Jürg Gertsch

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. ncbi request reprint How scientific is the science in ethnopharmacology? Historical perspectives and epistemological problems
    Jürg Gertsch
    Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
    J Ethnopharmacol 122:177-83. 2009
  2. pmc Beta-caryophyllene is a dietary cannabinoid
    Jürg Gertsch
    Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenossische Technische Hochschule ETH Zurich, 8092 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:9099-104. 2008
  3. ncbi request reprint Immunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid system
    Jürg Gertsch
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Planta Med 74:638-50. 2008
  4. ncbi request reprint New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors
    Jürg Gertsch
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    J Recept Signal Transduct Res 26:709-30. 2006
  5. ncbi request reprint Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways
    Juerg Gertsch
    Swiss Federal Institute of Technology, Institute of Pharmaceutical Sciences, Wolfgang Pauli Str 10 CH 8093 Zurich, Switzerland
    FEBS Lett 577:563-9. 2004
  6. ncbi request reprint Phyllanthus piscatorum, ethnopharmacological studies on a women's medicinal plant of the Yanomamï Amerindians
    Jürg Gertsch
    Swiss Federal Institute of Technology Zurich, Institute of Pharmaceutical Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Ethnopharmacol 91:181-8. 2004
  7. ncbi request reprint Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity
    Fabian Feyen
    ETH Zurich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Honggerberg, HCI H 405, 8093 Zurich, Switzerland
    Angew Chem Int Ed Engl 45:5880-5. 2006
  8. doi request reprint Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin
    Silvia Anthoine Dietrich
    Swiss Federal Institute of Technology ETH Zurich, Department of Chemistry and Applied Biosciences, HCI H405, Wolfgang Pauli Str 10, 8093 Zurich, Switzerland
    Chemistry 15:10144-57. 2009
  9. doi request reprint Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts
    Andrea Chicca
    ETH Zurich, Department of Chemistry and Applied Biosciences, CH 8093 Zurich, Switzerland
    Int Immunopharmacol 9:850-8. 2009
  10. ncbi request reprint Making epothilones fluoresce: design, synthesis, and biological characterization of a fluorescent N12-aza-epothilone (azathilone)
    Jürg Gertsch
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, HCI H405, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Chembiochem 10:2513-21. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint How scientific is the science in ethnopharmacology? Historical perspectives and epistemological problems
    Jürg Gertsch
    Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
    J Ethnopharmacol 122:177-83. 2009
    ..Given the almost exponential increase of scientific papers published it may be the moment to adapt to a falsificationist methodology...
  2. pmc Beta-caryophyllene is a dietary cannabinoid
    Jürg Gertsch
    Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenossische Technische Hochschule ETH Zurich, 8092 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:9099-104. 2008
    ..These results identify (E)-BCP as a functional nonpsychoactive CB(2) receptor ligand in foodstuff and as a macrocyclic antiinflammatory cannabinoid in Cannabis...
  3. ncbi request reprint Immunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid system
    Jürg Gertsch
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Planta Med 74:638-50. 2008
    ..The interference of plant FAAs with the animal endocannabinoid system could thus be a fortunate evolutionary cross point with yet unexplored therapeutic potential...
  4. ncbi request reprint New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors
    Jürg Gertsch
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    J Recept Signal Transduct Res 26:709-30. 2006
    ..This review focuses on N-alkyl amide secondary metabolites from plants and underscores that this group of compounds may provide novel lead structures for the development of CB2-directed drugs...
  5. ncbi request reprint Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways
    Juerg Gertsch
    Swiss Federal Institute of Technology, Institute of Pharmaceutical Sciences, Wolfgang Pauli Str 10 CH 8093 Zurich, Switzerland
    FEBS Lett 577:563-9. 2004
    ..This study is the first to report a possible molecular mechanism of action of Echinacea, highlighting the role of alkylamides as potent immunomodulators and potential ligands for CB2 receptors...
  6. ncbi request reprint Phyllanthus piscatorum, ethnopharmacological studies on a women's medicinal plant of the Yanomamï Amerindians
    Jürg Gertsch
    Swiss Federal Institute of Technology Zurich, Institute of Pharmaceutical Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Ethnopharmacol 91:181-8. 2004
    ....
  7. ncbi request reprint Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity
    Fabian Feyen
    ETH Zurich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Honggerberg, HCI H 405, 8093 Zurich, Switzerland
    Angew Chem Int Ed Engl 45:5880-5. 2006
  8. doi request reprint Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin
    Silvia Anthoine Dietrich
    Swiss Federal Institute of Technology ETH Zurich, Department of Chemistry and Applied Biosciences, HCI H405, Wolfgang Pauli Str 10, 8093 Zurich, Switzerland
    Chemistry 15:10144-57. 2009
    ..The potent inhibition of human cancer cell growth by epothilone analogues bearing functionalized benzimidazole side chains suggests that these systems might be conjugated with tumor-targeting moieties to form tumor-targeted prodrugs...
  9. doi request reprint Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts
    Andrea Chicca
    ETH Zurich, Department of Chemistry and Applied Biosciences, CH 8093 Zurich, Switzerland
    Int Immunopharmacol 9:850-8. 2009
    ..We show that N-alkylamides act in concert and exert pleiotropic effects modulating the endocannabinoid system by simultaneously targeting the CB2 receptor, endocannabinoid transport and degradation...
  10. ncbi request reprint Making epothilones fluoresce: design, synthesis, and biological characterization of a fluorescent N12-aza-epothilone (azathilone)
    Jürg Gertsch
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, HCI H405, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Chembiochem 10:2513-21. 2009
    ..Collectively, these data demonstrate that the cellular effects of 3 and, by inference, also of other azathilones are the result of their interactions with the cellular MT network...
  11. doi request reprint Total synthesis and configurational assignment of the marine natural product haliclamide
    Bernhard Pfeiffer
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, HCI H405, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
    J Org Chem 78:2553-63. 2013
    ..The antiproliferative activity of synthetic haliclamide against several human cancer cell lines was found to be in the high μM range. The compound showed no antifungal or antibiotic activity...
  12. doi request reprint Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide
    Jürg Gertsch
    Swiss Federal Institute of Technology ETH Zurich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, HCI H405, Wolfgang Pauli Strasse 10, Zurich, Switzerland
    Chembiochem 10:166-75. 2009
    ....
  13. ncbi request reprint Curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells
    Jürg Gertsch
    Swiss Federal Institute of Technology Zurich, Institute of Pharmaceutical Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Bioorg Med Chem 11:1057-63. 2003
    ..These findings confirm previous reports on the anti-neoplastic potential of curcumin and show that this compound differentially modulates the expression profile of Th1 cells and PBMCs...
  14. ncbi request reprint Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects
    Jürg Gertsch
    Institute for Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Biochem Pharmacol 66:2141-53. 2003
    ..Thus, it can be concluded that the biological effects of SLs are not only due to NF-kappa B inhibition, but must be coupled to other mechanisms...
  15. ncbi request reprint Antifungal, antiprotozoal, cytotoxic and piscicidal properties of Justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum
    Jürg Gertsch
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
    Planta Med 69:420-4. 2003
    ..Both compounds were piscicidal against zebra fish and it is shown for the first time that piscatorin (2) and justicidin B (1) are the piscicidal principles of P. piscatorum, exhibiting a potency that is comparable to rotenone...
  16. ncbi request reprint Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects
    Stefan Raduner
    Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    J Biol Chem 281:14192-206. 2006
    ....
  17. ncbi request reprint Yucatec Mayan medicinal plants: evaluation based on indigenous uses
    Anita Ankli
    Department of Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Ethnopharmacol 79:43-52. 2002
    ..Based on this evaluation, plants with strong activities should be further investigated phytochemically and pharmacologically to identify active fractions and compounds...
  18. ncbi request reprint Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides
    Stefan Raduner
    Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    J Nat Prod 70:1010-5. 2007
    ..These findings have important implications for biological studies with this class of compounds...
  19. ncbi request reprint Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting
    Silvia Anthoine Dietrich
    Swiss Federal Institute of Technology ETH Zurich, Institute of Pharmaceutical Sciences, ETH Honggerberg, HCI H 405, CH 8093 Zurich
    Chimia (Aarau) 64:136-9. 2010
    ..The additional functional groups may be used to synthesize conjugates of epothilone derivatives with a variety of tumor-targeting moieties...
  20. doi request reprint Synthesis and biological activity of 7,8,9-trideoxy- and 7R desTHP-peloruside A
    Christoph W Wullschleger
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, HCI H405, Wolfgang Pauli Str 10, 8093 Zurich Switzerland, Fax 41 44 6331369
    Chemistry 19:13105-11. 2013
    ..The higher potency of 4 highlights the importance of the bicyclic core structure of peloruside A for nM biological activity. ..
  21. doi request reprint Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives
    Didier Zurwerra
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Zurich, Switzerland
    Chemistry 18:16868-83. 2012
    ..Oxidation of the aldehyde functionality of ent-2 gave a carboxylic acid that was converted into the corresponding N-hexyl amide. The latter showed only μM antiproliferative activity, thus being several hundred-fold less potent than 1...
  22. doi request reprint Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity
    Christian N Kuzniewski
    Swiss Federal Institute of Technology ETH Zurich, HCI H405, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
    Org Lett 10:1183-6. 2008
    ....
  23. doi request reprint Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A
    Bernhard Pfeiffer
    Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
    Bioorg Med Chem Lett 19:3760-3. 2009
    ..The most potent compounds showed comparable activity with the natural product epothilone A. Modeling studies provide a preliminary rationale for the observed SAR...
  24. ncbi request reprint Quinolizidine alkaloids from the curare adjuvant Clathrotropis glaucophylla
    Anne Lise Sagen
    Department of Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstr 190, CH 8057, Zurich, Switzerland
    Phytochemistry 61:975-8. 2002
    ..To our knowledge, this is the first time quinolizidine alkaloids have been isolated from an arrow poison ingredient. It is also the first report on Clathrotropis species being used for preparation of arrow poison...
  25. ncbi request reprint Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization
    Fabian Feyen
    Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology ETH Zurich, HCI H405, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Acc Chem Res 41:21-31. 2008
    ....
  26. doi request reprint Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants
    Raphael Schiess
    Swiss Federal Institute of Technology ETH Zürich, HCI H405, Wolfgang Pauli Str 10, CH 8093 Zürich, Switzerland
    Org Lett 13:1436-9. 2011
    ..Formation of the macrocycle was achieved through RCM-based ring closure and introduction of the cyclopropane moiety involved a highly selective Charette cyclopropanation of allylic alcohol 7...
  27. ncbi request reprint Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold
    Karl Heinz Altmann
    Swiss Federal Institute of Technology ETH Zürich Institute of Pharmaceutical Sciences, ETH Honggerberg, HCI H 405, CH 8093 Zurich
    Chimia (Aarau) 64:8-13. 2010
    ..The latter modification leads to aza-macrolides that may be described as 'non-natural natural products'...
  28. ncbi request reprint Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-type sesquiterpene lactones
    Fatima Hilmi
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstr 190, CH 8057, Zurich, Switzerland
    Bioorg Med Chem 11:3659-63. 2003
    ..0 (1) and 1.2 microM (4). Thus, the NF-kappaB inhibition measured by EMSA, as well as the IL-6 luciferase assay did not reflect the differential modulation of pro-inflammatory genes measured with RT-rt-PCR...
  29. doi request reprint Identification of serotonin 5-HT1A receptor partial agonists in ginger
    Andreas Nievergelt
    Department of Chemistry and Applied Biosciences, ETH 8093 Zurich, Switzerland
    Bioorg Med Chem 18:3345-51. 2010
    ..In addition, the intestinal absorption of gingerols and shogaols was simulated and their interactions with P-glycoprotein were measured, suggesting a favourable pharmacokinetic profile for the 5-HT(1A) active compounds...
  30. ncbi request reprint Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents
    Karl Heinz Altmann
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH, HCI H405, Wolfgang Pauli Str 10, CH 8093, Zurich, Switzerland
    Nat Prod Rep 24:327-57. 2007
    ..These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery...