Nicola L Harris

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Intestinal bacteria condition dendritic cells to promote IgA production
    Joanna C Massacand
    Environmental Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    PLoS ONE 3:e2588. 2008
  2. ncbi Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation
    Nicola L Harris
    Malaghan Institute of Medical Research, Central Services Building, Victoria University, Wellington, New Zealand
    Microbes Infect 8:232-7. 2006
  3. ncbi Mechanisms of neonatal mucosal antibody protection
    Nicola L Harris
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    J Immunol 177:6256-62. 2006
  4. ncbi Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology
    Karl S Lang
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 175:5524-31. 2005
  5. pmc Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    J Clin Invest 116:2456-63. 2006
  6. doi Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, CH8091 Zurich, Switzerland
    Cell Host Microbe 4:362-73. 2008
  7. pmc Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function
    Joanna C Massacand
    Environmental Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology of Zurich, Wagistrasse 25, 8952 Schlieren, Switzerland
    Proc Natl Acad Sci U S A 106:13968-73. 2009
  8. ncbi CD4+ and CD8+ T cells exhibit differential requirements for CCR7-mediated antigen transport during influenza infection
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 181:6984-94. 2008
  9. doi Dysregulation of allergic airway inflammation in the absence of microbial colonization
    Tina Herbst
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Respir Crit Care Med 184:198-205. 2011
  10. doi Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    Eur J Immunol 38:479-88. 2008

Collaborators

Detail Information

Publications22

  1. pmc Intestinal bacteria condition dendritic cells to promote IgA production
    Joanna C Massacand
    Environmental Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    PLoS ONE 3:e2588. 2008
    ..These data indicate that exposure to pathogen-associated molecular patterns present on intestinal commensal bacteria condition DC to express a unique molecular footprint that in turn allows them to promote IgA production...
  2. ncbi Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation
    Nicola L Harris
    Malaghan Institute of Medical Research, Central Services Building, Victoria University, Wellington, New Zealand
    Microbes Infect 8:232-7. 2006
    ..These findings indicate that the activation status and tissue microenvironment of effector CD4+ T cells can determine their requirement for NFAT-mediated transcription...
  3. ncbi Mechanisms of neonatal mucosal antibody protection
    Nicola L Harris
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    J Immunol 177:6256-62. 2006
    ..This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect...
  4. ncbi Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology
    Karl S Lang
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 175:5524-31. 2005
    ..These data underscore the in vivo efficacy and immunopathological "safety" of neutralizing antibodies...
  5. pmc Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    J Clin Invest 116:2456-63. 2006
    ..Thus, nonspecific activation of innate immunity can drastically enhance susceptibility to immune destruction of a solid organ...
  6. doi Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, CH8091 Zurich, Switzerland
    Cell Host Microbe 4:362-73. 2008
    ....
  7. pmc Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function
    Joanna C Massacand
    Environmental Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology of Zurich, Wagistrasse 25, 8952 Schlieren, Switzerland
    Proc Natl Acad Sci U S A 106:13968-73. 2009
    ..Taken together, our data show that the primary function of TSLP is to directly suppress IL-12 secretion, thus supporting Th2 immune responses...
  8. ncbi CD4+ and CD8+ T cells exhibit differential requirements for CCR7-mediated antigen transport during influenza infection
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 181:6984-94. 2008
    ..Overall, our data show that CCR7-mediated active Ag transport is differentially required for CD4(+) and CD8(+) T cell expansion during influenza infection...
  9. doi Dysregulation of allergic airway inflammation in the absence of microbial colonization
    Tina Herbst
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Respir Crit Care Med 184:198-205. 2011
    ..The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora...
  10. doi Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages
    Benjamin J Marsland
    Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    Eur J Immunol 38:479-88. 2008
    ..Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema...
  11. pmc Antibodies and IL-3 support helminth-induced basophil expansion
    Tina Herbst
    Institute of Microbiology, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:14954-9. 2012
    ..polygyrus bakeri, parasite rejection following challenge infection was impaired. These data reveal a role for isotype-switched antibodies in promoting basophil expansion and effector function following helminth infection...
  12. ncbi Tissue localization and frequency of antigen-specific effector CD4 T cells determines the development of allergic airway inflammation
    Nicola L Harris
    Malaghan Institute of Medical Research, Wellington School of Medicine, University of Otago, Wellington, New Zealand
    Immunol Cell Biol 83:490-7. 2005
    ....
  13. ncbi IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
    Anja Fröhlich
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Switzerland
    Blood 109:2023-31. 2007
    ..Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses...
  14. doi Aggravation of viral hepatitis by platelet-derived serotonin
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzberstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 14:756-61. 2008
    ..Thus, vasoactive serotonin supports virus persistence in the liver and aggravates virus-induced immunopathology...
  15. pmc Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells
    Benjamin J Marsland
    Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand
    Proc Natl Acad Sci U S A 101:6116-21. 2004
    ....
  16. ncbi Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation
    Karl S Lang
    Institute of Experimental Immunology, Zurich, Switzerland
    Eur J Immunol 35:738-45. 2005
    ..Persistent antigen also suppressed IL-7Ralpha expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate...
  17. pmc HVEM signalling promotes colitis
    Corinne Schaer
    Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    PLoS ONE 6:e18495. 2011
    ..Several members of the TNFSF are closely associated with inflammatory bowel disease (IBD). Thus, they represent interesting new targets for therapeutic treatment of IBD...
  18. ncbi Natural IgE production in the absence of MHC Class II cognate help
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Immunity 24:329-39. 2006
    ..The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals...
  19. ncbi Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland
    Nat Med 11:138-45. 2005
    ..These data identify the 'inflammatory status' of the target organ as a separate and limiting factor determining the development of autoimmune disease...
  20. pmc Differential T cell function and fate in lymph node and nonlymphoid tissues
    Nicola L Harris
    Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand
    J Exp Med 195:317-26. 2002
    ..These distinct regulatory events in lymph node and nonlymphoid tissues reveal simple key mechanisms for both inducing and limiting T cell immunity...
  21. ncbi Interactions between commensal intestinal bacteria and the immune system
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091 Zurich, Switzerland
    Nat Rev Immunol 4:478-85. 2004
  22. ncbi Deliberate removal of T cell help improves virus-neutralizing antibody production
    Mike Recher
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 5:934-42. 2004
    ..These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found...