underlying both traits...
  2. pmc Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: II. Genetic Covariation and Identification of Nos1 as Linking Candidate Gene
    Julia Krebs
    Genomics of Regeneration, Center for Regenerative Therapies Dresden Dresden, Germany
    Front Neurosci 5:106. 2011
    ..Despite explaining on its own very little of the variance in the highly multigenic traits studied, our results suggest Nos1 may play a part in the complex genetic control of adult neurogenesis and IMF morphology...
  3. pmc Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS Biol 6:e272. 2008
    ..The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation...
  4. pmc Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use
    Sebastian Jessberger
    Institute of Cell Biology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland
    Trends Pharmacol Sci 30:61-5. 2009
    ..Here, we discuss the biological importance and potential therapeutic applications of retained fate plasticity of AHPs in the adult mammalian brain in addition to the future scientific inquiries indicated by this finding...
  5. pmc Directed differentiation of hippocampal stem/progenitor cells in the adult brain
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 11:888-93. 2008
    ..These data indicate that AHPs have substantial plasticity, which might have important implications for the potential use of endogenous AHPs in neurological disease...
  6. pmc Making a neuron: Cdk5 in embryonic and adult neurogenesis
    Sebastian Jessberger
    Institute of Cell Biology, Department of Biology, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland
    Trends Neurosci 32:575-82. 2009
    ....
  7. pmc Stem-cell-associated structural and functional plasticity in the aging hippocampus
    Sebastian Jessberger
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Psychol Aging 23:684-91. 2008
    ....
  8. doi request reprint Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus
    Helena Mira
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Stem Cell 7:78-89. 2010
    ..BMPs are therefore required to balance NSC quiescence/proliferation and to prevent loss of the stem cell activity that supports continuous neurogenesis in the mature hippocampus...
  9. ncbi request reprint Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:9400-7. 2007
    ....
  10. pmc Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis
    Oliver Bracko
    Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Neurosci 32:3376-87. 2012
    ..Thus, by gene expression profiling of NSCs and their progeny, we have identified IGF2 as a novel regulator of adult neurogenesis...
  11. pmc A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
    Emily A Mathews
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 518:4479-90. 2010
    ....
  12. pmc Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Learn Mem 16:147-54. 2009
    ....
  13. ncbi request reprint Spontaneous fusion and nonclonal growth of adult neural stem cells
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Stem Cells 25:871-4. 2007
    ..The nonclonal growth between distinct NSC populations strongly suggests the use of careful and precise culture conditions, such as single-cell assays, to characterize potency and growth of NSCs in vitro...
  14. ncbi request reprint Epigenetic modulation of seizure-induced neurogenesis and cognitive decline
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:5967-75. 2007
    ..Furthermore, our data indicate that the effectiveness of VPA as an antiepileptic drug may be partially explained by the HDAC-dependent inhibition of aberrant neurogenesis induced by seizure activity within the adult hippocampus...
  15. pmc Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis
    Ozlem Karalay
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:5807-12. 2011
    ....
  16. pmc Supersize me-new insights into cortical expansion and gyration of the mammalian brain
    Laboni Ghosh
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    EMBO J 32:1793-5. 2013
    ....
  17. ncbi request reprint Wnt signalling regulates adult hippocampal neurogenesis
    Dieter Chichung Lie
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Nature 437:1370-5. 2005
    ..Our data show that Wnt signalling is a principal regulator of adult hippocampal neurogenesis and provide evidence that Wnt proteins have a role in adult hippocampal function...
  18. ncbi request reprint Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain
    Cristina Porcheri
    Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland, and Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland
    J Neurosci 34:5222-32. 2014
    ..Thus, we here identified an intracellular signaling cascade linking extrinsic integrin-mediated signaling to NSPC proliferation and characterized a novel mechanism that regulates NSPC activity in the adult mammalian brain. ..
  19. pmc In vivo demonstration that alpha-synuclein oligomers are toxic
    Beate Winner
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:4194-9. 2011
    ..e., E57K and E35K), whereas the α-syn variants that form fibrils very quickly are less toxic. We show that α-syn oligomers are toxic in vivo and that α-syn oligomers might interact with and potentially disrupt membranes...
  20. ncbi request reprint Adult-born hippocampal neurons mature into activity-dependent responsiveness
    Sebastian Jessberger
    VolkswagenStiftung Research Group at the Department of Experimental Neurology, Charite University Hospital, Humboldt University Berlin, Robert Rossle Str 10, D 13125 Berlin, Berlin Buch, Germany
    Eur J Neurosci 18:2707-12. 2003
    ..Thus, new neurons appear quantitatively integrated into hippocampal circuits, suggestive of a relevant contribution to hippocampal function...
  21. ncbi request reprint Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice
    Moritz D Brandt
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Neurosci 24:603-13. 2003
    ..In these models the induction of cell proliferation was paralleled by an increase of CR-positive cells, indicating the stimulus-dependent progression from cell division to a postmitotic stage...
  22. ncbi request reprint Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice
    Barbara Steiner
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Berlin, Germany
    Glia 46:41-52. 2004
    ....
  23. ncbi request reprint Milestones of neuronal development in the adult hippocampus
    Gerd Kempermann
    VolkswagenStiftung Research Group, Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Trends Neurosci 27:447-52. 2004
    ..The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development...
  24. ncbi request reprint Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells
    Sebastian Jessberger
    VolkswagenStiftung Research Group at the Department of Experimental Neurology, Charite University Medicine, Berlin, Germany
    Exp Neurol 196:342-51. 2005
    ..Thus, seizure-generated neurons might contribute to the disease process of epilepsy...
  25. pmc Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation
    Tobias Plümpe
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Germany
    BMC Neurosci 7:77. 2006
    ..Alternatively, the temporal course of morphological maturation might be subject to additional regulatory events...
  26. ncbi request reprint Is neurogenesis reparative after status epilepticus?
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2200, USA
    Epilepsia 48:69-71. 2007
  27. ncbi request reprint Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli
    Golo Kronenberg
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, 13125 Berlin, Germany
    J Comp Neurol 467:455-63. 2003
    ..These findings allow us to break down what was broadly perceived as "proliferation" in earlier experiments into the relative contribution of several cell types, representing the earliest steps of neuronal development...
  28. doi request reprint Structural changes for adult-born dentate granule cells after status epilepticus
    Lee A Shapiro
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 1275, USA
    Epilepsia 49:13-8. 2008
    ..This article will describe these structural alterations of granule cells found in the dentate gyrus after SE and will also discuss the time course of these events and possible underlying causes...