R F Hurrell

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. ncbi request reprint Ferritin-iron is released during boiling and in vitro gastric digestion
    Matthias Hoppler
    Laboratory of Human Nutrition, ETH Zurich, Zurich 8092, Switzerland
    J Nutr 138:878-84. 2008
  2. doi request reprint Safety and efficacy of iron supplements in malaria-endemic areas
    Richard F Hurrell
    Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland
    Ann Nutr Metab 59:64-6. 2011
  3. ncbi request reprint Meat protein fractions enhance nonheme iron absorption in humans
    Richard F Hurrell
    Laboratory of Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Nutr 136:2808-12. 2006
  4. ncbi request reprint Phytate degradation determines the effect of industrial processing and home cooking on iron absorption from cereal-based foods
    Richard F Hurrell
    Swiss Federal Institute of Technology, Zurich, Switzerland
    Br J Nutr 88:117-23. 2002
  5. doi request reprint Iron bioavailability and dietary reference values
    Richard Hurrell
    Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 91:1461S-1467S. 2010
  6. ncbi request reprint Linking the bioavailability of iron compounds to the efficacy of iron-fortified foods
    Richard Hurrell
    ETH Zurich, Institute of Food Science and Nutrition, Laboratory of Human Nutrition, Zurich, Switzerland
    Int J Vitam Nutr Res 77:166-73. 2007
  7. ncbi request reprint Iron fortification: its efficacy and safety in relation to infections
    Richard F Hurrell
    ETH Zurich, Institute of Food Science and Nutrition, Zurich, Switzerland
    Food Nutr Bull 28:S585-94. 2007
  8. doi request reprint Use of ferrous fumarate to fortify foods for infants and young children
    Richard Hurrell
    Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, Zurich, Switzerland
    Nutr Rev 68:522-30. 2010
  9. ncbi request reprint Degradation of phytic acid in cereal porridges improves iron absorption by human subjects
    Richard F Hurrell
    Nestec Ltd, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 77:1213-9. 2003
  10. ncbi request reprint Revised recommendations for iron fortification of wheat flour and an evaluation of the expected impact of current national wheat flour fortification programs
    Richard Hurrell
    Swiss Federal Institute of Technology ETH, Institute of Food Science and Nutrition, ETH Zentrum, LFV D20, Schmelzbergstrasse 7, 8092 Zurich, Switzerland
    Food Nutr Bull 31:S7-21. 2010

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Ferritin-iron is released during boiling and in vitro gastric digestion
    Matthias Hoppler
    Laboratory of Human Nutrition, ETH Zurich, Zurich 8092, Switzerland
    J Nutr 138:878-84. 2008
    ..We concluded that ferritin-iron is efficiently released from the ferritin molecule during cooking and at gastric pH and that it should be absorbed as efficiently as all other nonheme iron in food...
  2. doi request reprint Safety and efficacy of iron supplements in malaria-endemic areas
    Richard F Hurrell
    Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland
    Ann Nutr Metab 59:64-6. 2011
    ..Iron absorption is decreased and the efficacy of the iron interventions would be expected to be lower in the presence of infections...
  3. ncbi request reprint Meat protein fractions enhance nonheme iron absorption in humans
    Richard F Hurrell
    Laboratory of Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Nutr 136:2808-12. 2006
    ..Our results support the hypothesis that the enhancing effect of muscle tissue on iron absorption is mainly protein related but indicate that other factors may also play a role...
  4. ncbi request reprint Phytate degradation determines the effect of industrial processing and home cooking on iron absorption from cereal-based foods
    Richard F Hurrell
    Swiss Federal Institute of Technology, Zurich, Switzerland
    Br J Nutr 88:117-23. 2002
    ....
  5. doi request reprint Iron bioavailability and dietary reference values
    Richard Hurrell
    Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 91:1461S-1467S. 2010
    ..It would therefore be timely to develop a range of iron bioavailability factors based not only on diet composition but also on subject characteristics, such as iron status and prevalence of obesity...
  6. ncbi request reprint Linking the bioavailability of iron compounds to the efficacy of iron-fortified foods
    Richard Hurrell
    ETH Zurich, Institute of Food Science and Nutrition, Laboratory of Human Nutrition, Zurich, Switzerland
    Int J Vitam Nutr Res 77:166-73. 2007
    ..In such situations, other public health measures may be necessary before we can ensure an improvement in iron status...
  7. ncbi request reprint Iron fortification: its efficacy and safety in relation to infections
    Richard F Hurrell
    ETH Zurich, Institute of Food Science and Nutrition, Zurich, Switzerland
    Food Nutr Bull 28:S585-94. 2007
    ..There have been no studies in malarious areas...
  8. doi request reprint Use of ferrous fumarate to fortify foods for infants and young children
    Richard Hurrell
    Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, Zurich, Switzerland
    Nutr Rev 68:522-30. 2010
    ....
  9. ncbi request reprint Degradation of phytic acid in cereal porridges improves iron absorption by human subjects
    Richard F Hurrell
    Nestec Ltd, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 77:1213-9. 2003
    ..Phytic acid in cereal-based and legume-based complementary foods inhibits iron absorption. Low iron absorption from cereal porridges contributes to the high prevalence of iron deficiency in infants from developing countries...
  10. ncbi request reprint Revised recommendations for iron fortification of wheat flour and an evaluation of the expected impact of current national wheat flour fortification programs
    Richard Hurrell
    Swiss Federal Institute of Technology ETH, Institute of Food Science and Nutrition, ETH Zentrum, LFV D20, Schmelzbergstrasse 7, 8092 Zurich, Switzerland
    Food Nutr Bull 31:S7-21. 2010
    ..Iron fortification of wheat flour is widely used as a strategy to combat iron deficiency...
  11. ncbi request reprint Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages
    R F Hurrell
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Br J Nutr 81:289-95. 1999
    ..Our findings demonstrate that herb teas, as well as black tea, coffee and coca can be potent inhibitors of Fe absorption. This property should be considered when giving dietary advice in relation to Fe nutrition...
  12. ncbi request reprint An evaluation of EDTA compounds for iron fortification of cereal-based foods
    R F Hurrell
    Nestec Ltd, Nestle Research Centre, Lausanne, Switzerland
    Br J Nutr 84:903-10. 2000
    ....
  13. ncbi request reprint Phytic acid degradation as a means of improving iron absorption
    Richard F Hurrell
    Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Int J Vitam Nutr Res 74:445-52. 2004
    ..Similarly with soy-based infant formulas, especially if manufactured from low-phytate isolates, ascorbic acid can be used to ensure adequate iron absorption...
  14. ncbi request reprint Enhancing the absorption of fortification iron. A SUSTAIN Task Force report
    Richard F Hurrell
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Int J Vitam Nutr Res 74:387-401. 2004
    ..An approach to the calculation of cost using a conservative estimate of the enhancing effects of the innovative technologies discussed in the supplement is given in the final section...
  15. doi request reprint Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children
    I Aeberli
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    Int J Obes (Lond) 33:1111-7. 2009
    ..Alternatively, obesity-related inflammation may increase hepcidin concentrations and reduce iron availability. Circulating hepcidin levels have not been compared in normal weight vs overweight individuals...
  16. ncbi request reprint A comparison of iron absorption in adults and infants consuming identical infant formulas
    R F Hurrell
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Br J Nutr 79:31-6. 1998
    ..Further studies, however, are required to extend these findings to weaning foods and complete meals...
  17. ncbi request reprint Iron-binding properties, amino acid composition, and structure of muscle tissue peptides from in vitro digestion of different meat sources
    S Storcksdieck genannt Bonsmann
    Inst of Food Science and Nutrition, ETH Zurich, 8092 Zurich, Switzerland
    J Food Sci 72:S019-29. 2007
    ..The enhancing effect of meat on nonheme iron bioavailability in humans is thought to be due to the release of low-molecular-weight (LMW) iron-binding peptides during digestion...
  18. doi request reprint A comparison of the bioavailability of ferrous fumarate and ferrous sulfate in non-anemic Mexican women and children consuming a sweetened maize and milk drink
    M Harrington
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Eur J Clin Nutr 65:20-5. 2011
    ..The objective of this study was to compare iron absorption from ferrous fumarate and ferrous sulfate in infants, young children and mothers...
  19. doi request reprint Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification
    M B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Int J Obes (Lond) 32:1098-104. 2008
    ..Therefore, we investigated the association between body mass index (BMI) and iron absorption, iron status and the response to iron fortification in populations from three transition countries (Thailand, Morocco and India)...
  20. ncbi request reprint Influence of ascorbic acid on iron absorption from an iron-fortified, chocolate-flavored milk drink in Jamaican children
    L Davidsson
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology, Ruschlikon
    Am J Clin Nutr 67:873-7. 1998
    ..Regular consumption of iron-fortified chocolate milk drinks containing added ascorbic acid could have a positive effect on iron nutrition in population groups vulnerable to iron deficiency...
  21. ncbi request reprint Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate
    L Davidsson
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology, R uschlikon, Switzerland
    Am J Clin Nutr 71:1597-602. 2000
    ..Infant cereals are commonly fortified with insoluble iron compounds with low relative bioavailability, such as ferric pyrophosphate, because of organoleptic changes that occur after addition of water-soluble iron sources...
  22. ncbi request reprint Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency
    M B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Eur J Clin Nutr 54:209-13. 2000
    ....
  23. ncbi request reprint Prevalence of iron deficiency with and without concurrent anemia in population groups with high prevalences of malaria and other infections: a study in Côte d'Ivoire
    F S Asobayire
    Laboratory of Human Nutrition, the Institute of Food Science, Swiss Federal Institute of Technology, , Switzerland
    Am J Clin Nutr 74:776-82. 2001
    ..The serum transferrin receptor is the most useful single indicator of iron deficiency because it was the only iron-status index unaffected by malaria or inflammation...
  24. ncbi request reprint A national survey of iron and folate status in pregnant women in Switzerland
    S Y Hess
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology, Zurich, Switzerland
    Int J Vitam Nutr Res 71:268-73. 2001
    ..01). Our findings indicate that iron and folate status appears to be adequate in the majority of pregnant women in Switzerland, and that use of iron and folate supplements may have a positive impact on status...
  25. ncbi request reprint Oxalic acid does not influence nonhaem iron absorption in humans: a comparison of kale and spinach meals
    S Storcksdieck genannt Bonsmann
    Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    Eur J Clin Nutr 62:336-41. 2008
    ..To evaluate the influence of oxalic acid (OA) on nonhaem iron absorption in humans...
  26. ncbi request reprint Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid
    L Davidsson
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology, Ruschlikon, Switzerland
    Br J Nutr 85:59-63. 2001
    ..After adjusting for differences in Fe status, our data indicate that Fe absorption from dephytinised pea protein might be less inhibitory than dephytinised soybean protein as measured in a previous study (Hurrell et al. 1998)...
  27. doi request reprint Regular consumption of a complementary food fortified with ascorbic acid and ferrous fumarate or ferric pyrophosphate is as useful as ferrous sulfate in maintaining hemoglobin concentrations >105 g/L in young Bangladeshi children
    Lena Davidsson
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, ETH Zentrum, Zurich, Switzerland
    Am J Clin Nutr 89:1815-20. 2009
    ..Non-water-soluble iron compounds have been reported to be less well absorbed than ferrous sulfate in young children, and concern has been raised about their usefulness as food fortificants...
  28. ncbi request reprint The usefulness of elemental iron for cereal flour fortification: a SUSTAIN Task Force report. Sharing United States Technology to Aid in the Improvement of Nutrition
    Richard Hurrell
    Swiss Federal Institute of Technology, Zurich, Switzerland
    Nutr Rev 60:391-406. 2002
    ..Because it is only approximately half as well absorbed as ferrous sulfate, it should be added to provide double the amount of iron...
  29. ncbi request reprint A national study of the prevalence of overweight and obesity in 6-12 y-old Swiss children: body mass index, body-weight perceptions and goals
    M B Zimmermann
    The Human Nutrition Laboratory, Institute for Food Science, Swiss Federal Institute of Technology, Zurich, Switzerland
    Eur J Clin Nutr 54:568-72. 2000
    ..To estimate the prevalence of overweight and obesity in Swiss children and to obtain information on weight perceptions and weight control practices in this population...
  30. ncbi request reprint Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant: erythrocyte incorporation of iron and apparent absorption of zinc, copper, calcium, and magnesium from a complementary food based on wheat and soy in healthy infants
    Lena Davidsson
    Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Ruschlikon, Switzerland
    Am J Clin Nutr 81:104-9. 2005
    ..No information is available on iron bioavailability from NaFeEDTA or the influence of NaFeEDTA on minerals and trace elements in infants...
  31. doi request reprint Development and optimization of iron- and zinc-containing nanostructured powders for nutritional applications
    F M Hilty
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    Nanotechnology 20:475101. 2009
    ..Thus, these powders are promising for food fortification and other nutritional applications...
  32. ncbi request reprint Bioavailability in infants of iron from infant cereals: effect of dephytinization
    L Davidsson
    Nestlé Research Center Lausanne, Switzerland
    Am J Clin Nutr 65:916-20. 1997
    ..01% phytic acid), respectively. Dephytinization of infant cereals containing a relatively low native phytic acid content and high amounts of ascorbic acid is thus unnecessary to ensure adequate bioavailability of iron...
  33. ncbi request reprint Erythrocyte incorporation of iron by infants: iron bioavailability from a low-iron infant formula and an evaluation of the usefulness of correcting erythrocyte incorporation values, using a reference dose or plasma ferritin concentrations
    L Davidsson
    Nestlé Research Center Lausanne, PO Box 44, 1000 Lausanne 26, Switzerland
    Br J Nutr 84:847-53. 2000
    ..Corrections of erythrocyte incorporation data based on plasma ferritin or erythrocyte incorporation of Fe from a reference dose were not found to be useful...
  34. ncbi request reprint Dietary magnesium intake in type 2 diabetes
    M K Wälti
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology ETH Zurich, Switzerland
    Eur J Clin Nutr 56:409-14. 2002
    ..Magnesium deficiency is common in type 2 diabetes and may have a negative impact on glucose homeostasis and insulin resistance, as well as on the evolution of complications such as retinopathy, thrombosis and hypertension...
  35. ncbi request reprint Human milk as a source of ascorbic acid: no enhancing effect on iron bioavailability from a traditional complementary food consumed by Bangladeshi infants and young children
    Lena Davidsson
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Ruschlikon, Switzerland
    Am J Clin Nutr 79:1073-7. 2004
    ..Iron bioavailability from traditional complementary foods based on cereals and legumes can be expected to be low unless ascorbic acid-rich foods are incorporated into the diet...
  36. doi request reprint Polyphenols and phytic acid contribute to the low iron bioavailability from common beans in young women
    Nicolai Petry
    Laboratory of Human Nutrition, Institute of Food Science and Nutrition, ETH, Zurich 8092, Switzerland
    J Nutr 140:1977-82. 2010
    ..Lowering only one inhibitor will have a modest influence on iron absorption...
  37. ncbi request reprint The effect of retinyl palmitate added to iron-fortified maize porridge on erythrocyte incorporation of iron in African children with vitamin A deficiency
    Lena Davidsson
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, PO Box 474, CH 8803 Ruschlikon, Switzerland
    Br J Nutr 90:337-43. 2003
    ..The lack of conclusive data on the effect of retinyl palmitate on Fe absorption indicates the complexity of the interactions between vitamin A status, dietary vitamin A and Fe metabolism...
  38. ncbi request reprint How to ensure adequate iron absorption from iron-fortified food
    Richard Hurrell
    Laboratory of Human Nutrition, Institute of Food Science EHZ, Ruschlikon, Switzerland
    Nutr Rev 60:S7-15; discussion S43. 2002
  39. ncbi request reprint Dephytinization of a complementary food based on wheat and soy increases zinc, but not copper, apparent absorption in adults
    Ines Egli
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, 8803 Rueschlikon, Switzerland
    J Nutr 134:1077-80. 2004
    ..The long-term nutritional benefits of dephytinization of complementary foods should be evaluated in young children...
  40. ncbi request reprint Iron absorption by human subjects from different iron fortification compounds added to Thai fish sauce
    T Walczyk
    Laboratory of Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology ETH Zurich, Switzerland
    Eur J Clin Nutr 59:668-74. 2005
    ....
  41. ncbi request reprint Monitoring the adequacy of salt iodization in Switzerland: a national study of school children and pregnant women
    S Y Hess
    Laboratory for Human Nutrition, Food Science Institute, , Switzerland
    Eur J Clin Nutr 55:162-6. 2001
    ..This approach could serve as a model for countries struggling to maintain dietary iodine intake in the face of shifting dietary habits and changes in the food supply...
  42. ncbi request reprint Fighting iron deficiency anemia with iron-rich rice
    Paola Lucca
    Institute for Plant Science ETHZ, Zurich, Switzerland
    J Am Coll Nutr 21:184S-190S. 2002
    ..Here we present experiments that aim to increase the iron content in rice endosperm and to improve its absorption in the human intestine by means of genetic engineering...
  43. ncbi request reprint Labeling the human skeleton with 41Ca to assess changes in bone calcium metabolism
    E Denk
    Laboratory of Human Nutrition, Institute of Food Science and Nutrition, ETH Zurich, Schmelzbergstrasse 7 LFV D19 3, 8092, Zurich, Switzerland
    Anal Bioanal Chem 386:1587-602. 2006
    ....
  44. ncbi request reprint Urinary excretion of an intravenous 26Mg dose as an indicator of marginal magnesium deficiency in adults
    M K Wälti
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Eur J Clin Nutr 60:147-54. 2006
    ..Measurement of magnesium (Mg) status is problematic because tissue Mg deficiency can be present without low serum Mg concentrations...
  45. ncbi request reprint Ascorbic acid supplementation and regular consumption of fresh orange juice increase the ascorbic acid content of human milk: studies in European and African lactating women
    Synøve Daneel-Otterbech
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Ruschlikon, Switzerland
    Am J Clin Nutr 81:1088-93. 2005
    ..Little is known about the influence of an increased intake of ascorbic acid (AA) on human milk AA output...
  46. ncbi request reprint Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire
    Rita Wegmüller
    Programme National de Nutrition, Abidjan, Cote d Ivoire
    J Nutr 136:1814-20. 2006
    ..Iron utilization may have been impaired by the high prevalence of malaria and concurrent nutrient deficiencies...
  47. ncbi request reprint Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland, and The Ministry of Health, Rabat, Morocco
    Am J Clin Nutr 84:580-6. 2006
    ..The mechanism of these effects is unclear. In vitro and in animal models, vitamin A treatment increases the production of erythropoietin (EPO), a stimulant of erythropoiesis...
  48. ncbi request reprint Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size
    Ralf Biebinger
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    J Nutr 137:573-7. 2007
    ..In concurrent VAD and ID, VAS, independent of iodine repletion, reduces thyroid hyperstimulation and size, an effect likely mediated through the effects of VA on pituitary TSHbeta gene expression...
  49. ncbi request reprint Iron fortification reduces blood lead levels in children in Bangalore, India
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Pediatrics 117:2014-21. 2006
    ..Our study objective was to determine if iron fortification reduces blood lead levels in urban, lead-exposed, iron-deficient children in Bangalore, India...
  50. ncbi request reprint Extruded rice fortified with micronized ground ferric pyrophosphate reduces iron deficiency in Indian schoolchildren: a double-blind randomized controlled trial
    Diego Moretti
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 84:822-9. 2006
    ..Iron fortification of rice could be an effective strategy for reducing iron deficiency anemia in South Asia...
  51. ncbi request reprint Effect of concurrent vitamin A and iodine deficiencies on the thyroid-pituitary axis in rats
    Ralf Biebinger
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    Thyroid 16:961-5. 2006
    ..Vitamin A deficiency (VAD) may adversely affect thyroid metabolism. The study aim was to investigate the effects of concurrent vitamin A and iodine deficiencies on the thyroid-pituitary axis in rats...
  52. ncbi request reprint Iron bioavailability: UK Food Standards Agency workshop report
    Mamta Singh
    Food Standards Agency, Aviation House, 125 Kingsway, London WC2B 6NH, UK
    Br J Nutr 96:985-90. 2006
    ..In the presence of abundant and varied food supplies, the health consequences of lower iron bioavailability are unclear and require further investigation...
  53. ncbi request reprint Iron metabolism in heterozygotes for hemoglobin E (HbE), alpha-thalassemia 1, or beta-thalassemia and in compound heterozygotes for HbE/beta-thalassemia
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 88:1026-31. 2008
    ..Despite large populations carrying traits for thalassemia in countries implementing universal iron fortification, there are few data on the absorption and utilization of iron in these persons...
  54. ncbi request reprint Iron absorption in young Indian women: the interaction of iron status with the influence of tea and ascorbic acid
    Prashanth Thankachan
    Division of Nutrition, St John s Research Institute, St John s National Academy of Health Sciences, Bangalore, India
    Am J Clin Nutr 87:881-6. 2008
    ..Ascorbic acid (AA) enhances and tea inhibits iron absorption. It is unclear whether iron status influences the magnitude of this effect...
  55. ncbi request reprint An analysis of the etiology of anemia and iron deficiency in young women of low socioeconomic status in Bangalore, India
    Prashanth Thankachan
    Division of Nutrition, St John s Research Institute, St John s National Academy of Health Sciences, Bangalore, India
    Food Nutr Bull 28:328-36. 2007
    ..Anemia and iron deficiency are significant public health problems in India, particularly among women and children. Recent figures suggest that nearly 50% of young Indian women are anemic...
  56. ncbi request reprint Nutritional iron deficiency
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Lancet 370:511-20. 2007
    ..Selective plant breeding and genetic engineering are promising new approaches to improve dietary iron nutritional quality...
  57. ncbi request reprint Iron deficiency predicts poor maternal thyroid status during pregnancy
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Eidgenössische Technische Hochschule Zürich, Schmelzbergstrasse 7, LFV E 19, CH 8092 Zurich, Switzerland
    J Clin Endocrinol Metab 92:3436-40. 2007
    ..Pregnant women are often iron deficient, and iron deficiency has adverse effects on thyroid metabolism. Impaired maternal thyroid function during pregnancy may cause neurodevelopmental delays in the offspring...
  58. ncbi request reprint Nonheme iron absorption in young women is not influenced by purified sulfated and unsulfated glycosaminoglycans
    Stefan Storcksdieck genannt Bonsmann
    Institute of Food Science and Nutrition, ETH Zurich, 8092 Zurich, Switzerland
    J Nutr 137:1161-4. 2007
    ..Geometric mean iron absorption from SSM containing NaH (21.2%) or CS (19.4%) did not differ from that of SSM without GAG (19.5 and 20.3%, respectively). NaH and CS at those levels do not affect human nonheme iron absorption...
  59. ncbi request reprint Synthesis, characterization, and bioavailability in rats of ferric phosphate nanoparticles
    Fabian Rohner
    Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    J Nutr 137:614-9. 2007
    ..In conclusion, nanoparticles of FePO(4) have a solubility and RBV not significantly different from FeSO(4). Reducing poorly soluble Fe compounds to nanoscale may increase their value for human nutrition...
  60. ncbi request reprint Mild riboflavin deficiency is highly prevalent in school-age children but does not increase risk for anaemia in Côte d'Ivoire
    Fabian Rohner
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Schmelzbergstrasse 7, 8092 Ziirich, Switzerland
    Br J Nutr 97:970-6. 2007
    ..Riboflavin deficiency did not predict Hb and/or anaemia, but did predict iron deficiency among children free of malaria...
  61. ncbi request reprint Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans
    Diego Moretti
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 83:632-8. 2006
    ..Although ferric pyrophosphate is a promising compound for iron fortification of foods, few data are available on the effect of food matrices, processing, and ascorbic acid on its bioavailability...
  62. ncbi request reprint Iron absorption from ferrous fumarate in adult women is influenced by ascorbic acid but not by Na2EDTA
    Meredith C Fidler
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology ETH Zurich, PO Box 474 Seestrasse 72, 8803 Rueschlikon, Switzerland
    Br J Nutr 90:1081-5. 2003
    ....
  63. ncbi request reprint Influence of vegetable protein sources on trace element and mineral bioavailability
    Richard F Hurrell
    Institute of Food Science ETHZ, Laboratory of Human Nutrition, CH 8803 Ruschlikon, Switzerland
    J Nutr 133:2973S-7S. 2003
    ..5. At these low levels of phytic acid (20-30 mg/100 g dried product), zinc absorption should be satisfactory...
  64. ncbi request reprint Measurement of magnesium absorption and retention in type 2 diabetic patients with the use of stable isotopes
    Monika K Wälti
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Am J Clin Nutr 78:448-53. 2003
    ..The etiology of magnesium depletion in diabetes is unclear. Animal studies suggest that diabetes may impair magnesium absorption; however, there are no published data on magnesium absorption in humans with diabetes...
  65. ncbi request reprint Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women
    Pham Van Thuy
    National Institute of Nutrition, Hanoi, Vietnam
    Am J Clin Nutr 78:284-90. 2003
    ..Fish sauce is consumed daily by a large proportion of the Vietnamese population and could therefore be a potentially useful food vehicle for iron-fortification programs...
  66. ncbi request reprint Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA
    Meredith C Fidler
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 78:274-8. 2003
    ..Fish sauce and soy sauce have been suggested as food vehicles for iron fortification in Asia. NaFeEDTA is a potentially useful fortificant because it can be added to these condiments without causing precipitation during storage...
  67. ncbi request reprint Low plasma magnesium in type 2 diabetes
    Monika K Wälti
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Swiss Med Wkly 133:289-92. 2003
    ..The aim of this study was to compare plasma magnesium concentrations of type 2 diabetics and healthy controls in Switzerland...
  68. ncbi request reprint Thyroid size and goiter prevalence after introduction of iodized salt: a 5-y prospective study in schoolchildren in Côte d'Ivoire
    Michael B Zimmermann
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 77:663-7. 2003
    ..Normalization of the goiter rate probably indicates disappearance of iodine deficiency disorders as a public health problem. However, thyroid size may not return to normal for months or years after correction of iodine deficiency...
  69. ncbi request reprint Dual fortification of salt with iodine and microencapsulated iron: a randomized, double-blind, controlled trial in Moroccan schoolchildren
    Michael B Zimmermann
    Human Nutrition Laboratory, Instituts of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 77:425-32. 2003
    ..In many developing countries, children are at high risk of both goiter and iron deficiency anemia...
  70. ncbi request reprint No enhancing effect of vitamin A on iron absorption in humans
    Thomas Walczyk
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology Zurich, Ruschlikon, Switzerland
    Am J Clin Nutr 77:144-9. 2003
    ..Vitamin A and beta-carotene were recently reported to enhance iron absorption by counteracting the inhibitory effect of phytic acid in cereal-based meals and of polyphenol-containing beverages on nonheme-iron absorption in humans...
  71. ncbi request reprint Addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous, iron-deficient children: a randomized, double-blind, controlled trial
    Michael B Zimmermann
    The Human Nutrition Laboratory, Swiss Federal Institute of Technology, Seestrasse 72 PO Box 474, CH 8803 Ruschlikon, Switzerland
    Eur J Endocrinol 147:747-53. 2002
    ..The study aim was to determine if co-fortification of iodized salt with Fe would improve efficacy of the iodine in goitrous children with a high prevalence of anemia...
  72. ncbi request reprint Iron deficiency anemia reduces thyroid peroxidase activity in rats
    Sonja Y Hess
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Nutr 132:1951-5. 2002
    ..05). These data indicate that Fe deficiency sharply reduces TPO activity and suggest that decreased TPO activity contributes to the adverse effects of IDA on thyroid metabolism...
  73. ncbi request reprint Improving iron, zinc and vitamin A nutrition through plant biotechnology
    Michael B Zimmermann
    Laboratory of Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, PO Box 474, CH 8803 Ruschlikon, Switzerland
    Curr Opin Biotechnol 13:142-5. 2002
    ..Improving the micronutrient composition of plant foods may become a sustainable strategy to combat deficiencies in human populations, replacing or complementing other strategies such as food fortification or nutrient supplementation...
  74. ncbi request reprint Fortification: overcoming technical and practical barriers
    Richard F Hurrell
    Laboratory of Human Nutrition, Institute of Food Science ETHZ, Ruschlikon, Switzerland CH8803
    J Nutr 132:806S-12S. 2002
    ..Finally, a new and useful additional approach to ensuring adequate iron absorption from cereal based complementary foods is the complete degradation of phytic acid with added phytases or by activating native cereal phytases...
  75. ncbi request reprint Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire
    Sonja Y Hess
    Human Nutrition Laboratory, The Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 75:743-8. 2002
    ..In many developing countries, children are at high risk of both goiter and iron deficiency anemia. Iron deficiency adversely affects thyroid metabolism and may reduce the efficacy of iodine prophylaxis in areas of endemic goiter...
  76. ncbi request reprint Erythorbic acid is a potent enhancer of nonheme-iron absorption
    Meredith C Fidler
    Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Rueschlikon, Switzerland
    Am J Clin Nutr 79:99-102. 2004
    ..Erythorbic acid, a stereoisomer of ascorbic acid with similar physicochemical properties, is widely used as an antioxidant in processed foods...
  77. ncbi request reprint A micronised, dispersible ferric pyrophosphate with high relative bioavailability in man
    Meredith C Fidler
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology ETH Zurich, PO Box 474 Seestrasse 72, CH 8803 Ruschlikon, Switzerland
    Br J Nutr 91:107-12. 2004
    ..The high relative Fe bioavailability of micronised, dispersible ferric pyrophosphate indicates the potential usefulness of this compound for food fortification...
  78. ncbi request reprint Comparison of urinary monitoring, faecal monitoring and erythrocyte analysis of stable isotope labels to determine magnesium absorption in human subjects
    Torsten Bohn
    Swiss Federal Institute of Technology ETH, Institute of Food Science and Nutrition, Laboratory for Human Nutrition, 8803 Ruschlikon, Switzerland
    Br J Nutr 91:113-20. 2004
    ..The choice of technique depends on practical and financial considerations...
  79. ncbi request reprint Meat consumption in a varied diet marginally influences nonheme iron absorption in normal individuals
    Manju B Reddy
    Department of Food Science and Human Nutrition, Iowa State University, Ames, 50011, USA
    J Nutr 136:576-81. 2006
    ..013). We conclude that the higher iron status associated with the consumption of an omnivorous diet is due more to the intake of heme iron than to the enhancing effect on nonheme iron absorption...
  80. ncbi request reprint Comparison of the efficacy of wheat-based snacks fortified with ferrous sulfate, electrolytic iron, or hydrogen-reduced elemental iron: randomized, double-blind, controlled trial in Thai women
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 82:1276-82. 2005
    ..Although elemental iron powders are widely used to fortify cereal products, little data exist on their efficacy in humans...
  81. ncbi request reprint Comparison of manual and automated ELISA methods for serum ferritin analysis
    Fabian Rohner
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Clin Lab Anal 19:196-8. 2005
    ..We conclude that the automated assay has several potential advantages compared to the manual method, including better precision, less operator dependence, and faster sample through-put...
  82. ncbi request reprint Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 81:615-23. 2005
    ..Although transferrin receptor (TfR) and zinc protoporphyrin (ZnPP) are often used to define iron status in school-age children in developing countries, the diagnostic cutoffs for this age group are uncertain...
  83. ncbi request reprint Improved technologies enhance the efficacy of food iron fortification
    Richard F Hurrell
    Int J Vitam Nutr Res 74:385. 2004
  84. ncbi request reprint Iron deficiency due to consumption of a habitual diet low in bioavailable iron: a longitudinal cohort study in Moroccan children
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 81:115-21. 2005
    ..In many developing countries, cereal and legume-based diets contain low amounts of bioavailable iron, which may increase the risk of iron deficiency...
  85. ncbi request reprint Effect of ascorbic acid and particle size on iron absorption from ferric pyrophosphate in adult women
    Meredith C Fidler
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology ETH Zurich, Switzerland
    Int J Vitam Nutr Res 74:294-300. 2004
    ..Decreasing the mean particle size to 6.7 microm did not significantly increase iron absorption from ferric pyrophosphate...
  86. ncbi request reprint Particle size reduction and encapsulation affect the bioavailability of ferric pyrophosphate in rats
    Rita Wegmüller
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Institute of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Nutr 134:3301-4. 2004
    ..Encapsulation of FePP with hydrogenated palm oil at a capsule:substrate ratio of 60:40 decreased RBV. Particle size reduction increases the RBV of FePP and may make this compound more useful for food fortification...
  87. ncbi request reprint Triple fortification of salt with microcapsules of iodine, iron, and vitamin A
    Michael B Zimmermann
    Human Nutrition Laboratory and the Food Process Engineering Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 80:1283-90. 2004
    ..In many developing countries, children are at high risk of goiter, vitamin A deficiency, and iron deficiency anemia...
  88. ncbi request reprint Dual fortification of salt with iodine and micronized ferric pyrophosphate: a randomized, double-blind, controlled trial
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 80:952-9. 2004
    ..In areas of subsistence farming in rural Africa, salt is one of the few regularly purchased food items and could be a good fortification vehicle for iodine and iron, provided that a stable yet bioavailable iron fortificant is used...
  89. ncbi request reprint Helicobacter pylori infection, iron absorption, and gastric acid secretion in Bangladeshi children
    Shafiqul A Sarker
    International Centre for Diarrhoeal Disease Research, Bangladesh Centre for Health and Population Research, Mohakali, Dhaka, Bangladesh
    Am J Clin Nutr 80:149-53. 2004
    ..Nonheme-iron absorption requires an acidic milieu. Reduced gastric acid output as a consequence of Helicobacter pylori infection could be an important limiting factor for iron absorption...
  90. ncbi request reprint Fractional magnesium absorption is significantly lower in human subjects from a meal served with an oxalate-rich vegetable, spinach, as compared with a meal served with kale, a vegetable with a low oxalate content
    Torsten Bohn
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Br J Nutr 91:601-6. 2004
    ..e. not based on an evaluation of added (or removed) oxalic acid, the difference in Mg absorption observed in the present study is attributed to the difference in oxalic acid content between the two vegetables...
  91. ncbi request reprint Phytic acid added to white-wheat bread inhibits fractional apparent magnesium absorption in humans
    Torsten Bohn
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich
    Am J Clin Nutr 79:418-23. 2004
    ..Phytic acid has been reported to impair the absorption of minerals and trace elements such as calcium, zinc, and iron in humans. However, limited information is available on the effect of phytic acid on magnesium absorption...
  92. ncbi request reprint Iron bioavailability from iron-fortified Guatemalan meals based on corn tortillas and black bean paste
    Lena Davidsson
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Ruschlikon, Switzerland
    Am J Clin Nutr 75:535-9. 2002
    ..Corn masa flour is widely consumed in Central America and is therefore a potentially useful vehicle for iron fortification...
  93. ncbi request reprint Evaluation of 41calcium as a new approach to assess changes in bone metabolism: effect of a bisphosphonate intervention in postmenopausal women with low bone mass
    Eberhard Denk
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland
    J Bone Miner Res 22:1518-25. 2007
    ..Six women with low BMD were labeled with 41Ca up to 700 days and treated for 6 mo with risedronate. Effect of treatment on bone could be identified using 41Ca after 4-8 wk in each individual...